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Artificial intelligence analysis of videos to augment clinical assessment:an overview

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Neural Regeneration Research 2024年第4期19卷 717-718页

作者： david C.wong Stefan Williams University of Leeds Leeds Teaching Hospitals Trust LeedsUK

Observation is a fundamental part of the practice of clinical *** of movement is particularly important for the *** such as Parkinson’s disease,multiple sclerosis,stroke,epilepsy,and many others affect a person’s movement in characteristic *** some conditions,changes in the patient’s voice can be included in this-changes in sound caused by changes in the movements of *** clinician’s detection of a characteristic abnormality,and their judgment of its severity,plays a central role in both diagnosis and the assessment of prognosis or response to ***,that practice depends upon a limited resource of experienced *** addition,these experts are limited by human visual judgment,which cannot reliably or precisely detect and measure small or subtle changes in movement(Williams et al.,2023).

关键词： clinical epilepsy diagnosis

Data Center Power System Stability-Part II: System Modeling and Analysis

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 420-438页

作者： Jian Sun Melaku Mihret Mauricio Cespedes david wong Mike Kauffman Rensselaer Polytechnic Institute-ECSE 1108th Street Room CII 8015Troy 12180United States Meta Platforms Inc. 1601 Willow RdMenlo ParkCalifornia 94025-1452United States

This is the second part of a two-part paper on stability study of data center power systems by impedance-based *** the basis for this application,Part I[1]developed new impedance models for power supplies that are the most dominant loads in data *** second part presents system modeling and analysis methods that can support practical data center power system design to ensure *** proposed methods comprise:1)building distribution network modeling by impedance scaling;2)system modeling and model reduction based on equivalent source impedance;3)system stability analysis in the sequence domain to include zero-sequence dynamics;and 4)expansion of system models and analyses to account for network asymmetry and uneven *** methods are used to characterize practical resonance problems observed in data centers,explain their root causes,and develop *** systems using Y-connected power supply units(PSUs),the zero sequence is identified as the weakest link and the first to become *** expanded system model and analysis reveal a new,differential-mode instability that is responsible for high frequency *** guarantee system stability,new impedance-based product and system design specifications are developed based on sufficient conditions derived from the Nyquist stability *** and field measurements are presented to substantiate the proposed methods and conclusions.

关键词： Data center power systems frequency-domain methods impedance modeling system stability system resonance

Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding

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World Journal of Gastroenterology 2016年第31期22卷 6972-6986页

作者： Joseph Paul Weiner Andrew Thomas wong david Schwartz Manuel Martinez Ayse Aytaman david Schreiber Department of Radiation Oncology VA NY Harbor Healthcare System Brooklyn Campus Department of Radiation Oncology SUNY Downstate Medical Center Department of Gastro-enterology VA NY Harbor Healthcare System Brooklyn Campus Department of Gastroenterology SUNY Downstate Medical Center

Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical intervention. Commonly utilized medical therapy includes sucralfate enemas, antibiotics, 5-aminosalicylic acid derivatives, probiotics, antioxidants, short-chain fatty acids, formalin instillation and fractionated hyperbaric oxygen. More invasive treatments include endoscopic-based, focally ablative interventions such as dilation, heater and bipolar cautery, neodymium/yttrium aluminum garnet argon laser, radiofrequency ablation or argon plasma coagulation. Despite its relatively common frequency, there is a dearth of existing literature reporting headto-head comparisons of the various treatment options via a randomized controlled approach. The purpose of our review was to present the reader a consolidation of the existing evidence-based literature with the goal of highlighting the comparative effectiveness and risks of the various treatment approaches. Finally, we outline a pragmatic approach to the treatment of radiation proctitis. In light of the lack of randomized data, our goal is to pursue as least invasive an approach as possible, with escalation of care tailored to the severity of the patient's symptoms. For those cases that are clinicallyasymptomatic or only mildly symptomatic, observation or medical management can be considered. Once a patient fails such management or symptoms become more severe, invasive procedures such as endoscopically based focal ablation or surgical intervention can be considered. Although not all recommendations are supported by level I evidence, reported case series and single-institutional studies in the literature suggest that successful treatment with cessation of symptoms can be obtained in the majority of cases.

关键词： Prostate cancer Radiation therapy Radiation proctitis Radiation proctopathy Medical treatment Endoscopic treatment Hyperbaric oxygen Neodymium/ yttrium aluminum garnet argon laser Argon plasma coagulation

Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

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World Journal of Gastroenterology 2022年第31期28卷 4390-4398页

作者： Alnoor Ramji Karen Doucette Curtis Cooper Gerald Yosel Minuk Mang Ma Alexander wong david wong Edward Tam Brian Conway david Truong Philip wong Lisa Barrett Hin Hin Ko Sarah Haylock-Jacobs Nishi Patel Gilaad G Kaplan Scott Fung Carla S Coffin Department of Medicine University of British ColumbiaVancouver v6t 1z3Canada Department of Medicine University of AlbertaEdmonton t6g 2r7Canada Department of Medicine The Ottawa Hospital Research InstituteUniversity of OttawaOttawa ON K1H 8L6Canada Department of Medicine University of ManitobaWinnipeg r3e 3j7Canada Department of Medicine University of SaskatchewanSaskatoon s7n 5e5Canada Department of Medicine University Health NetworkToronto m5g 2c4Canada Pacific Gastroenterology Associates Vancouver v6z 2k5Canada Vancouver Infectious Disease Centre Vancouver v6z 2c7Canada Department of Medicine McGill UniversityMontreal h3a 0g4Canada Department of Microbiology and Immunology Dalhousie UniversityHalifax b3h 4r2Canada Cumming School of Medicine University of CalgaryCalgary t2n 1n4Canada

BACKGROUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)*** is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSM)(i.e.,FibroScan®).METHODS Retrospective,observational cohort study from the Canadian HBV *** collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and *** were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year *** In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAM-treated with similar median duration of 3.9 and 3.7 years,*** mean baseline LSM was 11.2 kPa(TDF)vs 8.3 kPa(LAM)(P=0.003).At 5-year follow-up,the mean LSM was 7.0 kPa in TDF vs 6.7 kPa in LAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAM,P<0.05).The last available data on treatment showed that all had normal ALT,but more TDF patients were virologically suppressed(<10 IU/mL)(n=170/190,89%)vs LAM-treated(n=35/58,60%)(P<0.05).None cleared *** In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss.

关键词： Nucleos(t)ide analog therapy Functional cure Hepatitis B virus surface antigen loss Fibrosis regression Liver stiffness measurement Transient elastography

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CC趋化因子偶联受体信号途径(英文)

Acta Biochimica et Biophysica Sinica 2003年第9期35卷 779-788页

作者： NEW david C.,wong Yung H. 香港科技大学生物化学系香港科技大学生物化学系九龙清水湾香港九龙清水湾香港

The isolation and characterization of multiple CC chemokine receptors (CCRs) in a wide range of tissues and cells signifies the functional diversity of CC chemokines. The realization that multiple chemokines activate individual receptors and that some chemokines are functional at several different CCRs, indicates that interplay between a complex network of intracellular pathways is required for the full expression of the physiological function of each ligand. In different cellular environments, chemokines can regulate distinct second messengers or even positively or negatively regulate the same signal transduction pathway. The specific interactions between many signalling molecules have been discerned in an increasing number of cellular systems and this information is being used to explain the physiological actions of chemokines. This review will attempt to summarize recent research by many groups that has revealed numerous subtleties of the CC chemokine-coupled signalling pathways.

关键词： CC chemokine receptor (CCR) chemokines chemotaxis G protein G protein-coupled receptor (GPCR)

Do we need a heavy silicone?-Experience after 120 cases.

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Do we need a heavy silicone?-Experience after 120 cases.

Double peeling of Macular Pucker

中华医学会第十二届全国眼科学术大会

作者： david wong Royal Liverpool University Hospital University of HongKong

Introduction:The use of heavy silicone is *** doubted its safety and *** questioned the need for heavy *** development of Densiron takes into consideration the tampon- ade efficiency of liquid tamponade agents,their a...

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Double peeling of Macular Pucker

The results of re-operating on full thickness nmcular holes

中华医学会第十二届全国眼科学术大会

作者： david wong The University of Hong Kong Royal Liverpool University

Introduction:Histologically,epiretinal membranes (ERM) removed from eyes during surgical peeling procedures have often shown to contain internal limiting ***

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The results of re-operating on full thickness nmcular holes

The potential development of drug resistance in rheumatoid arthritis patients identified with p53 mutations

中华医学会第十二届全国眼科学术大会

作者： david wong University of Hong Kong Royal Liverpool University

Objective:To evaluate the visual outcome after a second surgical attempt to close idiopathic full-thickness macular holes (FTMH) in patients who underwent unsuccessful pri-

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Genes & Diseases 2023年第6期10卷 2252-2255页

作者： Congling Qiu Joyce Tsz Wai Chan david Wei Zhang Io Nam wong Yaling Zeng Betty Yuen Kwan Law Simon Wing Fai Mok Ivo Ricardo De Seabra Rodrigues Dias Wenfeng Liu Liang Liu Vincent Kam Wai wong Dr.Neher's Biophysics Laboratory for Innovative Drug Discovery State Key Laboratory of Quality Research in Chinese MedicineMacao University of Science and TechnologyMacao SAR 999078China Department of Public Health and Preventive Medicine School of MedicineJinan UniversityGuangzhouGuangdong 510000China Faculty of Medicine Macao University of Science and TechnologyMacao SAR 999078China School of Biotechnology and Health Sciences Wuyi UniversityJiangmenGuangdong 529000China

Rheumatoid arthritis(RA)is a chronic inflammatory disease characterized by cartilage and bone damage with the presence of pannus formation which causes uncontrollable proliferation and invasion of fibroblast-like synoviocytes(FLS).Since rheumatoid arthritis is a chronic disorder,the patients normally need to undergo prolonged antirheumatic treatment with the use of disease-modifying antirheumatic drugs(DMARDs),steroids,and nonsteroidal anti-inflammatory drugs(NSAIDs).The efficacy of such long-term pharmaceutical intervention can be significantly affected by the development of drug *** pathological relationship between rheumatoid arthritis and cancer hinted that some chemotherapeutic drugs,such as methotrexate(MTX),could be used for RA *** idea was reinforced by the analysis of mutations in p53 tumor suppressor *** 50%of p53 somatic mutations observed from various cancers are also identified in the synovium of RA patients1(Fig.1A).Of note,the hyperplastic synovium in RA with overexpressed p53 mutants contributed to the destruction of joints in patients with erosive RA.

关键词： patients drugs rheumatoid