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Aggressive behaviour of solid-pseudopapillary tumor of the pancreas in adults:A case report and review of the literature

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World Journal of Gastroenterology 2008年第6期14卷 960-965页

作者： Cosimo Sperti Mattia Berselli Claudio Pasquali davide pastorelli Sergio Pedrazzoli Department of Medical and Surgical Sciences Clinica Chirurgica Ⅳ University of Padua Padua 35128 Italy Department of Oncology Istituto Oncologico Veneto Padua Italy

Solid-pseudopapillary tumor (SPT) is a rare neoplasm of the pancreas that usually occurs in young females. It is generally considered a low-grade malignant tumor that can remain asymptomatic for several years. The occurrence of infiltrating varieties of SPT is around 10%-15%. Between 1986 and 2006, 282 cystic tumors of the pancreas were observed. Among them a SPT was diagnosed in 8 patients (2.8%) with only one infiltrating variety. This was diagnosed in a 49-year-old female 13 years after the sonographic evidence of a small pancreatic cystic lesion interpreted as a pseudocyst. The tumor invaded a long segment of the portal- mesenteric vein confluence, and was removed with a total pancreatectomy, resection of the portal vein and reconstruction with the internal jugular vein. Histological examination confirmed the R-0 resection of the primary SPT, although a vascular invasion was demonstrated. The postoperative course was uneventful, but 32 mo after surgery the patient experienced diffuse liver metastases. Chemotherapy with different drugs was started. The patient is alive and symptom-free, with stable disease, 75 mo after surgery. Twenty-five patients with invasion of the portal vein and/or of mesenteric vessels were retrieved from the literature, 16 recent patients with tumor relapse after potentially curative resection were also retrieved. The best treatment remains a radical resection whenever possible, even in locally advanced or metastatic disease. The role of chemotherapy, and/or radiotherapy, is still to be defined.

关键词： Solid-pseudopapillary tumor Pancreatectomy Vascular resection Liver metastases Follow-up

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Tumor biopsy and patient enrollment in clinical trials for advanced hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第13期23卷 2448-2452页

作者： Lorenza Rimassa Maria Reig Giovanni Abbadessa Markus Peck-Radosavljevic William Harris Vittorina Zagonel davide pastorelli Elena Rota Caremoli Camillo Porta Nevena Damjanov Hitendra Patel Bruno Daniele Maria Lamar Brian Schwartz Terri Goldberg Armando Santoro Jordi Bruix Medical Oncology and Hematology Unit Humanitas Cancer CenterHumanitas Clinical and Research Center Barcelona Clinic Liver Cancer Group Liver UnitHospital ClinicUniversity of BarcelonaIDIBAPSCIBERehd Clinical Development Ar QuleInc Department of Gastroenterology HepatologyEndrocrinologyand NephrologyKlinikum Klagenfurt am Worthersee Department of Medicine Oncology DivisionUniversity of Washington School of Medicine Department of Clinical and Experimental Oncology Medical Oncology 1Veneto Institute of Oncology-IRCCS Department of Oncology Santa Maria del Prato Hospital Department of Oncology Papa Giovanni XXIII Hospital Department of Oncology Fondazione IRCCS Policlinico San Matteo Division of Gastrointestinal Oncology Abramson Cancer Center of the University of Pennsylvania Department of Medicine The University of Arizona Cancer Center Department of Oncology G.Rummo Hospital Clinical Development Daiichi Sankyo Medical Oncology and Hematology Unit Humanitas Cancer CenterHumanitas Clinical and Research CenterHumanitas University

Tumor biopsies may help to reliably distinguish hepatocellular carcinoma(HCC) from other tumors, mostly cholangiocarcinoma as well as to identify the patient populations who most benefit from target-driven HCC treatments, in order to improve the success rate of experimental therapies. Clarifying tumor biology may also lead to identify biomarkers with prognostic role and/or enabling to predict response or resistance to therapies. Recently, clinical trials have more efficiently included biomarker endpoints and increasingly collected tumor tissue from enrolled patients. Due to their frail status and sometimes fast-progressing disease, the performance status of patients with HCC progressing on first-line therapy can deteriorate quickly, preventing their enrollment in clinical trials. However, the challenge of identifying the proper patient at the proper time can be overcome by periodic inter-department meetings involving the key specialists taking care of HCC patients, and solid networks between research centers and referring institutions. An early planned biopsy would also facilitate timely inclusion of patients in biology-driven clinical trials. Ultimately, institution of multidisciplinary teams can optimize treatment choice, biopsy timing, and quick enrollment of patients in clinical trials, before their performance status deteriorates.

关键词： Liver neoplasms Biopsy Biomarkers Clinical trial Tumor

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Systemic therapies for hepatocellular carcinoma: arecap of the current status

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Hepatoma Research 2018年第4期4卷 1-13页

作者： Petros Giovanis Manuela De Bona Fabio Farinati Andrea Buda Riccardo Berletti Fable Zustovich Simona D'Ippolito Michele De Boni Umberto Cillo davide pastorelli Operative Unit of Medical Oncology Santa Maria del Prato HospitalFeltre 32032Italy Department of Gastroenterology and Digestive Endoscopy Santa Maria del Prato HospitalFeltre 32032Italy Department of Surgery University of PaduaPadua 35128Italy Operative Unit of Radiology and Interventional Radiology Santa Maria del Prato HospitalFeltre 32032Italy Operative Unit of Medical Oncology San Martino HospitalBelluno 32100Italy

After decades of frustrating nihilism due to lack of innovative therapeutic solutions, the onco-hepatological community is facing up to important novelties for the treatment of intermediate and advanced stages of liver cancer. Four new drugs have been investigated and resulted in positive data: lenvatinib resulted not inferior to the standard of care sorafenib in first line, regorafenib and cabozantinib demonstrated prolonging survival in patients progressed to sorafenib and nivolumab approved by FDA as option after first-line. Contemporary, the knowledge acquired after ten years' experience of sorafenib in patient selection and adverse events management revealed an increase of the outcomes. Physicians dedicated to treat advanced and intermediated liver cancer are close to live a new era where systemic treatments could have a huge impact on the disease. The aim of this review is to anticipate this new approach at the disease, summarizing data currently available for these therapies to identify therapeutic strategies of sequences and choosing drugs according to the patient profile.

关键词： Hepatocellular carcinoma liver cancer sorafenib regorafenib lenvatinib cabozantinib nivolumab

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Cardio-Toxicity during chemotherapy: feasibility of new diagnostic approaches

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Health 2010年第4期2卷 376-380页

作者： Fable Zustovich Mario Trivellato Renato Ceravolo davide pastorelli Rosanna Canton Lorena Buratin Monica Mion Martina Zaninotto Martina Mattiazzi Mario Plebani Giuseppe Cartei 不详

Chemotherapy induced cardio-toxicity is a well known side effect of anticancer treatments, moreover the 70% of all tumors involve patients over 65 years-old, frequently with cardiac co- morbidity. We evaluated the feasibility of the application during chemotherapy administration of some of the most recent diagnostic techniques as 12-diagnostic leads telemetry, 7 days EKG monitoring device (R-Test Evolution 3R), blood level dosage of Brain Natriuretic Peptide (BNP) and Ischemia Modified Albumin (IMA). Some sub-clinical changes in the investigated parameters were found in patients undergoing chemotherapy, mostly containing fluorouracil, as shown in the following paper. Far from suggesting a widespread use of these methods during chemotherapy administration, we think that some more tools are needed to prevent cardiac toxicity in high-risk patients and some of what we studied may deserve further valuation in chemotherapy clinical trials.

关键词： Cardio-Toxicity Diagnostic

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Bacterial symbiosis in Bactrocera oleae,an Achilles’heel for its pest control

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Insect Science 2021年第4期28卷 874-884页

作者： Gaia Bigiotti Patrizia Sacchetti Roberta pastorelli Carol R.Lauzon Antonio Belcari Department of Agriculture FoodEnvironment and Forestry(DAGRI)University of FlorenceItaly Research Centre for Agriculture and Environment Consiglio perlaricerca in agricoltura e I'analisi dell'economia agraria(CREA-AA)FlorenceItaly Department of Biological Sciences California State UniversityHaywardUSA

Investigations on microbial symbioses in Tephritidae have increased over the past 30 years owing to the potential use of these relationships in developing new control strategies for economically important fruit *** oleae(Rossi)—the olive fruit fly—is a monophagous species strictly associated with the olive tree,and among all the tephritids,its symbionts are the most *** bacterium Candidatus Erwinia dacicola is the major persistent resident endosymbiont in wild *** *** relationship with *** has been investigated since being identified in *** endosymbiont is vertically transmitted through generations from the female to the *** exists at every developmental stage,although it is more abundant in larvae and ovipositing females,and is necessary for both larvae and *** ***–***,or other ***–microbe interactions,will allow us to develop modern biological control systems for area-wide olive protection and set an example for similar programs in other important food *** review summarizes the information available on tephritid–microbe interactions and investigates relationships among fruit flies,bacteria and host plants;however,its focus is on *** and its strict association with *** to promote environmentally friendly control strategies for area-wide pest management.

关键词： bacterial symbiosis esophageal bulb IPM olive fly Tephritid

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New Primers for Denaturing Gradient Gel Electrophoresis Analysis of Nitrate-Reducing Bacterial Community in Soil

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Pedosphere 2013年第3期23卷 340-349页

作者： R.pastorelli R.PICCOLO S.SIMONCINI S.LANDI Consiglio per la Ricerca e la Sperimentazione in Agricoltura-Centro di Ricerca per l'Agrobiologia e la Pedologia CRA-ABP

The narG gene is frequently used as a molecular marker for bacterial nitrate-reducing community analysis. In this study, a new set of primers targeting the narG gene was designed and applied to semi-nested polymerase chain reaction-denaturing gradient gel electrophoresis （PCR-DGGE） assay. The potential of the new primers was verified on DNA directly extracted from soils from five different experimental sites distributed in Central and Southern Italy. Specificity of the primers was determined by excision, amplification, and sequencing of bands resolved by DGGE. A phylogenetic analysis showed the correlation between the sequences retrieved from the soils studied and the narG sequences from βand y-Proteobacteria. These primers expanded the existing molecular tools for ecological study on the size and diversity of nitrate-reducing bacterial community in soil.

关键词： DNA gene sequence narG phylogenetic analysis Proteobacteria

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Proteomic insights on the metabolism in inflammatory bowel disease

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World Journal of Gastroenterology 2020年第7期26卷 696-705页

作者： Laura Francesca Pisani Manuela Moriggi Cecilia Gelfi Maurizio Vecchi Luca pastorelli Gastroenterology and Digestive Endoscopy Unit IRCCS Policlinico San DonatoSan Donato Milanese 20097Italy Department of Biomedical Science for Health University of the Study of MilanIRCCS Istituto Ortopedico GaleazziMilan 20122Italy Gastroenterology and Endoscopy Unit IRCCS Ca'Granda FoundationPoliclinico HospitalUniversity of the Study of MilanMilan 20122Italy Department of Biomedical Science for Health University of the Study of MilanMilan 20122Italy

Inflammatory bowel diseases(IBD)are chronic and relapsing inflammatory conditions of the gut that include Crohn's disease and ulcerative *** pathogenesis of IBD is not completely unraveled,IBD are multi-factorial diseases with reported alterations in the gut microbiota,activation of different immune cell types,changes in the vascular endothelium,and alterations in the tight junctions’structure of the colonic epithelial *** represents a useful tool to enhance our biological understanding and to discover biomarkers in blood and intestinal *** is expected to provide reproducible and quantitative data that can support clinical assessments and help clinicians in the diagnosis and treatment of *** a differential diagnosis of Crohn's disease and ulcerative colitis and the prediction of treatment response can be deducted by finding meaningful *** some non-invasive biomarkers have been described,none can be considered as the“gold standard”for IBD diagnosis,disease activity and therapy *** these reason new studies have proposed an“IBD signature”,which consists in a panel of biomarkers used to assess *** above described approach characterizes“omics”and in this review we will focus on proteomics.

关键词： Proteomics Inflammatory bowel disease Cronh’s disease Ulcerative colitis Proteins Biomarkers discovery

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Differential diagnosis in inflammatory bowel disease colitis:State of the art and future perspectives

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World Journal of Gastroenterology 2015年第1期21卷 21-46页

作者： Gian Eugenio Tontini Maurizio Vecchi Luca pastorelli Markus F Neurath Helmut Neumann Gastroenterology and Digestive Endoscopy Unit IRCCS Policlinico San Donato20097 San Donato MilaneseItaly Department of Medicine I University of Erlangen-Nuremberg91054 ErlangenGermany Department of Biomedical Sciences for Health University of Milan20122 MilanoItaly

Distinction between Crohn's disease of the colonrectum and ulcerative colitis or inflammatory bowel disease(IBD) type unclassified can be of pivotal importance for a tailored clinical management,as each entity often involves specific therapeutic strategies and ***,no gold standard is available and the uncertainty of diagnosis may frequently lead to misclassification or repeated ***,we have performed a literature search to address the problem of differential diagnosis in IBD colitis,revised current and emerging diagnostic tools and refined disease classification ***,the differential diagnosis is an untangled issue,and the proper diagnosis cannot be reached in up to 10% of patients presenting with IBD *** topic is receiving emerging attention,as medical therapies,surgical approaches and leading prognostic outcomes require more and more disease-specific strategies in IBD *** optimization of standard diagnostic approaches based on clinical features,biomarkers,radiology,endoscopy and histopathology appears to provide only marginal ***,emerging diagnostic techniques in the field of gastrointestinal endoscopy,molecular pathology,genetics,epigenetics,metabolomics and proteomics have already shown promising *** advanced endoscopic imaging techniques and biomarkers can shed new light for the differential diagnosis of IBD,better reflecting diverse disease behaviors based on specific pathogenic pathways.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bo

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Phase control of femtosecond pulses on the nanoscale using second harmonic nanoparticles

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Light(Science & Applications) 2014年第1期3卷 335-341页

作者： Nicolo Accanto Jana B Nieder Lukasz Piatkowski Marta Castro-Lopez Francesco pastorelli Daan Brinks Niek F van Hulst ICFO—Institut de Ciencies Fotoniques 08860 Castelldefels(Barcelona)Spain Institut Fresnel CNRS UMR7249Aix-Marseille University13397 MarseilleFrance ICREA—Institucio Catalana de Recerca i Estudis Avanc¸ats(ICREA) 08010 BarcelonaSpain

Investigations of ultrafast processes occurring on the nanoscale require a combination of femtosecond pulses and nanometer spatial ***,controlling femtosecond pulses with nanometer accuracy is very challenging,as the limitations imposed both by dispersive optics on the time duration of a pulse and by the spatial diffraction limit on the focusing of light must be overcome *** this paper,we provide a universal method that allows full femtosecond pulse control in subdiffraction-limited *** achieve this aim by exploiting the intrinsic coherence of the second harmonic emission from a single nonlinear nanoparticle of deep subwavelength *** method is proven to be highly sensitive,easy to use,quick,robust and *** approach allows measurements of minimal phase distortions and the delivery of tunable higher harmonic light in a nanometric ***,the method is shown to be compatible with a wide range of particle sizes,shapes and materials,allowing easy optimization for any given *** method will facilitate the investigation of light–matter interactions on the femtosecond–nanometer level in various areas of scientific study.

关键词： diffraction limit Fourier limit multiphoton intrapulse interference phase scan nanoparticle nanophotonics phase control second harmonic generation ultrafast

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Neurological disorders and inflammatory bowel diseases

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World Journal of Gastroenterology 2014年第27期20卷 8764-8782页

作者： Giovanni Casella Gian Eugenio Tontini Gabrio Bassotti Luca pastorelli Vincenzo Villanacci Luisa Spina Vittorio Baldini Maurizio Vecchi Medical Department Desio Hospital Gastroenterology and Gastrointestinal Endoscopy Unit IRCCS Policlinico San Donato 20097 San Donato Milanese Italy Gastroenterology Section Department of Medicine University of Perugia Medical School Department of Biomedical Sciences for the Health University of Milan Institute of Pathology Spedali Civili 25123 Brescia Italy

Extraintestinal manifestations occur in about one-third of patients living with inflammatory bowel disease(IBD) and may precede the onset of gastrointestinal symptoms by many years. Neurologic disorders associated with IBD are not frequent, being reported in 3% of patients, but they often represent an important cause of morbidity and a relevant diagnostic issue. In addition, the increasing use of immunosuppressant and biological therapies for IBD may also play a pivotal role in the development of neurological disorders of different type and pathogenesis. Hence, we provide a complete and profound review of the main features of neurological complications associated with IBD, with particular reference to those related to drugs and with a specific focus on their clinical presentation and possible pathophysiological mechanisms.

关键词： Inflammatory bowel diseases Crohn's disease Ulcerative colitis Extraintestinal manifestations Neurological disorders Multiple sclerosis Progressive multifocal encephalopathy Demyelinating neuropathies Cerebrovascular diseases Side effects

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