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Evaluation of Clinical Characteristics and Plasma Cortisol Concentrations in Individuals with COVID-19 and Post-COVID syndrome

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Case Reports in Clinical Medicine 2024年第1期13卷 12-24页

作者： david Alejandro García López stephania Ramos Hernández Yamile López-Hernández María Argelia López Luna Elena Donaji Ramírez Alvarado Rosa María Ramírez santoyo sergio Hugo sánchez Rodríguez Laboratorio de Biología Celular y Neurobiología Universidad Autónoma de Zacatecas México Zacatecas Unidad Académica de Ciencias Químicas Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Metabolómica y Proteómica Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Bacterias y Hongos filamentosos Universidad Autónoma de Zacatecas México Zacatecas

COVID-19 generates systematic alterations in humans both in active stages of infection and over time, called post-COVID syndrome. Cortisol is a hormone that is overexpressed in inflammation and cellular stress processes. Its main function is to return to physiological homeostasis, so its evaluation together with other clinical parameters can allow us to determine the degree of systemic affectation by COVID-19. Objective: To evaluate changes in clinical parameters and plasma cortisol concentrations in patients with active COVID-19 and post-COVID syndrome. Material and Methods: Healthy patients, in stages of mild infection, critical and with post-COVID syndrome, were recruited, obtaining, through clinical diagnoses and interviews, their main clinical characteristics, in addition to plasma, in which cortisol concentrations were determined using competitive ELIsA. Results: The critical stage group had higher frequencies of comorbidities, clinical symptoms, as well as more altered laboratory parameters compared to the other subgroups. In the post-COVID syndrome group after the initial infection, most laboratory parameters recovered, however, several clinical symptoms remained latent over time. The determination of cortisol showed an increase in its concentration, being higher in patients in critical stage and with post-COVID syndrome. Conclusion: COVID-19 disease generates clinical alterations that trigger an increase in plasma cortisol. These alterations increase as the stages of infection become more severe and some of them remain altered in patients with post-COVID syndrome.

关键词： COVID-19 Cortisol Post-COVID syndrome

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音乐产业遇上人工智能——你是在跟着一个人还是一台电脑哼唱呢?

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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 30-31,47,48页

作者： david salaza 不详

一位“韩流”艺人刚出道时,歌迷通常预期其歌曲以韩语为主,并且混人一些英语。这是韩国流行音乐在全球广受欢迎之际所发展出来的一种趋势——不过,这种趋势仍然让许多潜在歌迷因为语言隔阅而被排除在外。

关键词：人工智能音乐产业韩国流行音乐趋势

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A novel diagnostic gene region for distinguishing between two pest fruit flies:Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis(Hardy)(Diptera:Tephritidae)

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Insect science 2024年第4期31卷 1285-1295页

作者： Melissa L.starkie Elizabeth V.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt david Gopurenko Matt N.Krosch Francesca strutt Karen F.Armstrong Hamish Patrick Mark K.schutze Mark J.Blacket Department of Agriculture and Fisheries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Industries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forensic services Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pest-management and Conservation Lincoln UniversityLincolnNew Zealand Better Border Biosecurity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis are morphologically similar sibling pest fruit fly species that possess different biological attributes,geographic distributions,and host *** need to differentiate between the two species is critical for accurate pest status assessment,management,biosecurity,and maintenance of reference *** morphologically similar,adults may be separated based on subtle characters;however,some characters exhibit intraspecific variability,creating overlap between the two ***,there is currently no single molecular marker or rapid diagnostic assay that can reliably distinguish between *** and ***;therefore,ambiguous samples remain *** we report the first molecular marker that can consistently distinguish between *** and *** diagnostic region consists of two adjacent single nucleotide polymorphisms(sNPs)within the pangolin(pan)gene *** confirmed the genotypes of each species are consistent across their distributional range,then developed a tetra-primer amplification refractory mutation system(ARMs)PCR assay for rapid diagnosis of the *** assay utilizes four primers in multiplex,with two outer universal primers,and two internal primers:one designed to target two adjacent sNPs(AA)present in *** and the other targeting adjacent sNPs present in ***(GG).The assay accurately discriminates between the two species,but their sNP genotypes are shared with other nontarget tephritid fruit fly ***,this assay is most suited to adult diagnostics where species confirmation is necessary in determining ambiguous surveillance trap catches;maintaining pure colony lines;and in sterile Insect Technique management responses.

关键词： ARMs-PCR colony molecular diagnostics pangolin tetra-primer

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The influence of reflections from the train body and the ground on the sound radiation from a railway rail

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Railway sciences 2024年第1期3卷 1-17页

作者： david J.Thompson Dong Zhao Evangelos Ntotsios Giacomo squicciarini Ester Cierco Erwin Jansen Institute of sound and Vibration Research University of SouthamptonSouthamptonUK Ingenierıa para el Control del Ruido sL BarcelonaSpain TNO Acoustics and sonar Den HaagThe Netherlands

Purpose – The vibration of the rails is a significant source of railway rolling noise, often forming the dominantcomponent of noise in the important frequency region between 400 and 2000 Hz. The purpose of the paper is toinvestigate the influence of the ground profile and the presence of the train body on the sound radiation fromthe ***/methodology/approach – Two-dimensional boundary element calculations are used, in which therail vibration is the source. The ground profile and various different shapes of train body are introduced in themodel, and results are observed in terms of sound power and sound pressure. Comparisons are also made withvibro-acoustic measurements performed with and without a train *** – The sound radiated by the rail in the absence of the train body is strongly attenuated by shieldingdue to the ballast shoulder. When the train body is present, the sound from the vertical rail motion is reflectedback down toward the track where it is partly absorbed by the ballast. Nevertheless, the sound pressure at thetrackside is increased by typically 0–5 dB. For the lateral vibration of the rail, the effects are much smaller. Oncethe sound power is known, the sound pressure with the train present can be approximated reasonably well withsimple line source ***/value – Numerical models used to predict the sound radiation from railway rails have generallyneglected the influence of the ground profile and reflections from the underside of the train body on the soundpower and directivity of the rail. These effects are studied in a systematic way including comparisons with measurements.

关键词： Rolling noise sound radiation Railway track Boundary elements Ground reflections Directivity

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social determinants of gastrointestinal malformation mortality in Brazil:a national study

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World Journal of Pediatric surgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Amanda Rosendo Luiza Telles Aricia Gomes Miranda Madeleine Carroll Bruna Oliveira Trindade sarah Bueno Motter Esther Freire Gabriella Hyman Julia Ferreira Fabio Botelho Roseanne Ferreira david P Mooney Joaquim Bustorff-silva Program in Global surgery and social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of Medicine and Health sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Division of Pediatric surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação Médica(IDOMED/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of Medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da saude de Porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil Department of Health Research Methods McMaster UniversityHamiltonSouthern OntarioCanada Department of Pediatric surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born with a congenital disorder,potentially fatal without *** study aims to evaluate the relationship between gastrointestinal congenital malformation(GICM)mortality,health indicators,and socioeconomic factors in *** GICM admissions(Q39-Q45)between 2012 and 2019 were collected using national *** demographics,socioeconomic factors,clinical management,outcomes,and the healthcare workforce density were also accounted *** surgical Workforce density and the number of neonatal intensive care units in a region were extracted from national datasets and combined to create a clinical index termed'Neosurg'.socioeconomic variables were combined to create a socioeconomic index termed socEcon'.simple linear regression was used to investigate if the temporal changes of both indexes were *** correlation between mortality and the different indicators in Brazil was evaluated using Pearson's correlation *** Over 8 years,Brazil recorded 12804 GICM *** southeast led with 6147 cases,followed by the Northeast(2660),south(1727),North(1427),and Midwest(843).The North and Northeast reported the highest mortality,lowest Neosurg,and socEcon Index ***,mortality rates declined across regions from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and Midwest experienced the most substantial reductions,at 63%and 75%,*** significantly correlated with the indexes in nearly all regions(psion Our study highlights the correlation between social determinants of health and GICM mortality in Brazil,using two novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

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Amyloid-beta and tau protein beyond Alzheimer's disease

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Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad sina shadfar shahab Mirshahvaladi Veer Gupta Christine T.O.Nguyen david I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.salekdeh stuart L.Graham Mehdi Mirzaei ProGene Technologies Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA school of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia school of Natural sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

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Bone–cartilage crosstalk:a conversation for understanding osteoarthritis

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Bone Research 2016年第3期4卷 121-132页

作者： david M Findlay Julia s Kuliwaba Discipline of Orthopaedics and Trauma The University of Adelaide

Although cartilage degradation is the characteristic feature of osteoarthritis （OA）, it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction （crosstalk） between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well- char described *** destructive tges in the ~cular cartilage, which parallel characteristic changes in the underlying hone, This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.

关键词： OA Bone

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New Generations: sequencing Machines and Their Computational Challenges

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Journal of Computer science & Technology 2010年第1期25卷 3-9页

作者： david C. schwartz Michael s. Waterman Laboratory for Molecular and Computational Genomics Departme4nt of Chemistry and Laboratory of Genetics University of Wisconsin-Madison Department of Biological sciences University of Southern California Department of Automation Tsinghua University

New generation sequencing systems are changing how molecular biology is practiced. The widely promoted $1000 genome will be a reality with attendant changes for healthcare, including personalized medicine. More broadly the genomes of many new organisms with large samplings from populations will be commonplace. What is less appreciated is the explosive demands on computation, both for CPU cycles and storage as well as the need for new computational methods. In this article we will survey some of these developments and demands.

关键词： genome sequencing new generation sequencing read mapping optical mapping sequence assembly Eulerian graphs

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Allogenic stem Cell Transplantation and COVID-19 Antibodies: Mechanistic Insights and Recipient Concerns

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Open Journal of Immunology 2024年第2期14卷 16-32页

作者： Amna Umer Asma Umer Khayam Nasar Khan david Lawrence Greene Umm E. Habiba sabiha shamim Pak-American Hospital Pvt. Ltd. Islamabad Pakistan R3 Medical Research LLC Scottsdale USA Bello Bio Labs and Therapeutics (sMC) Pvt. Ltd. Islamabad Pakistan Department of Biochemistry Rawalpindi Medical University Rawalpindi Pakistan Bello Bio LLC Scottsdale USA

Collecting umbilical cord stem cells is widely practiced due to its numerous benefits. Over the past decade, umbilical cord stem cells (UCsCs) have shown effectiveness in treating various conditions, such as bone pathologies, neuropsychiatry disorders, hereditary diseases, and metabolic disorders. However, factors like immunization affect the quantity and quality of cord harvesting. studies suggest that antibodies from the mother pass through the umbilical cord to protect the infant against infections. Cleaning the umbilical cord before stem cell extraction is crucial to maintain sterility and cell integrity. Vaccinating a female donor, including for COVID-19, typically does not directly affect the stem cells. Although vaccines aim to trigger an immunological response, they generally do not affect the donor’s stem cells.

关键词： Vaccination stem Cell Allogeneic COVID Antibodies

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Effects of Maternal Death on Children Living in the sagnarigu Municipality

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Open Journal of Obstetrics and Gynecology（妇产科期刊） 2024年第3期 334页

作者： david Z.Kolbila Abdul-Razak Doat david s.Nigarim Wilfred Kwose sylvanus Kampo

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