Objective:To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin r euptake inhibitors(ssrIs)in ***:Cohort ***:Tertiary car e *...
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Objective:To compare the prevalence and clinical characteristics of neonatal abstinence syndrome in neonates exposed and not exposed to selective serotonin r euptake inhibitors(ssrIs)in ***:Cohort ***:Tertiary car e ***:One hundred twenty term infants,of whom 60 had prolonged in utero exposure to ssrIs,including paroxetine hydrochloride,fluoxetine,citalo pram hydrobromide,sertraline hydrochloride,and venlafaxine *** Outcome Measures:Neonatal abstinence syndrome was assessed with the Finnegan s core as follows:score of 8 or above,severe;score of 4 to 7,mild;and score o f 0 to 3,*** infants were followed up with a standardized protocol that included repeated Finnegan score assessments and cardiorespiratory monitoring u ntil normalization of the Finnegan ***:Of the 60 neonates exposed to ssrIs in utero,8 showed severe and 10 showed mild symptoms of a neonatal absti nence *** nonexposed neonates had a normal Finnegan *** neonates who developed severe symptoms,the maximum mean daily Finnegan scores were reco rded within 2 days after birth,although maximum individual scores were recorded as long as 4 days after ***:Neonatal abstinence syndrome occurs in 30%of neonates exposed to ssrIs in *** neonates should be monitore d for at least 48 hours after *** longterm effects of prolonged exposure to ssrIs,particularly in neonates who develop severe symptoms,have yet to be d etermined.
Background: Frontotemporal dementia (FTD) and Alzhei- mer’ s disease are clinically distinct disorders, yet neuropsychological stu dies have had variable success in distinguishing them. A possible reason is that stud...
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Background: Frontotemporal dementia (FTD) and Alzhei- mer’ s disease are clinically distinct disorders, yet neuropsychological stu dies have had variable success in distinguishing them. A possible reason is that studies typically rely on overall accuracy scores, which may obscure difference s in reasons for failure. Objectives: To explore the hypothesis that analysis of qualitative performance characteristics and error types, in addition to overall numerical scores, would enhance the neuropsychological distinction between FTD and Alzheimer’ s disease. Methods: 38 patients with FTD and 73 with Alzheimer’ s disease underwent assessment of language, visuospatial abilities, memory, and executive function, using a neuropsychological screening instrument and standar d neuropsychological tests. In each of these cognitive domains, performance char acteristics and error types were documented, in addition to numerical scores on tests. results: Whereas comparison of neuropsychological test scores revealed so me group differences, these did not occur consistently across tests within cogni tive domains. However, analysis of performance characteristics and error types r evealed qualitative differences between the two groups. In particular, FTD patie nts displayed features associated with frontal lobe dysfunction, such as concret e thought, perseveration, confabulation, and poor organisation, which disrupted performance across the range of neuropsychological tests. Conclusions: Numerical scores on neuropsychological tests alone are of limited value in differentiatin g FTD and Alzheimer’ s disease, but performance characteristics and error types enhance the distinction between the two disorders. FTD is associated with a pro found behavioural syndrome that affects performance on cognitive assessment, obs curing group differences. Qualitative information should be included in neuropsy chological research and clinical assessments.
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