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动脉瘤性蛛网膜下腔出血患者的重症监护处理：神经危重症监护学会多学科共识会议的推荐意见

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国际脑血管病杂志 2013年第5期21卷 324-347页

作者： michael N. Diringer Thomas P. Bleck J. Claude Hemphill david menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez miriam Tresgiari ming-Yuan Tseng mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿英英(译) From the Neurology/Neurosurgery Intensive Care Unit Washingion University St. Louis MO USA Rush medical College Chicago IL USA University of California at San Francisco San Francisco CA USA University of Cambridge Cambridge UK University of Cincinnati Cincinnati OH USA University of California at Los Angeles LOs Angeles CA USA Universit6 de la m.diterranae Marsedle France Columbia University New York NY USA San Gerardo Hospital Monza Italy University of Virginia Charlottesville VA USA Heinrich-Heine University Dttsseldorf Germany University of Florida Gainesville FL USA mayo Clinic Rochester MN USA University of Pennsylvania Philadelphia PA USA University Hospital Innsbruck lnnsbruck Austria Fondazione IRCCS Ch Granda- Ospedale Policlinico Milan University Milan Italy University of Washington St. Louis MO USA Baylor College of medicine Houston TX USA Nottingham University Hospitals Nottingham UK University of Utrecht Utrecht The Netherlands Freie Universitit Berlin Berlin Germany Washington University St. Louis MO USA 首都医科大学宣武医院神经内科北京100053

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法... 详细信息

蛛网膜下腔出血（subarachnoidhemorrhage，SAH）是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏，使得治疗方法各异，可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防，很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域，此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验，选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价（GradesofRecommendationsAssessment，DevelopmentandEvaluation，GRADE）系统进行文献回顾，结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见，其制定原则不仅强调研究资料的质量，而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见，即使缺乏高质量的证据。

关键词：蛛网膜下腔出血重症监护动脉瘤血管痉挛抗惊厥药低钠血症血管内发热

An Earth-mass planet in a time of COVID-19:KmT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan JoséDias do Nascimento Júnior Dan maoz matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry david P.Bennett Aparna Bhattacharya martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto man Cheung Alex Li Yutaka matsubara Yasushi muraki Shota miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KmT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(m1,m2,m3)~(0.3 m⊙,1.0 m⊕,17 mJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KmT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

出生第一年交通相关空气污染暴露与7岁时行为评分

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环境与职业医学 2013年第9期30卷 657-657页

作者： Nicholas C.Newman Patrick Ryan Grace Lemasters Linda Levin david Bernstein Gurjit K.Khurana Hershey James E.Lockey manuel Villareal Tiina Reponen Sergey Grinshpun Heidi Sucharew Kim N.Dietrich

[背景]交通相关的空气污染(TRAP)对发育中大脑的潜在影响受到越来越多的关注。由于流行病学研究有限,TRAP暴露对儿童期行为的影响尚不完全清楚。[目的]采用一种TRAP替代品(归因于交通的元素碳,ECAT)探讨生命早期TRAP暴露与7岁时注意力缺... 详细信息

[背景]交通相关的空气污染(TRAP)对发育中大脑的潜在影响受到越来越多的关注。由于流行病学研究有限,TRAP暴露对儿童期行为的影响尚不完全清楚。[目的]采用一种TRAP替代品(归因于交通的元素碳,ECAT)探讨生命早期TRAP暴露与7岁时注意力缺失/多动症(ADHD)症状之间的关联。[方法]从辛辛那提儿童过敏与空气污染研究(CCAAPS)出生队列中,收集婴儿期ECAT暴露和7岁时行为得分的数据。入组CCAAPS的儿童,其父母中至少有一位患遗传性过敏症,并且出生居所距离一条主要公路m或者>1500m。这些儿童的随访时间为自婴儿期至7岁。根据27个空气采样点的测量值和土地利用回归模型,估计生命第一年的ECAT暴露。当儿童7岁时,由家长填写完成儿童行为评估系统(第2版)。通过过度活跃(hyperactivity)、注意力问题(attention problem)、攻击性(aggression)、行为问题(conduct problems)和非典型(atypicality)分量表对ADHD相关症状进行评估。[结果]儿童生命第一年中ECAT暴露位于最高三分位数,与其7岁时处于"风险"范围的过度活跃T评分明显相关[调整后比值比(aOR)=1.7;95%CI:1.0～2.7]。对母亲教育程度分层后发现,在母亲具有较高教育程度的儿童中关联性更强(aOR=2.3;95%CI:1.3～4.1)。[结论]婴儿期ECAT暴露与儿童较高多动症评分相关,这种关联限于母亲具有高中以上教育程度的儿童。

关键词：行为评分空气污染交通遗传性过敏症 TRAP 儿童期流行病学生命早期

急性缺血性卒中动脉内导管介入治疗培训指南介入放射学学会特别写作组的声明

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国际脑血管病杂志 2011年第9期19卷 649-662页

作者： J.J. Connors david Sacks Carl m. Black E. Bruce mcIff m.J.B. Stallmeyer John W. Cole Howard A. Rowley Joan C. Wojak Robert A. mericle Kieran J. murphy John F. Cardella 刘朝来（译）李永坤（译）刘新峰（译） From the Departments of Radiology Vanderbilt University Medical Center Nashville Tennessee Neurological Sktrgery Vanderbilt University Medical Center Nashville Tennessee Neurology Vanderbilt University Medical Center Nashville Tennessee Department of Interventional Radiology The Reading Hospital and Medical Center West Reading System Radiology Geisinger Health System Danville Pennsylvania Utah Valley Interventional Associates Utah Valley Regional Medical Center Provo Utah Department of Interventionat Neuroradiology Our Lady of Lourdes Regional Medical Center Lafayette Louisiana Department of Neurology Maryland Stroke Center University of Maryland School of Medicine Baltimore Maryland Department of Radiology University of Wisconsin Madison Wisconsin Department of medical Imaging University of Toronto Toronto Ontario Canada 南京军区南京总医院神经内科 210002

在美国，卒中是引起成年人残疾的首位原因，也是人口死亡的第三大原因，已成为一个重要的公共健康问题。卒中每年危及近80万人的健康，其治疗费用位居所有疾病之首。10％的卒中患者在发病后1个月内死亡，约1乃的卒中患者遗留严重残疾并... 详细信息

在美国，卒中是引起成年人残疾的首位原因，也是人口死亡的第三大原因，已成为一个重要的公共健康问题。卒中每年危及近80万人的健康，其治疗费用位居所有疾病之首。10％的卒中患者在发病后1个月内死亡，约1乃的卒中患者遗留严重残疾并在发病后6个月内死亡。这些数据提示，卒中的死亡率高于癌症。

关键词：急性缺血性卒中导管介入治疗介入放射学培训指南动脉内写作学会健康问题

神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用并有助于移植细胞与宿主胶质细胞间缝隙连接的建立

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神经损伤与功能重建 2014年第2期9卷 F0003-F0003页

作者： Rocío Talaverón Esperanza R.matarredona Rosa R.de la Cruz david macías Victoria Gálvez and Angel M. Pastor Departamento de Fisiología Facultad de Biología Universidad de Sevilla Avenida Reina Mercedes

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经... 详细信息

移植神经干/祖细胞有助于受损脑组织形态和功能的恢复。移植部位的微环境及移植细胞与宿主细胞间的通讯在神经干/祖细胞移植的神经保护机制中有重要意义。笔者既往研究显示,对中枢轴索损伤动物进行神经干/祖细胞移植有助于恢复损伤神经元的电活动及突触联系,并可增加神经营养因子的释放。本研究拟观察移植的神经干/祖细胞与宿主胶质细胞间的解剖关系,以探讨神经干/祖细胞移植的神经保护作用的可能机制。从新生大鼠的脑室下区提取神经干/祖细胞移植到内侧纵束横断伤模型大鼠脑内。移植后8周取脑进行相关检测。免疫组化检测结果显示,与未移植神经干/祖细胞的大鼠相比,移植了神经干/祖细胞的大鼠脑内更多的小胶质细胞被激活。移植的神经干/祖细胞聚集在激活的小胶质细胞和星形胶质细胞附近。缝隙连接蛋白CX-43表达在损伤部位的神经干/祖细胞和胶质细胞上,且较多的存在于移植细胞和胶质细胞相连接的部位。移植的神经干/祖细胞和宿主胶质细胞及宿主小胶质细胞间均形成了缝隙连接,但移植的神经干/祖细胞和宿主胶质细胞间的缝隙连接较多。本研究结果显示,神经干/祖细胞移植对脑损伤导致的胶质细胞活化有调节作用,并可能通过在移植细胞和宿主细胞间建立缝隙连接来调节细胞间的通讯,这可能是细胞移植的神经保护作用的机制之一。

关键词：星形胶质细胞轴索断裂缝隙连接蛋白-43 小胶质细胞脑室下区

Small P values may not yield robust findings:an example using REST-meta-PD

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-ming Dong Jia-Wei Sun marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling Saurabh Garg moran Gilat martin Gorges Shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara madhyastha Ni-Ni mao Grainne mcAlonan martin J.mcKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica Hui-Fang Shang James m.Shine Priyank Shukla Tomas Slavicek Xiao-Peng Song Gioacchino Tedeschi Alessandro Tessitore david Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang min-ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&mcGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f mRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(mCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent mCC)is widely recommended[1].

关键词：帕金森病 precise correction

不可逆电穿孔术:致细胞完全死亡的先进肝脏消融技术

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国际医学放射学杂志 2010年第4期 371-372页

作者： E.W.Lee V.E.Prieto S.m.Dry C.T.Loh S.T.Kee 郭丽君 Department of Radiology Ronald Reagan Medical Center at UCLA david Geffen School of medicine at UCLA

目的评价不可逆电穿孔术(IRE)消融肝组织的有效性及IRE诱导细胞死亡的放射-病理相关性。材料与方法经动物研究委员会批准,对16头约克郡猪行超声引导下正常肝组织IRE消融。共计55

关键词：不可逆电穿孔术细胞

主动脉弓上动脉成像:3.0T高空间分辨率mR血管成像对比剂用量减少的可行性研究

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国际医学放射学杂志 2009年第1期32卷 78-79页

作者： A. Tomasian N. Salamon D.G. Lohan m. Jalili J.P. Villablanca J.P. Finn 陈仁彪 Department of Radiological Sciences David Geffen School of Medicine University of California at Los Angeles Suite 3371 Peter V. Ueberroth Building 10945 Le Conte Ave Los Angeles CA 90095-7206 USA

目的评估和比较3种不同剂量的对比剂给药方案对主动脉上动脉的3．0T高空间分辨率三维mR血管成像的诊断影像质量。材料和方法本研究经机构委员会批准，免除知情同意，遵从HIPAA。120例接受主动脉上动脉3．0T三维高空间分辨率对比增... 详细信息

目的评估和比较3种不同剂量的对比剂给药方案对主动脉上动脉的3．0T高空间分辨率三维mR血管成像的诊断影像质量。材料和方法本研究经机构委员会批准，免除知情同意，遵从HIPAA。120例接受主动脉上动脉3．0T三维高空间分辨率对比增强mR血管成像的连贯的病人按同样的检查序列检查，

关键词： mR血管成像空间分辨率主动脉弓对比剂用量 HIPAA 影像质量给药方案

应用mR成像确定在机器人辅助腹腔镜前列腺切除术中神经血管束的保留

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国际医学放射学杂志 2012年第3期 271-272页

作者： T.D.mcClure D.J.A.margolis R.E.Reiter J.W.Sayre m.A.Thomas R.Nagarajan 张华 Department of Radiology David Geffen School of Medicine at UCLA200 Medical Plaza

目的确定术前直肠内线圈mRI的表现是否影响机器人辅助性腹腔镜前列腺切除术(RALP)中神经血管束的保留和手术切缘的范围。材料与方法本研究符合HIPAA,经伦理审查委员会批准,免除病人知情同意书。在2004年1月—2008年4月间有104例经活检... 详细信息

目的确定术前直肠内线圈mRI的表现是否影响机器人辅助性腹腔镜前列腺切除术(RALP)中神经血管束的保留和手术切缘的范围。材料与方法本研究符合HIPAA,经伦理审查委员会批准,免除病人知情同意书。在2004年1月—2008年4月间有104例经活检证实为前列腺癌的男性

关键词：血管束腹腔镜前列腺切除术手术计划 mR 神经