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Uncovering the persistent gap:The ongoing challenge of integrating sex and gender in biomedical research

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Journal of Biomedical Research 2025年第1期39卷 18-22页

作者： Janet delgado Monica Cano Abadia Kaya Akyüz Melanie Goisauf david Rodriguez-Arias Department of Nursing School of Health SciencesYamaguchi University Graduate School of MedicineUbeYamaguchi 755-8505Japan Department of Philosophy University of GranadaCampus de la Cartuja s/nGranada 18071Spain ELSI Services&Research Department Biobanking and BioMolecular Resources Research Infrastructure-European Research Infrastructure ConsortiumGraz 8010Austria

Introduction Gender and sex are related to important quality and safety issues in scientific,health,and clinical *** refers to biological characteristics,while gender encompasses the sociocultural norms,identities,and relationships that shape communities and organizations,as well as influence actions,behaviors,contexts,and *** gender and sex intersect with other social *** this context,in addition to sex or gender,the intersectionality refers to overlapping or interdependent systems of discrimination by more than one factor,such as age,disability,ethnicity,geographic location,socioeconomic status,and sexuality,among others.

关键词： integrating intersection addition

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Strong resistance toβ-cyfluthrin in a strain of the beetle Alphitobius diaperinus:a de novo transcriptome analysis

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Insect Science 2025年第1期32卷 209-226页

作者： Gwenola Gouesbet david Renault Stéphane APDerocles HervéColinet CNRS ECOBIO(EcosystèmesBiodiversitéÉvolution)—UMR 6553University of RennesRennesFrance Institut Universitaire de France 1 rue DescartesCEDEX 05ParisFrance

The lesser mealworm,Alphitobius diaperinus,is an invasive tenebrionid beetle and a vector of *** to the emergence of insecticide resistance and consequent outbreaks that generate significant phytosanitary and energy costs for poultry farmers,it has become a major insect pest *** better understand the molecular mechanisms behind this resistance,we studied a strain of *** from a poultry house in Brittany that was found to be highly resistant to theβ-*** strain survivedβ-cyfluthrin exposures corresponding to more than 100 times the recommended *** used a comparative de novo RNA-Seq approach to explore genes expression in resistant versus sensitive *** de novo transcriptomic analyses showed that responses toβ-cyfluthrin likely involved a whole set of resistance *** related to detoxification,metabolic resistance,cuticular hydrocarbon biosynthesis and proteolysis were found to be constitutively overexpressed in the resistant compared to the sensitive ***-up enzymatic assays confirmed that the resistant strain exhibited high basal activities for detoxification enzymes such as cytochrome P450 monooxygenase and *** in-depth analysis of differentially expressed genes suggests the involvement of complex regulation of signaling *** knowledge of these resistance mechanisms is essential for the establishment of effective pest control.

关键词： Alphitobius diaperinus de novo transcriptome insecticide resistance P450 xenobiotic metabolism

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Why is China Promoting Economic Globalization?A Leadership Theory of Globalization

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China & World Economy 2025年第1期33卷 1-35页

作者： Meixin Guo david Daokui Li Kun Lang Academic Center for Chinese Economic Practice and Thinking School of Social ScienceTsinghua UniversityChina School of Marxism Tsinghua UniversityChina

This article proposes a leadership theory of globalization to explain how economic globalization occurs and evolves,and why China wants to take a leading role in *** theory posits that an economy equipped with advanced industrial technology,a substantial domestic market,and robust institutional capacity is more likely to take the lead in driving economic *** advantages in high-tech industries position an economy favorably within the global value chains,maximizing its benefits from economic globalization.A large domestic market can entice other countries to agree to open their markets *** capacity enables governments to deter opposition to globalization from those disadvantaged by economic *** paper presents studies of historical cases of economic globalization and provides a three-stage model of *** argues that China has been gaining on three fronts in recent decades and is therefore willing to promote economic globalization.

关键词： economic globalization institutional advantage leadership market advantage technological advantage

Transforming osteosarcoma care:from historical milestones to precision medicine advances

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Science Bulletin 2025年第3期70卷 290-294页

作者： Jichuan Wang david S.Geller Luyang Sun Xiaodong Tang Musculoskleletal Tumor Center Beijing Key Laboratory for Musculoskeletal TumorsPeking University People’s HospitalBeijing 100041China Department of Orthopedic Surgery Montefiore Medical CenterAlbert Einstein College of MedicineBronx 10471USA Department of Biochemistry and Molecular Biology School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China

Osteosarcoma(OS),one of the earliest recognized cancers in humans,is a rare yet significant malignant bone tumor,diagnosed in 2-6 cases per million annually[1].It predominantly affects adolescents and young adults,with a second peak in incidence occurring around age *** osteosarcoma typically arises in areas of rapid bone growth,such as the knee and shoulder,and often presents persistent bone pain and progressive *** osteosarcoma often has a classic radiographic appearance,diagnosis is ultimately confirmed histologically.

关键词： osteosarcoma diagnosis annually

Large Banks and Systemic Risk:Insights from a Mean-Field Game Model

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Journal of Systems Science & Complexity 2025年第01期 460-494页

作者： CHANG Yuanyuan FIROOZI Dena BENATIA david Department of Decision Sciences HEC Montréal Department of Applied Economics HEC Montréal

This paper presents a dynamic game framework to analyze the role of large banks in interbank markets. By extending existing models, a large bank is incorporated as a dynamic decision-maker interacting with multiple small banks. Using the mean-field game methodology and convex analysis, best-response trading strategies are derived, leading to an approximate equilibrium for the interbank market. The influence of the large bank is investigated on the market stability by examining individual default probabilities and systemic risk, through the use of Monte Carlo simulations. The proposed findings reveal that, when the size of the major bank is not excessively large, it can positively contribute to market stability. However, there is also the potential for negative spillover effects in the event of default, leading to an increase in systemic risk. The magnitude of this impact is further influenced by the size and trading rate of the major bank. Overall, this study provides valuable insights into the management of systemic risk in interbank markets.

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Co-Located Battery Energy Storage Optimisation for Dynamic Containment Under the UK Frequency Response Market Reforms

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CSEE Journal of Power and Energy Systems 2025年第1期11卷 340-351页

作者： Fulin Fan John Nwobu david Campos-Gaona Department of Electronic and Electrical Engineering University of StrathclydeGlasgowG11XWU.K Offshore Renewable Energy Catapult GlasgowG11RDU.K.

Accelerated development of battery technologies heightens an interest in co-locating battery energy storage systems (BESSs) with renewable power plants for stacking of multiple revenue streams such as frequency response services to AC grids. Frequency response market reforms in the UK introduce new end-state services and require evaluating techno-economic feasibility of co-location projects in new circumstances. This paper develops a BESS optimisation method to optimize capacity and operating strategy of a co-located BESS for providing latest Dynamic Containment (DC) services based on the UK perspective. BESS optimisation method simulates BESS delivering DC responses and following operational baselines for state of energy (SoE) restoration, as well as, coordinating with its co-located power plant. Then net present value of BESS co-location project is estimated from power flows across the system and maximised to suggest optimal BESS capacity, target energy footroom and/or headroom levels for baseline estimation, and possible SoE ranges suitable for energy interchange with its co-located power plant. BESS optimisation method is tested based on a particular transmission-level wind farm in the UK and discussed alongside operation and profitability of a BESS co-location project under frequency response market reforms.

关键词： Battery energy storage optimisation co-location Dynamic Containment operating strategy UK perspective.

Seismites of the Late Triassic Lockatong Formation,Pennsylvania,USA:implications for Newark Basin border fault movement

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Journal of Palaeogeography 2025年第1期14卷 1-14页

作者： Edward L.Simpson Michael C.Wizevich david L.Fillmore Department of Physical Sciences Kutztown University of Pennsylvania Department of Earth and Space Sciences Central Connecticut State University

Numerous soft-sediment deformation structures(SSDS) within thin-bedded, heterolithic lacustrine shoreline deposits of the Upper Triassic Tumble Falls Member, Lockatong Formation of eastern Pennsylvania, demonstrate liquefaction, fluidization and shearing features processes affecting sediment. This study employs thin-section analysis of SSDS to interpret them as probable seismites from the Triassic-Jurassic Newark Basin. Sedimentary structures include right-lateral offset of desiccation cracks and ichnofossils, thrust,reverse, and normal faults with mm-scale offsets, horsts and grabens, lateral spreads, and single and complex multiple networks of dikes and sills and associated sedimentary volcanoes, thin mudflows on a paleosurface linked to sediment dikes, load and flame structures, ball and pillow structures, recumbent folds, and incipient breccias. Dike fill consists of mudstone, angular sedimentary clasts, sandstone margins with mudstone cores,and plastically deformed sediment fill. The SSDS indicate that Late Triassic lacustrine shoreline sediments were subjected to forces, probably compressive with a minimal shear component reflected in the offset of the dikes and ichnofossils, that induced liquefaction followed by fluidization and vertical movement of *** forces that altered sediment vertical stability, leading to deformation of the sediment included gravitationally unstable density gradients, vertical shear stress, and gravitational body forces. SSDS can be induced by seismic and aseismic processes. However, this unique combination of forces and resulting sedimentary structures indicate an origin by earthquake activity, likely produced by the nearby, active Newark Basin border fault system. The Lockatong Formation SSDS seismites improve our understanding via thin section analysis of the rheology and preservation potential of SSDS in lacustrine shoreline deposits, critical for the geologic history of Newark Basin, as well as the refinement for paleos

关键词： Seismites Triassic Lockatong Formation Lacustrine Soft-sediment deformation structures