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Robot-assisted radical cystectomy with neobladder diversion in females:Safety profile and functional outcomes

Asian Journal of Urology 2024年第4期11卷 618-624页

作者： Andrea Pacchetti Alberto Caviglia Vito Lorusso Nicolas Branger Thomas Maubon Stanislas Rybikowski davide perri Giorgio Bozzini Geraldine Pignot Jochen Walz Division of Urology Sant'Anna HospitalSan Fermo della BattagliaComoItaly Department of Urology ASST Grande Ospedale Metropolitano NiguardaMilanItaly Division of Urology ASST Fatebenefratelli SaccoMilanItaly Department of Urology Institut Paoli-Calmettes Cancer CentreMarseilleFrance

Objective Radical cystectomy(RC)is a standard treatment for localized muscle invasive bladder cancer and high-risk or very high-risk non-muscle invasive bladder cancer not responding to adequate endovesical *** women,traditionally RC is performed with hystero-adnexectomy and resection of the anterior vaginal wall,often resulting in sexual ***-sparing techniques have been developed to improve functional *** present study explores the safety and the functional outcome of vaginal-sparing *** We retrospectively analyzed all consecutive female patients undergoing robot-assisted RC(RARC)with neobladder diversion between October 2017 and February *** indications for vaginal-sparing RC were absence of tumor on bladder neck or urethra and no sign of infiltration of posterior bladder wall at the preoperative *** results were evaluated with the aid of five questions out of the Bladder Cancer Index *** were reported according to the Clavien–Dindo classification and cancer control was evaluated by recurrence-free and cancer-specific *** A total of 22 female patients underwent RARC with neobladder *** chemotherapy was given in 17(77%)***–Dindo grades III–IV complications occurred in four(18%)*** a mean follow-up of 29(interquartile range 16–44)months,six(27.3%)patients developed distant metastases,and one(4.5%)woman loco-regional ***-sparing surgery was performed in 19(86%)patients,and in the others the anterior vaginal wall was resected,but neobladder was still *** daytime,no patients reported total incontinence and 73%(11/15)reported total continence or only occasional *** results showed that seven of 15(47%)women regained sexual activity after surgery,with a quality reported as“good”or“very good”in 40%of all 19 *** RARC in female with anterior vaginal wall preservation is *** approach showed

关键词： Sexual-sparing Robot-assisted radical cystectomy Female Functional outcome Continence Sexual function

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Chemical and minero-petrographical changes on granulite rocks affected by weathering processes

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Frontiers of Earth Science 2019年第2期13卷 247-261页

作者： Carmine APOLLARO Francesco perri Emilia LE PERA Ilaria FUOCO Teresa CRITELLI DiBEST University of Calabria1-87036 Arcavacata di Rende (CS)Italy

The purpose of this work is to study the weathering processes of the granulite rocks of the Serre Massif (southern Calabria,Italy) using a multidisciplinary approach based on field studies,geochemical modeling,and minero?petrographical *** granulite rocks are plagioclase-rich with minor amphibole,clinopyroxene,orthopyroxene,biotite,and garnet and their texture are *** reaction path modeling was performed to simulate the evolution of groundwaters upon interaction with local granulite by means of the software package EQ3/6,version *** were performed in kinetic (time) mode under a closed system at a constant temperature of 11.5℃,(which reproduces the average temperature of local area) and fixing the fugacity of CO2 at 10-2.34 bar (mean value).During the most advanced stage of weathering the main mineralogical changes are: partial destruction and transformation of biotite and plagioclase associated with neoformation of ferruginous products and secondary clay minerals producing a change in the origin rock *** secondary solid phases observed during the geochemical modeling (kaolinite,vermiculite and ferrihydrite) are similar to those found in this natural ***,the soil-like material mainly characterized by mostly sand to gravel grain-size fractions is the final result of the weathering processes.

关键词： Serre Massif granulitic rocks mineralogy petrography weathering profile reaction path-modeling

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Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies

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World Journal of Clinical Oncology 2011年第12期2卷 377-383页

作者： Francesco perri davide Bosso Carlo Buonerba Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati Oncology Division Division INT Fondazione“G.Pascale”80131 NaplesItaly Oncology and Rare Cancer Center FedericoⅡUniversity80131 NaplesItaly

Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast *** T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at *** fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam *** treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy *** trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or *** compounds,anthracyclines and taxanes are among the chemotherapy agents *** review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach.

关键词： Chemotherapy Nasopharyngeal carcinoma Radiotherapy Treatment

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MIS 5e sea surface temperature estimation;a multi-proxy approach using a marine macrofossil assemblage(Mar Piccolo,Gulf of Taranto,Southern Italy)

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Journal of Palaeogeography 2024年第2期13卷 327-350页

作者： Pierluigi Santagati Edoardo perri Maria Pia Bernasconi Mario Borrelli Salvatore Guerrieri Salvatore Critelli Dipartimento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipartimento di Ingegneria Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a multi-proxy palaeoclimatic study conducted on a MIS 5e calcarenite from the Mar Piccolo Basin(MP),Gulf of Taranto(GT)(Central Mediterranean).The calcarenite returned a rich malacofauna consisting of 120 extant species,including four of the tropical Senegalese Fauna,today absent in the *** biogeographic-climatic affinity of the assemblage shows,compared to today,a double percentage of warm affinity species,while the cold affinity species are nearly equally represented,indicating a warmer but not strictly tropical *** is confirmed by the most recurring preferred SST ranges of the assemblage,indicating an average of 20℃.The skeletal compositions of five well-preserved molluscan and coral specimens were analyzed for trace elements and stable isotopes for further mean SST *** the comparison of the results of several equations available in literature,it appears that only some SST estimations are realistic,converging into similar values of,on average,20.8±0.9℃.Considering all the used proxies,the MIS 5e SST difference compared to today falls in the range 1.2—2.0℃for the GT(being a more reasonable scenario)and 2.0—2.8℃for the *** is not a firmly tropical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃more than today’s GT and MP,*** approximations and assumptions made for obtaining SST values with any single proxy indicate the need of a multi-proxy approach to define the best SST estimation.

关键词： MiS 5e Sea surface temperature Palaeoclimate proxy Fossil fauna Gulf of Taranto

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Gastric low-grade mucosal-associated lymphoid tissue-lymphoma: Helicobacter pylori and beyond

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World Journal of Gastrointestinal Oncology 2010年第4期2卷 181-186页

作者： Angelo Zullo Cesare Hassan Francesca Cristofari Francesco perri Sergio Morini Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita"Hospital00153 RomaItaly Francesco PerriGastroenterology and Digestive Endoscopy"Casa Sollievo della Sofferenza"HospitalIRCCS71013 San Giovanni Rotondo(FG)Italy

The stomach is the most frequently involved site for extranodal lymphomas,accounting for nearly two-thirds of all gastrointestinal *** is widely accepted that gastric B-cell,low-grade mucosal-associated lymphoid tissue(MALT)-lymphoma is caused by Helicobacter pylori(***)***-lymphomas may engender different clinical and endoscopic ***,diagnosis is confirmed in patients with only vague dyspeptic symptoms and without macroscopic lesions on gastric *** eradication leads to lymphoma remission in a large number of patients when treatment occurs at an early stage(Ⅰ-Ⅱ1).Neoplasia confined to the submucosa,localized in the antral region of the stomach,and without API2-MALT1 translocation,shows a high probability of remission following *** *** both bacterial infection and lymphoma recur,further eradication therapy is generally ***,chemotherapy and,in selected cases,surgery are the available therapeutic options with a high success rate for those patients who fail to achieve remission,while data on immunotherapy with monoclonal antibodies (rituximab)are still *** 5-year survival rate is higher than 90%,but careful,long-term follow-up is required in these patients since lymphoma recurrence has been reported in some cases.

关键词： Mucosal-associated lymphoid tissue Therapy Helicobacter pylori Gastric lymphoma Predictive factors Endoscopy Clinical presentation

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Mitochondrial dysfunction in Parkinson＇s disease： a possible target for neuroprotection

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Frontiers in Biology 2014年第6期9卷 489-503页

作者： Jacqueline A. GLEAVE Peter D. perri Joanne E. NASH Centre for Neurobiology of Stress Department of Biological Sciences University of Toronto Scarborough Toronto Ontario M1C1A4Canada

Mitochondria are dynamic organelles which are required for maintaining cellular homeostasis. Thus, it is not surprising that irregularities in mitochondrial function result in cellular damage and are linked with neurodegenerative diseases, such as Parkinson＇s disease. Evidence that mitochondrial dysfunction is key to the pathogenesis of Parkinson＇s disease is founded in studies in post-mortem tissue from patients with Parkinson＇s disease, and also from genetic studies stemming from patients with familial Parkinson＇s disease. Whether triggered by environmental or genetic factors, mitochondrial dysfunction occurs early in the pathogenic process, and is central to Parkinson＇s disease pathology. As such, targeting the mitochondria to slow or halt disease progression is an attractive strategy for disease-modifying agents in Parkinson＇s disease. Indeed, several therapies which target the mitochondria have been investigated as neuroproteetive treatments for Parkinson＇s disease. This review will discuss the evidence supporting mitochondrial dysfunction in Parkinson＇s disease pathology as well as treatment strategies that target the mitochondria.

关键词： Parkinson's disease mitochondria oxidative stress lysosome UPS

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Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis

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World Journal of Gastroenterology 2006年第48期12卷 7821-7825页

作者： Angelo Iacobellis Matilde Marcellini Angelo Andriulli Francesco perri Gioacchino Leandro Rita Devito Valerio Nobili Division of Gastroenterology Hospital "Casa Sollievo della Sofferenza" IRCCS San Giovanni Rotondo Italy Liver Unit Bambino Gesu' Children's Hospital Rome Italy Division of Gastroenterology "De Bellis" Hospital IRCCS Castellana Grotte Italy Pathology Department Bambino Gesu' Children's Hospital Rome Italy

AIM: To identify the independent predictors of hepatic fibrosis in 69 children with nonalcoholic steatohepatitis (NASH) due to nonalcoholic fatty liver disease (NAFLD). METHODS: All patients with clinically suspected NASH underwent liver biopsy as a confirmatory test. The following clinical and biochemical variables at baseline were examined as likely predictors of fibrosis at histology: age, body mass index (BMI), systolic blood pressure (SBP), dyastolic blood pressure (DBP), fasting glucose, fasting insulin, homeostatic model assessment for insulin resistence (HOMA-IR), cholesterol, tryglicerides, alanine aminotransferase (ALT), aspartate aminotransferase (AST), AST/ALT ratio, gamma glutamil transferase (GT), platelet count, prothrombin time (PT). RESULTS: At histology 28 (40.6%) patients had no fibrosis and 41 (59.4%) had mild to bridging fibrosis. At multivariate analysis, BMI > 26.3 was the only independent predictor of fibrosis (OR = 5.85, 95% CI = 1.6-21). CONCLUSION: BMI helps identify children with NASH who might have fibrotic deposition in the liver.

关键词： Nonalcoholic steatohepatitis Obesity Bodymass index Liver fibrosis Non invasive diagnosis

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Role of interleukin polymorphisms in gastric cancer: “Pros and cons”

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World Journal of Gastrointestinal Oncology 2010年第6期2卷 265-271页

作者： Francesco perri Fulvia Terracciano Marco Gentile Antonio Merla Daniela Scimeca Angelo Zullo Department of Gastroenterology and Digestive Endoscopy "Casa Sollievo della Sofferenza" Hospital Department of Gastroenterology and Digestive Endoscopy "Nuovo Regina Margherita" Hospital

Helicobacter pylori (H. pylori ) infection is the leading cause of gastric cancer worldwide. Infection with this bacterium causes a chronic active immune response that persists for the life of the host. The combination of bacterial factors, environmental insults, and the host immune response drives the initiation and progression of mucosal atrophy, metaplasia, and dysplasia toward GC. Among the host factors, IL-1 gene cluster polymorphisms (IL-1B encoding IL-1β and IL-1RN encoding IL-1ra, its naturally occurring receptor antagonist) play a decisive role in modulating the risk of developing hypochlorhydria, gastric atrophy and GC in the presence of H. pylori infection. In particular, one single nucleotide polymorphism in the IL-1B promoter (IL-1B-511C T), and the short allele of a 86-bp variable number of tandem repeats polymorphism in the IL-1RN second intron (IL-1RN*2) are associated with an increased risk for GC. However this hypothesis is still to be fully confirmed. This review focuses on the divergent results obtained by several epidemiological and functional in vitro and in vivo studies and show that IL-1 genotyping has still no role in the clinical management of patients with H. pylori infection.

关键词： Cytokine Gastric cancer Gene Interleukin Helicobacter pylori Polymorphism

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Comparison of a monoclonal antigen stool test (Hp StAR) with the ^(13)C-urea breath test in monitoring Helicobacter pylori eradication therapy

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World Journal of Gastroenterology 2005年第37期11卷 5878-5881页

作者： Francesco perri Michele Quitadamo Rosalba Ricciardi Ada Piepoli Rosa Cotugno Annamaria Gentile Alberto Pilotto Angelo Andriulli Department of Internal Medicine Gastroenterology Unit "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo Italy Department of Internal Medicine Geriatrics Unit "Casa Sollievo della Sofferenza" Hospital IRCCS San Giovanni Rotondo Italy

AIM： To evaluate the agreement between a mAb-based stool test （HP STAR） and the urea breath test （UBT） in monitoring （H pylon） infection after eradication therapy. METHODS： Patients with discordant results on UBT and Hp STAR underwent endoscopy with biopsies for rapid urease test, culture, and histology to confirm H pylori status. RESULTS： Among 250 patients （50±14 years）, 240 （96.0%） had concordant UBT and Hp STAR tests with a significant correlation between DOB and A values （R = 0.87; P〈0.0001）. The remaining 10 （4.0%） patients had discordant tests （positive Hp STAR and negative UBT） with the Hp STAR inaccurate in five cases （false positive） and UBT inaccurate in the other five cases （false negative）. The “maximal expected” sensitivity, specificity, ＋PV, -PV, ＋LR, and -LR were 91%, 100%, 100%, 97.4%, ∞, and 8.2 respectively, for the UBT, and 100%, 97.4%, 91%, 100%, 38.8, and 0, respectively, for the Hp STAR. Overall accuracy for both tests was 98%. CONCLUSION： Both the UBT and the Hp StAR are equally accurate in monitoring H pylori infection. Nowadays, the choice of the “best” non-invasive H pylori test in the post-treatment setting should be done not only in terms of diagnostic accuracy but also in view of cost and local facilities.

关键词： Diagnosis Helicobacter pylor Stool antigen test Urea breath test

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Oleuropein-Specific-β-Glucosidase Activity Marks the Early Response of Olive Fruits (Olea europaea) to Mimed Insect Attack

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Agricultural Sciences in China 2008年第6期7卷 703-712页

作者： Antonia Spadafora Silvia Mazzuca Francesca Fiorella Chiappetta Attilio Parise Enzo perri Anna Maria Innocenti Laboratorio di Citofisiologia Vegetale Dipartimento di Ecologia Cubo 6b Ponte Bucci Università della Calabria 87030 Rende (CS) Italy C.R.A. Centro di Ricerca per l'Olivicoltura e l'Industria Olearia Contrada Li Rocchi 87030 Rende Italy

Olive fruits are seriously deteriorated by pre and postharvest damage due to the attack of insects, such as Bactrocera olaea, which strongly alters the quality of olives. Defence response in olive fruits injured both by pathogens and by mechanical damages has been associated with the enzyme β-glucosidase, which specifically hydrolyses oleuropein, producing highly reactive aldehyde molecules. In situ detection of ^-glucosidase activity in olive fruit tissues following injury, which simulates Bactrocera oleae punctures, is reported. The assay was performed in two cultivars showing different degrees of susceptibilities to fly infestation. In both cultivars, the histochemical assay for β-glucosidase showed that within 20 min after the injury, a strong ^-glucosidase activity could be observed in the damaged tissues. Thereafter a progressive enzyme inactivation occurred starting from tissues around the boundary of the injury with decrease of the enzyme activity and stopped after 3 h. Whereas the mass of active cells reached a distance of （300±50） μm from the edge of the injury. Biochemical analyses showed that in extracts of the injured fruit, β-glucosidase activity rapidly increased within 20 min from injury, thereafter decreasing and reaching values comparable with those in intact fruits. Following puncture, the oleuropein contents did not change significantly in the high susceptibility cultivar, whereas it rapidly decreased in the cultivar showing low susceptibility. The results strongly suggest that olive fruits susceptible towards fly infestation could be related to the ability of the oleuropein-degrading-β-glucosidase to produce the highly reactive molecules in the damaged tissues. As a consequence of puncture, high level of peroxidase activity was detected. This feature also suggested that this enzyme could play a key role in the defence response against insect injuries.

关键词： β-glucosidase (EC 3.2.1.21) oleuropein Olea europaea Bactrocera oleae infestation cultivar resistance

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