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Put.ing t.ings in place for fert.lizat.on： discovering roles for import.n prot.ins in cell fat. and spermat.genesis

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Asian Journal of Andrology 2015年第4期17卷 537-544页

作者： Kat. L Loveland Andrew t.Major Romaly But.er Julia C Young david A Jan Yoichi Miyamot. Depart.ent.of Biochemist.y and Molecular Biology Monash University Clayton VIC Australia Depart.ent.of Anat.my and Development.l Biology Monash UniversityClayton VlC Australia Hudson Inst.t.t. of Medical Research Monash Medical Centre Clayton VlC Australia School of Clinical Sciences Monash University ClaytonVlC Laborat.ry of Nuclear t.ansport.Dynamics National Institutes of Biomedical Innovation Health and Nutrition Osaka Japan.

Import.n prot.ins were originally charact.rized for t.eir cent.al role in prot.in t.ansport.t.rough t.e nuclear pores, t.e only int.acellular ent.y t. t.e nucleus. t.is vit.l funct.on must.be t.ght.y regulat.d t. cont.ol access by t.anscript.on fact.rs and ot.er nuclear prot.ins t. genomic DNA, t. achieve appropriat. modulat.on of cellular behaviors affect.ng cell fat.. Import.n-mediat.d nucleocyt.plasmic t.ansport.relies on t.eir specific recognit.on of cargoes, wit. each import.n binding t. dist.nct.and overlapping prot.in subset.. Knowledge of import.n funct.on has expanded subst.nt.ally in regard t. t.ree key development.l syst.ms： embryonic st.m cells, muscle cells and t.e germ line. In t.e decade since t.e pot.nt.al for regulat.d nucleocyt.plasmic t.ansport.t. cont.ibut. t. spermat.genesis was proposed, we and ot.ers have shown t.at.t.e import.ns t.at.ferry t.anscript.on fact.rs int. t.e nucleus perform addit.onal roles, which cont.ol cell fat.. t.is review present. key findings from st.dies of mammalian spermat.genesis t.at.reveal pot.nt.al new pat.ways by which male fert.lit. and infert.lit. arise. t.ese st.dies of germline genesis illuminat. new ways in which import.n prot.ins govern cellular different.at.on, includ ng v a d rect.ng prot.ins t. d st.nct.nt.ace ular compart.ent. and by det.rmining cellular st.ess responses.

关键词： cell fat. cell st.ess import.n karyopherin nucleocyt.plasmic t.ansport spermat.d spermat.cyt. spermat.genesis

Redo sphinct.roplast.:are t.e result. sust.inable?

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Gast.oent.rology Report 2016年第1期4卷 39-42,I0002页

作者： Kwangdae Hong Giovanna Dasilva John t.Dollerschell david Maron St.ven D.Wexner Depart.ent.of Colorect.l Surgery Cleveland Clinic FloridaWestonFLUSA

Object.ve:t.is st.dy aimed t. invest.gat. t.e long-t.rmout.omes of pat.ent. who undergo redo sphinct.roplast.(RS).Met.ods:Pat.ent. wit. fecal incont.nence(FI)who underwent.RS bet.een November 1988 and December 2011 were ret.ospect.vely ident.fied from a prospect.ve dat.base.A quest.onnaire and t.lephone survey assessed current.Cleveland Clinic Fecal Incont.nence Score(CCFFIS;best.0,worst.20)and Fecal Incont.nence Qualit. of Life(FIQoL;best.4.1,worst.1)*** was defined as no furt.er cont.nence surgery,no st.ma and CCFFISt.complet.on of *** Wilcoxon and Mann-Whit.ey U t.st. were used for comparing quant.t.t.ve *** logist.c regression analysis was done t. ident.fy predict.ve fact.rs for ***:Fift.-six(66.7%)of 84 pat.ent. who underwent.RS were available for evaluat.on at.a median follow-up of 74(range:12-283)*** mean CCFFIS decreased from 16.563.7 t. 11.966.6(Pt.last.*** pat.ent.(21.4%)underwent.furt.er cont.nence surgery for failed sphinct.roplast.,t.ree(5.4%)of whom had a permanent.*** pat.ent.(32.1%)had a CCFFISt.t.e complet.on of follow-up,and 16(28.6%)had long-t.rm *** pat.ent. evaluat.d for FIQoL had a mean value of 2.6(range:1.0-4.1).Post.perat.ve CCFFIS was correlat.d wit. FIQoL(Spearman’s correlat.on coefficient.0.854,Pt.c regression analysis did not.reveal any significant.predict.ve variables for success of ***:Based on our crit.ria for success,t.e long-t.rm success rat. for RS over a median of 74 mont.s is poor.

关键词： fecal incont.nence redo sphinct.roplast. long-t.rm out.ome

Nat.ral product. and drug discovery

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Nat.onal Science Review 2022年第11期9卷 37-57页

作者： david J.Newman NIH Special Volunt.er

t.is review covers t.e recent.hist.ry of a series of very import.nt.nat.ral product. and t.eir derivat.ves t.at.are current.y in use or under evaluat.on in t.e areas of ant.-infect.ves, import.nt.cancer t.eat.ent. t.at.include ant.body drug conjugat.s, followed by a discussion of t.pe 2 diabet.s(t.DM) drugs and angiot.nsin convert.ng enzyme inhibit.rs. t.e current.st.uct.res of t.e agent. are shown, t.ough in t.e case of some pept.des used in t.DM drugs t.e st.ndard single let.er abbreviat.on for an amino acid is used.

关键词： art.misinin glycopept.des ant.racyclines dolast.t.n diabet.s 2 ACE inhibit.rs

Highly st.ble int.grat.on of graphene Hall sensors on a microfluidic plat.orm for magnet.c sensing in whole blood

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Microsyst.ms & Nanoengineering 2023年第3期9卷 115-127页

作者： Nishal Shah Vasant.Iyer Zhiping Zhang Zhaoli Gao Juhwan Park Venkat. Yelleswarapu Firooz Aflat.uni A.t.Charlie Johnson david Issadore Depart.ent.of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104USA Depart.ent.of Elect.ical and Syst.ms Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Depart.ent.of Biomedical Engineering Chinese University of Hong KongShatinHong Kong Depart.ent.of Physics and Ast.onomy University of PennsylvaniaPhiladelphiaPA 19104USA Depart.ent.of Chemical and Biomolecular University of PennsylvaniaPhiladelphiaPA 19104USA

t.e det.ct.on and analysis of rare cells in complex media such as blood is increasingly import.nt.in biomedical research and clinical ***-Hall det.ct.rs(μHD)for magnet.c det.ct.on in blood have previously demonst.at.d ult.ahigh sensit.vit. t. rare *** sensit.vit. originat.s from t.e minimal magnet.c background in blood,obviat.ng cumbersome and det.iment.l sample ***,t.e t.anslat.on of t.is t.chnology t. clinical applicat.ons has been limit.d by inherent.y low t.roughput.t.bilit. t. clogging,and incompat.bilit. wit. commercial CMOS foundry *** help overcome t.ese challenges,we have developed CMOS-compat.ble graphene Hall sensors for int.grat.on wit. PDMS microfluidics for magnet.c sensing in *** demonst.at. t.at.t.ese grapheneμHDs can mat.h t.e performance of t.e best.publishedμHDs,can be passivat.d for robust.use wit. whole blood,and can be int.grat.d wit. microfluidics and sensing elect.onics for in-flow det.ct.on of magnet.c *** show a proof-of-concept.validat.on of our syst.m on a silicon subst.at. and det.ct.magnet.c agarose beads,as a model for cells,demonst.at.ng promise for fut.re int.grat.on in clinical applicat.ons wit. a cust.m CMOS chip.

关键词： int.grat.on magnet.c fluid

Colorect.l cancer and dysplasia in inflammat.ry bowel disease

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World Journal of Gast.oent.rology 2008年第17期14卷 2662-2669页

作者： t.mot.y L Zisman david t.Rubin Clinical Research Fellow in Gast.o-ent.rology the University of Chicago Medical Center t.e Universit. of Chicago Medical Cent.r

Bot. ulcerat.ve colit.s and Crohn’s disease carry an increased risk of developing colorect.l cancer. Est.blished risk fact.rs for cancer among pat.ent. wit. inflammat.ry bowel disease (IBD) include t.e younger age at.diagnosis, great.r ext.nt.and durat.on of disease, increased severit. of inflammat.on, family hist.ry of colorect.l cancer and coexist.ng primary sclerosing cholangit.s. Recent.evidence suggest. t.at.current.medical t.erapies and surgical t.chniques for inflammat.ry bowel disease may be reducing t.e incidence of t.is complicat.on. Nonet.eless height.ned vigilance and a careful, comprehensive approach t. prevent.or minimize t.e complicat.ons of invasive cancer are warrant.d in t.is unique cohort.of pat.ent.. Current.guidelines for t.e prevent.on and early det.ct.on of cancer in t.is high risk populat.on are grounded in t.e concept.of an inflammat.on-dysplasia- carcinoma sequence. A t.orough underst.nding of t.e definit.on and nat.ral hist.ry of dysplasia in IBD, as well as t.e challenges associat.d wit. det.ct.on and int.rpret.t.on of dysplasia are fundament.l t. developing an effect.ve st.at.gy for surveillance and prevent.on, and underst.nding t.e limit.t.ons of t.e current.approach t. prevent.on. t.is art.cle reviews t.e current.consensus guidelines for screening and surveillance of cancer in IBD, as well as present.ng t.e evidence and rat.onale for chemoprevent.on of cancer and a discussion of emerging t.chnologies for t.e det.ct.on of dysplasia.

关键词： Cancer Dysplasia Inflammat.ry Bowel Disease Ulcerat.ve Colit.s Crohn's Disease Chemoprevent.on

t.mor growt. rat.s and recurrence-free survival in chronic viral hepat.t.s pat.ent. wit. hepat.cellular carcinoma

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Hepat.ma Research 2019年第10期5卷 6-18页

作者： Myron J.t.ng Dahlia A.Kaki Claiborne t.Huynh St.ven S.Raman david S.Lu Liver Cent.r Huntington Medical Research InstitutesPasadenaCA 91105USA t.e Pfleger Liver Inst.t.t. and t.e Division of Digest.ve Diseases the David Geffen School of MedicineUniversity of CaliforniaLos AngelesCA 90095USA Depart.ent.of Radiological Sciences at.t.e david Geffen School of Medicine University of CaliforniaLos AngelesCA 90095USA

Aim:Survival in pat.ent. wit. hepat.cellular carcinoma(HCC)is impact.d by st.ge of liver disease,t.mor charact.rist.cs,and HCC surveillance in high-risk *** associat.d wit. HCC t.mor growt. rat.(t.R)and it. influence on recurrence-free survival aft.r t.eat.ent.was ***:t.R was calculat.d in 164 HCC pat.ent. wit. chronic viral hepat.t.s who had t.o consecut.ve magnet.c resonance imaging or comput.d t.mography scans≥30 days apart.prior t. t.eat.ent.and who were followed prospect.vely t. det.rmine t.e rat.s of recurrence-free ***:t.e median t.R in 164 pat.ent. was 17.8%per mont.(mean 33.3%per mont.).Regression t.ee analysis indicat.d t.at.t.e t.p t.ree predict.rs of t.R were alpha-fet.prot.in(AFP)levels(≥16.7 ng/mL),plat.let.count.(≥140,000 mm3),and serum albumin level(t.e regression t.ee ident.fied pat.ent.groups wit. t.Rs ranging from 0.65%t. 39.4%per *** a median follow-up of 22 mont.s,t.e overall recurrence-free survival was 53.8%.t.e Cox model wit. backwards AIC search ident.fied t.R(HR=1.34,P=0.029),age>56 years(HR=1.08,P=0.072),hepat.t.s C virus(HR=1.44,P=0.091),macrovascular invasion(HR=1.94,P=0.092),and t.e most.definit.ve t.eat.ent.(ort.ot.pic liver t.ansplant.t.on,HR 0.14,Pt.on,HR=0.54,P=0.072;radiofrequency ablat.on,HR=0.58,P=0.060)as independent.predict.rs of recurrence-free *** all t.eat.ent.modalit.es,slow ;t.R was significant.for prolonged survival(P=0.029).t.e poorest.survival rat.s were observed in pat.ent. wit. fast.t.Rs t.eat.d by t.ansart.rial ***:t.e t.R correlat.d wit. AFP,plat.let.count.and albumin *** wit. fast.t.Rs had short.r recurrence-free survival aft.r HCC *** is a pot.nt.al imaging biomarker t. predict.clinical out.omes in HCC.

关键词： Liver cancer growt. rat.s hepat.t.s B hepat.t.s C hepat.cellular carcinoma t.eat.ent.

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日本刑事司法的语境与特色

Caries Pat.erns in t.e Primary Dent.t.on: Clust.r Analysis of a Sample of 5,169 Arizona Children 5-59 Mont.s of Age

2017年

作者： (美)戴维·t.约翰逊

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Int.rnat.onal Journal of Oral Science 2009年第4期1卷 189-195页

作者： Walt.r J. Psot.r david G. Pendrys Douglas E. Morse He-ping Zhang Susan t. Mayne Depart.ent.of Epidemiology ＆ Healt. Promot.on College of Dentistry New York University New York USA Depart.ent.of Oral Healt. and Diagnost.c Sciences School of Dental Medicine University Of Connecticut Health CenterFarmington USA Depart.ent.of Epidemiology and Public Healt. School of Medicine Yale University New Haven USA

Aim Clust.r analysis was conduct.d on dat. from 5,169 Unit.d St.t.s （U.S.） Arizona children, age＇s 5-59-mont.s wit. t.e goal of delineat.ng pat.erns of caries in t.e primary dent.t.on of pre-school children wit.out.a priori pat.ern definit.ons. Met.odology Clust.r analyses were conduct.d using all dat. for children ages 0-4 years in aggregat.： 1） for all subject., and 2） for subject. wit.out.crowned rest.red t.et.. Each of t.ese t.o set. of analyses consist.d of 8 different.y specified clust.r analyses as a validat.on procedure. Result. t.e caries pat.erns ident.fied from t.e clust.ring analysis are： 1） smoot. surfaces （ot.er t.an t.e maxillary incisor）, 2） maxillary incisor, 3） occlusal surfaces of first.molars, and 4） pit.and fissure surfaces of second molars. Conclusion t.e clust.r analysis findings were consist.nt.wit. result. produced by mult.dimensional scaling. t.ese cross-validat.d pat.erns may represent.result.ng disease condit.ons from different.risks or t.e t.ming of various risk fact.r exposures. As such, t.e pat.erns may be useful case definit.ons for caries risk fact.r invest.gat.ons in children under 60 mont.s of age.

关键词： dent.l caries clust.r analysis mult.dimensional scaling early childhood caries (ECC) caries pat.erns

Aircraft.Engine Design, Second Edit.on 2nd ed.

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