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Engineering Cu^(+)/CeZrO_(x) interfaces to promote CO_(2) hydrogenation to methanol

Journal of Energy Chemistry 2023年第2期77卷 45-53,I0002页

作者： Jingpeng Zhang Xiaohang Sun Congyi Wu Wenquan Hang Xu Hu Dawei qiao Binhang Yan Department of Chemical Engineering Tsinghua UniversityBeijing 100084China School of Science China University of GeosciencesBeijing 10084China Jiangsu Huadian Jurong Power Station Co.LTD Zhenjiang 212000JiangsuChina

Cu-based catalysts are widely employed for CO_(2) hydrogenation to methanol,which is expected as a promising process to achieving carbon neutrality.However,most Cu-based catalysts still suffer from low methanol yield with a passable CO_(2) conversion and lack insight into its reaction mechanism for guiding the design of catalysts.In this work,Cu^(+)/CeZrO_(x) interfaces are engineered by employing a series of ceria-zirconia solid solution catalysts with various Ce/Zr ratios,forming a Cu^(+)-O_(v)-Ce^(3+)structure where Cu^(+)atoms are bonded to the oxygen vacancies(O_(v))of ceria.Compared to Cu/CeO_(2) and Cu/ZrO_(2),the optimized catalyst(i.e.,Cu_(0.3)Ce_(0.3)Zr_(0.7))exhibits a much higher mass-specific methanol formation rate(192g_(MeOH)/kg_(cat)/h)at 240℃and 3 MPa.Through a series of in-situ and ex-situ characterization,it is revealed that oxygen vacancies in solid solutions can effectively assist the activation of CO_(2) and tune the electronic state of copper to promote the formation of Cu^(+)/CeZrO_(x) interfaces,which stabilizes the key*CO intermediate,inhibits its desorption and facilitates its further hydrogenation to methanol via the reverse watergas-shift(RWGS)+CO-Hydro pathway.Therefore,the concentration of*CO or the apparent Cu^(+)/(Cu^(+)+Cu^(0))ratio could be employed as a quantitative descriptor of the methanol formation rate.This work is expected to give a deep insight into the mechanism of metal/support interfaces in CO_(2) hydrogenation to methanol,offering an effective strategy to develop new catalysts with high performance.

关键词： CO_(2)hydrogenation Methanol synthesis In-situ characterization Cu^(+)/CeZrO_(x)interfaces Oxygen vacancies

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Is there a great unconformity between Xiamaling and Longshan formations in the North China Craton?

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Science China Earth Sciences 2023年第5期66卷 959-984页

作者： Hongwei KUANG Nan PENG Yongqing LIU Yuchong WANG Mingming CUI Xiaoshuai CHEN Dawei qiao Keining QI Institute of Geology Chinese Academy of Geological SciencesBeijing100037China School of Earth Science and Mapping Engineering China University of Mining and Technology(Beijing)Beijing100083China School of Resource and Environmental Engineering Hefei University of TechnologyHefei230009China

The existence of a 0.3 Ga"great unconformity"between the Mesoproterozoic"Undefined System"Xiamaling Formation and the"Neoproterozoic"Longshan Formation has long been controversial.In this study,stratigraphy,sedimentology,detrital zircon dating,lithium isotope,and major and trace elements were applied to systematically analyze their relationship.Results demonstrate that coarse to fine sandstone-mudstone normal cycles with different grades and thicknesses exist from the Xiamaling to the Longshan formations.Sedimentary succession formed from a restricted platform with lagoon-shallow marine shelf-tidal flat-beach and tidal shoal developing in ascending order.The pebbly sandstone at the bottom of the Long shan Formation does not have the properties of basal conglomerate with tectonic significance.The youngest detrital zircon is older than 1.6 Ga for the Long shan Formation and overlying Jing'eryu Formation sandstones.In addition,no(zircon)provenance has been found from the large igneous province of 1.32-1.2 Ga in Xiamaling Formation.Theδ^(7)Li isotope values exhibit a gradually increasing trend.The Li content and CIA(Chemical index of alteration)gradually decreases from the top of the Xiamaling Formation to the lower part of the Long shan Formation.Simultaneously,as K_(2)O/Al_(2)O_(3)and FeO/Fe_(2)O_(3)decreases,Na_(2)O/Al_(2)O_(3)increases,and Li/Al,V/Cr,and V/(V+Ni)fluctuates slightly.At the boundary,the Ce/Ce^(*)and Eu/Eu^(*)show positive and negative anomalies,respectively.Further,the Rb/Sr and Al/Si values decrease,and U/Th values increase.This indicates that the geochemistry of the weathering crust at the interface of the Xiamaling Formation-Long shan Formation is not characteristic.However,it indicates a weakening of continental weathering intensity from the bottom to the top of the interface.These results do not support the existence of a large unconformity between the Xiamaling and the Longshan formations.Therefore,it is suggested that the Long shan Formation-Jing'eryu Formation should be moved to the lower l

关键词： North China Craton Mesoproterozoic Transition period Unconformity Continuous sedimentation

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Overlay CR-NOMA Assisted Intelligent Transportation System Networks with Imperfect SIC and CEEs

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Chinese Journal of Electronics 2023年第6期32卷 1258-1270页

作者： LI Xingwang GAO Xuesong LIU Yingting HUANG Gaojian ZENG Ming qiao dawei Physics and Electronic Information Engineering Henan Polytechnic University School of Electronic and Information Engineering Lanzhou Jiaotong University State Grid Gansu Electric Power Research Institute School of Electronic Engineering Beijing University of Posts and Telecommunications Department of Electrical and Computer Engineering Laval University School of Emergency Management Henan Polytechnic University

With the development of the mobile communication and intelligent information technologies,the intelligent transportation systems driven by the sixth generation(6G) has many opportunities to achieve ultralow latency and higher data transmission rate. Nonetheless, it also faces the great challenges of spectral resource shortage and large-scale connection. To solve the above problems, non-orthogonal multiple access(NOMA) and cognitive radio(CR) technologies have been proposed. In this regard, we study the reliable and ergodic performance of CR-NOMA assisted intelligent transportation system networks in the presence of imperfect successive interference cancellation(SIC) and non-ideal channel state information. Specifically, the analytical expressions of the outage probability(OP) and ergodic sum rate(ESR) are derived through a string of calculations. In order to gain more insights, the asymptotic expressions for OP and ESR at high signal-to-noise ratio(SNR) regimes are discussed. We verify the accuracy of the analysis by Monte Carlo simulations, and the results show: i) Imperfect SIC and channel estimation errors(CEEs) have negative impacts on the OP and ESR; ii) The OP decreases with the SNR increasing until convergence to a fixed constant at high SNR regions; iii) The ESR increases with increasing SNR and there exists a ceiling in the high SNR region.

关键词： Cognitive radio network Ergodic rate Imperfect successive interference cancellation Non-orthogonal multiple access Outage probability

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Pitx2 suppression at meiotic stages associates with seasonal inhibition of testis development in Rattus norvegicus caraco

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Integrative Zoology 2023年第3期18卷 543-551页

作者： Lin TIAN Xixuan LI Yaqi YING Lewen WANG Yanting qiao dawei WANG Ying SONG Ning LI Xiaohui LIU State Key Laboratory for Biology of Plant Diseases and Insect Pests Key Laboratory of Weed and Rodent Biology and ManagementInstitute of Plant ProtectionChinese Academy of Agricultural SciencesBeijingChina

The bicoid-related transcription factor 2(Pitx2)plays a crucial role in the development of many organs and tissues by affecting the mitotic cell cycle.Postnatal testis development is related to mitosis and meiosis in mul-tiple cell types,but the role of Pitx2 gene in seasonal inhibition of testicular development remains unknown in rodents.We analyzed PITX2 protein and Pitx2 mRNA expression features using both laboratory and wild male Rattus norvegicus caraco.In postnatal testicle of laboratory colony,we found that PITX2 was expressed in Leydig cells,pachytene spermatocytes,round spermatids,and elongating spermatids rather than spermatogonia and lep-totene/zygotene spermatocytes.Pitx2b expression signiﬁcantly increased along with the occurrence of pachytene spermatocytes and round spermatids,while decreased along with the processes of elongated spermatids.In wild male rats with similar testes weight,a signiﬁcantly suppressed Pitx2b expression occurred with an active meiotic stage in the inhibited testes in autumn and winter,compared with the normally developing testes in spring and summer.These results indicate that Pitx2b expression suppression plays a crucial role in the seasonal inhibition of testis development.

关键词： Pitx2 postnatal testis development Rattus norvegicus seasonal inhibition

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Overlay Cognitive Radio-assisted NOMA Intelligent Transportation Systems with Imperfect SIC and CEEs

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Chinese Journal of Electronics 2023年

作者： LI Xingwang GAO Xuesong LIU Yingting HUANG Gaojian ZENG Ming qiao dawei School of Electronic Engineering Beijing University of Posts and Telecommunications State Grid Gansu Electric Power Research Institute Department of Electrical and Computer Engineering Laval University School of Computer Science and Engineering Northwest Normal University Physics and Electronic Information Engineering Henan Polytechnic University School of Emergency Management Henan Polytechnic University

With the development of the mobile communication and intelligent information technologies,the intelligent transportation systems(ITS) driven by the sixth generation(6G) has many opportunities to achieve ultra-low latency and higher data transmission rate. Nonetheless, it also faces the great challenges of spectral resource shortage and large-scale connection. To solve the above problems, non-orthogonal multiple access(NOMA)and cognitive radio(CR) technologies have been proposed. In this regard, we study the reliable and ergodic performance of CR-NOMA assisted ITS networks in the presence of imperfect successive interference cancellation(ip SIC) and non-ideal channel state information(CSI).Specifically, the analytical expressions of the outage probability(OP) and ergodic sum rate(ESR) are derived through a string of calculations. In order to gain more insights, the asymptotic expressions for OP and ESR at high signal-to-noise ratio(SNR) regimes are discussed.We verify the accuracy of the analysis by Monte Carlo simulations, and the results show: i) ipSIC and channel estimation errors(CEEs) have negative impacts on the OP and ESR; ii) The OP decreases with the SNR increasing until convergence to a fixed constant at high SNR regions; iii) The ESR increases with increasing SNR and there exists a ceiling in the high SNR region.

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Combining immune checkpoint blockade with ATP-based immunogenic cell death amplifier for cancer chemo-immunotherapy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3694-3709页

作者： Jiulong Zhang Xiaoyan Sun Xiufeng Zhao Chunrong Yang Menghao Shi Benzhuo Zhang Haiyang Hu Mingxi qiao dawei Chen Xiuli Zhao School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China Department of Oncology Affiliated Hongqi Hospital of Mudanjiang Medical CollegeMudanjiang 157011China Department of Pharmacy Shantou University Medical CollegeShantou 515041China Department of Neurology The Second Affiliated Hospital of Mudanjiang Medical CollegeMudanjiang 157009China

Amplifying“eat me signal”during tumor immunogenic cell death(ICD)cascade is crucial for tumor immunotherapy.Inspired by the indispensable role of adenosine triphosphate(ATP,a necessary“eat me signal”for ICD),a versatile ICD amplifier was developed for chemotherapy-sensitized immunotherapy.Doxorubicin(DOX),ATP and ferrous ions(Fe^(2+))were co-assembled into nanosized amplifier(ADO-Fe)throughπ‒πstacking and coordination effect.Meanwhile,phenylboric acid-polyethylene glycol-phenylboric acid(PBA-PEG-PBA)was modified on the surface of ADO-Fe(denoted as PADO-Fe)by the virtue of d-ribose unit of ATP.PADO-Fe could display active targetability against tumor cells via sialic acid/PBA interaction.In acidic microenvironment,PBA-PEG-PBA would dissociate from amplifier.Moreover,high H_(2)O_(2)concentration would induce hydroxyl radical(·OH)and oxygen(O_(2))generation through Fenton reaction by Fe^(2+).DOX and ATP would be released from the amplifier,which could induce ICD effect and“ICD adjuvant”to amplify this process.Together with programmed death ligands 1(PD-L1)checkpoint blockade immunotherapy,PADO-Fe could not only activate immune response against primary tumor,but also strong abscopal effect against distant tumor.Our simple and multifunctional ICD amplifier opens a new window for enhancing ICD effect and immune checkpoint blockade therapy.

关键词： Immunogenic cell death amplifier ATP Fenton reaction Immune checkpoint blockade Coordination polymer nanoparticles pH/ROS sensitive Phenylboric acid

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Advanced industrial informatics towards smart,safe and sustainable roads:A state of the art

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第2期10卷 143-158页

作者： Hui Yao Zijin Xu Yue Hou qiao Dong Pengfei Liu Zhoujing Ye Xin Pei Markus Oeser Linbing Wang dawei Wang Beijing Key Laboratory of Transportation Engineering Faculty of ArchitectureCivil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China Department of Civil Engineering Swansea UniversitySwansea SA28PPUK School of Transportation Southeast UniversityNanjing 211189China Institute of Highway Engineering RWTH Aachen UniversityAachen D52074Germany National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China Department of Automation Tsinghua UniversityBeijing 100084China School of Environmental CivilAgricultural and Mechanical EngineeringUniversity of GeorgiaAthensGA 30602USA School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150006China

The road is one of the most important civil infrastructures for serving society,where its service quality and life have direct impacts on the safety and comfort of users.Therefore,road construction,condition detection and monitoring,and timely maintenance are particularly important for engineers.Many engineering applications of industrial informatics approaches,like image processing technology,widely used computer-based algorithms,and advanced sensors,have been initially and gradually applied to roads.This state-of-the-art review first summarized the research on industrial applications of advanced information technologies in recent years,while analyzing and comparing the advantages and disadvantages of each technology.Especially,five topics were focused on road construction,road maintenance with decision strategy,road structure evaluation,smart sensing in the road,and cooperative vehicle infrastructure system.It is expected that advanced industrial informatics can help engineers promote the development of smart,safe,and sustainable roads.

关键词： Advanced industrial informatics Road construction Road maintenance Decision strategy Pavement structure and material Smart sensing Cooperative vehicle infrastructure system

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Preparation and evaluation of poly(L-histidine) based pH-sensitive micelles for intracellular delivery of doxorubicin against MCF-7/ADR cells

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Asian Journal of Pharmaceutical Sciences 2017年第5期12卷 433-441页

作者： Nan Jia Yuqing Ye Qi Wang Xiuli Zhao Haiyang Hu dawei Chen Mingxi qiao Department of Pharmaceutics School of Pharmacy Shenyang Pharmaceutical University

In this study, a p H-sensitive micelle self-assembled from poly(L-histidine) based triblock copolymers of poly(ethylene glycol)–poly(D,L-lactide)–poly(L-histidine)(mPEG-PLA-PHis) was prepared and used as the intracellular doxorubicin(Dox) delivery for cancer chemotherapy. Dox was loaded into the micelles by thin-film hydration method and a Box–Behnken design for three factors at three levels was used to optimize the preparations. The optimized mPEG-PLA-Phis/Dox micelles exhibited good encapsulation efficiency of 91.12%,a mean diameter of 45 nm and narrow size distribution with polydispersity index of 0.256.In vitro drug release studies demonstrated that Dox was released from the micelles in a p Hdependent manner. Furthermore, the cellular evaluation of Dox loaded micelles displayed that the micelles possessed high antitumor activity in vitro with an IC50 of 35.30 μg/ml against MCF-7/ADR cells. The confocal microscopy and flow cytometry experiments indicated that m PEG-PLA-Phis micelles mediated efficient cytoplasmic delivery of Dox with the aid of poly(Lhistidine) mediated endosomal escape. In addition, blank m PEG-PLA-Phis micelles were shown to be nontoxic to MCF-7/ADR cells even at a high concentration of 200 μg/ml. The pHsensitive mPEG-PLA-PHis micelles have been demonstrated to be a promising nanosystem for the intracellular delivery of Dox for MDR reversal.

关键词： Doxorubicin(Dox) mPEG-PLA-Phis pH sensitive micelles Box–Behnken design

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Co-delivery of resveratrol and docetaxel via polymeric micelles to improve the treatment of drug-resistant tumors

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 78-85页

作者： Xiong Guo Zhiyue Zhao dawei Chen Mingxi qiao Feng Wan Dongmei Cun Yi Sun Mingshi Yang Wuya College of Innovation Shenyang Pharmaceutical UniversityWenhua Road No.103Shenyang 110016China School of Graduate Liaoning University of Traditional Chinese MedicineChong Shan Road No.79Shenyang 110847China School of Pharmacy Shenyang Pharmaceutical UniversityWenhua Road No.103Shenyang 110016China Department of Pharmacy Faculty of Health and Medical SciencesUniversity of CopenhagenUniversitetsparken 2DK-2100 Copenhagen ODenmark Department of Micro-and Nanotechnology Technical University of Denmarkφsteds PladsKgs.Lyngby 2800Denmark

Co-delivery of anti-cancer drugs is promising to improve the efficacy of cancer treatment.This study was aiming to investigate the potential of concurrent delivery of resveratrol(RES)and docetaxel(DTX)via polymeric nanocarriers to treat breast cancer.To this end,methoxyl poly(ethylene glycol)-poly(D,L-lactide)copolymer(mPEG-PDLA)was prepared and characterized using FTIR and 1H NMR,and their molecular weights were determined by GPC.Isobologram analysis and combination index calculation were performed to find the optimal ratio between RES and DTX to against human breast adenocarcinoma cell line(MCF-7 cells).Subsequently,RES and DTX were loaded in the mPEG-PDLA micelles simultaneously,and the morphology,particle size distribution,in vitro release,pharmacokinetic profiles,as well as cytotoxicity to the MCF-7 cells were characterized.IC50 of RES and DTX in MCF-7 cells were determined to be 23.0μg/ml and 10.4μg/ml,respectively,while a lower IC50 of 4.8μg/ml of the combination of RES and DTX was obtained.The combination of RES and DTX at a ratio of 1:1(w/w)generated stronger synergistic effect than other ratios in the MCF-7 cells.RES and DTX loaded mPEG-PDLA micelles exhibited prolonged release profiles,and enhanced cytotoxicity in vitro against MCF-7 cells.The AUC(0→t)of DTX and RES in mPEG-PDLA micelles after i.***.administration to rats were 3.0-fold and 1.6-fold higher than that of i.***.injections of the individual drugs.These findings indicated that the co-delivery of RES and DTX using mPEG-PDLA micelles could have better treatment of tumors.

关键词： Resveratrol Docetaxel Methoxyl poly(ethylene glycol)-poly(d,l-lactide)copolymer (mPEG-PDLA) Micelles Drug resistance tumor

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Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 655-661页

作者： Chun Chu Ping Xu Haoyue Zhao Qing Chen dawei Chen Haiyang Hu Xiuli Zhao Mingxi qiao Shenyang Pharmaceutical University

Various biotin-modified liposomes incorporated with docetaxel(DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome(PDL), 0.5%(mol) biotin modified liposome(0.5 BDL), 1%(mol) biotin modified liposome(1 BDL) and 2%(mol) biotin modified liposome(2 BDL) were prepared using thin film dispersion method. The prepared liposomes were characterized by measuring encapsulation efficiency(EE), particle size, Zeta-potential, physical stability and drug release profiles in vitro. MTT assay was performed to elevate the cytotoxicity of liposomes on MCF-7 cells. In vivo evaluation was further performed to investigate the effect of biotin surface density on the pharmacokinetic profiles. All the prepared liposomes exhibited high encapsulation efficiency, small particle size, narrow particle distribution and sustained release profiles in vitro. In MTT assay, 0.5 BDL showed largest tumor cell toxicity, compared with DTX solution. All liposomes containing DTX showed prolonged blood circulation in vivo, and 0.5 BDL showed the longest circulation time among the biotin modified liposome. Surface modification of liposome had a negative impact on the circulation of liposomes in the blood, which needs to be considered when designing the ligand mediated targeting delivery systems. A proper amount of biotin liposome with 0.5% molar ratio is expected to produce the best anti-tumor effect.

关键词： Docetaxel Liposomes Biotin Ligand density Tumor targeting

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