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Liver pathology in COVID-19 related death and leading role of autopsy in the pandemic

World Journal of Gastroenterology 2023年第1期29卷 200-220页

作者： Martina Zanon Margherita Neri Stefano Pizzolitto davide radaelli Monica Concato Michela Peruch Stefano D'Errico Department of Medical Surgical and Health Sciences University of TriesteTrieste 34149Italy Department of Medical Sciences University of FerraraFerrara 44121Italy Department of Pathology Santa Maria della Misericordia University HospitalUdine 33100Italy

BACKGROUND Information on liver involvement in patients with coronavirus disease 2019 is currently fragmented.AIM To highlight the pathological changes found during the autopsy of severe acute respiratory syndrome coronavirus 2 positive patients.METHODS A systematic literature search on PubMed was carried out until June 21,2022.RESULTS A literature review reveals that pre-existing liver disease and elevation of liver enzyme in these patients are not common;liver enzyme elevations tend to be seen in those in critical conditions.Despite the poor expression of viral receptors in the liver,it seems that the virus is able to infect this organ and therefore cause liver damage.Unfortunately,to date,the search for the virus inside the liver is not frequent(16%of the cases)and only a small number show the presence of the virus.In most of the autopsy cases,macroscopic assessment is lacking,while microscopic evaluation of livers has revealed the frequent presence of congestion(42.7%)and steatosis(41.6%).Less frequent is the finding of hepatic inflammation or necrosis(19%)and portal inflammation(18%).The presence of microthrombi,frequently found in the lungs,is infrequent in the liver,with only 12%of cases presenting thrombotic formations within the vascular tree.CONCLUSION To date,the greatest problem in interpreting these modifications remains the association of the damage with the direct action of the virus,rather than with the inflammation or alterations induced by hypoxia and hypovolemia in patients undergoing oxygen therapy and decompensated patients.

关键词： Liver COVID-19 Autopsy Immunohistochemistry In situ hybridization Immunofluorescence

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Pancreatic transplant surgery and stem cell therapy:Finding the balance between therapeutic advances and ethical principles

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World Journal of Stem Cells 2022年第8期14卷 577-586页

作者： Martina Padovano Matteo Scopetti Federico Manetti Donato Morena davide radaelli Stefano D’Errico Nicola Di Fazio Paola Frati Vittorio Fineschi Department of Anatomical HistologicalForensic and Orthopaedic SciencesSapienza University of RomeRome 00185Italy Department of Medical Surgical Sciences and Translational Medicine Sapienza University of RomeRome 00189Italy Department of Medicine Surgery and HealthUniversity of TriesteTrieste 34149Italy

The latest achievements in the field of pancreas transplantation and stem cell therapy require an effort by the scientific community to clarify the ethical implications of pioneering treatments,often characterized by high complexity from a surgical point of view,due to transplantation of multiple organs at the same time or at different times,and from an immunological point of view for stem cell therapy.The fundamental value in the field of organ transplants is,of course,a solidarity principle,namely that of protecting the health and life of people for whom transplantation is a condition of functional recovery,or even of survival.The nature of this value is that of a concept to which the legal discipline of transplants entrusts its own ethical dignity and for which it has ensured a constitutional recognition in different systems.The general principle of respect for human life,both of the donor and of the recipient,evokes the need not to put oneself and one’s neighbor in dangerous conditions.The present ethical reflection aims to find a balance between the latest therapeutic advances and several concepts including the idea of the person,the respect due to the dead,the voluntary nature of the donation and the consent to the same,the gratuitousness of the donation,the scientific progress and the development of surgical techniques,and the policies of health promotion.

关键词： Pancreas transplantation Multi-organ transplants Stem cell therapy Ethical principles Donor Recipient

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设计师大卫

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中国建筑装饰装修 2010年第2期 272-273页

作者： davide radaelli

大卫1977年出生于意大利米兰。2002年毕业于米兰理工大学工业设计专业。从2003年开始自由设计创作．并与一些设计工作室合作。2008年，大卫于米兰开设了自己的工作室，为设计的各个领域提供国际顾问服务。

关键词：设计师设计工作室工业设计专业设计创作顾问服务米兰意大利

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