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Large edge magnetism in oxidized few-layer black phosphorus nanomeshes

Nano Research 2017年第2期10卷 718-728页

作者： Yudai Nakanishi Ayumi Ishi Chika Ohata david soriano Ryo Iwaki Kyoko Nomura~ Miki Hasegawa Taketomo Nakamura Shingo Katsumoto Stephan Roche Junji Haruyama Faculty of Science and Engineering Aoyama Gakuin University 5- I0-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Chemistry and Biological Science Aoyama Gakuin University 5-10-1 Fuchinobe Sagamihara Kanagawa 252-5258 Japan Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and The Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Institucio Catalana de Recercai Estudis Avancats (ICREA) 08010 Barcelona Spain Institute for solid state physics The University of Tokyo 5- I-5 Kashiwanoha Kashiwa Chiba 277-8581 Japan

The formation and control of a room-temperature magnetic order in two- dimensional （2D） materials is a challenging quest for the advent of innovative magnetic- and spintronic-based technologies. To date, edge magnetism in 2D materials has been experimentally observed in hydrogen （H）-terminated graphene nanoribbons （GNRs） and graphene nanomeshes （GNMs）, but the measured magnetization remains far too small to allow envisioning practical applications. Herein, we report experimental evidences of large room-temperature edge ferromagnetism （FM） obtained from oxygen （O）-terminated zigzag pore edges of few-layer black phosphorus （P） nanomeshes （BPNMs）. The magnetization values per unit area are -100 times larger than those reported for H-terminated GNMs, while the magnetism is absent for H-terminated BPNMs. The magnetization measurements and the first-principles simulations suggest that the origin of such a magnetic order could stem from ferromagnetic spin coupling between edge P with O atoms, resulting in a strong spin localization at the edge valence band, and from uniform oxidation of full pore edges over a large area and interlayer spin interaction. Our findings pave the way for realizing high-efficiency 2D flexible magnetic and spintronic devices without the use of rare magnetic elements.

关键词： black phosphorus nanomesh edge magnetism spintronics zigzag edge oxygen termination rare-metal free

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Spermotrend Improves Semen Quality and Infertility in Men with Varicocele —Spermotrend and Male Infertility

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Advances in Reproductive Sciences 2024年第2期12卷 83-97页

作者： Melida Aguilar Chamorro Sergio Antonio Vargas Collado david Marquez soriano Clinica Seniors Managua Nicaragua Scientific Department Catalysis S.L. Madrid Spain

Background: Infertility affects 8% - 12% of couples globally, with approximately half of the cases reported in males. Oxidative stress is a common factor increased in the varicocele condition and particularly affects spermatozoa, due to their sensitivity to oxidative signals and testicular hypotrophy. The objective of this clinical trial is to study the effectiveness of Spermotrend in the improvement of sperm parameters in male infertility. Methods: A total of 170 males aged > 18 years with a diagnosis of infertility and varicocele were consecutively enrolled in a Phase II, open-label clinical trial. Spermotrend was administered 1 capsule (450 mg) orally every 8 hours for 6 months and was evaluated through semen analysis at 4 and 6 months of follow-up. Results: The trial results show a significant improvement following the administration of Spermotrend over 6 months in sperm concentration (44.1% at baseline vs. 64.1% at 6 months), sperm survival (28.2% with sperm survival ≥ 2 hours vs.56.5%), normalization of sperm morphology (31.2% vs. 72.9%). Varicocele condition decreased in all patients and, by the end of the study, 55.3% of patients had normal venous flow and dilation. Only 5.9% of the patients showed grade 2 varicocele at the end of the study, while 38.8% showed grade 1 varicocele, with no patients showing grade 3 varicocele. Regarding testicular hypotrophy, 90.6% of the patients completed the study with normalized testicular volume by recovering normal venous flow. Conclusion: A short-term course of Spermotrend may significantly improve sperm parameters associated with male infertility. Clinical Trial Registration: The clinical trial protocol was registered in the international clinical trial registry, ***, with the code: NCT05222841 on 15/06/2021.

关键词： Antioxidants Dietary Supplementation Male Infertility Spermatogenesis Varicocele Pygeum africanum

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Cost-Effectiveness Analysis of Renalof® versus Extracorporeal Shockwave Lithotripsy (ESWL) for the Treatment of Kidney Stones ≤ 1 cm in Nicaragua

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Health 2024年第7期16卷 674-687页

作者： Mélida M. Aguilar Chamorro Sergio Vargas Collado Leslie Pérez Ruíz david Márquez soriano Jorge Luis soriano García Clínica Senior Managua Nicaragua Centro de Inmunología Molecular Havana Cuba Catalysis S.L. Madrid Spain

Objectives: To assess the efficiency in terms of cost-effectiveness (CE) of oral Renalof® treatment versus extracorporeal shockwave lithotripsy (ESWL) in the treatment of kidney stones ≤ 1 cm in Nicaragua. Methods: A cost-effectiveness economic evaluation was carried out based on the results obtained in the randomised, prospective, observational, single-blind, prospective, phase 2 clinical trial. Cost-effectiveness and the incremental cost-effectiveness ratio (ICER) were calculated. Economic data were obtained from the Economics Department of Clínica Senior in Managua, Nicaragua. The monetary cost was expressed in US dollars (USD). Results: Treatment with Renalof® yielded a CE of $1,323.08/% remission, while ESWL was $9,498.54/% remission. The ICER shows that, in order to achieve a high percentage of kidney stone remission with ESWL, an extra $4,734.70 per patient must be invested. Conclusions: The use of Renalof® is shown to be a more cost-effective option than ESWL. It is recommended for the treatment of kidney stones ≤ 1 cm in size.

关键词： Economic Evaluation Pharmacoeconomics Renalof® Extracorporeal Shockwave Lithotripsy Kidney Stones

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Blue Cap Is Effective and Safe for the Treatment of Atopic Dermatitis in Children

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Open Journal of Pediatrics 2024年第3期14卷 609-622页

作者： Mirjana Gajić-Veljić Biljana Marenović Margita Mijušković Vesna Reljić Danica Tiodorović Danijela Popović Sanja Zorić-Blagojević Milica Vučinić david Marquez-soriano Jovan Lalošević University of Belgrade Faculty of Medicine Department of Dermatology and Venereology University Clinical Center of Serbia Beograd Serbia University of Niš Faculty of Medicine Department of Dermatology and Venereology University Clinical Center of Ni&#353 Ni&#353 Serbia City Institute for Skin and Venereal Diseases Beograd Serbia Scientific Department Catalysis S.L. Madrid Spain

Background: Atopic dermatitis (AD) is the most common inflammatory skin disease in children. Treatment of AD is based on skin barrier repair and reduction of inflammation. We analyzed the efficacy and safety of activated piroctone olamine (APO)—Blue Cap—in children with AD. Materials and Methods: An open-label interventional clinical study was carried out at three clinical centers in Serbia. A total of 58 patients with AD, aged between 3 and 18 years were included and treated with Blue Cap Foam (100 ml;CATALYSIS S.L. Madrid)—Activated Piroctone Olamine—applied twice a day in the affected areas with eczema for 30 days and final assessment at 45 days from baseline. Photographic documentation, clinical evaluation, therapy effectiveness and safety questionnaires were assessed at baseline, 15, 30 and 45 days. Results: Our results demonstrated a significant reduction in signs (erythema, scaling, infiltration, excoriations, xerosis) and symptoms (pruritus) at weeks 2 and 4 of the study. At the end of the study, most patients had moderate (28.6%) to great (62.5%) disappearance of manifestations and moderate (25%) to great (71.4%) skin quality improvement. The effect and tolerability of the therapy were evaluated as very good in 66.1 % and 67.9% and good in about 14.3% and 17.9%, assessed by the investigator and patient, respectively. Three patients experienced a burning sensation at the beginning of the study, the side-effects were resolved as the patients continued applying the foam. After two weeks of cessation of the investigated foam, a significant percentage of patients experienced worsening in the final assessment done by the investigator as well as the participant. In the final assessment, a significantly high percentage (57.1%) of patients had a total reduction of manifestation, and a significant number of participants considered the applied product as treatment success, assessed by the investigator (62.5%) as well as the participants (66.4%). Conclusions: Blue Cap

关键词： Pediatric Dermatology Atopic Dermatitis Piroctone Olamine Skin Care

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Engineering magnetic nanostructures with inverse hysteresis loops

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Nano Research 2016年第8期9卷 2347-2353页

作者： Beatriz Mora Nastassia soriano Carolina Redondo Alberto Arteche david Navas Rafael Morales Dpto. de Quimica-Fisica Universidad del Pais Vasco UPWEHU 48940 Leioa Spain IFIMUP-IN and Dept. Fisica e Astronomia Universidade do Porto 4169007 Porto Portugal Dpto. de Qulmica-Ffsica & BCMaterials Universidad del Pals Vasco UPV/EHU 48940 Leioa Spain IKERBASQUE Basque Foundation for Science 48011 Bilbao Spain

Top-down lithography techniques allow the fabrication of nanostructured elements with novel spin configurations, which provide a new route to engineer and manipulate the magnetic response of sensors and electronic devices and understand the role of fundamental interactions in materials science. In this study, shallow nanostructure-patterned thin films were designed to present inverse magnetization curves, i.e., an anomalous magnetic mechanism characterized by a negative coercivity and negative remanence. This procedure involved a method for manipulating the spin configuration that yielded a negative coercivity after the patterning of a single material layer. Patterned NiFe thin films with trench depths between 15%-25% of the total film thickness exhibited inverse hysteresis loops for a wide angular range of the applied field and the trench axis. A model based on two exchange-coupled subsystems accounts for the experimental results and thus predicts the conditions for the appearance of this magnetic behavior. The findings of the study not only advance our understanding of patterning effects and confined magnetic systems but also enable the local design and control of the magnetic response of thin materials with potential use in sensor engineering.

关键词： magnetic nanostructures magnetic patterning effects inverted loops negative coercivity negative remanence

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Intersectional gene inactivation: there is more to conditional mutagenesis than Cre

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Science China(Life Sciences) 2018年第9期61卷 1115-1117页

作者： Philippe soriano Department of Cell Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai

The efforts of many laboratories worldwide and large scale international mutagenesis consortia have resulted in mutagenesis of nearly all mouse genes, and present efforts are devoted to large scale phenotyping of germline null mutant mice (Ayadi et al., 2012). Although early lethality associated with loss of function of a given gene may prevent elucidating its function at a later stage or in a given tissue, conditional alleles in which a critical part of the gene is flanked by recombinase target sites provide an opportunity for addressing gene function at later stages (Branda and Dymecki,2004). Fortunately, many of the mutant alleles generated by the consortia allow for conditional mutagenesis using site directed recombinases.

关键词： there is more to conditional mutagenesis than Cre

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STABLE AND UNSTABLE STATIONARY TRAJECTORIES

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Applied Mathematics and Mechanics(English Edition) 2005年第1期26卷 52-57页

作者： J.M.soriano Departamento de Anlisis Matemtico Facultad de MatemticasUniversidad de Sevilla Aptdo.1160 Sevilla 41808 Spain

The stability of stationary trajectories of a particular autonomous system is *** proof of the result is based upon continuation methods.

关键词： autonomous system continuation method trajectory critical point zero point stationary trajectory stable solution asymptotically stable

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A REGULAR VALUE OF COMPACT DEFORMATION

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Applied Mathematics and Mechanics(English Edition) 2006年第9期27卷 1265-1274页

作者： J.M.soriano Departamento de Análisis Matemático Facultad de Matemáticas Universidad de Sevilla Aptdo. 1160 Sevilla 41080 Spain

Sufficient conditions were given to assert that between any two Banach spaces over K, Fredholm mappings share at least one .value in a specific open ball. The proof of the result is constructive and based upon continu... 详细信息

关键词： regular value continuation methods continuous dependence theorem C^1- homotopy proper mapping compact mapping Fredholm mapping topological complement Sard-Smale theorem

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