检索结果-南通市图书馆

SImAP500: A novel risk score to identify recipients at higher risk of hepatocellular carcinoma recurrence following liver transplantation

引用

World Journal of Transplantation 2024年第3期14卷 132-143页

作者： Amr Alnagar Nekisa Zakeri Konstantinos Koilias Rosemary E Faulkes Rachel Brown Owen Cain m Thamara P R Perera Keith J Roberts Rebeca Sanabria-mateos david C Bartlett Yuk Ting ma Shivan Sivakumar Shishir Shetty Tahir Shah Bobby V m Dasari Department of HBP and Liver Transplantation Surgery Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Centre for Liver Research Institute of Biomedical ResearchBirmingham B152TTUnited Kingdom Department of Hepatology Queen Elizabeth HospitalUniversity Hospitals BirminghamBirmingham B152GWUnited Kingdom Department of Pathology University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Department of Oncology Queen Elizabeth HospitalUniversity Hospitals of BirminghamBirmingham B152GWUnited Kingdom

BACKGROUND Recurrence of hepatocellular carcinoma(HCC)following liver transplantation(LT)has a devastating influence on recipients’survival;however,the risk of recur-rence is not routinely *** stratification is vital with a long LT waiting time,as that could influence the recurrence despite strict listing *** This study aims to identify predictors of recurrence and develop a novel risk pre-diction score to forecast HCC recurrence following *** A retrospective review of LT for HCC recipients at University Hospitals Bir-mingham between July 2011 and February *** and multivariate analyses were performed to identify recurrence predictors,based on which the novel SImAP500(satellite nodules,increase in size,microvascular invasion,AFP>500,poor differentiation)risk score was *** 234 LTs for HCC were performed with a median follow-up of 5.3 *** developed in 25 patients(10.7%).On univariate analyses,RETREAT score>3,α-fetoprotein(AFP)at listing 100-500 and>500,bridging,increased tumour size between imaging at the listing time and explant histology,increase in the size of viable tumour between listing and explant,presence of satellite nodules,micro-and macrovascular invasion on explant and poor differentiation of tumours were significantly associated with recurrence,based on which,the SImAP500 risk score is *** SImAP500 demonstrated an excellent predictive ability(c-index=0.803)and outper-formed the RETREAT score(c-index=0.73).SImAP500 is indicative of the time to disease *** SImAP500 risk score identifies the LT recipients at risk of HCC *** stratification allows patient-centric post-transplant surveillance *** validation of the score is recommended.

关键词： Liver transplantation Hepatocellular carcinoma Recurrence Survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacodynamic Study of Parallel Groups Comparing the Effect of Rivaroxaban 20 mg (Laboratorios Leti, S.A.V.) vs Rivaroxaban 20 mg (Bayer Laboratories) on Prothrombin Time

引用

International Journal of Clinical medicine 2024年第3期15卷 123-133页

作者： Elsy Rodriguez de Roa maría Gonzalez Yibirin david Rincón matute Carolina Aguilera Centro médico Uslar Distrito Capital Caracas Venezuela Investigación Clínica Grupo Leti Guarenas Venezuela

Background: The prevalence of both atrial fibrillation (FA) and diabetes mellitus (Dm) is increasing and they often occur together and constitute a high risk of thrombosis. Rivaroxaban is a Factor Xa inhibitor with a rapid onset and disappearance of action after oral administration;it acts by inhibiting the active form of the coagulation factor. In order to reflect the effect of the action of Rivaroxaban, we used the prothrombin time (PT);however, it′s not the most accurate, but it is the one available in our community. methods: This was a prospective, randomized, analyst-blinded, parallel group clinical study to verify the efficacy of Rivaroxaban Leti 20 mg (RL) (12 volunteers vs Rivaroxaban Bayer 20 mg (RB) (13 volunteers). The variables were determination of PT and Partial Thromboplastin Time (aPTT) at baseline and at 24, 48 and 72 hours after administering a daily dose of 20 mg for three days. The determination was carried out with the IDG method (Integrated Diagnostics Group Sanzay Corporation) with an International Sensitivity Index (ISI) of 1.17 PT and aPTT were taken before the first dose, and then, every day during the next 3 days, three hours after the ingestion of their daily dose at 7 am. Results: The 25 healthy volunteers were similar in age, BmI, and SBP/DBP level with a greater number of men in the Bayer group. The efficacy of rivaroxaban was similar in both groups with prolongation of PTT to the 2nd day of treatment with PT, and percentage changes from baseline (14.46 ± 0.97 for RB vs 14.17 ± 0.94 RL p: 0.45), PTT results and percentage changes from the base (RB: 34 ± 4.53 RL: 33.46 ± 2.82). The safety of rivaroxaban was good in both groups with no serious adverse events. The equivalence in the logarithmically transformed PT result (ln) on day two, mean and CI (90%) 99.2 (94.4-104) and 100 (99.5-100.8);neither the means nor the 90% confidence intervals of the PT variable transformed logarithmically to ensure its normality, were far from the 80%-125%

关键词： Pharmacodynamic Study Rivaroxaban Clinical Trial PT aPTT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In memory of Professor david Alexander Yuen

引用

Earthquake Research Advances 2024年第2期4卷 1-6页

作者： Gabriele morra Henry m.Tufo Ⅲ Department of Physics University of Louisiana at Lafayette 104 E University AveLafayette70504LouisianaUSA Department of Computer Science University of Colorado at BoulderBoulderCO80309USA

david Alexander Yuen was born on June 14,1948,in Shanghai during the Chinese Civil *** family moved to Hong Kong the following *** to the help of Senator mike mansfield,a Democrat from montana,who met Dave's father during World War II,the entire family of seven moved to New York City in *** showed much enthusiasm as a student,graduating from Xavier High School in Lower manhattan in 1965,along with other successful Americans such as Supreme Court Justice Antonin *** proceeded to Caltech to study chemical physics and then moved to the chemistry department at the University of California,Berkeley in 1969,where the beginning of the plate tectonics revolution inspired him to change his focus to geophysics.

关键词： Berkeley moved Lower

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Theory for Charge Density Wave and Orbital-Flux State in Antiferromagnetic Kagome metal FeGe

引用

Chinese Physics Letters 2024年第4期41卷 90-104页

作者：马海洋殷嘉鑫 m.Zahid Hasan 刘健鹏 School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China ShanghaiTech Laboratory for Topological Physics ShanghaiTech UniversityShanghai 201210China Quantum Science Center of Guangdong-HongKong-macao Greater Bay Area Shenzhen 518045China Laboratory for Topological Quantum matter and Advanced Spectroscopy(B7) Department of PhysicsPrinceton UniversityPrincetonNew Jersey 08544USA Princeton Institute for Science and Technology of materials Princeton UniversityPrincetonNew Jersey 08544USA materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Liaoning Academy of materials Shenyang 110167China

We theoretically study the charge order and orbital magnetic properties of a new type of antiferromagnetic kagome metal *** on first-principles density functional theory calculations,we study the electronic structures,Fermi-surface quantum fluctuations,as well as phonon properties of the antiferromagnetic kagome metal *** is found that charge density wave emerges in such a system due to a subtle cooperation between electron-electron interactions and electron–phonon couplings,which gives rise to an unusual scenario of interaction-triggered phonon instabilities,and eventually yields a charge density wave(CDW)*** further show that,in the CDW phase,the ground-state current density distribution exhibits an intriguing star-of-david pattern,leading to flux density *** orbital fluxes(or current loops)in this system emerge as a result of the subtle interplay between magnetism,lattice geometries,charge order,and spin-orbit coupling(SOC),which can be described by a simple,yet universal,tight-binding theory including a Kane-mele-type SOC term and a magnetic exchange *** further study the origin of the peculiar step-edge states in FeGe,which sheds light on the topological properties and correlation effects in this new type of kagome antiferromagnetic material.

关键词： interaction phonon orbital

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The embryology of persistent cloaca and urogenital sinus malformations

引用

Asian Journal of Andrology 2020年第2期22卷 124-128页

作者： david F m Thomas University of Leeds LeedsWest Yorkshire LS29JTUK

Cloacal malformations are characterized by the confluence of the lower urinary tract,the female reproductive tract,and the rectum to create a common channel with a single opening on the *** presence of a cloaca is a normal phase of early human embryological *** the 4^th and 7^th weeks of gestation,the cloaca undergoes subdivision to form the hindgut and urogenital *** of this process results in the congenital anomaly termed persistent cloaca(PC).The term urorectal septum malformation sequence(URSmS)is also used to describe this *** classic description of this process which is still cited in many standard textbooks dates from the 19th ***,this has been increasingly called into question by the findings of studies using modern scientific *** sinus anomalies are defined by the confluence of the urethra and vagina to form a common channel of varying length with a single perineal *** this condition,the anorectal canal opens separately on the *** presence of a urogenital sinus represents a transient phase of the normal development of the lower genital tract in the female ***,the form of urogenital sinus most commonly encountered in the developed world is a feature of disordered sexual differentiation and does not arise simply from the persistence of the anatomical structure which is a feature of normal fetal development.

关键词： cloaca embryology urogenital sinus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Duplication and diversification of insulin genes in ray-finned fish

引用

Zoological Research 2019年第3期40卷 185-197页

作者： david m.Irwin Department of Laboratory medicine and Pathobiology University of Toronto Banting and Best Diabetes Centre University of Toronto

Insulin is a key hormone for the regulation of metabolism in *** is produced by pancreatic islet cells in response to elevated glucose levels and leads to the uptake of glucose by tissues such as liver and adipose tissue to store *** also has additional functions in regulating *** work has shown that the proglucagon gene,which encodes hormones counter regulating insulin,is duplicated in teleost fish,and that the peptide hormones encoded by these genes have diversified in function.I sought to determine whether similar processes have occurred to insulin genes in these *** of fish genomes revealed an unexpected diversity of insulin genes.A triplication of the insulin gene occurred at the origin of teleost fish,however one of these three genes,insc,has been lost in most teleost fish *** two other insulin genes,insa and insb,have been retained but show differing levels of selective constraint suggesting that they might have diversified in ***,a duplicate copy of the insa gene,which I named insab,is found in many *** coding sequenee encoded by insab genes is under weak selective constraint,with its predicted protein sequences losing their potential to be processed into a two-peptide ***,these sequences have retained perfectly conserved cystine residues,suggesting that they maintain insulin's three-dimensional structure and therefore might modulate the processing and secretion of insulin produced by the other genes.

关键词： Insulin Teleost fish Gene duplicati on Adaptive evolution Gene loss

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

古新世-始新世极热事件期间的浊积岩沉积对气候变化和天文旋回的响应

引用

第四纪研究 2024年第5期44卷 1225-1234页

作者：金思敏 david B.KEmP 张仲石黄春菊刘晴中国地质大学(武汉)环境学院大气科学系湖北武汉430074 中国地质大学(武汉)地球科学学院生物地质与环境地质国家重点实验室关键带演化湖北省重点实验室湖北武汉430074

浊流是地表最重要的沉积物运移过程之一,主导了沉积物从大陆架到深海的输送。通过研究深时极热事件期间浊流的分布规律,可为类比推测未来全球变暖背景下浊流活动的变化趋势提供重要参考。前期研究发现,古新世-始新世极热事件(PETm)期间... 详细信息

浊流是地表最重要的沉积物运移过程之一,主导了沉积物从大陆架到深海的输送。通过研究深时极热事件期间浊流的分布规律,可为类比推测未来全球变暖背景下浊流活动的变化趋势提供重要参考。前期研究发现,古新世-始新世极热事件(PETm)期间,英国东部北海盆地的高频浊积砂岩沉积受到了气候变化的影响。本研究进一步对西班牙Basque盆地Zumaia剖面古新统-始新统458层浊积岩(深度范围为-19.76~37.12 m)进行了时间序列分析,发现浊积岩沉积存在着显著的405 ka长偏心率周期信号。通过总结古新统-始新统浊积岩记录对天文旋回的响应,发现仅在英国北海盆地和西班牙Basque盆地识别出了天文旋回信号,且这两个点位的地理位置与模拟结果显示的年平均降水对轨道参数变化的敏感区相吻合。此外,本研究还讨论了PETm期间不同沉积环境中浊积岩沉积记录对海平面变化和全球升温的响应。

关键词：古新世-始新世极热事件天文旋回浊积岩偏心率岁差

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sensory Phenotypic and molecular Identification of Aromatic Rice Accessions Cultivated in Benin

引用

Advances in Bioscience and Biotechnology 2024年第3期15卷 195-206页

作者： Chimène Nadège mahoussi Nanoukon Koffi david montcho Hambada Deless Edmond Fulgence Thiémélé Bignon meyrix Pamela Franzel Loumedjinon Babatoundé Franel Carel Wenceslas Affolabi Amed Sèmèvo Havivi Kéllya Laurinzo Déguénon Grâce Finagnon Vitoekpon Arielle Bankole Lambert Gustave Djedatin Laboratory of molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Bio-technologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of molecular Biology and Bioinformatics Applied to Genomics National School of Applied Biosciences and Biotechnologies National University of Science Technology Engineering and Mathematics Dassa-Zoumè Benin Laboratory of Plant Horticultural and Forestry Sciences National University of Agriculture Kétou Benin Genetics Teaching and Research Unit Department of Biochemistry-Genetics Peleforo GON COULIBALY University Korhogo C&#244te d’Ivoire

Rice is one of the most widely cultivated cereals in the world, and its aroma is increasingly in demand. With the advancement of research, a major rice flavor gene has been identified on rice chromosome 8. It encodes non-functional betaine aldehyde dehydrogenase leading to the accumulation of 2-acetyl-1-pyrroline which is the major olfactory compound that confers the fragrant character to rice. The aroma of rice is considered a special trait of enormous economic importance that determines the prime price in world trade. To satisfy the needs of the population and reduce rice imports into Benin, we conducted this study to identify aromatic rice accessions grown in Benin. Seventy-two rice accessions collected across Benin were PCR amplified with three SSR markers Rm 7049, Aro 7, and Rm 223, linked to the fgr (fragrance of rice) aroma gene. molecular analysis revealed that 12 of the 72 accessions, namely Bagou 19, Bagou 22, Tchaka 34, Foun 15, Tchaka 41, Nana 32, Kan 61, Kung 69, Kung 67, Bagou 20, Agbab 101 and Koum 55 possess the fgr gene and can be considered as aromatic rice accessions. A sensory phenotypic test using KOH was carried out on rice accessions carrying fgr gene. Of the twelve positives, only one had the smell of aromatic rice, like the Azucena control. These results show that Benin also has aromatic rice varieties that can be sold on national and international markets.

关键词： Aromatic Rice 2-Acetyl-1-Pyrroline SSR markers Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Social determinants of gastrointestinal malformation mortality in Brazil:a national study

引用

World Journal of Pediatric Surgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Amanda Rosendo Luiza Telles Aricia Gomes miranda madeleine Carroll Bruna Oliveira Trindade Sarah Bueno motter Esther Freire Gabriella Hyman Julia Ferreira Fabio Botelho Roseanne Ferreira david P mooney Joaquim Bustorff-Silva Program in Global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of medicine and Health Sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Division of Pediatric Surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of Surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação médica(IDOmED/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da Saude de Porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil Department of Health Research methods McMaster UniversityHamiltonSouthern OntarioCanada Department of Pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born with a congenital disorder,potentially fatal without *** study aims to evaluate the relationship between gastrointestinal congenital malformation(GICm)mortality,health indicators,and socioeconomic factors in *** GICm admissions(Q39-Q45)between 2012 and 2019 were collected using national *** demographics,socioeconomic factors,clinical management,outcomes,and the healthcare workforce density were also accounted *** Surgical Workforce density and the number of neonatal intensive care units in a region were extracted from national datasets and combined to create a clinical index termed'NeoSurg'.Socioeconomic variables were combined to create a socioeconomic index termed SocEcon'.Simple linear regression was used to investigate if the temporal changes of both indexes were *** correlation between mortality and the different indicators in Brazil was evaluated using Pearson's correlation *** Over 8 years,Brazil recorded 12804 GICm *** Southeast led with 6147 cases,followed by the Northeast(2660),South(1727),North(1427),and midwest(843).The North and Northeast reported the highest mortality,lowest NeoSurg,and SocEcon Index ***,mortality rates declined across regions from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and midwest experienced the most substantial reductions,at 63%and 75%,*** significantly correlated with the indexes in nearly all regions(pminants of health and GICm mortality in Brazil,using two novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factors influencing mercury accumulation in three species of forage fish from Caddo Lake, Texas, USA

引用

Journal of Environmental Sciences 2010年第8期22卷 1158-1163页

作者： matthew m Chumchal Ray W Drenner david R Cross K david Hambright Department of Biology Texas Christian University 2800 S. University Dr Department of Psychology Texas Christian University 2800 S. University Dr Program in Ecology and Evolutionary Biology Biological Station and Department of Zoology 730 Van Vleet Oval University of Oklahoma

most studies that have examined mercury （Hg） contamination of fish have focused on game species feeding near the top of the food web, while studies that examine forage fish that feed near the base of the food web are rare. We conducted a survey of Hg contamination in three species of forage fish, brook silverside （Labidesthes sicculus）, threadfin shad （Dorosoma petenense） and gizzard shad （Dorosoma cepedianum）, from Caddo Lake, Texas, USA and found species-specific differences in Hg concentrations. We examined total length, age, trophic position （determined using δ15N）, and growth rate of forage fish as factors that could have influenced within-and between-species differences in Hg concentration. Total length and age were the best predictors of within-species differences in Hg concentration. Between-species differences in Hg concentrations were most strongly influenced by trophic position.

关键词： mercury trophic position forage fish

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：