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Nanocellulose-based porous materials: Regulation and pathway to commercialization in regenerative medicine

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Bioactive Materials 2023年第11期29卷 151-176页

作者： Filipe V.Ferreira Alana G.souza Rubina Ajdary Lucas P.de souza Jo˜ao h.Lopes Daniel S.Correa Gilberto Siqueira hernane S.Barud Derval dos S.Rosa Luiz h.C.Mattoso Orlando J.Rojas Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa Instrumentation-Rua XV de Novembro1452S˜ao CarlosSP13560-979Brazil Center for Engineering Modelingand Applied Social Sciences(CECS)Federal University of ABC(UFABC)Santo Andr´eBrazil Department of Bioproducts and Biosystems School of Chemical EngineeringAalto UniversityP.O.Box 16300AaltoEspooFIN-00076Finland College of Engineering and Physical Sciences Aston Institute of Materials ResearchAston UniversityBirminghamUK Department of Chemistry Division of Fundamental Sciences(IEF)Technological Institute of Aeronautics(ITA)S˜ao Jose dos CamposSPBrazil Laboratory for Cellulose&Wood Materials Empa-Swiss Federal Laboratories for Materials Science and TechnologyÜberlandstrasse 1298600DübendorfSwitzerland Biopolymers and Biomaterials Laboratory(BIOPOLMAT) University of Araraquara(UNIARA)Araraquar114801-340S˜ao PauloBrazil Bioproducts Institute Department of Chemical&Biological EngineeringDepartment of Chemistry andDepartment of Wood ScienceThe University of British Columbi12360 East MallVancouverBCV6T 1Z3Canada

We review the recent progress that have led to the development of porous materials based on cellulose nanostructures found in plants and other resources. In light of the properties that emerge from the chemistry, shape and structural control, we discuss some of the most promising uses of a plant-based material, nanocellulose, in regenerative medicine. Following a brief discussion about the fundamental aspects of self-assembly of nanocellulose precursors, we review the key strategies needed for material synthesis and to adjust the architecture of the materials (using three-dimensional printing, freeze-casted porous materials, and electrospinning) according to their uses in tissue engineering, artificial organs, controlled drug delivery and wound healing systems, among others. For this purpose, we map the structure-property-function relationships of nanocellulose-based porous materials and examine the course of actions that are required to translate innovation from the laboratory to industry. Such efforts require attention to regulatory aspects and market pull. Finally, the key challenges and opportunities in this nascent field are critically reviewed.

关键词： Cellulose nanofibrils Cellulose nanocrystals Regenerative medicine Biomaterial Sustainable materials Green nanomaterials

Synthetic biology identifies the minimal gene set required for paclitaxel biosynthesis in a plant chassis

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Molecular Plant 2023年第12期16卷 1951-1961页

作者： Youjun Zhang Lorenz Wiese hao Fang Saleh Alseekh Leonardo Perez de souza Federico Scossa John Molloy Mathias Christmann Alisdair R.Fernie Max-Planck-Institut fur Molekulare Pflanzenphysiologie Am Muhlenberg 114476 Potsdam-GolmGermany Center of Plant Systems Biology and Biotechnology 4000 PlovdivBulgaria Institute of Chemistry and Biochemistry Freie Universitat BerlinTakustraBe 314195 BerlinGermany Department of Biomolecular Systems Max Planck Institute of Colloids and Interfaces14476 PotsdamGermany Research Center for Genomics and Bioinformatics(CREA-GB) Via Ardeatina 54600178 RomeItaly

The diterpenoid paclitaxel(Taxol)is a chemotherapy medication widely used as a first-line treatment against several types of solid *** supply of paclitaxel from natural sources is ***,missing knowledge about the genes involved in several specific metabolic steps of paclitaxel biosynthesis has rendered it difficult to engineer the full *** this study,we used a combination of transcriptomics,cell biology,metabolomics,and pathway reconstitution to identify the complete gene set required for the heterologous production of *** identified the missing steps from the current model of paclitaxel biosynthesis and confirmed the activity of most of the missing enzymes via heterologous expression in Nicotiana ***,we identified a new C4β-C20 epoxidase that could overcome the first bottleneck of metabolic *** used both previously characterized and newly identified oxomutases/epoxidases,taxane 1β-hydroxylase,taxane 9aα-hydroxylase,taxane 9α-dioxygenase,and phenylalanine-CoA ligase,to successfully biosynthesize the key intermediate baccatin Ill and to convert baccatin Ill into paclitaxel in *** combination,these approaches establisha metabolic route to taxoidbiosynthesis and provide insights into the unique chemistry that plants use to generate complex bioactive metabolites.

关键词： paclitaxel biosynthesis synthetic biology baccatin Ill biosynthesis Taxus

The corpus cavernosum after treatment with dutasteride or finasteride： a histomorphometric study in a benign prostatic hyperplasia rodent model

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Asian Journal of Andrology 2018年第5期20卷 505-510页

作者： Marcello h A Da Silva Waldemar S Costa Francisco J B Sampaio Diogo B De souza Urogenital Research Unit Rio de Janeiro State University Rio de Janeiro RJ 20551-030 Brazil

Erectile dysfunction is a common side effect of finasteride and dutasteride treatments. The objective of this study was to investigate the structural changes in the penis using a benign prostatic hyperplasia （BPh） rodent model treated with dutasteride or finasteride. Sixty male rats were divided into the following groups： C, untreated control rats; C ＋ D, control rats receiving dutasteride; C ＋ F, control rats receiving finasteride; h, untreated spontaneously hypertensive rats （ShRs）; h ＋ D, ShRs treated with dutasteride; and h ＋ F, ShRs treated with finasteride. Treatments were performed for 40 days, and penises were collected immediately thereafter. The organs were analyzed using histomorphometric methods to determine the cross-sectional penile area, as well as the surface density （Sv） of smooth muscle fibers, connective tissue, elastic system fibers, and sinusoidal spaces of the corpus cavernosum. The results were compared using a one-way ANOVA with Bonferroni＇s posttest. Groups C ＋ D and C ＋ F had a significantly smaller penile cross-sectional area, but more elastic system fiber Sv compared to Group C. Group C ＋ D showed less smooth muscle Sv, and Group h showed more connective tissue but a smaller sinusoidal space Sv in the corpus cavernosum compared to Group C. Groups h ＋ D and h ＋ F had less smooth muscle Sv than Group h. Group h ＋ D also had more connective tissue and elastic system fiber Sv than Group h. Both dutasteride and finasteride promoted penile modifications in the control rat penis, although this affect was ~reater in Group h animals. In this rodent model, dutasteride was the drug that most affected the corpus cavernosum.

关键词： animal models benign prostatic hyperplasia dutasteride erectile dysfunction finasteride penis

Existence and Multiplicity Results for a Class of Nonlinear Schrödinger Equations with Magnetic Potential Involving Sign-Changing Nonlinearity

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Analysis in Theory and Applications 2022年第2期38卷 148-177页

作者： Francisco Odair de Paiva Sandra Machado de souza Lima Olimpio hiroshi Miyagaki Departamento de Matematica UFSCarSao CarlosSP13560-970 Brazil Departamento de Ciencias Exatas Biologicas e da TerraINFES-UFFSanto Antonio de Padua-RJ28470-000Brazil

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈h_(A)^(1)(R^(N)),(P)with 2hat can change sign and sat... 详细信息

In this work we consider the following class of elliptic problems{−Δ_(A)u+u=a(x)|u|^(q−2)u+b(x)|u|^(p−2)u in R^(N),u∈h_(A)^(1)(R^(N)),(P)with 2hat can change sign and satisfy some additional conditions;u∈h_(A)^(1)(R^(N))and A:R^(N)→R^(N) is a magnetic *** using the Nehari method in combination with other complementary arguments,we discuss the existence of infinitely many solutions to the problem in question,varying the assumptions about the weight functions.

关键词： Magnetic potential sign-changing weight functions Nehari manifold Fibering map

hydrogen-based direct reduction of iron oxide at 700℃:heterogeneity at pellet and microstructure scales

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International Journal of Minerals,Metallurgy and Materials 2022年第10期29卷 1901-1907页

作者： Yan Ma Isnaldi R.souza Filho Xue Zhang Supriya Nandy Pere Barriobero-Vila Guillermo Requena Dirk Vogel Michael Rohwerder Dirk Ponge hauke Springer Dierk Raabe Max-Planck-Institut für Eisenforschung Max-Planck-Straße 140237 DüsseldorfGermany Corrosion Center Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Lehr-und Forschungsgebiet Metallische Strukturen und Werkstoffsysteme für die Luft-und Raumfahrt RWTH Aachen University52062 AachenGermany Institut für Bildsame Formgebung RWTH Aachen UniversityIntzestraße 1052072 AachenGermany

Steel production causes a third of all industrial CO_(2) emissions due to the use of carbon-based substances as reductants for iron ores,making it a key driver of global ***,research efforts aim to replace these reductants with sustainably produced ***-based direct reduction(hyDR)is an attractive processing technology,given that direct reduction(DR)furnaces are routinely operated in the steel industry but with Ch_(4) or CO as *** diffuses considerably faster through shaft-furnace pellet agglomerates than carbon-based ***,the net reduction kinetics in hyDR remains extremely sluggish for high-quantity steel production,and the hydrogen consumption exceeds the stoichiometrically required amount ***,the present study focused on the improved understanding of the influence of spatial gradients,morphology,and internal microstructures of ore pellets on reduction efficiency and metallization during *** this purpose,commercial DR pellets were investigated using synchrotron high-energy X-ray diffraction and electron microscopy in conjunction with electron backscatter diffraction and chemical *** the interplay of different phases with internal interfaces,free surfaces,and associated nucleation and growth mechanisms provides a basis for developing tailored ore pellets that are highly suited for a fast and efficient hyDR.

关键词： hydrogen-based direct reduction iron oxide microstructure spatial gradient metallization

The oceanic cycles of the transition metals and their isotopes

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Acta Geochimica 2017年第3期36卷 359-362页

作者： Derek Vance Corey Archer Susan h.Little Michael Kobberich Gregory F.de souza Department of Earth Sciences Institute of Geochemistry and Petrology ETH Zürich Clansiusstrasse 25 8092 Zürich Switzerland Department of Earth Science and Engineering Imperial College London South Kensington Campus Exhibition Road London SW7 2AZ UK

The stable isotope systems of the transition metals potentially provide constraints on the current and past operation of the biological pump,and on the state of ocean redox in Earth *** we focus on two exemplar metals,nickel(Ni)and zinc(Zn).The oceanic dissolved pool of both elements is isotopically heavier than the known inputs,implying an output with light isotope *** modern oceanic cycle of both these elements is dominated by biological uptake into photosynthesised organic matter and output to *** is increasingly clear,however,that such uptake is associated with only very minor isotope *** suggest that the isotopic balance is instead closed by the sequestration of light isotopes to sulphide in anoxic and organic-rich sediments,so that it is ocean chemistry that controls these isotope systems,and suggesting a different but equally interesting array of questions in Earth history that can be addressed with these systems.

关键词：稳定同位素海洋循环过渡金属氧化还原状态地球历史生物吸收同位素分馏同位素平衡

Chemical speciation of copper and manganese in solution of a copper-contaminated soil and young grapevine growth with amendment application

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Pedosphere 2023年第3期33卷 496-507页

作者： Daniela Basso FACCO Edicarla TRENTIN Gerson Laerson DRESChER Rodrigo Knevitz hAMMERSChMITT Carlos Alberto CERETTA Leandro souza DA SILVA Gustavo BRUNETTO Paulo Ademar Avelar FERREIRA Department of Soil Science Federal University of Santa MariaSanta Maria 97105-900(Brazil) University of Arkansas System Division of Agriculture Arkansas 72704(USA) Federal University of Santa Maria Campus Cachoeira do SulCachoeira do Sul 96506-310(Brazil)

Copper(Cu)-based fungicide application to control foliar diseases in grapevine(Vitis vinifera L.)can increase soil Cu *** soils have high natural Cu and manganese(Mn)concentrations,increasing the potential for toxicity to grapevine *** of amendment substances can reduce the concentrations of toxic chemical species of Cu and Mn in soil solution,especially for the soils grown with young *** evaluated the chemical speciation of Cu and Mn in soil solution and young grapevine growth using a contaminated soil with amendment *** seedlings of Paulsen 1103rootstock were grown for 12 months on an old vineyard(>30 years of cultivation)soil without(control)and with vermicompost or limestone *** dry matter,root morphological characteristics,and plant tissue Cu and Mn concentrations were *** cation and anion concentrations,dissolved organic carbon,p h,and chemical speciation of Cu and Mn in soil solution from different soil layers were *** application did not reduce Cu and Mn phytotoxicity,and grapevine plants died after winter *** soluble Mn concentration in soil(5.56 mg L-1in 0–45 cm soil layer)and Mn concentration in plant tissue at pruning(380.8 mg kg-1)might be the primary cause of plant *** application reduced Cu2+and Mn2+chemical species in soil solution,thereby increasing plant *** Cu2+and Mn2+species were negatively correlated(Ph grapevine shoot production at pruning(r=-0.92 and-0.97,respectively)and at the end of the trial(r=-0.73 and-0.51,respectively).Limestone application increased grapevine shoot and root dry matter production by 36%and 41%,respectively,while also presenting the highest root length and volume in the 5–10 cm soil *** application is a viable and profitable alternative for reducing soil Cu and Mn availability and their phytotoxic effects.

关键词： bioavailability heavy metal limestone phytoxicity vermicompost vineyard Visual MINTEQ

3D Printing Technology for Tapered Optical Fiber Protection With Gas Sensing Possibilities

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Photonic Sensors 2020年第4期10卷 298-305页

作者： Kaleb Roncatti de souza Jonas h.OSÓRIO Juliana B.CARVALhO Beatriz Mota LIMA Cristiano M.B.CORDEIRO Gleb Wataghin Physics Institute State University of CampinasCampinas 13083-970Brazil

We present a new procedure for protecting micro-optical fibers(tapered fibers)by using the 3-dimensional(3D)printing technology.A standard single-mode optical fiber was tapered down to the diameter of 1mm and embedded in a polymeric matrix obtained by an additive manufacturing *** show that the proposed structure protects the fiber taper against environmental humidity while keeping permeability to gas flow and the possibility of the realization of gas detection *** our knowledge,this is the first time 3D printed casings were applied to protect fiber tapers from humidity *** envisage this new approach will allow the development of new fiber taper devices to better resist in humid environments.

关键词： 3D printing additive manufacturing optical fiber tapered fibers sensing

Techno-functionality of fisetin-enriched yoghurt fermented with Lactobacillus acidophilus bio-capsules produced via osmoporation

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Systems Microbiology and Biomanufacturing 2022年第4期2卷 743-749页

作者： Eduardo Wagner Vasconcelos de Andrade Sebastien Dupont Laurent Beney Edilene souza da Silva Roberta Targino hoskin Márcia Regina da Silva Pedrini Bioprocess Laboratory Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil Laboratory of Bioactive Compounds Chemical Engineering DepartmentUniversidade Federal do Rio Grande do NorteLagoa NovaNatalRN 59078-900Brazil UMR Procédés Alimentaires et Microbiologiques(PAM UMR A 02.102)Univ.Bourgogne Franche-ComtéAgroSup Dijon21000 DijonFrance

Osmoporation is a novel encapsulation approach for bioactive compounds based on the osmoresistance mechanisms of microbial *** the best of our knowledge,this is the first study investigating the production of fisetin-enriched yoghurt using Lactobacillus acidophilus-based bio-capsules via osmoporation as the starter *** showed that the milk acidification with fisetin-loaded *** progressed at a slower pace due to complex mechanisms induced by osmopo-ration and internalized *** fermentation using fisetin bio-capsules reached a maximum acidification rate of 0.18 ph units/h after 23 h and ph 4.6 was achieved after 32 ***,the antioxidant activity of yoghurts produced with fisetin bio-capsules did not change during cold storage,while the antioxidant activity of yoghurt produced with non-encapsulated fisetin was reduced by 2.5-fold after 28 ***,this study shows that fisetin osmoporation using *** is a versatile encapsulation bioprocess that enables the delivery of preserved phytoactives into fermented foods like *** strategy has the potential to be extended to other applications in the dairy industry using lactic acid bacteria as both the encapsulation matrix and fermentation agent.

关键词： Cell-based carriers Probiotic bacteria Dairy fermented products Food biotechnology Functional foods