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Drug resistance pattern of Mycobacterium tuberculosis isolates from patients of five provinces of Iran

Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 193-196页

作者： Mohammad Javad Nasiri Faranak Rezaei Samin Zamani davod darban-sarokhalil Abbas Ali Imani Fooladi Hasan Shojaei Mohammad Mehdi Feizabadi Department of Microbiology School of Medicine.Tehran University of Medical Sciences Department of Microbiology School of Medicine.Alborz University of Medical Sciemces Applied Microbiology Research Centre Baqiyatallah University of Medical Sciences Department of Microbiology School of Medicine.Isfahan University of Medical Sciences

Objective:To determine the patterns of resistance to first line anti-tuberculosis(TB)drugs among a collection of Mycobacterium tuberculosis(MTB)isolates from 5 provinces of ***:A total of the 6 426 clinical specimens from patients suspected of active TB were collected from March 2010 to June *** specimens were subjected for microscopy and culture tests in the TB centers of studies *** susceptibility testing to the first line anti-TB drugs for culture positive MTB was performed on Lwenstein-Jensen(LJ)medium using proportion ***:Of 6 426 clinical specimens,261 were culture positive for mycobacteria,of which 252 were MTB and 9 were MOTT(mycobacteria other than tuberculosis).Of 252 MTB isolates.211(83.7%)were pan-susceptible and 41(16.3%)were resistant to at least one *** was most common to streptomycin.30 isolates(12.0%),followed by isoniuzid,20isolates(8.0%),rifampin,15 isolates(6.0%)and ethambutol,14 isolates(5.5%).Sixteen(6.3%)MTB isolates were MDR.A clear evidence of heterogeneity amongst the 5 provinces in the proportions with resistance to one or more drugs was observed[χ~2=12.209(4 degrees of freedom),P values=0.015 9].Conclusions:The prevalence of drug resistance in this study area underscoring the need for further enforcement of TB control strategies in the *** susceptibility testing for all TB cases to provide optimal treatment,establishing advanced diagnostic facilities for rapid detection of MDR-TB and continuous monitoring of drug resistance are recommended for prevention and control of drug-resistant TB.

关键词： Mycobacterium tuberculosis MDR tuberculosis Drug resistance Iran

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