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输尿管软镜下钬激光碎石术应用于肾结石患者治疗的临床效果及对睡眠质量的影响

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世界睡眠医学杂志 2021年第10期8卷 1699-1700页

作者：陈科黄保成卢强徐波颜鹏吴飞饶大伟谷城县人民医院谷城441700

目的:分析输尿管软镜下钬激光碎石术治疗肾结石的疗效及对睡眠质量的影响。方法:选取2019年1月至2019年12月谷城县人民医院收治的肾结石患者100例作为研究对象,随机分成观察组和对照组,每组50例。观察组患者采用输尿管软镜下钬激光碎石... 详细信息

目的:分析输尿管软镜下钬激光碎石术治疗肾结石的疗效及对睡眠质量的影响。方法:选取2019年1月至2019年12月谷城县人民医院收治的肾结石患者100例作为研究对象,随机分成观察组和对照组,每组50例。观察组患者采用输尿管软镜下钬激光碎石术治疗,对照组患者采用经皮肾镜碎石取石术治疗,比较2组的治疗效果。结果:观察组患者人均碎石次数、结石排净时间、住院时间均明显少于对照组,匹兹堡睡眠质量指数(PSQI)各项评分、不良反应发生率均低于对照组,差异均有统计学意义(均P<0.05)。结论:输尿管软镜下钬激光碎石术在肾结石患者的临床治疗中效果显著,不仅可以减少患者排石次数,改善一次性排尽效果,还可以改善患者的睡眠质量,值得推广应用。

关键词：输尿管软镜下钬激光碎石术肾结石睡眠质量疗效

Precise Regulation of Ga-Based Liquid Metal Oxidation

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Accounts of Materials Research 2021年第11期2卷 1093-1103页

作者： dawei Wang Xiaohong Wang Wei rao Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

CONSPECTUS:Liquid metals,defined as metals or alloys with melting points below or near room temperature,can be regarded as an amorphous solid without any crystallinity in the molten state,exhibiting fundamentally different fluidities and metallicities from solid metals and other *** the past decade,gallium as a typical representative liquid metal with a melting point of∼29.8°C,virtually nonexistent vapor pressure,and negligible toxicity has been proposed as a base material for the construction of gallium(Ga)-based liquid metals(LMs).This class of extraordinary materials with unique physicochemical properties,such as superb thermal and electrical conductivity,fluidity,shape transformability,self-healing capability and biocompatibility,biodegradability,catalytic properties,plasmonic effect,and facile functionalization accessibility,has attracted considerable attention in widespread ***,under the action of ambient oxygen and water,the ultrathin oxide layers will be formed at the LM−ambient environment interface,which may provide a physical,chemical,and electrical barrier to prevent the LMs from further *** introduction of excitations,such as electrical,chemical,electrochemical,mechanical,and ultrasonic,and the alteration of reaction conditions including ingredients,temperature,and time will promote oxide ***,the existence of oxides is a double-edged sword,sometimes considered as a nuisance because of the deterioration of performance and stability;for example,the oxides will adhere to the system,which brings problems for fluidic applications(such as heat-transfer media,pump media,and microfluidity).Conversely,in some cases,oxides are considered essential to improve functionality,such as shape transformation,substrate adhesion,intracellular uptake,*** this reason,the main aim of oxidation regulation is to alter the fundamental physicochemical properties or even endow distinct and fascinating properties for the LMs,the

关键词： oxides ambient Liquid

A New-Nipponbare Rice Germplasm with High Seed-Setting Rate

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Journal of Genetics and Genomics 2014年第10期41卷 549-552页

作者： Jiang Hu Guojun Dong Yunxia Fang Yuchun rao Jie Xu dawei Xue Haiping Yu Changwei Ge Zhenyuan Shi Jiangjie Pan Li Zhu Dali Zeng Guangheng Zhang Longbiao Guo Qian Qian State Key Laboratory of Rice Biology China National Rice Research Institute College of Chemistry and Life Sciences Zhejiang Normal University College of Life and Environment Sciences Hangzhou Normal University

Rice （Oryza sativa L.） is an important crop providing staple food for more than half the world＇s population and also considered as a model plant for molecular biological study of the cereals. In 1998, the large-scale sequencing of japonica rice cultivar Nipponbare （bred at Aichi Agricultural Center in Japan and released in 1963） was initiated by International Rice Genome Sequencing Project （IRGSP） and the high-quality draft of genome was announced in 2002 （Goff et al,, 2002）. Owing to its easy genetic transformation and released whole genome sequencing data, Nipponbare is widely used in functional genomic research （Piffanelli et al., 2007; Luan et al., 2008; Hu et al., 2010; Thang et al., 2010; Tabuchi et al., 2011; Zhang et al., 2011; Jiang et al., 2012; Lu et al.. 2013）.

关键词： length In more A New-Nipponbare Rice Germplasm with High Seed-Setting Rate than

Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling

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Bioactive Materials 2023年第7期25卷 472-484页

作者： Runci Wang Meng Hao Xiaoxing Kou Bingdong Sui Maria Laura Sanmillan Xiao Zhang dawei Liu Jun Tian Wenjing Yu Chider Chen Ruili Yang Lingyun Sun Yi Liu Claudio Giraudo Deepak A.rao Nan Shen Songtao Shi Shanghai Institute of Rheumatology/Department of Rheumatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai200002China Department of Anatomy and Cell Biology School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPA19104USA Department of Rheumatology and Immunology West China HospitalSichuan UniversityChengduSichuan610000China Division of Rheumatology Inflammation and ImmunityBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA02105USA South China Center of Craniofacial Stem Cell Research Hospital of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhouGuangdong510080China Department of Microbiology and Immunology Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPA19107USA Department of Rheumatology and Immunology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjingJiangsu210008China

Mesenchymal stem cells(MSCs)influence T cells in health,disease and therapy through messengers of intercellular communication including extracellular vesicles(EVs).Apoptosis is a mode of cell death that tends to promote immune tolerance,and a large number of apoptotic vesicles(apoVs)are generated from MSCs during *** an effort to characterize these apoVs and explore their immunomodulatory potential,here we show that after replenishing them systemically,the apoV deficiency in Fas mutant mice and pathological lymphoproliferation were rescued,leading to the amelioration of inflammation and lupus *** directly interacted with CD4^(+)T cells and inhibited CD25 expression and IL-2 production in a dose-dependent manner.A broad range of Th1/2/17 subsets and cytokines including IFNγ,IL17A and IL-10 were suppressed while Foxp3^(+)cells were ***,exposed phosphatidylserine(PtdSer/PS)on apoVs mediated the interaction with T cells to disrupt proximal T cell receptor signaling ***,administration of apoVs prevented Th17 differentiation and memory formation,and ameliorated inflammation and joint erosion in murine ***,our findings unveil a previously unrecognized crosstalk between MSC apoVs and CD4^(+)T cells and suggest a promising therapeutic use of apoVs for autoimmune diseases.

关键词： Autoimmunity T cell MSC Apoptosis Extracellular vesicles

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332

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Protein & Cell 2022年第9期13卷 689-693页

作者： Yao Zhao Chao Fang Qi Zhang Ruxue Zhang Xiangbo Zhao Yinkai Duan Haofeng Wang Yan Zhu Lu Feng Jinyi Zhao Maolin Shao Xiuna Yang Leike Zhang Chao Peng Kailin Yang dawei Ma Zihe rao Haitao Yang Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Bioorganic&Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell BiologyChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China National Facility for Protein Science in Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Taussig Cancer Center Cleveland ClinicClevelandOH 44195USA Laboratory of Structural Biology School of Life Sciences and School of MedicineTsinghua UniversityBeijing 100091China State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell ResponseCollege of Life SciencesNankai Universityand Tianjin Key Laboratory of Protein SciencesTianjin 300071China

Dear Editor,Since December 2019,the pandemic of coronavirus disease 2019(COVID-19)has taken a heavy toll on global health,creating an urgent need to develop effective strategies for prevention and *** etiological agent,known as severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected nearly 229.2 million people worldwide with more than 4.7 million deaths as of September 15,*** age and preexisting health conditions are associated with worse clinical prognosis including higher mortality rates(Zhou et al.,2020).The global race to combat this pandemic has led to rapid deployment of numerous effective vaccines against SARS-CoV-2(Tregoning et al.,2021).However,the emergence of viral variants,including the Delta variant(B.1.617.2),compromised vaccine effectiveness with resurgence of SARS-CoV-2 infection among highly vaccinated population(Keehner et al.,2021).Therefore,development of therapeutics against the more conserved viral targets would be essential to contain the spread of COVID-19 and reduce mortality.

关键词： mortality prevention Crystal

护理高职生对基础护理学课程闯关式考核的体验

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中华护理教育 2023年第11期20卷 1319-1324页

作者：饶艳江大为申雨鑫饶和平衢州职业技术学院医学院浙江省衢州市324000

目的了解护理高职生对基础护理学课程中实施闯关式考核体验,为完善闯关式考核提供依据。方法在高职基础护理学课程中实施闯关式考核,并从中选取13名学生进行半结构式访谈法,运用Colaizzi 7步分析法对资料进行整理分析,提炼主题。结果共... 详细信息

目的了解护理高职生对基础护理学课程中实施闯关式考核体验,为完善闯关式考核提供依据。方法在高职基础护理学课程中实施闯关式考核,并从中选取13名学生进行半结构式访谈法,运用Colaizzi 7步分析法对资料进行整理分析,提炼主题。结果共提炼出闯关式考核的积极体验(促进自我关怀、获得精准指导、提升学习成就感、增进师生和同伴互动、建立临床思维)、闯关式考核带来的挑战和对闯关式考核的期望(对闯关小组的期望、对自身和教师的期望)3个主题。结论闯关式考核起到了以考促学的作用,学生的认可度高,并对组建闯关小组、教师支持等方面提出了更高的要求。

关键词：护理高职生闯关式考核质性研究基础护理学学习成就感

脑卒中后发生急性肾损伤风险预测模型的构建及验证

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中国全科医学 2022年第23期25卷 2885-2891页

作者：饶艳姚梅琪江大为毛翠衢州职业技术学院医学院浙江省衢州市324000 浙江大学医学院附属第二医院护理部浙江省杭州市310009

背景急性肾损伤(AKI)是脑卒中患者常见的严重并发症之一,与患者不良的短期和长期预后密切相关,因此需要探索特异性的AKI筛查工具,以便早期识别AKI的高危人群。目的构建并验证脑卒中后发生AKI风险预测模型,并编制简易风险评分量表。方法... 详细信息

背景急性肾损伤(AKI)是脑卒中患者常见的严重并发症之一,与患者不良的短期和长期预后密切相关,因此需要探索特异性的AKI筛查工具,以便早期识别AKI的高危人群。目的构建并验证脑卒中后发生AKI风险预测模型,并编制简易风险评分量表。方法采用便利抽样法选取2021年1—9月在浙江大学医学院附属第二医院神经内科住院治疗且病历资料完整的760例脑卒中患者为建模组,根据是否发生AKI将其分为AKI亚组和非AKI亚组。采用多因素Logistic回归分析进行影响因素分析,并构建脑卒中后发生AKI风险预测模型,采用HosmerLemeshow和受试者工作特征曲线(ROC曲线)检验模型的拟合优度及预测效果。采用便利抽样法选取2021年10—12月在本院治疗的脑卒中患者310例作为模型外部验证组,其中AKI者53例、非AKI者257例。将预测模型在验证组人群进行验证,并编制脑卒中后发生AKI简易风险评分量表。结果建模组760例脑卒中患者中发生AKI 140例,AKI发生率为18.42%。多因素Logistic回归分析结果显示,性别、高血压史、美国国立卫生研究院脑卒中量表(NIHSS)评分、袢利尿剂用药史、机械取栓史、血清β_(2)微球蛋白(β_(2)-MG)、尿素氮、血清胱抑素C(sCysC)是脑卒中后发生AKI的独立影响因素(P<0.05)。构建脑卒中后发生AKI风险预测模型:y=1/(1+e^(-a)),其中a=-4.047+1.222×男性+1.386×高血压史+1.716×NIHSS评分+1.098×袢利尿剂用药史+0.830×机械取栓史+1.739×β_(2)-MG+1.202×尿素氮+2.160×sCysC。Hosmer-Lemeshow检验预测模型拟合效果,χ^(2)=6.523,P=0.367。脑卒中后发生AKI风险预测模型在建模组中预测脑卒中患者发生AKI的ROC曲线下面积(AUC)为0.916〔95%CI(0.891,0.940)〕,最佳截断值为12.8%,灵敏度为0.857,特异度为0.832,约登指数为0.689。脑卒中后发生AKI风险预测模型在验证组中预测脑卒中患者发生AKI的AUC为0.906〔95%CI(0.853,0.960)〕。结合多因素Logistic回归分析结果得出的变量的系数四舍五入到最近整数,赋分后编制量表,最终建立了总分值为11分、截断值为4分、AUC为0.900〔95%CI(0.843,0.957),P<0.001〕的脑卒中后发生AKI简易风险评分量表,实际应用的正确率为88.39%。结论本研究构建的脑卒中后发生AKI风险预测模型可以有效地预测脑卒中后AKI发生风险,灵敏度、特异度较高,且据此编制的脑卒中后发生AKI简易风险评分量表为临床提供了一种简便可行的客观、量化高危患者的评估工具,为医护人员早期及时对不同AKI发生风险的脑卒中患者采取预防性治疗提供借鉴。

关键词：卒中急性肾损伤风险预测模型评估工具筛查预测影响因素分析

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基于商业模式反馈系统的视频网站商业模式分析——Netflix与爱奇艺案例研究

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管理评论 2017年第2期29卷 245-254页

作者：饶佳艺徐大为乔晗汪寿阳中国科学院大学经济与管理学院北京100190 中国科学院大学中丹学院北京100190 国家外汇管理局中央外汇业务中心北京100032 中国科学院数学与系统科学研究院北京100190

随着互联网的快速普及,网络视频行业的生态格局发生了深刻变化。本文提出商业模式反馈系统,包括由价值主张、业务系统和盈利模式构成的商业模式显性知识,以及由关键资源能力与外部环境构成的商业模式隐性知识。运用此模型,本文对视频网... 详细信息

随着互联网的快速普及,网络视频行业的生态格局发生了深刻变化。本文提出商业模式反馈系统,包括由价值主张、业务系统和盈利模式构成的商业模式显性知识,以及由关键资源能力与外部环境构成的商业模式隐性知识。运用此模型,本文对视频网站行业具有代表性的领军者Netflix与爱奇艺的商业模式进行了系统分析与深入比较,发现商业模式显性知识与隐性知识间存在反馈作用,并对企业商业模式和网络视频行业发展提出了相应的启示与建议。

关键词：商业模式商业模式反馈系统视频网站商业模式冰山理论

内禀自同步虚拟同步发电机对系统低频振荡特性的影响

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太阳能学报 2021年第12期42卷 410-418页

作者：王倩孙大卫盛四清张饶刘辉巩宇华北电力大学电气与电子工程学院保定071003 国网冀北电力科学研究院(华北电力科学研究院有限责任公司) 北京100045 三峡大学电气与新能源学院宜昌443002

首先建立同步发电机(SG)和虚拟同步发电机(VSG)的小信号模型,基于相同的控制理论,分析SG和VSG的调频能力与惯量水平对系统低频振荡模态的影响,对比SG和VSG对低频振荡特性产生影响的差别,并研究产生差别的原因。研究结果表明,VSG的虚拟... 详细信息

首先建立同步发电机(SG)和虚拟同步发电机(VSG)的小信号模型,基于相同的控制理论,分析SG和VSG的调频能力与惯量水平对系统低频振荡模态的影响,对比SG和VSG对低频振荡特性产生影响的差别,并研究产生差别的原因。研究结果表明,VSG的虚拟阻抗控制环节是使VSG与SG低频振荡特性不一致的关键因素,当虚拟阻抗较小时,VSG对低频振荡模态的影响与SG类似。

关键词：虚拟同步发电机低频振荡小信号模型虚拟阻抗