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Physical separation from the mate diminishes male＇s attentiveness towards other females： a study in monogamous prairie voles Microtus ochrogaster

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Current Zoology 2017年第5期63卷 537-544页

作者： Christine J. DELEVAN Natalia A. RODRIGUEZ Karine M. LEGZIM Fayeza ALIOU Jamie T. parker Maryam BAMSHAD Department of Biological Sciences Lehman College--The City University of New York Bronx NY 10468 USA

We tested whether continuous cohabitation in monogamous voles affects the mated male＇s atten-tiveness to his breeding partner versus another female. Each male was housed in a 3-chamber ap-paratus with a Focal female （FF） and a Control female （CF） for 13 days then placed in a T-maze toassess his attentiveness to and memory of those females. The Distal male remained physically sep-arated from both females, but received their distal cues. The Separate male cohabited with the FFfor 3 days then remained physically separated from both females. The Disrupt male＇s continuouscohabitation with the FF was disrupted by having him physically separated from her after 10 daysand placed with the CF for the last 3 days. The Continuous male cohabited continuously with the FFfor 13 days. With females in the T-maze, the Separate and Disrupt males spent more time near theFF＇s box and the Disrupt males spent more time manipulating the FF＇s box than the CF＇s box. TheSeparate males groomed themselves more when near the FF＇s box than the CF＇s box. The Distaland Continuous males＇ attentiveness to the two females did not differ. Results suggest that phys-ical distance from the partner may reduce male＇s attentiveness toward other potential *** voles might be similar to socially monogamous primates in using tactile cues as a signal formaintaining their social bonds.

关键词： attachment, monogamy, partner preference, partner separation, social cognition.

Brain injury and neural stem cells

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Neural Regeneration Research 2018年第1期13卷 7-18页

作者： parker E.Ludwig Finosh G.Thankam Arun A.Patil Andrea J.Chamczuk Devendra K.Agrawal Department of Clinical and Translational Science Creighton University School of Medicine Department of Neurosurgery Creighton University School of Medicine

Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury.

关键词： brain injury brain trauma infarction ischemia neural stem cells neuronal regeneration stroke

Metabolite profile comparisons between ascending and descending colon tissue in healthy adults

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World Journal of Gastroenterology 2020年第3期26卷 335-352页

作者： Bridget A Baxter Kristopher D parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsFort CollinsCO 80523United States University of Colorado Health Gastroenterology Clinic Fort CollinsCO 80524United States Department of Clinical Sciences Colorado State UniversityFort CollinsCO 80523United States Harmony Surgery Center Fort CollinsCO 80528United States Director of Clinical Operations Harmony Surgery CenterFort CollinsCO 80523United States

BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely *** study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese *** To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer *** Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite *** colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal *** Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass *** acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite *** weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending *** and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese *** There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy *** lipids and other metabolites in

关键词： Colon Ascending Descending Metabolomics Obesity Stool

Relating environmental variables with aquatic community structure in an agricultural/urban coldwater stream

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Ecological Processes 2021年第1期10卷 481-499页

作者： Daniel T.L.Myers Richard R.Rediske James N.McNair Aaron D.parker E.Wendy Ogilvie Annis Water Resources Institute Grand Valley State University740 W Shoreline DriveMuskegonMI 49401USA. Michigan Department of Environment Great Lakesand Energy525 W Allegan StreetLansingMI 48909USA. Grand Valley Metropolitan Council 678 Front Avenue NWSuite 200Grand RapidsMI 49504USA.

Background:Urban areas are often built along large rivers and surrounded by agricultural *** may lead to small tributary streams that have agricultural headwaters and urbanized lower *** study objectives assessed are as follows:(1)landscape,geomorphic,and water quality variables that best explained variation in aquatic communities and their integrity in a stream system following this agricultural-to-urban land use gradient;(2)ways this land use gradient caused aquatic communities to differ from what would be expected for an idealized natural stream or other longitudinal gradients;and(3)whether the impacts of this land use gradient on aquatic communities would grow larger in a downstream direction through the agricultural and urban *** study area was an impaired coldwater stream in Michigan,***:Many factors structured the biological communities along the agricultural-to-urban land use *** woody debris had the strongest relationship with EPT(Ephemeroptera,Plecoptera,and Trichoptera)abundance and richness and were most common in the lower,urbanized *** streambed substrate had the strongest relationship with Diptera taxa and surface air breather macroinvertebrates and was dominant in agricultural *** community assemblage was influenced largely by stream flow and temperature regimes,while poor fish community integrity in lower urban reaches could be impacted by geomorphology and episodic urban pollution *** macroinvertebrates were most abundant in deforested,first-order agricultural headwaters,while EPT macroinvertebrate richness was the highest downstream of agricultural areas within the urban zone that had extensive forest ***:Environmental variables and aquatic communities would often not conform with what we would expect from an idealized natural *** richness improved downstream of agricultural *** shows promise for the recovery of aquatic systems using we

关键词： Land use Habitat Stream Fish Macroinvertebrate Gradient

Acute hemorrhagic edema of infancy: the experience of a large tertiary pediatric center in Israel

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World Journal of Pediatrics 2017年第4期13卷 341-345页

作者： Limor parker Keren Shahar-Nissan Liat Ashkenazi-Hoffnung Liora Harel Jacob Amir Omer Trivizki Efraim Bilavsky Department of Pediatrics B Assaf Harofeh Medical CenterZriffinIsrael Departments of Pediatrics C Schneider Children's Medical CenterPetah TiqvaIsrael Sackler Faculty of Medicine Tel Aviv UniversityTel AvivIsrael

Background:Acute hemorrhagic edema of infancy (AHEI) is a rare leukocytoclastic vasculitis of the small vessels occurring at a young age and considered as a benign self-limited *** to its low prevalence,there are limited data on the presentation and complications of this ***:All computerized files of children who were hospitalized at a tertiary pediatric center due to AHEI over a 10 year period were ***,laboratory and histopathological data were ***:Twenty-six patients were included in our study,accounting for 0.7 cases per 1000 admissions of children aged 2 years or *** age was 12.9 *** than two thirds of the children had preceding symptoms compatible with a viral *** admission,all patients presented with typical findings of a rash and *** was most profound over the lower extremities (73%).Concomitant viral or bacterial infections were found in six *** biopsy was performed in six patients revealing leukocytoclastic *** children (50%) had systemic involvement including joint involvement (n=9),gastrointestinal hemorrhage (n=4),microscopic hematuria (n=1) and compartment syndrome of the limb (n=1).The latter was diagnosed in a patient with familial Mediterranean ***:Our largest data series highlighted what is known regarding clinical and histological findings in children with ***,contrary to what was previously reported,we found a higher rate of systemic *** AHEI is a rare entity,pediatricians should be familiar with its presentation,management and our reported complications.

关键词： acute hemorrhagic edema Finkelstein-Seidlmayer disease Henoch-Sch(o)nlein purpura vasculitis

Cold Winter Warm Thoughts

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英语画刊（初三版） 2012年第7期 26-27页

作者： Mary Jessie parker

暴风雪越来越凶猛，狂风怨吼着，鹅毛般的雪花拍打着车窗。寒冷的夜，是什么温暖着我们？＂Are you OK？＂ asked *** car had slid off the country road into a snowdrift（雪堆）.A white world surrounded us--the snowdrift on my ... 详细信息

暴风雪越来越凶猛，狂风怨吼着，鹅毛般的雪花拍打着车窗。寒冷的夜，是什么温暖着我们？＂Are you OK？＂ asked *** car had slid off the country road into a snowdrift（雪堆）.A white world surrounded us--the snowdrift on my side,and the wall of blowing snow on Daddy＇s. Daddy tried to start the car. Nothing happened. ＂We＇re stuck,＂ he said. ＂Well.

关键词：中学英语课外阅读阅读材料

Self-Regulated Reading Comprehension Strategy Selection Through Diagnostic-Prescriptive Instruction： A Case Study

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Sociology Study 2015年第10期5卷 768-774页

作者： Kelly M. parker Beijing Normal University-Hong Kong Baptist UniversityUnited International College China

This demonstration of concept applies diagnostic-prescriptive reading instruction, a methodology useo m omteu atd^u~ developmental education, toward improving reading comprehension and self-regulated comprehension strategy selection in Chinese postsecondary education. A single tutor, also the researcher, works closely with one Chinese university student to develop student-centered comprehension strategies that she can practice on her own. After a battery of formal and informal assessments and interviews, decoding and understanding deficiencies are identified, characterized, and discussed. Both the student and her tutor develop and execute a study plan, which was completed during the spring semester of 2010 at Sha＇anxi University of Science and Technology （SUST） in Xi＇an, People＇s Republic of China （PRC）. By focusing on the subject＇s primary decoding deficiency, spelling, and her primary understanding deficiency, lack of background knowledge, the subject and her reading tutor are able to strategically tackle five reading comprehension goals：（1） spelling; （2） phonemic awareness; （3） noticing structural and cohesive elements; （4） comparing argumentative and evaluative texts; and （5） analyzing expository texts in business and economics. A final discussion analyzes both qualitative and quantitative data, including unexpected discoveries such as the salience of cohesion in reading comprehension and the cultural biases of standardized reading assessments.

关键词： Reading comprehension self-regulation diagnostic-prescriptive strategies

Quantifying E2F1 protein dynamics in single cells

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Quantitative Biology 2020年第1期8卷 20-30页

作者： Bernard Mathey-Prevot Bao-Tran parker Carolyn Im Cierra Hong Peng Dong Guang Yao Lingchong You Department of Pharmacology and Cancer Biology Duke University School of MedicineDurhamNC 27710USA Duke University School of Medicine DurhamNC 27710USA Molecular and Cellular Biology University of ArizonaTucsonAZ 85721USA Department of Biomedical Engineering Duke UniversityDurhamNC 27705USA Center for Genomic and Computational Biology Duke UniversityDurhamNC 27705USA Department of Molecular Genetics and Microbiology Duke University School of MedicineDurhamNC 27708USA Department of Pediatrics Duke University School of MedicineDurhamNC 27708USA University of North Carolina School of Medicine Chapel HillNC 27516USA Janelia Research Campus Howard Hughes Medical InstituteAshburnVA 20147USA

Background:E2F1 protein,a major effector of the Rb/E2F pathway plays a central role in regulating cell-fate decisions involved in proliferation,apoptosis,and *** expression is highly dynamic and tightly modulated through a combination of transcriptional,translational and posttranslational ***,the mechanisms by which its expression and activity can promote different cellular outcomes remain to be fully *** better document E2F1 expression in live cells,we have engineered a series of fluorescent E2F1 protein reporters that quantitatively capture E2F1 protein ***:Reporter constructs,under the control of the mouse or human E2F1 proximal promoter,were designed to express an E2F1-Venus fusion protein incapable of binding *** addition,constructs either included or excluded the y untranslated region(3fUTR)of the E2F1 *** constructs were introduced into fibroblasts and epithelial cells,and expression of the fusion reporter protein was validated and quantified in single cells using live ***:In all cases,expression of the reporter protein effectively recapitulated the behavior of E2F1 under various conditions,including cell cycle progression and genotoxic *** or little fluorescent signal of the reporter was detected in G〇,but as the cycle progressed,expression of the reporter protein steadily increased in the nucleus,peaking a few hours before cell division,but declining to baseline 2-3 h prior to the onset of *** absence of the E2F13 fUTR in the constructs led to considerably higher steady-state levels of the fusion protein,which although normally regulated,exhibited a slightly less complex dynamic profile during the cell cycle or genotoxic ***,the presence or absence of Rb failed to impact the overall detection and levels of the reporter ***:Our validated E2F1 protein reporters complement nicely other reporters of the Rb/E2F pathway and provide a unique tool to f

关键词： protein E2F1 reporter cell cycle

Study Urges Weight Gain Be Curbed in Pregnancy

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科技英语学习 2009年第7期 14-15页

作者： Tara parker-Pope 彭美娟

过度肥胖的女士在怀孕期间如果体重过量增重，将增加其患妊娠期糖尿病等多种并发症的风险，严重威胁母婴健康。最近，医学专家对过度肥胖女士的孕期增重标准进行了更深入的研究，认为过度肥胖的女士怀孕期间的体重增长应该控制在11到20... 详细信息

过度肥胖的女士在怀孕期间如果体重过量增重，将增加其患妊娠期糖尿病等多种并发症的风险，严重威胁母婴健康。最近，医学专家对过度肥胖女士的孕期增重标准进行了更深入的研究，认为过度肥胖的女士怀孕期间的体重增长应该控制在11到20磅之间。

关键词：英语学习学习方法翻译阅读