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Modification in self-rated health in patients discharged by a geriatric rehabilitation ward

Health 2013年第6期5卷 94-98页

作者： Eleonora Marelli Giuseppe Procino Maria Cottino Giorgio Previderè Silvio Giorgi davide dell’acqua Santina Bruno Marco Cairati Danila Ferrari Rosella Capuano Mauro Colombo Geriatric Institute “Camillo Golgi” Milan Italy Geriatric Institute “Camillo Golgi” Milan Italy

Self-rated health is a valuable outcome in geriatric rehabilitation besides objective results. The present work aims at measuring and analyzing overall health as it is perceived at admission into and at discharge from a geriatric rehabilitation ward. Overall health was self-appraised through a visual-analogue scale (VAS), spanning from 0 (worst) to 10 (best). We studied 1997 patients (70% females), aged 79 (standard deviation, s.d. 8.7) years;most were frail, either functionally, clinically and cognitively. 80% of patients were discharged to home after a length of stay lasting 47.5 (s.d. 22.7) days. At admission, 3/5 patients appraised favorably their overall health (VAS ≥ 6/10): at discharge, the proportion rose to 3/4, with a mean (s.d.) gain = 2 (2) points. The improvement in self-perceived health score positively correlates with the grade expressing clients’ overall satisfaction for the stay (p 0.001), and with discharge versus admission differences in: Barthel Index (BI) total score (p < 0.001), Tinetti total score, Mini Mental State Examination (MMSE), Geriatric Depression Scale (5?items GDS), pain (VAS 0 to 10). A Linear regression model predicting the changes in self-perceived health included changes in BI, MMSE, GDS, pain, dropping Tinetti test. Changes in self-rated health were positively correlated to functional gain adjusted for pre-morbid level, and to relative functional gain. By analysis of variance, health self-appraisal changed more favorably in patients discharged to home than for other social outcomes (all p < 0.001). As expected, trends in self-perceived health parallel improvements in objective functional gauges and subjective indicators.

关键词： Cognition Functional Gains Geriatric Rehabilitation Mood Pain Self-Rated Health

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A Geometrical Approach to Compute Upper Limb Joint Stiffness

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Computer Modeling in Engineering & Sciences 2020年第4期123卷 23-47页

作者： davide Piovesan Roberto Bortoletto Biomedical Industrial and Systems EngineeringGannon University109 University SquareEriePA16541USA 2221e Ltd. Piazza dell’Artigianato1035031 Abano Terme(PD)Italy

Exoskeletons are designed to control the forces exerted during the physical coupling between the human and the *** the human is an active system,the control of an exoskeleton requires coordinated action between the machine and the load so to obtain a reciprocal *** in the control loop can be modeled as active mechanical loads whose stiffness is continuously *** direct measurement of human stiffness is difficult to obtain in real-time,thus posing a significant limitation to the design of wearable robotics ***(EMG)recordings can provide an indirect estimation of human muscle force and stiffness,but current methods for the acquisition of the signals limit their use and *** work proposes a hybrid method for the estimation of upper limb joint stiffness during reaching movements that combines EMG-driven muscle models and constrained *** these two stages process,we estimated an optimal joints’stiffness bounded in a physiologically sound variability *** information is crucial when designing exoskeletons user interfaces in which the limb stiffness is an integral part of the control ***-to-point human reaching movements were analyzed to reconstruct the joint stiffness of the upper *** accurate 3D model of the arm,encompassing all bones from the hand to the scapula and the majority of the upper limb muscles,was developed to represent the sliding center of rotation of the joints.A well-posed parallel mechanism between the skeleton and the configuration of the tracking markers was ***,the muscles’force and joint stiffness were calculated using a generalized pseudo-inversion of the Jacobian transformation between the muscles and Cartesian *** maximal and minimal forces exertable by the muscles were set as the boundary condition for the generalized pseudo-inverse by means of a state-of-the-art muscle model.

关键词： Stiffness inverse problem force method constrained optimization EMG.

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Cardiovascular magnetic resonance in myocardial infarction with non-obstructive coronary arteries patients: A review

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World Journal of Cardiology 2020年第6期12卷 248-261页

作者： Marco Gatti Andrea Carisio Tommaso D’Angelo Fatemeh Darvizeh Serena dell’Aversana davide Tore Maurizio Centonze Riccardo Faletti Faletti Riccardo Department of Surgical SciencesUniversity of TurinTurin 10126Italy Department of Biomedical Sciences and Morphological and Functional Imaging “G.Martino”University Hospital MessinaMessina 98100Italy Department of advanced biomedical sciences University of Naples Federico ⅡNaples 80138Italy Department of Diagnostic Imaging APSS di TrentoTrento 38123Italy

The diagnosis of myocardial infarction with non-obstructive coronary arteries(MINOCA)necessitates documentation of an acute myocardial infarction(AMI),non-obstructive coronary arteries,using invasive coronary angiography or coronary computed tomography angiography and no clinically overt cause for *** patients with MINOCA represent a clinical dilemma with subsequent uncertain clinical *** diagnosis is crucial to choose the best therapeutic option for ischemic and non-ischemic MINOCA *** magnetic resonance(CMR)is able to analyze cardiac structure and function simultaneously and provides tissue ***,CMR could identify the cause of MINOCA in nearly two-third of patients providing valuable information for clinical decision ***,it allows stratification of patients with worse outcomes which resulted in therapeutic changes in almost half of the *** this review we discuss the features of CMR in MINOCA;from exam protocols to imaging findings.

关键词： Cardiovascular magnetic resonance Acute coronary syndrome unobstructed coronaries Acute myocardial infarction Acute myocarditis Takotsubo cardiomyopathy

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Diabetic retinopathy: a matter of retinal ganglion cell homeostasis

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Neural Regeneration Research 2020年第7期15卷 1253-1254页

作者： Elisabetta Catalani davide Cervia Department for Innovation in Biological Agro-food and Forest systems (DIBAF) Università degli Studi della Tuscialargo dell’Università snc

Diabetic retinopathy(DR)is the most common complication of diabetes and the leading cause of visual impairment in the working-age population in the Western world(http://***/).One of the earliest events observed in DR is the impairment of retinal perfusion,caused by the constriction of retinal blood vessels,inducing biochemical and metabolic alterations,perycites/endothelial degeneration,and retina ischemia(Wong et al.,2016).Severe stages of DR include proliferative DR,caused by the abnormal growth of new vessels,and diabetic macular oedema in the central part of the *** is strongly associated with a prolonged duration of diabetes,hypertension,and hyperglycaemia but it can persist even after replacement of normal glycaemic status(Wong et al.,2016).

关键词： homeostasis alterations impairment

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Novel emphasis on somatostatinergic system in retinal ganglion cell neuroresilience

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Neural Regeneration Research 2024年第1期19卷 148-149页

作者： Elisabetta Catalani davide Cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitàdegli Studi della Tuscialargo dell’UniversitàsncViterboItaly

The neuromodulatory peptide somatostatin(somatotropin release inhibiting factor,SRIF)-14 acts at multiple levels through five SRIF receptor subtypes(sst1 to sst5).SRIF-28 is also derived from a common propeptide translated from a single SRIF gene,although SRIF-14 is the predominant form in the mammalian nervous *** to its short half-life,synthetic SRIF analogs have been developed over the years and are available for therapeutic approaches.

关键词： life system predominant

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A Drosophila perspective on retina functions and dysfunctions

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Neural Regeneration Research 2022年第2期17卷 341-343页

作者： Elisabetta Catalani Federica Silvestri davide Cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitadegli Studi della Tuscialargo dell’UniversitasncViterboItaly

Due to the high degree of conservation of genes and mechanisms, the fruit fly Drosophila melanogaster is a powerful experimental in vivo tool to investigate complex diseases, thus complementing traditional vertebrate systems. Drosophila is also an advantageous system regarding the animal husbandry and the short generation time and lifespan.

关键词： Drosophila husbandry functions

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Cardiovascular magnetic resonance of cardiac tumors and masses

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World Journal of Cardiology 2021年第11期13卷 628-649页

作者： Marco Gatti Tommaso D’Angelo Giuseppe Muscogiuri Serena dell'aversana Alessandro Andreis Andrea Carisio Fatemeh Darvizeh davide Tore Gianluca Pontone Riccardo Faletti Radiology Unit Department of Surgical SciencesUniversity of TurinTurin 10126Italy Department of Biomedical Sciences and Morphological and Functional Imaging “G.Martino”University Hospital MessinaMessina 98100Ita Department of Radiology IRCCS Istituto Auxologico ItalianoSan Luca HospitalMilan 20149Italy Department of Radiology S.Maria Delle Grazie HospitalPozzuoli 80078Italy Department of Medical Sciences University of TurinTurin 10126Italy School of Medicine Vita-Salute San Raffaele UniversityMilan 20121Italy Department of Cardiovascular Imaging Centro Cardiologico MonzinoIRCCSMilan 20138Italy

Cardiac masses diagnosis and treatment are a true challenge,although they are infrequently encountered in clinical *** encompass a broad set of lesions that include neoplastic(primary and secondary),non-neoplastic masses and *** clinical presentation of cardiac tumors is highly variable and depends on several factors such as size,location,relation with other structures and *** presumptive diagnosis is made based on a preliminary non-invasive diagnostic work-up due to technical difficulties and risks associated with biopsy,which is still the diagnostic gold *** findings should always be interpreted in the clinical context to avoid misdiagnosis,particularly in specific conditions(e.g.,infective endocarditis or thrombi).The modern multi-modality imaging techniques has a key role not only for the initial assessment and differential diagnosis but also for management and surveillance of the cardiac *** magnetic resonance(CMR)allows an optimal non-invasive localization of the lesion,providing multiplanar information on its relation to surrounding ***,with the additional feature of tissue characterization,CMR can be highly effective to distinguish pseudomasses from masses,as well as benign from malignant lesions,with further differential diagnosis of the *** histopathological assessment is important to make a definitive diagnosis,CMR plays a key role in the diagnosis of suspected cardiac masses with a great impact on patient *** literature review aims to provide a comprehensive overview of cardiac masses,from clinical and imaging protocol to pathological findings.

关键词： Cine magnetic resonance imaging Multiparametric magnetic resonance imaging Heart neoplasm Multimodal imaging Late-gadolinium enhancement Early gadolinium enhancement

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Polyetheretherketone and titanium surface treatments to modify roughness and wettability–Improvement of bioactivity and antibacterial properties

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Journal of Materials Science & Technology 2021年第36期95卷 213-224页

作者： davide Porrelli Mario Mardirossian Nicola Crapisi Marco Urban Nicola Andrea Ulian Lorenzo Bevilacqua Gianluca Turco Michele Maglione Department of Medical Surgical and Health SciencesUniversity of TriestePiazza dell'Ospitale 134129TriesteItaly

Among the materials available for implant production,titanium is the most used while polyetheretherketone(PEEK)is emerging thanks to its stability and to the mechanical properties similar to the ones of the bone *** surface properties like roughness and wettability play a paramount role in cell adhesion,cell proliferation,osteointegration and implant ***,the bacterial adhesion to the biomaterial and the biofilm formation depend on surface smoothness and *** this work,two different treatments,sandblasting and air plasma,were used to increase respectively roughness and wettability of two materials:titanium and *** effects were analyzed with profilometry and contact angle *** biological properties of the material surfaces were also investigated in terms of cell adhesion and proliferation of NIH-3T3 cells,MG63 cells and human Dental Pulp Stem ***,the ability of Staphylococcus aureus to adhere and form a viable biofilm on the samples was *** biological properties of both treatments and both materials were compared with samples of Synthegra;titanium,which underwent laser ablation to obtain a porous micropatterning,characterized by a smooth surface to discourage bacterial *** cell types used were able to adhere and proliferate on samples of the tested *** adhesion was higher on sandblasted PEEK samples for both MG63 and NIH-3T3 cell lines,on the contrary,the highest proliferation rate was observed on sandblasted titanium and was only slightly dependent on wettability;h DPSCs were able to proliferate similarly on sandblasted samples of both tested *** highest osteoblast differentiation was observed on laser micropatterned titanium samples,but similar effects,even if limited,were also observed on both sandblasted materials and air plasma treated *** lowest bacterial adhesion and biofilm formation was observed on micropatterned titanium samples whereas,the

关键词： PEEK Titanium Micropatterning Roughness Wettability Differentiation

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Photonic extreme learning machine by free-space optical propagation

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Photonics Research 2021年第8期9卷 1446-1454页

作者： davide PIERANGELI GIULIA MARCUCCI CLAUDIO CONTI Institute for Complex System National Research Council(ISC-CNR)00185 RomeItaly Physics Department Sapienza University of Rome00185 RomeItaly Centro Ricerche Enrico Fermi(CREF) 00184 RomeItaly Department of Physics University of OttawaOttawaOntario K1N 6N5Canada

Photonic brain-inspired platforms are emerging as novel analog computing devices,enabling fast and energyefficient operations for machine *** artificial neural networks generally require tailored optical elements,such as integrated photonic circuits,engineered diffractive layers,nanophotonic materials,or time-delay schemes,which are challenging to train or ***,we present a neuromorphic photonic scheme,i.e.,the photonic extreme learning machine,which can be implemented simply by using an optical encoder and coherent wave propagation in free *** realize the concept through spatial light modulation of a laser beam,with the far field acting as a feature mapping *** experimentally demonstrate learning from data on various classification and regression tasks,achieving accuracies comparable with digital kernel machines and deep photonic *** findings point out an optical machine learning device that is easy to train,energetically efficient,scalable,and fabrication-constraint *** scheme can be generalized to a plethora of photonic systems,opening the route to real-time neuromorphic processing of optical data.

关键词： extreme propagation free

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Large-scale photonic natural language processing

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Photonics Research 2022年第12期10卷 2846-2853页

作者： CARLO M.VALENSISE IVANA GRECCO davide PIERANGELI CLAUDIO C Enrico Fermi Research Center(CREF) 00184 RomeItaly Physics Department Sapienza University of Rome00185 RomeItaly Institute for Complex Systems National Research Council(ISC-CNR)00185 RomeItaly

Modern machine-learning applications require huge artificial networks demanding computational power and ***-based platforms promise ultrafast and energy-efficient hardware,which may help realize nextgeneration data processing ***,current photonic networks are limited by the number of inputoutput nodes that can be processed in a single *** restricted network capacity prevents their application to relevant large-scale problems such as natural language ***,we realize a photonic processor for supervised learning with a capacity exceeding 1.5×10^(10)optical nodes,more than one order of magnitude larger than any previous implementation,which enables photonic large-scale text encoding and *** exploiting the full three-dimensional structure of the optical field propagating in free space,we overcome the interpolation threshold and reach the over-parameterized region of machine learning,a condition that allows high-performance sentiment analysis with a minimal fraction of training *** results provide a novel solution to scale up light-driven computing and open the route to photonic natural language processing.

关键词： demanding overcome exceeding

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