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轻度或中度慢性肾脏疾病对冠状动脉再狭窄发生率的影响:来自PrESTO试验的结果

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世界核心医学期刊文摘（心脏病学分册） 2005年第3期1卷 53-54页

作者： best P.J.M. b.r.er P.b. davis b.r. 杜媛

The goal of this study was to determine if restenosis is increased in mild and moderate chronic kidney disease (CKD) patients after percutaneous coronary intervention (PCI). Mortality is increased in CKD after PCI. restenosis may contribute to increased late mortality. We analyzed 11,187 patients with a creatinine >1.8 mg/dl from the Prevention of rEStenosis with Tranilast and its Outcomes (PrESTO) trial, grouped by estimated creatinine clearance(CrCl)(89ml/min). The Cox proportional hazards models investigated the association between CrCl group and death, myocardial infarction, and target vessel revascularization(TVr). Generalized estimating equation regression models determined the association between CrCl group and lesion-specific restenosis. At 30 days, therewas no difference in myocardial infarction, death, or TVr between the CrCl groups. At nine months, mortality was higher in the lowest CrCl group(2.2%, 1.2%, 0.8%; p >0.001), which was no longer significant after adjusting for confounding variables. Myocardial infarction and TVr were not different between the groups. In patients undergoing protocol follow-up angiography, restenosis(reased with CKD(32%, 32%, 37%; p=0.02). Mortality nine months after PCI is mildly increased in mild or moderate CKD patients. However, restenosis is not and does not account for the increased mortality.

关键词：慢性肾脏疾病 PrESTO 再狭窄发生率慢性肾病靶血管血运重建肌酐清除率晚期死亡曲尼司特肌酐水平混杂变量

Liver abnormalities following SArS-CoV 2 infection in children 1 to 10 years of age

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Family Medicine and Community Health 2024年第1期12卷 28-35页

作者： Pauline Terebuh Veronica r Olaker Ellen K Kendall David C Kaelb.r.rong Xu Pamela b davis Center for Artificial Intelligence in Drug Discovery Case Western Reserve UniversityClevelandOHUSA The Center for Clinical Informatics research and Education The MetroHealth SystemClevelandOHUSA Department of Medicine PediatricsDepartment of Population and Quantitative Health SciencesCase Western Reserve UniversityClevelandOHUSA Center for Community Health Integration Case Western Reserve UniversityClevelandOHUSA

Objective beginning in Octob.r.2021 in the USA and elsewhere,cases of severe paediatric hepatitis of unknown aetiology were identified in young *** the adenovirus and adenovirus-associated virus have emerged as leading aetiological suspects,we attempted to investigate a potential role for SArS-CoV 2 in the development of subsequent liver *** We conducted a study using retrospective cohorts of deidentified,aggregated data from the electronic health records of over 100 million patients contributed by US healthcare *** Compared with propensity score matched children with other respiratory infections,children aged 1-10 years with COVID-19 had a higher risk of elevated transaminases(Hr(95%CI)2.16(1.74 to 2.69))or total bilirubin(Hr(95%CI)3.02(1.91 to 4.78)),or new diagnoses of liver diseases(Hr(95%CI)1.67(1.21 to 2.30))from 1 to 6 months after *** with pre-existing liver abnormalities,liver abnormalities surrounding acute infection,younger age(1-4 years)or illness requiring hospitalisation all had similarly elevated *** who developed liver abnormalities following COVID-19 had more pre-existing conditions than those who developed abnormalities following other *** These results indicate that SArS-CoV 2 may prime the patient for subsequent development of liver infections or non-infectious liver *** rare(~1 in 1000),SArS-CoV 2 is a risk for subsequent abnormalities in liver function or the diagnosis of diseases of the liver.

关键词： elevated diagnosis subsequent

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant biology 2024年第6期66卷 1192-1205页

作者： Santosh Kumar rana Hum Kala rana Jacob bLandis Tianhui Kuang Juntong Chen Hengchang Wang Tao Deng Charles C.davis Hang Sun CAS Key Lab.r.tory for Plant Diversity and biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA bTI Computational biology Center Boyce Thompson InstituteIthacaNew York 14853USA CAS Key Lab.r.tory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest China comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

Lead-phase and red-stripe color morphs of red-backed salamanders Plethodon cinereus differ in hematological stress indices:A consequence of differential predation pressure?

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Current Zoology 2010年第2期56卷 238-243页

作者： Andrew K.davis Joseph r.MILANOVICH D.b. Warnell School of Forestry and Natural resources The University of Georgia

Throughout the animal kingdom there are species that have two or more phenotypic forms or ‘morphs＇, and many of these are amphibians. In North America, the red-backed salamander Plethodon cinereus can have either a red dorsal stripe or no dorsal stripe （lead-phase form）, and evidence to date indicates the lead-phase form incurs a greater numb.r.of attacks from predators. In a recent collection of 51 P cinereus, blood smears of both color morphs （35 red-stripe, 16 lead-phase） were examined to obtain numb.r. of circulating leukocytes （via light microscopy）, which can be used to indirectly estimate levels of stress hormones in vertebrates via a ‘hematological stress index＇, which is the ratio between the numb.r.of two leukocyte types （neutrophils and lymphocytes）. Our results showed that lead-phase salamanders tended to have greater numb.r. of circulating neutrophils and lower numb.r. of circulating lymphocytes than red-stripe morphs, leading to higher average neutrophil-lymphocyte ratios in lead-phase individuals. Since the salamanders were held （refrigerated） for 7 days before sampling, we cannot be certain if this effect is a stress reaction to the captivity or the normal level for this morph. However comparison with two sets of related salamanders that were captured and sampled immediately indicates the red-stripe salamanders were either not stressed from the captivity at all, or their white blood cell distributions had returned to normal after 7 days of captivity. Taken together, our results indicate that lead-phase forms of P. cinereus have higher stress levels than the red-stripe forms, which may be a consequence of their higher exposure to, and/or attacks from, predators. They may also indicate that the lead-phase form is less-suited to captivity than the red-stripe form of this species.

关键词： red-backed salamander Plethodon cinereus Color polyrnorphism Hematological stress index Corticosterone

Pelage color of red bats Lasiurus b.r.alis varies with body size:An image analysis of museum specimens

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Current Zoology 2010年第4期56卷 401-405页

作者： Andrew K.davis Steven b.CASTLEb.r.Y D.b. Warnell School of Forestry and Natural resources The University of Georgia

Mammalian pelage color can vary among individuals of many species, although this intraspecific variation is oftenoverlooked by researchers, perhaps because of its sometimes subtle nature and difficulty in assessing it quantitatively. Thus, suchvariation is rarely studied in mammals, and this is especially true within the order Chiroptera, where there has been very little empiricalresearch. We examined museum specimens of red bats (Lasiurus b.r.alis, family Vespertilionidae) from Georgia, USA, todetermine the extent of sexual dimorphism in pelage color and to explore possible associations between body size and pelagecolor. We photographed 54 specimens under uniform lighting, and used an image analysis program to measure pelage hue on theuropatagium region, which is fully furred in memb.r. of the genus Lasiurus. Statistical analyses of pelage hue scores showedmales had significantly redder pelage than females when considered alone, but when examined together with effects of body sizeand collection year, sex was not significant, and collection year and body size were. More recent specimens tended to be less redthan older specimens, which might indicate a wearing of the buffy tips of hairs from older specimens, and smaller bats of bothsexes tended to be more red. These interesting findings are encouraging and we suggest that future explorations into intraspecificvariation in pelage color of bats using this or similar approaches are warranted to clarify the significance of the patterns. Thisstudy also demonstrated that care must be taken in analyses of mammalian pelage color from older museum skins, or at least thatresearchers must take into account the age of the specimens .

关键词： Pelage color Sexual dimorphism red bats Lasiurus b.r.alis Image analysis

LIQUID-GAS TWO PHASE FLOW rATES METErING bY DUAL PrESSUrE DIFFErENTIAL MEASUrEMENTS

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Journal of Hydrodynamics 1994年第3期6卷 85-96页

作者： M.r.davis Dept of Civil and Mechanical Engineering University of TasmaniaG.P.O.Box 252cHobartTasmania 7001Australia

The measurement of the overall mass flow rates in a two phase, gas/liquid pipeline is considered on the basis of dual pressure differential measurements for a combined contraction/frictional pipe type of flow meter and a numerical model to predict overall mass flow rates from pressure differentials measured from this type of flow meter is presented. The experiments generally conform with the predictions of the flow rates prediction model. Whilst the practicability of such metering of two phase flows is clearly demonstrated, application of the method would require careful calibration to allow for the influence of nozzle coefficients, pipe reynolds numb.r.and void fraction upon the one dimensional compressible flow equations through wall friction factor and interphase slip effects.

关键词： two phase flow measurement pressure differential.

Fundamentals of operations management / Mark M. davis, Nicholas J. Aquilano, richard b. Chase. 4th ed.

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Discrete composition control of two-dimensional morphologic all-inorganic metal halide perovskite nanocrystals

丛书名： McGraw-Hill/Irwin series operations and decision sciences

2003年

作者： Mark M. davis Nicholas J. Aquilano richard b. Chase.

First ed. published under: Aquilano, Nicholas J.

ISBN: (数字)0072402857

ISBN: (纸本)007119469X

First ed. published under: Aquilano, Nicholas J.

关键词： Production management.

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Journal of Energy Chemistry 2021年第8期30卷 257-275,I0006页

作者： Andrew Hunter davis Weiwei Zheng Department of Chemistry Syracuse University13244 SyracuseUnited States

Metal halide perovskite nanocrystals(NCs)exhibit impressive optical and electronic properties,making them an important class of functional materials with promising applications in solar cells,light emitting diodes(LEDs),photodetectors,and *** addition to the widely studied 0-dimensional(0 D)metal halide perovskite NCs,such as nanocubes,low dimensional perovskites,such as 2 D all-inorganic perovskite(AIP)NCs,subsist with directionally relevant quantum *** anisotropic NCs have the propensity to exhibit interesting optoelectronic properties that are exceedingly difficult to introduce into 0 D systems,yet as of late are largely *** this review,we discuss the recent synthetic progress of 2 D all-inorganic metal halide perovskite NCs with AbX3 ***,we highlight the discrete composition control of the cations(A and b sites)and anions(X site)by dopant incorporation and alloying in 2 D metal halide perovskite *** will also discuss more complex perovskite crystal structures,such as ruddlesden-Popper double perovskites,and compare these materials to 0 D perovskite ***,our work culminates in the future interests and perspectives of this field with a focus on the wide applicability of 2 D systems and the large variance in structure capable with discrete compositional tuning.

关键词： All-inorganic perovskites Two-dimensional nanocrystals Composition Doping Alloying Ion exchange

Estimating geographic variation of infection fatality ratios during epidemics

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Infectious Disease Modelling 2024年第2期9卷 634-643页

作者： Joshua Ladau Eoin L.brodie Nicola Falco Ishan bansal Elijah b.Hoffman Marcin P.Joachimiak Ana M.Mora Angelica M.Walker Haruko M.Wainwright Yulun Wu Mirko Pavicic Daniel Jacobson Matthias Hess James b.brown Katrina Abuab.r. Departments of Computational Precision Health and Dermatology University of CaliforniaSan FranciscoCA94115USA Arva Intelligence Inc.Salt Lake CityUT84101USA Computational biosciences Group Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Earth and Environmental Sciences Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Graduate Group in biostatistics University of CaliforniaBerkeleyCA94720USA biosystems Data Science Environmental Genomics and Systems BiologyLawrence Berkeley National LaboratoryBerkeleyCA94720USA Center for Environmental research and Community Health(CErCH) School of Public HealthUniversity of CaliforniaBerkeleyCA94720USA bredesen Center for Interdisciplinary research and Graduate Education University of TennesseeKnoxvilleTN37996USA Department of Nuclear Science and Engineering Massachusetts Institute of TechnologyBostonMA02139USA biosciences Oak Ridge National LaboratoryOak RidgeTN37830USA University of California DavisCA95616USA Statistics Department University of CaliforniaBerkeleyCA94720USA Division of Epidemiology and biostatistics University of California Berkeley School of Public Health2121 Berkeley WayBerkeleyCA94720USA

Objectives We aim to estimate geographic variability in total numb.r. of infections and infection fatality ratios(IFr;the numb.r.of deaths caused by an infection per 1,000 infected people)when the availability and quality of data on disease b.r.en are limited during an *** We develop a noncentral hypergeometric framework that accounts for differential probabilities of positive tests and reflects the fact that symptomatic people are more likely to seek *** demonstrate the robustness,accuracy,and precision of this framework,and apply it to the United States(U.S.)COVID-19 pandemic to estimate county-level SArS-CoV-2 *** The estimators for the numb.r. of infections and IFrs showed high accuracy and precision;for instance,when applied to simulated validation data sets,across counties,Pearson correlation coefficients between estimator means and true values were 0.996 and 0.928,respectively,and they showed strong robustness to model *** the county-level estimators to the real,unsimulated COVID-19 data spanning April 1,2020 to Septemb.r.30,2020 from across the U.S.,we found that IFrs varied from 0 to 44.69,with a standard deviation of 3.55 and a median of *** The proposed estimation framework can be used to identify geographic variation in IFrs across settings.

关键词： Infection fatality ratio Infection fatality rate Noncentral hypergeometric distribution COVID-19 SArS-CoV-2