检索结果-南通市图书馆

Physical and chemical processes promoting dominance of the toxic cyanobacterium Cylindrospermopsis raciborskii

Chinese Journal of Oceanology and Limnology 2011年第4期29卷 883-891页

作者： Michele A. BURFORD Timothy w. davis Australian Rivers Institute Griffith University Nathan Qld. 4111 Australia

The freshwater cyanobacterium, Cylindrospermopsis raciborskii （woloszyflska） Seenayya and Subba Raju is a common species in lakes and reservoirs globally. In some areas of the world it can produce cytoand hepatotoxins （cylindrospermopsins, saxitoxins）, making blooms of this species a serious health concern for humans. In the last 10 15 years, there has been a considerable body of research conducted on the ecology, physiology and toxin production of this species and this paper reviews these studies with a focus on the cylindrospermopsin （CYN）-producing strains. C. raciborskii has low light requirements, close to neutral buoyancy, and a wide temperature tolerance, giving it the capacity to grow in many lentic waterbodies. It also has a flexible strategy with respect to nitrogen （N） utilisation; being able to switch between utilising fixed and atmospheric N as sources of N fluctuate. Additionally this species has a high phosphate （DIP） affinity and storage capacity. Like many cyanobacteria, it also has the capacity to use dissolved organic phosphorus （DOP）. Changes in nutrient concentrations, light levels and temperature have also been found to affect production of the toxin CYN by this species. However, optimal toxin production does not necessarily occur when growth rates are optimal. Additionally, different strains of C. raciborskii vary in their cell quota of CYN, making it difficult to predict toxin concentrations, based on C. raciborskii cell densities. In summary, the ecological flexibility of this organism means that controlling blooms of C. raciborskii is a difficult undertaking. However, improved understanding of factors promoting the species and toxin production by genetically capable strains will lead to improved predictive models of blooms.

关键词： cyanobacteria freshwater algal toxins nutrients light temperature

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Focal therapy for localized prostate cancer:is there a “middle ground” between active surveillance and definitive treatment?

引用

Asian Journal of Andrology 2019年第1期21卷 37-44页

作者： Cihan H Demirel Muammer Altok John w davis Department of Urology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA.

In recent years,it has come a long way in the diagnosis,treatment,and follow-up of prostate *** this,it was argued that definitive treatments could cause overtreatment,particularly in the very low,low,and favorable risk *** alternative treatment and follow-up methods are being considered for this group of patients,active surveillance is seen as a good alternative for patients with very low and low-risk groups in this ***,it has become necessary to find other alternatives for patients in the favorable risk group or patients who cannot adopt active *** the light of technological developments,the concept of focal therapy was introduced with the intensification of research to treat only the lesioned area instead of treating the entire organ for prostate lesions though there are not many publications about many of them *** to the initial results,it was understood that the results could be good if the appropriate focal therapy technique was applied to the appropriate ***,focal therapies have begun to find their"middle ground"place between definitive therapies and active follow-up.

关键词： focal therapy multiparametric magnetic resonance imaging prostate biopsy prostate cancer prostatic neoplasms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer

引用

world Journal of Gastrointestinal Oncology 2021年第6期13卷 550-559页

作者： Harold w davis Ahmet Kaynak Subrahmanya D Vallabhapurapu Xiaoyang Qi Division of Hematology/Oncology Department of Internal MedicineUniversity of Cincinnati College of MedicineBrain Tumor Center at UC Neuroscience InstituteCincinnatiOH 45267United States Department of Biomedical Engineering College of Engineering and Applied ScienceUniversity of CincinnatiCincinnatiOH 45221United States

Pancreatic cancer is one of the deadliest of cancers with a five-year survival of roughly 8%.Current therapies are:surgery,radiation and *** is curative only if the cancer is caught very early,which is rare,and the latter two modalities are only marginally effective and have significant side *** have developed a nanosome comprised of the lysosomal protein,saposin C(SapC)and the acidic phospholipid,dioleoylphosphatidylserine(DOPS).In the acidic tumor microenvironment,this molecule,SapC-DOPS,targets the phosphatidylserine cancer-biomarker which is predominantly elevated on the surface of cancer ***,SapC-DOPS can selectively target pancreatic tumors and ***,SapC-DOPS has exhibited an impressive safety profile with only a few minor side effects in both preclinical experiments and in phase I clinical *** the dismal outcomes for pancreatic cancer there is an urgent need for better treatments and SapC-DOPS is a good candidate for addition to the oncologist’s toolbox.

关键词： Pancreatic cancer Saposin C Dioleoylphosphatidylserine Phosphatidylserine-targeted therapy Chemotherapy Radiation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prostate cancer upgrading or downgrading of biopsy Gleason scores at radical prostatectomy:prediction of"regression to the mean"using routine clinical features with correlating biochemical relapse rates

引用

Asian Journal of Andrology 2019年第6期21卷 598-604页

作者： Muammer Altok Patricia Troncoso Mary F Achim Surena F Matin Graciela N Gonzalez John w davis Department of Urology University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Pathology University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Biostatistics University of Texas MD Anderson Cancer CenterHoustonTX 77030USA.

Recommendations for managing clinically localized prostate cancer are structured around clinical risk criteria,with prostate biopsy(PB)Gleason score(GS)being the most important *** to radical prostatectomy(RP)specimen upgrading/downgrading is welldescribed,and is often the ratio nale for costly imaging or genomic *** prese nt simple,no-cost an a lyses of clinical parametersto predict which GS 6 and GS 8 patients will change to GS 7 at *** May 2006 to December 2012,1590 patientsunderwent robot-assisted radical prostatectomy(RARP).After exclusions,we identified a GS 6 cohort of 374 patients and a GS 8cohort of 91 *** this era,>1000 additional patients were enrolled in an active surveillanee(AS)*** GS 6,265(70.9%)of 374 patients were upgraded,and the cohort included 183(48.9%)patients eligible for AS by the Prostate Cancer ResearchInternational Active Surveillance Study(PRIAS)standards,of which 57.9%were *** features that predicted a>90%chanceof upgrading included≥7 cores positive,maximum foci length≥8 mm in any core,and total tumor involvement≥30%.For GS 8,downgrading occurred in 46(50.5%),which was significantly higher for single core versus multiple cores(80.4%vs 19.6%,P=0.011).Biochemical recurre nee(BCR)occurred in 3.4%of GS 6 upgraded versus 0%non upgraded,and in GS 8,19.6%downgraded versus42.2%nondown *** coun seling men with clin ically localized prostate can cer,the odds of GS cha nge should be presented,andcertain men with high-volume GS 6 or low-volume GS 8 can be counseled with GS 7-based recommendations.

关键词： biopsy down grade Gleas on score prostate cancer upgrade

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The International Prostate Forum introduction and history

引用

Asian Journal of Andrology 2015年第6期17卷 863-863,I0006页

作者： John w davis Tsuneharu Miki Atif Akdas Hiroki watanabe Ziya Kirkali Run wang R Joseph Babaian Department of Urology The University of Texas MDAnderson Cancer Center Houston Texas 77030 USA Department of Urology Kyoto Prefectural University ofMedicine Kyoto Japan Department of Urology Schoolof Medicine Marmara University Istanbul Turkey watanabe Memorial Choumei Research Laboratory Shiga Japan Dokuz EylOI University School ofMedicine Department of Urology Izmir Turkey Division of Urology University of Texas Medical Schoolat Houston Department of Urology Houston TexasUSA Department of Urology University of Texas MDAnderson Cancer Center Houston Texas 77030 USA

The International Prostate Forum （IPF） originally started with three urology departments in Japan, Turkey, and the United States. The forum emphasized discussions and presentations of new knowledge in all areas of prostate diseases with an early emphasis on ultrasound and diagnostics. The meeting has generally run every 2 years and rotated through the three sites with new leadersjoining the effort. Over the years, the meeting has enjoyed a diverse locale and points of emphasis. The latter agendas now cover all aspects of the benign prostate disease, prostate cancer screening, prostate cancer diagnosis and staging, and therapies. Table 1 summarizes the dates of the meetings, locations, and chairman.

关键词： International Prostate history

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cross-scale modeling of surface temperature and tree seedling establishment in mountain landscapes

引用

Ecological Processes 2013年第1期2卷 313-327页

作者： John R Dingman Lynn C Sweet Ian McCullough Frank w davis Alan Flint Janet Franklin Lorraine E Flint Earth Research Institute University of California Santa BarbaraSanta BarbaraCA 93106USA U.S.Geological Survey California Water Science CenterSacramentoCA 95819USA Bren School of Environmental Science&Management University of California Santa BarbaraSanta BarbaraCA93106USA School of Geographical Sciences and Urban Planning Arizona State UniversityTempeAZ85287USA

Introduction:Estimating surface temperature from above-ground field measurements is important for understanding the complex landscape patterns of plant seedling survival and establishment,processes which occur at heights of only several ***,future climate models predict temperature at 2 m above ground,leaving ground-surface microclimate not well ***:Using a network of field temperature sensors and climate models,a ground-surface temperature method was used to estimate microclimate variability of minimum and maximum *** lapse rates were derived from field temperature sensors and distributed across the landscape capturing differences in solar radiation and cold air drainages modeled at a 30-m spatial ***:The surface temperature estimation method used for this analysis successfully estimated minimum surface temperatures on north-facing,south-facing,valley,and ridgeline topographic settings,and when compared to measured temperatures yielded an R2 of 0.88,0.80,0.88,and 0.80,*** surface temperatures generally had slightly more spatial variability than minimum surface temperatures,resulting in R2 values of 0.86,0.77,0.72,and 0.79 for north-facing,south-facing,valley,and ridgeline topographic ***-Poisson regressions predicting recruitment of Quercus kelloggii(black oak)seedlings from temperature variables were significantly improved using these estimates of surface temperature compared to air temperature modeled at 2 ***:Predicting minimum and maximum ground-surface temperatures using a downscaled climate model coupled with temperature lapse rates estimated from field measurements provides a method for modeling temperature effects on plant *** methods could be applied to improve projections of species’range shifts under climate *** of complex topography can provide intricate microclimates that may allow species to redistribute locally as climate

关键词： Black oak Climate change Generalized linear models Microclimate Topography Spatial scale Surface temperature

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dog10K: an international sequencing effort to advance studies of canine domestication, phenotypes and health

引用

National Science Review 2019年第4期6卷 810-824页

作者： Elaine A.Ostrander Guo-Dong wang Greger Larson Bridgett M.von Holdt Brian w.davis Vidhya Jagannathan Christophe Hitte Robert K.wayne Ya-Ping Zhang National Human Genome Research Institute National Institutes of Health State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Palaeogenomics and Bio-Archaeology Research Network School of Archaeology University of Oxford Department of Ecology and Evolutionary Biology Princeton University College of Veterinary Medicine and Biomedical Sciences Texas A&M University Institute of Genetics Vetsuisse Faculty University of Bern IGDR CNRS University of Rennes Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles the Dog10K Consortium

Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10 K Consortium(http://***10 ***) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 *** effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

关键词： genomics genome-wide association studies(GwAS) breed selection variation evolution

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Early onset of a microcystin-producing cyanobacterial bloom in an agriculturally-influenced Great Lakes tributary

引用

Journal of Oceanology and Limnology 2018年第4期36卷 1112-1125页

作者： Robert Michael L.McKAY Taylor TUTTLE Laura A.REITZ George S.BULLERJAHN william R.CODY Adam J.McDOwELL Timothy w.davis Department of Biological Sciences Bowling Green State University Bowling Green OH 43403 USA Aquatic Taxonomy Specialists Malinta OH 43535 USA City of Defiance Water Division Defiance OH 43512 USA NOAA Great Lakes Environmental Research Laboratory Ann Arbor MI USA

In late May 2016, a cyanobacterial harmful algal bloom(cHAB) was detected in the Maumee River, the largest tributary to Lake Erie, the southernmost lake of the Laurentian Great Lakes system. Testing on 31 May identified Planktothrix agardhii as the dominant cyanobacterium with cell abundance exceeding 1.7×10~9 cells/L and total microcystins(MC) reaching 19 μg/L MC-LR equivalents, a level over 10-fold higher than the 2015 revised U.S. Environmental Protection Agency(EPA) national health advisory levels for drinking water exposure to adults. Low river discharge coincident with negligible precipitation through the latter half of May coincided with an 80% decline in river turbidity that likely favored bloom formation by a low-light adapted P. agardhii population. Also contributing to the c HAB were high initial nutrient loads and an increase of the river temperature from 13℃ to 26℃ over this same period. The bloom persisted through 5 June with microcystins exceeding 22 μg/L MC-LR equivalents at the bloom peak. By 6 June, the river had returned to its muddy character following a rain event and sampling on 7 June detected only low levels of toxin(water systems located near the bloom origin. The elevated toxin production associated with this early onset bloom was without precedent for the Maumee River and an unique attribute of the c HAB was the high proportion of potentially-toxic genotypes. whereas Planktothrix spp. is common in lotic environments, and has been previously detected in the Maumee, blooms are not commonly reported. This early onset, microcystin-producing c HAB provided a rare opportunity to glean insights into environmental factors that promote bloom development and dominance by Planktothrix in lotic environments.

关键词： cyanobacteria microcystin Planktothrix qPCR river

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultrasound use and contamination of injection sites

引用

中华物理医学与康复杂志 2015年第5期37卷 393-393页

作者： Sherman T Ferguson J davis w

BACKGROUND AND OBJECTIVE Localized corticosteroid injection is used to treat a number of musculoskeletal disorders of the knee and *** have estimated the risk of post-injection infection to be 4.6 per 100,000 *** ultrasound(US)is commonly used to assist with these injections,this study was designed to determine whether the use of nonsterile gel increases the risk of contamination.

关键词：注射部位细菌污染超声骨骼疾病肩关节凝胶膝关节类固醇

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Corsair断层面之下的构造在三维地震资料中成象

引用

国外油气勘探 1996年第5期8卷 598-603页

作者： davis w.Ratcliff David J.weber 马迪生四川石油管理局天然气信息研究所

仔细地将传统的处理和解释方法用于新的三维地震资料,确定出墨西哥湾成熟地区的勘探远景。用这些方法已发现Corsair断层上升盘上(该断层面以下的区域上)有大的构造。Corsair是一个发育的狭长断层系统,沿得克萨斯陆棚延伸320km。尽管该... 详细信息

仔细地将传统的处理和解释方法用于新的三维地震资料,确定出墨西哥湾成熟地区的勘探远景。用这些方法已发现Corsair断层上升盘上(该断层面以下的区域上)有大的构造。Corsair是一个发育的狭长断层系统,沿得克萨斯陆棚延伸320km。尽管该系统的下降盘是一个成熟的生产区,但断层的上升盘却一直未引起勘探人员的注意。图1和图2展示了构造是怎样开始在该上升沉积体中出现的。

关键词：断层面构造三维地震数据成象地震勘探

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：