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尼日利亚Gwagwalada原发性开角型青光眼患者的社会人口学和临床特征

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国际眼科杂志 2024年第7期24卷 1005-1012页

作者： Abdulkabir Ayansiji Ayanniyi Abdulraheem Olarongbe Mahmoud Yetunde Olamide JohnSam Rauf Ibrahim Rauf david Paul Ejeba Rosita Ujunwa Akasike-Enuh Emmanuel Oluwatosin Bisiriyu Margaret Uche Afam-Osemene Eunice Adamma Chijioke Pankyes Amos Damter Nkosi Linus Agwadu 阿布贾大学眼科尼日利亚阿布贾902101 阿布贾教学医院眼科尼日利亚Gwagwalada902101 伊洛林大学眼科尼日利亚伊洛林240003 阿布贾大学统计学教研室尼日利亚阿布贾902101

目的:探讨比较尼日利亚Gwagwalada原发性开角型青光眼(POAG)与非青光眼患者的临床社会人口学特征。方法:横断面对比研究。共调查235例成年患者,其中96例POAG及139例非青光眼。记录患者年龄、性别、教育程度、职业、种族、青光眼家族史... 详细信息

目的:探讨比较尼日利亚Gwagwalada原发性开角型青光眼(POAG)与非青光眼患者的临床社会人口学特征。方法:横断面对比研究。共调查235例成年患者,其中96例POAG及139例非青光眼。记录患者年龄、性别、教育程度、职业、种族、青光眼家族史、眼痒、糖尿病和高血压情况。眼部检查包括视力、中央视野、杯盘比、前房角评估和眼压。结果:平均年龄为49.88±13.75岁,其中男114例(48.5%)。POAG患者包括42个种族,其中伊博人(24/96,25.0%)和约鲁巴人(20/96,20.8%)最为常见。大多数POAG(74/96,77.1%)年龄在40-69岁之间。POAG(73/96,76.0%)有不同程度的视力障碍。POAG组与非青光眼组的对比如下:青光眼阳性家族史(34/96,35.4%)vs(25/139,18.0%;P=0.012);糖尿病史(8/96,8.3%)vs(6/139,4.3%);高血压病史(24/96,25.0%)vs(28/139,20.1%);糖尿病合并高血压病史(1/96,1.0%)vs(4/139,2.9%;P=0.268);使用抗糖尿病药物者(5/96,5.2%)vs(7/139,5.0%);使用降压药者(24/96,25.0%)vs(23/139,16.5%);联合使用抗糖尿病和抗高血压药物者(4/96,4.2%)vs(5/139,3.6%;P=0.328);有眼痒症状者(18/96,18.7%)vs(37/139,26.6%;P=0.328);视力障碍[右眼(RE):51/96,53.1%;左眼(LE):60/96,62.5%]vs(RE:40/139,28.7%;LE:37/139,26.6%;P=0.000);垂直杯盘比>0.4(RE:96/96,100%;LE:96/96,100%)vs(RE:131/139,94.2%;LE:124/139,89.2%)(RE:P=0.307;LE:P=0.006);眼压>22 mmHg(RE:17/96,17.7%;LE:22/96,22.9%)vs(RE:2/139,1.4%;LE:2/139,1.4%;P=0.006)。大多数POAG患者(60/96,62.5%)正在服用抗青光眼药物,(23/96,24.0%)尚未开始用药,P=0.000。许多POAG(32/96,33.3%)正在服用β受体阻滞剂、前列腺素抑制剂和碳酸酐酶抑制剂的联合抗青光眼药物。结论:青光眼具有与其他眼部疾病不同的临床社会人口学特征。许多参与者肯定了青光眼的家族史,大多数青光眼参与者正在接受抗青光眼治疗。包括失明在内的视力障碍与青光眼显著相关。该研究证实,开角型青光眼与高杯盘比和高眼内压有关。

关键词：原发性开角型青光眼尼日利亚青光眼社会人口学

Orbital magneto-optical response of periodic insulators from first principles

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npj Computational Materials 2019年第1期5卷 874-882页

作者： Irina v.Lebedeva david A.Strubbe Ilya v.Tokatly Angel Rubio Nano-Bio Spectroscopy Group and ETSF Departamento de Física de MaterialesUniversidad del País Vasco UPV/EHU20018 San SebastiánSpain Department of Physics School of Natural SciencesUniversity of CaliforniaMercedCA 95343USA Donostia International Physics Center(DIPC) Manuel de Lardizabal 520018 San SebastiánSpain IKERBASQUE Basque Foundation for Science48011 BilbaoSpain Max Planck Institute for the Structure and Dynamics of Matter and Center for Free-Electron Laser Science Luruper Chaussee 14922761 HamburgGermany

Magneto-optical response,*** response in the presence of a magnetic field,is commonly used for characterization of materials and in optical ***,quantum mechanical description of electric and magnetic fields in crystals is not straightforward as the position operator is ill *** present a reformulation of the density matrix perturbation theory for time-dependent electromagnetic fields under periodic boundary conditions,which allows us to treat the orbital magneto-optical response of solids at the ab initio *** efficiency of the computational scheme proposed is comparable to standard linearresponse calculations of absorption spectra and the results of tests for molecules and solids agree with the available experimental data.A clear signature of the valley Zeeman effect is revealed in the continuum magneto-optical spectrum of a single layer of hexagonal boron *** present formalism opens the path towards the study of magneto-optical effects in strongly driven low-dimensional systems.

关键词： periodic magneto solids

Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord

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Neural Regeneration Research 2023年第8期18卷 1852-1856页

作者： Jesús Chato-Astrain Olga Roda david Sánchez-Porras Esther Miralles Miguel Alaminos Fernando Campos Óscar Darío García-García víctor Carriel Department of Histology(Tissue Engineering Group) University of GranadaInstituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain Department of Human Anatomy and Embryology University of GranadaGranadaSpain Unit of Clinical Neurophysiology University Hospital San CecilioGranadaSpain

Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton *** have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone ***,the limited regenerative capacity of the central nervous system due to an inhibitory environment prevents major changes in neurite outgrowth and should be presumably associated with low levels of growth-associated protein 43 ***,central alterations due to peripheral nerve damage have never been assessed using the growthassociated protein 43 *** this study,we used the tubulization technique to repair 1 cm-long nerve gaps in the rat nerve injury/repair model and detected growth-associated protein 43 expression in the peripheral and central nervous ***,histological analysis of the regeneration process confirmed an active regeneration process of the nerve gaps through the conduit from 10 days *** growth-associated protein 43 expression profile varied across regions and follow-up times,from a localized expression to an abundant and consistent expression throughout the regeneration tissue,confirming the presence of an active nerve regeneration ***,spinal cord changes were also histologically assessed,and no apparent changes in the structural and cellular organization were observed using routine staining ***,remarkable differences and local changes appeared in growth-associated protein 43 expression at the spinal cord level,in particular at 20 days post-repair and ***-associated protein 43 protein was first localized in the gracile fasciculus and was homogeneously distributed in the left posterior *** findings differed from the growth-associated protein 43 pattern observed in the healthy control,which did not express growth-associated protein 43 at these *** results revealed a differential expression in growth-associate

关键词： growth-associated protein 43(GAP-43) immunohistochemistry nerve guide nerve tissue regeneration peripheral nerve repair spinal cord tissue engineering

Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics

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World Journal of Gastroenterology 2022年第18期28卷 1996-2007页

作者： Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo david C Bartlett Bobby v Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias HPB and Liver Transplant Unit Queen Elizabeth HospitalBirmingham B152GWUnited Kingdom Department of HPB and Liver Transplantation Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152THUnited Kingdom

BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer *** are conflicting on the role of IGBC diagnosis in oncological *** studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others *** To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative *** Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary *** comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was *** analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank *** analysis was performed with univariable and multivariable Cox regression *** The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC *** was longer in patients with IGBC in the whole cohort(29 vs 4 mo,Pvs 2 mo,Pvs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and *** diagnosis was identified as an independent predictor of *** IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour *** studies are required to further investigate this,including detailed

关键词： Gallbladder cancer Incidental gallbladder cancer Non-incidental gallbladder cancer Gallbladder cancer survival

Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon Jill L.Edmondson david Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli Christopher D.F.Rogers Runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which have the potential to effectively reduce summer air *** many reviews,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review synthesizes the evidence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were reviewed,based on 51 GBGI types categorized under 10 main *** GBGI(green walls,parks,street trees)have been well researched for their urban cooling ***,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling was observed in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary walls extreme

Next Generation Transcriptome Sequencing and Quantitative Real-Time PCR Technologies for Characterisation of the Bemisia tabaci Asia 1 mtCOI Phylogenetic Clade

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Journal of Integrative Agriculture 2012年第2期11卷 281-292页

作者： Susan Seal Mitulkumar v Patel Carl Collins John Colvin david Bailey Natural Resources Institute University of GreenwichChatham Maritime Kent ME4 4TBUnited Kingdom

A programme of functional genomics research is underway at the University of Greenwich,UK,to develop and apply genomics technologies to characterise an economically-important but under-researched Bemisia tabaci（Hemiptera：Aleyrodidae）,the Asia 1 mtCOI phylogenetic group.A comparison of this putative species from India with other important *** populations and insect species may provide targets for the development of more effective whitefly control *** a first step,next-generation sequencing（NGS）has been used to survey the transcriptome of adult female whitefly,with high quality RNA preparations being used to generate cDNA libraries for NGS using the Roche 454 Titanium DNA sequencing *** assemblies constructed from the resultant sequences（301 094 reads）using the software program CLC Genomics Workbench generated 3 821 core *** of a selection of these contigs with related sequences from other *** genetic groups has revealed good alignment for some genes（e.g.,HSP90）but misassemblies in other datasets（e.g.,the vitellogenin gene family）,highlighting the need for manual curation as well as collaborative international efforts to obtain accurate assemblies from the existing next generation sequence ***,data emerging from the NGS has facilitated the development of accurate and reliable methods for analysing gene expression based on quantitative real-time RT-PCR,illustrating the power of this approach to enable rapid expression analyses in an organism for which a complete genome sequence is currently lacking.

关键词： Bemisia tabaci whitefly transcriptome next generation sequencing quantitative real-time (QRT)-PCR Asia 1 mtCOI

Harnessing the synergy of perfusable muscle flap matrix and adipose-derived stem cells for prevascularization and macrophage polarization to reconstruct volumetric muscle loss

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Bioactive Materials 2023年第4期22卷 588-614页

作者： Qixu Zhang Yulun Chiu Youbai Chen Yewen Wu Lina W.Dunne Rene D.Largo Edward I.Chang david M.Adelman Mark v.Schaverien Charles E.Butler Department of Plastic Surgery The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Department of Plastic Surgery Chinese PLA General HospitalBeijing100853China

Muscle flaps must have a strong vascular network to support a large tissue volume and ensure successful *** developed porcine stomach musculofascial flap matrix(PDSF)comprising extracellular matrix(ECM)and intact *** had a dominant vascular pedicle,microcirculatory vessels,a nerve network,well-retained 3-dimensional(3D)nanofibrous ECM structures,and no allo-or ***-depth proteomic analysis demonstrated that PDSF was composed of core matrisome proteins(e.g.,collagens,glycoproteins,proteoglycans,and ECM regulators)that,as shown by Gene Ontology term enrichment analysis,are functionally related to musculofascial biological ***,PDSF􀀀human adipose-derived stem cell(hASC)synergy not only induced monocytes towards IL-10􀀀producing M2 macrophage polarization through the enhancement of hASCs’paracrine effect but also promoted the proliferation and interconnection of both human skeletal muscle myoblasts(HSMMs)and human umbilical vein endothelial cells(HUvECs)in static triculture ***,PDSF was successfully prevascularized through a dynamic perfusion coculture of hASCs and HUvECs,which integrated with PDSF and induced the maturation of vascular networks in *** a xenotransplantation model,PDSF demonstrated myoconductive and immunomodulatory properties associated with the predominance of M2 macrophages and regulatory T *** a volumetric muscle loss(vML)model,prevascularized PDSF augmented neovascularization and constructive remodeling,which was characterized by the predominant infiltration of M2 macrophages and significant musculofascial tissue *** results indicate that hASCs’integration with PDSF enhances the cells’dual function in immunomodulation and *** in part to this PDSF-hASC synergy,our platform shows promise for vascularized muscle flap engineering for vML reconstruction.

关键词： Muscle flap fabrication Extracellular matrix Decellularization vascularization Macrophage polarization volumetric muscle loss

Milliwatt terahertz harmonic generation from topological insulator metamaterials

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Light(Science & Applications) 2022年第11期11卷 2766-2773页

作者： Klaas-Jan Tielrooij Alessandro Principi david Saleta Reig Alexander Block Sebin varghese Steffen Schreyeck Karl Brunner Grzegorz Karczewski Igor Ilyakov Oleksiy Ponomaryov Thales v.A.G.de Oliveira Min Chen Jan-Christoph Deinert Carmen Gomez Carbonell Sergio O.valenzuela Laurens W.Molenkamp Tobias Kiessling Georgy v.Astakhov Sergey Kovalev Catalan Institute of Nanoscience and Nanotechnology(ICN2) BIST and CSICCampus UABBellaterraBarcelona 08193Spain Department of Applied Physics TU EindhovenDen Dolech 25612 AZ EindhovenThe Netherlands School of Physics and Astronomy University of ManchesterM139PL ManchesterUK Physikalisches Institut(EP3) Universitat WurzburgAm Hubland97074 WurzburgGermany Institute of Physics Polish Academy of ScienceAl.Lotnikow 32/46PL-02668 WarsawPoland Helmholtz Zentrum Dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Institute for Topological Insulators Am HublandD-97074 WurzburgGermany

Achieving effcient,high-power harmonic generation in the terahertz spectral domain has technological applications,for example,in sixth generation(6G)communication *** Dirac fermions possess extremely large terahertz nonlinear susceptibilities and harmonic conversion ***,the observed maximum generated harmonic power is limited,because of saturation effects at increasing incident powers,as shown recently for ***,we demonstrate room-temperature terahertz harmonic generation in a Bi_(2)Se_(3) topological insulator and topological-insulator-grating metamaterial structures with surface-selective terahertz field *** obtain a third-harmonic power approaching the miliwatt range for an incident power of 75 mW-an improvement by two orders of magnitude compared to a benchmarked graphene *** establish a framework in which this exceptional performance is the result of thermodynamic harmonic generation by the massless topological surface states,benefiting from ultrafast dissipation of electronic heat via surface-bulk Coulomb *** results are an important step towards on-chip terahertz(opto)electronic applications.

关键词： harmonic insulator incident

Diversity and production in an Afromontane Forest

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Forest Ecosystems 2016年第4期3卷 275-286页

作者： Klaus v.Gadow GongQiao Zhang Graham Durrheim david Drew Armin Seydack Georg-August University in Gottingen Gottingen Germany Department of Forestry and Wood Science University of Stellenbosch Stellenbosch South Africa Chinese Academy of Forestry in Beijing Beijing China South African National Parks Knysna South Africa

Background：This contribution evaluates the effect of forest structure and tree species diversity on plot productivity and individual tree growth in the unique Knysna forests in Southern Africa using mapped tree data from an observational study that has been re-measured over a period of 40 ***：The effects of tree species diversity and forest structure on tree growth and forest production are evaluated on three levels of resolution：a） the forest community（canopy,sub-canopy species）,b） the subplots（number of trees per ha,skewness of the diameter distribution,diameter coefficient of variation） and c） the immediate neighborhood of selected reference trees（＂Mingling＂,＂Dominance＂,Aggregation＂ and ＂Size variation＂）.Results：An analysis of the community level identified two distinct clusters,one including dominant/canopy species with the highest growth rates and a greater variation of growth,and another cluster which includes the remaining subcanopy species which have a smaller maximum size and lower rates of *** area-based structure variables on plot level have a highly significant effect on total basal area ***,the effects of forest density and species richness on productivity were not straight *** basal area production of about 0.75 m^2/ha/year is achieved at medium levels of richness（around 20 species per ha） and medium levels of density（around 30 m^2/ha basal area） using percentile regression *** relative ＂Dominance＂ of a selected reference tree had a highly significant effect on individual tree growth on all investigated *** neighbourhood structure variables were only occasionally significant or not significant at ***：This contribution presents a new theoretical framework for analysing natural forests that includes community,plot and neighborhood variables of forest structure and diversity,and a first specific analysis of the structure and dynamics of the Knysna Afromontane Forest,based on a unique s

关键词： canopy neighborhood forests richness basal straight productivity occasionally remaining tropical