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The Effect of Funding Cuts on the Utilization of an Oral Pathology Diagnostic Service

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International Journal of Oral Science 2009年第3期1卷 151-155页

作者： Deepika Chugh r. John McComb david Mock Faculty of Dentistry University of Toronto Toronto Canada

Aim To examine what impact the loss of funding had on the utilization of the oral pathology service. Methodology Biopsy records were retrieved and examined in the two year period before and after the elimination of the subsidies in *** After the loss of fimding, there was a 31% decrease in the number of specimens submitted from practitioners in private practice, with the greatest drop noted in submissions from endodontists. Conclusion Despite the immediate decrease in the number of biopsies submitted after the introduction of fee-for-service, the number of specimens being submitted appears to be on the rise again, as practitioners appear to recognize the value of a specialized oral pathology diagnostic service.

关键词： oral pathology diagnostic services funding

Accelerating phase-field-based microstructure evolution predictions via surrogate models trained by machine learning methods

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npj Computational Materials 2021年第1期7卷 9-19页

作者： david Montes de Oca Zapiain James A.Stewart rémi Dingreville Center for Integrated Nanotechnologies Sandia National LaboratoriesAlbuquerqueNM 87185USA Energetic Materials Dynamic and reactive Science Sandia National LaboratoriesAlbuquerqueNM 87185USA

The phase-field method is a powerful and versatile computational approach for modeling the evolution of microstructures and associated properties for a wide variety of physical,chemical,and biological ***,existing high-fidelity phase-field models are inherently computa fonally expensive,requiring high-performance computing resources and sophisticated numefical integration schemes to achieve a useful degree of *** this paper,we present a computationally inexpensive,accurate,data-driven surmogate model that directly learns the microstructural evolution of targeted systems by combining phase-field and history-dependent machine-learning *** integrate a statisti cally representative,low-dimensianal description of the micrastructure,obtained direcdy from phase-field simulations,with either a time-series multivariate adaptive regression splines autoregressive al garithm or a lang short-term memory neural *** neural-network-trained surrogate model shows the bestperformance and accurately predicts the nanlinear microstructure evolutian of a two-phase mixture during spinodal decomposition in seconds,without the need for"on-the-fly"solutions of the phase-field equations of *** also show that the predictions from our machine learned surrogate model can be fed directly as an input into a classical high-fideli ty phase-field model in order to accelerate the high-fidelity phase field simulations by leaping in *** machine-learned phase-field framework opens a promising path forward to use accelerated phase field simulations for discovering,understanding,and predicting processing-microstructure-performance relationships.

关键词： phase versatile statist

Structural Properties of Homomorphism Dilation Systems

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Chinese Annals of Mathematics,Series B 2020年第4期41卷 585-600页

作者： Deguang HAN david r.LArSON Bei LIU rui LIU Department of Mathematics University of Central FloridaOrlando 32816USA. Department of Mathematics Texas A&M UniversityCollege Station 77843USA. School of Science Tianjin University of TechnologyTianjin 300384China. Corresponding author.School of Mathematical Sciences and LPMC Nankai UniversityTianjin 300071China.

Inspired by some recent development on the theory about projection valued dilations for operator valued measures or more generally bounded homomorphism dilations for bounded linear maps on Banach algebras,the authors explore a pure algebraic version of the dilation theory for linear systems acting on unital algebras and vector *** introducing two natural dilation structures,namely the canonical and the universal dilation systems,they prove that every linearly minimal dilation is equivalent to a reduced homomorphism dilation of the universal dilation,and all the linearly minimal homomorphism dilations can be classified by the associated reduced subspaces contained in the kernel of synthesis operator for the universal dilation.

关键词： Linear systems Linearly minimal homomorphism dilation systems Principle and universal dilations Equivalent dilation systems

Germination strategies of annual and short-lived perennial species in the Arabian Desert

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Journal of Arid Land 2020年第6期12卷 1071-1082页

作者： Arvind BHATT david J GALLACHEr Paulo r M SOUZA-FILHO Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China School of Life and Environmental Sciences The University of SydneyNarrabri NSW 2390Australia Multidisciplinary Center of Barra Federal University of Western BahiaBarra 47100-000Brazil

Germination timing is highly regulated in short-lived plant species since it strongly influences recruitment success of *** deserts,the spatiotemporal distribution of plant-available water is highly episodic and unpredictable,making winter months more favorable for seed germination when other abiotic conditions *** hypothesized that changes in photoperiod and thermoperiod would impact germination more in seeds that had undergone in situ *** assessed 21 annual and short-lived perennial species in the Arabian Desert to find(1)if seeds were dormant at maturity,(2)if in situ seed storage increased germination percentage compared with no storage,(3)if photoperiod and thermoperiod germination requirements were influenced by in situ storage,and(4)if a phylogenetic association in seed germination could be *** of each species collected in early 2017 were divided into two *** was tested for germination within one week(fresh seeds).The other was stored in situ at the maternal location(stored seeds)until October 2017 and tested for seed germination in the first week of *** germination was conducted in incubators at two thermoperiods(15℃/20℃ and 20℃/30℃;12 h/12 h),and two photoperiods(12 and 0 h light per day).results indicated that seed germination percentages of 13 species were significantly enhanced by in situ storage.A thermoperiod response was exhibited by stored,but not fresh *** exposure increased germination of fresh seeds but had only a minimal effect on stored *** traits exhibited no phylogenetic *** result indicated that selection pressure for germination strategy was stronger than that for taxonomic traits of these desert species.

关键词： desert species dormancy germination light temperature phylogeny

Ambient Temperature is A Strong Selective Factor Influencing Human Development and Immunity

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Genomics, Proteomics & Bioinformatics 2020年第5期18卷 489-500页

作者： Lindan Ji Dongdong Wu Haibing Xie Binbin Yao Yanming Chen david M.Irwin Dan Huang Jin Xu nelson L.S.Tang Yaping Zhang State Key Laboratory of Genetic resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Department of Biochemistry Medical School of Ningbo UniversityNingbo 315211China Department of Preventive Medicine Medical School of Ningbo UniversityNingbo 315211China Department of Laboratory Medicine and Pathobiology University of TorontoTorontoON M5S 1A8Canada Banting and Best Diabetes Centre University of TorontoTorontoON M5S 1A8Canada Department of Chemical Pathology and Laboratory for Genetics of Disease SusceptibilityLi Ka Shing Institute of Health SciencesFaculty of MedicineThe Chinese University of Hong KongHong Kong Special Administrative RegionChina KIZ/CUHK Joint Laboratory of Bioresources and Molecular research in Common Diseases Kunming 650223China Laboratory for Conservation and Utilization of Bio-resource Yunnan UniversityKunming 650091China

Solar energy,which is essential for the origin and evolution of all life forms on Earth,can be objectively recorded through attributes such as climatic ambient temperature(CAT),ultraviolet radiation(UVr),and sunlight duration(SD).These attributes have specific geographical variations and may cause different adaptation ***,the adaptation profile of each attribute and the selective role of solar energy as a whole during human evolution remain ***,we performed a genome-wide adaptation study with respect to CAT,UVr,and SD using the Human Genome Diversity Project-Centre Etude Polymorphism Humain(HGDP-CEPH)panel *** singled out CAT as the most important driving force with the highest number of adaptive loci(6 SNPs at the genome-wide 1×10^(-7)level;401 at the suggestive 1×10^(-5)level).Five of the six genomewide significant adaptation SNPs were successfully replicated in an independent Chinese population(N=1395).The corresponding 316 CAT adaptation genes were mostly involved in development and *** addition,265(84%)genes were related to at least one genome-wide association study(GWAS)-mapped human trait,being significantly enriched in anthropometric loci such as those associated with body mass index(χ^(2);Prome,and cancer(χ^(2);Pr these adaptive SNPs,balancing selection was evident in Euro-Asians,whereas obvious positive and/or purifying selection was observed in *** together,our study indicates that CAT is the most important attribute of solar energy that has driven genetic adaptation in development and immunity among global human *** also supports the non-neutral hypothesis for the origin of disease-predisposition alleles in common diseases.

关键词： Solar radiation Ambient temperature Natural selection Development Immunity

Forest Fairy ring Fungi Clitocybe nebularis, Soil Bacillusspp., and Plant Extracts Exhibit in VitroAntagonism on Dieback PhytophthoraSpecies

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Natural resources 2013年第2期4卷 189-194页

作者： Catherine Hearst david nelson Graham McCollum Shekhar Sharma Juluri r. rao Applied Plant Science Division Agri-Food & Biosciences Institute Belfast UK Grosvenor Grammar School Belfast UK

In vitro Kirby-Bauer disc-diffusion assays coupled with bio-imaging software techniques were used to assess native forest dwelling “fairy ring” forming fungi (Clitocybe nebularis) and co-habitant forest tree-root colonising non pathogenic, antibiotic producing bacteria (Bacillus licheniformis, Bacillus pumilis) for their antagonism towards Japanese larch dieback oomycetes phytopathogens which also affects ornamental alternative hosts. The aqueous extracts of C. nebularis exhibited the highest clearance (inhibitory) zone of 21.4 × 105 pixels = 573%) against Phytophthora ramorum than growth/clear zone Cartesian integrates recorded in untreated (control) disc (3.7 × 105 pixels = 100%) over 3-day incubation. The fairy ring fungal extracts also exhibited substantive antagonism against P. kernoviae (147%), P. lateralis (347%) and a solanaceous crop infecting P. infestans (86%). Quite encouragingly, the soil oomycete phytopathogen P. ramorum was inhibited strongly (mean ~ 177%) by both forest bacilli. Aqueous extracts of non-forest antifungal herbaceous plants (garlic and elderberry) expressed similar inhibitory effects (mean ~ 70%). A seaweed fungal elicitor component fucoidan showed moderate levels (mean ~ 85%) of antagonism against P. ramorum, P. kernoviae, P. lateralis and P. infestans. The results in this in vitro study highlight the intensity and vigor of antagonistic forest microflora and non-forest herbaceous antifungal agents such as garlic and other plant extracts as serious candidates for suppression of the oomycete Phytophthora pathogenic fungi in forest soils. This study calls for urgent scoping and impact assessment studies in pot experiments and mini-plot forest trials to gauge the fitness of these natural resources for field level potential biotechnological applications to combat the devastating dieback disease in the native woodlands and horticulture.

关键词： Natural Forest resources Antifungal Extracts Clitocybe nebularis Bacillus licheniformis Bacillus pumilis Phytophthora Species Japanese Larch Dieback Disease

Universal silicon ring resonator for error-free transmission links

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Photonics research 2024年第4期12卷 701-711页

作者： JUNBO ZHU WEIWEI ZHANG KE LI BHArAT PANT MArTIN EBErT XINGZHAO YAN MEHDI BANAKAr DEHN T.TrAN CALLUM G.LITTLEJOHNS FUWAN GAN GrAHAM rEED david J.THOMSON Optoelectronics research Centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of Chinese Academy of Sciences Beijing 100049China Peng Cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for C band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling C band 50 Gb/s NrZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

Population-based affective-disorder-related biomedical/biophysical multi-hyper-morbidity across the lifespan:A 16-year population study

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World Journal of Psychiatry 2023年第7期13卷 423-434页

作者： david r L Cawthorpe Dan Cohen Community Health Sciences and Psychiatry Cumming School of MedicineCalgary T2N4N1AlbertaCanada Mental Health Organization North-Holland North Utrecht UniversityAlkmaar 1811North HollandNetherlands

BACKGrOUND There are few if any life-span population-based studies of psychiatric disorderassociated biomedical and biophysical disorders and diseases(morbidity).AIM To scope the present state of research regarding the biomedical and biophysical morbidity associated with affective and mental disorder in epidemiological samples,and to examine the life-span relationship between affective disorders and biomedical/biophysical disorders to illustrate a novel approach employing the odds ratio to represent the intensity of biomedical and biophysical morbidity associated in time in a *** A repeatable systematic literature search of PubMed was represented in ***,a regional population-based dataset was constructed and analyzed to represent the age-and sex-specific diagnoses(International Classification of Diseases Version 9,ICD-9)for those with and without affective *** analysis presents a novel index of the relative age-specific frequency of life-span biomedical and biophysical diagnoses associated with affective *** The volume of biomedical and biophysical morbidity associated with mental disorder literature has increased,yet few studies measure comprehensive temporal hyper-morbidity(over-representation of diseases over time,either before or after the index diagnostic event)in ***,there have been only a few population-based studies examining the morbidity associated with affective disorder and only one that examines the full diagnostic range of lifespan *** differences arose between males and females with more females than males having greater frequencies of *** age-specific distributions of the maximum proportional diagnosis frequency ratios for each sex illustrate the greatest diagnosis-specific differences when comparing the biomedical and biophysical diagnoses of those with and without affective disorder when the same diagnosis was represented in each grouping at the same a

关键词： Biomedical/biophysical morbidity Temporal hyper-morbidity Mental disorder Population Epidemiology

The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan Juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya ramesh Aaron W.James david Hudson Kevin N.Dalby Lin Xu robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell rNA sequencing(scrNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreEr^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreEr^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scrNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant