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Post-Hospital Syndrome and Hyponatremia

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Health 2021年第8期13卷 846-856页

作者： José Bellod-Tonda Julio Blázquez-Encinar María Dolores Jover-Ríos Carmen Seguí-Pérez Juan Méndez-Mora Francisco Caparrós-Hernández Álex Méndez-Jover Marc Seguí-Pérez david Baláž leticia Espinosa del Barrio Jesús Corbacho-Redondo Carles García-Cervera Juan Manuel Núñez-Cruz Isidro Hernández-Isasi Javier Guzmán-Martínez Angie Gómez-Uranga Pedro Esteve-Atiénzar Jorge Peris-García Veronica Martínez-Sempere Eliana Damonte-White Óscar Hernando Ruiz-Ariza Juan Carlos lópez-Corbalán lourdes lajara-Villar Andrea Riaño-Pérez Paloma Chazarra-Pérez María Escamilla-Espínola Maria luisa Asensio-Tomás Miguel Ángel Auladell-Alemany laura Serna-Torres Asunción Pérez-Fullana Amparo Gómez-Siurana Sergio Menargues-Irles José Miguel Seguí-Ripoll Internal Medicine Department University Hospital of San Juan Alicante Spain Internal Medicine Department Torrevieja University Hospital Alicante Spain Internal Medicine Department Hospital La Vega Baja of Orihuela Alicante Spain CEU Cardinal Herrera University Veterinary Hospital Valencia Spain Secondary School Marist Brothers High School Alicante Spain Department of Clinical Medicine Miguel Hernández University Elche Spain Primary Care Medicine Benilloba Spain Sub-Delegation of the Government Alicante Spain Chemical Engineering Department University of Alicante Alicante Spain

Introduction: Post-hospital syndrome (PHS) is defined as a period of vulnerability during the first 30 days after a patient is discharged from hospital, in which multiple factors come into play. Hyponatremia is the most frequent hydroelectrolytic disorder in hospitalized patients and may be related to the appearance of PHS. Objective: The objective is to estimate the prevalence of PHS that is assessed as the rate of readmissions in the first 30 days after discharge, in patients with hyponatremia. Material and Methods: It is a descriptive observational study of patients with hyponatremia who were discharged from 1 September 2010 to 2 February 2020 at the Internal Medicine Service of the Hospital University of San Juan (Alicante, Spain). Results: Of the 25 included patients, 5 (20%) were readmitted within a month of discharge, after a mean of 11.4 days (standard deviation [SD] 5.1). The overall mortality of the study was 20% (n = 5), with one case of death in the first 30 days post-hospitalization (4%). In 12 patients (48%) the origin of the hyponatremia was undetermined. The most frequently recorded etiology for the condition was pharmacological (n = 7, 28%), and there was pronounced variability in its clinical and laboratory study. The most widely used corrective measure was drug withdrawal, in 16 patients (64%). Water intake restriction was the most common treatment after discharge (5 patients, 20%), followed by urea (2 patients, 8%), while tolvaptan was not used. Conclusion: Hyponatremia may be the cause of PHS, which could increase the rate of early readmission. Hyponatremia is an underdiagnosed and undertreated entity, so it is necessary to apply an appropriate system to optimize its management and, in future studies, to assess its impact on PHS.

关键词： Hospitalization Hyponatremia Patient Readmission Inappropriate ADH Syndrome

Regulation of energy expenditure by brain stem peptidergic neurons

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Regulation of energy expenditure by brain stem peptidergic n...

芍药甘草汤治疗葡萄膜炎的网络药理学机制研究

中国生理学会张锡钧基金第十五届全国青年优秀生理学学术论文交流及评奖会议;中国生理学会第十三届全国青年生理学工作者学术会议

作者： Wen Z.Yang Xiaosa Du Wen Zhang Hengchang Xie Yan Xiao Xiaoning Jia Jiashu liu Jianhui Xu Xin Fu Xinyan Ni Weizhe Hong Miao He Jiajun Yang Haitao Yang Xiao-hong Xu Wei l.Shen Shanghai Institute for Advanced Immunochemical Studies & School of life Science and Technology Shanghaitech University CAS Key laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic ChemistryChinese Academy of Sciences Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyShanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Department of Neurology Shanghai Sixth People's Hospital East Affiliated to Shanghai University of Medicine & Health Science Thermoregulation and Inflammation laboratory Chengdu Medical College Department of Biological Chemistry and Department of Neurobiology David Geffen School of MedicineUniversity of California Institutes of Brain Science State Key Laboratory of Medical NeurobiologyFudan University

Homeostatic control of body temperature and energy expenditure (EE) are crucial for the survival and fitness in mammals which are achieved by precise coordination between dedicated brain pathways and peripheral effector *** temperature signals to hypothalamic centers represent a key layer of thermal and energy ***,the mechanism by which these signals are transmitted into the hypothalamus remains poorly *** find that broad photoactivation of

关键词： PBN Regulation of energy expenditure by brain stem peptidergic neurons

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黑龙江医学 2023年第7期47卷 773-776页

作者：谢婷刘静霞吕瑞民黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040

目的:基于网络药理学方法探究芍药甘草汤治疗葡萄膜炎的效应机制。方法:从我国研发的中药系统药理学数据库与分析平台(TCMSP),筛选得到芍药甘草汤的主要成分及作用靶点,并通过GeneCards、OMIM、DisGeNET、DrugBank数据库获取葡萄膜炎相... 详细信息

目的:基于网络药理学方法探究芍药甘草汤治疗葡萄膜炎的效应机制。方法:从我国研发的中药系统药理学数据库与分析平台(TCMSP),筛选得到芍药甘草汤的主要成分及作用靶点,并通过GeneCards、OMIM、DisGeNET、DrugBank数据库获取葡萄膜炎相关的疾病靶点,进而筛选出相同的靶点作为“药物—疾病”交集靶点。利用STRING数据平台和Cytoscape进行PPI分析与网络构建。在david进行富集分析。结果:获得芍药甘草汤成分93个,中药相关靶点214个,疾病靶点1463个,交集靶点93个。芍药甘草汤治疗葡萄膜炎的重要有效成分有槲皮素、山奈酚、β-谷甾醇、柚皮素、芒柄花素等,主要靶点为AKT1、TNF、Il6、STAT3、PTGS2,通过Il-17信号通路、TNF信号通路、Toll样受体信号通路、Th17细胞分化、弓形虫病等通路发挥作用。结论:芍药甘草汤治疗葡萄膜炎具备多活性成分、多靶点、多渠道的调节免疫、抑制炎症反应的优势,为其临床应用提供了一定的理论依据。

关键词：芍药甘草汤葡萄膜炎网络药理学作用机制

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

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世界最新医学信息文摘 2015年第5期 9-9页

作者： Shi-Bing Yang Hye Young lee david Matthew Young An-Chi Tien Ashley Rowson-Baldwin Yu Yu Shu Yuh Nung Jan lily Yeh Jan

Rapamycin, a specific inhibitor for m TOR complex 1, is an FDA-approved immunosuppressant for organ transplant. Recent developments have raised the prospect of using rapamycin to treat cancer or diabetes and to delay aging. It is therefore important to assess how rapamycin treatment affects glucose homeostasis. Here, we show that the same rapamycin treatment reported to extend mouse life span significantly impaired glucose homeostasis of aged mice. Moreover, rapamycin treatment of lean C57B/l6 mice reduced glucose-stimulated insulin secretion in vivo and ex vivo as well as the insulin content and beta cell mass of pancreatic islets. Confounding the diminished capacity for insulin release, rapamycin decreased insulin *** multitude of rapamycin effects thus all lead to glucose intolerance. As our findings reveal that chronic rapamycin treatment could be diabetogenic, monitoring glucose homeostasis is crucial when using rapamycin as a therapeutic as well as experimental reagent.

关键词： Rapamycin m TOR Glucose intolerance Insulin Diabetes

文献快报(5):社交媒体使用消极体验而非使用时长增加青少年自杀意念

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中国学校卫生 2024年第5期45卷 614-614页

作者： HAMIlTON J lDAlACK M BOYD S I 李琪(编译) Department of Psychology Rutgers University Piscataway NJ USA Department of Psychology George Washington University Washington DC USA Department of Psychiatry University of Pittsburgh Pittsburgh PA USA

社交媒体使用与青少年自杀风险的关联受到广泛关注。匹兹堡大学david教授领衔的团队在美国各地招募了60名青少年进行了为期8周的监测,通过每日3次生态瞬时评估询问青少年社交媒体使用相关的消极体验(如感到焦虑)、积极体验(如受到鼓励)... 详细信息

社交媒体使用与青少年自杀风险的关联受到广泛关注。匹兹堡大学david教授领衔的团队在美国各地招募了60名青少年进行了为期8周的监测,通过每日3次生态瞬时评估询问青少年社交媒体使用相关的消极体验(如感到焦虑)、积极体验(如受到鼓励)及自杀意念,首次通过密集监测设计探讨青少年社交媒体体验与自杀意念间的关联,结果显示,频繁经历消极的社交媒体体验的青少年更可能报告自杀意念,而积极的社交媒体体验与自杀意念报告率降低有关。此外,未发现社交媒体的使用时间(视屏时间)与自杀意念间的显著关联。研究提示社交媒体经历可能是青少年自杀可修饰的风险因素,未来的研究应将增强青少年社交媒体的积极体验感作为改善青少年心理健康和预防自杀的目标,而不仅仅是限制视屏时间。

关键词：社交媒体匹兹堡大学自杀意念青少年自杀积极体验青少年心理健康监测设计消极体验

肝细胞黏附分子对膀胱移行癌细胞基因表达谱的影响

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中国医学科学院学报 2013年第2期35卷 190-198页

作者：王秋菊吕长坤陶佳杜红飞范砚茹宋学东罗春丽重庆医科大学检验医学院临床检验诊断学教育部重点实验室重庆400016

目的利用Affymetrix基因表达谱芯片探讨肝细胞黏附分子(hepaCAM)对膀胱移行癌细胞基因表达谱的影响及作用的分子机制。方法运用Affymetrix Human plus 2.0全基因组芯片检测膀胱移行癌细胞株EJ细胞腺病毒-绿色荧光蛋白-hepaCAM感染组与... 详细信息

目的利用Affymetrix基因表达谱芯片探讨肝细胞黏附分子(hepaCAM)对膀胱移行癌细胞基因表达谱的影响及作用的分子机制。方法运用Affymetrix Human plus 2.0全基因组芯片检测膀胱移行癌细胞株EJ细胞腺病毒-绿色荧光蛋白-hepaCAM感染组与腺病毒-绿色荧光蛋白感染组的基因表达谱,用SAM法进行差异基因分析、david软件进行基因本体论分析及wikiPathway分析,并用RT-PCR和Western blot验证芯片结果。结果 hepaCAM能引起EJ细胞系基因表达谱的广泛变化,表达差异超过2倍以上的基因共2469个,其中上调基因1602个、下调基因867个。这些差异表达的基因功能主要涉及细胞周期、细胞增殖调节等方面。用RT-PCR对差异基因DNA修复蛋白,肝脏激酶B1和细胞周期蛋白D1进行验证,结果与基因芯片相符;进一步在3细胞株中用Western blot佐证DNA修复蛋白、肝脏激酶B1变化与芯片结果一致。结论 hepaCAM能够诱导EJ细胞基因表达谱的广泛变化,在基因水平通过多条通路作用于膀胱癌细胞。

关键词：肝细胞黏附分子膀胱移行细胞癌基因表达谱芯片

母亲暴露于常规空气污染物与后代的先天性心脏缺陷:来自全国出生缺陷预防研究的结果

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环境与职业医学 2014年第12期31卷 929-929页

作者： Jeanette A.Stingone Thomas J.luben Julie l.Daniels Montserrat Fuentes david B.Richardson Arthur S.Aylsworth Amy H.Herring Marlene Anderka lorenzo Botto Adolfo Correa Suzanne M.Gilboa Peter H.langlois Bridget Mosley Gary M.Shaw Csaba Siffel Andrew F.Olshan National Birth Defects Prevention Study

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配... 详细信息

[背景]流行病学文献表明,空气污染物暴露与胎儿的发育相关联。[目的]探讨产妇在妊娠2-8周期间的空气污染物暴露及其与先天性心脏缺陷的关联。[方法]此项出生缺陷预防研究是一项由9个州参加的病例对照研究。给参加这项研究的妊娠妇女分配1周和7周里一氧化碳、二氧化氮、臭氧、二氧化硫的每日最高浓度平均值,以及细颗粒物和粗颗粒物的24 h测量值,采用的方法是在妊娠早期收集这些妇女住所50 km内最接近的空气监测点的测量值。根据不同的污染物,最多4 632例活产对照和3 328例活产、死胎或流产病例有空气污染暴露的数据。应用分层回归模型,并以产妇的人口统计学、烟草和酒精使用情况进行调整。对于多污染物共同暴露的情况,则采用主成分分析来评估这些关联。[结果]二氧化氮暴露与主动脉缩窄及肺动脉瓣狭窄之间存在正性关联。细颗粒物暴露与左室发育不良心脏综合征呈正性相关,但与房间隔缺损呈负性相关。检测个体的暴露周数表明,使用7周的平均水平未观察到污染物与缺陷之间的关联。多污染物分析的结果支持左室流出道阻塞与二氧化氮之间、左室发育不良心脏综合征与颗粒物之间存在关联,尽管在最高的暴露水平时估计值是下降的。[结论]采用每日最高污染物水平探讨个体暴露周数揭示了某些污染物与心脏缺陷之间存在一些正向关联,并且提示在妊娠期间存在潜在的敏感性窗口期。

关键词：先天性心脏缺陷空气污染物出生缺陷预防母亲暴露病例对照研究心脏综合征细颗粒物后代

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr luying Yan Keisha Roden david Troilo Chanyi lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan lu Jie Chen Jinhua Bao liang Hu Qinmei Wang Zibing Jin Frances Rucker Stephanie Britton Stephan Hanowsky Molly Spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin Sun Ian G. Morgan Jeremy A. Guggenheim Rupal l. Shah Cathy Williams Jinglei Yang Peter S. Reinach Sen Zhang Wenfeng Sun Bo liu Fen li Xiaoqing li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii Shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank Schaeffel ladan Ghodsi William K. Stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran S. Sidhu P. Michael Iuvone Michael J Collins Nethrajeith Srinvasalu Sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho SW Cheung Pei-Chang Wu Quan V. Hoang Duk C. lee Erica G. landis Michael A. Bergen Curran Sidhu Samer Hattar Richard A. Stone Ravi Metlapally Ruiqin li Qinglin Xu Hong Zhong Chenglin Pan Weizhong lan Xiaoning li ling Chen Zhikuan Yang Scott A. Read Seang-Mei Saw Shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun li Guo-Zhong Xu Furong Huang Xiong-li Yang Yong-Mei Zhong Earl l Smith, III Baskar Arumugam li-Fang Hung lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen lam Samantha Shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit li Quan liu Chi-ho To Timothy J. Gawne John T. Siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological Sciences SUNY College of Optometry New York NY 10036 USA School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical Science and Disease New England College of Optom Boston MA USA School of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia State Key laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China School of Optometry & Vision Sciences Cardiff University Cardiff UK School of Social and Community Medicine University of Bristol Bristol UK School of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China State Key laboratory Cultivation Base and Key laboratory of Vision Science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China Shanghai Key laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

基于网络药理学技术探讨桑椹治疗便秘的作用机制

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蚕桑通报 2023年第1期54卷 34-37页

作者：郭君鑫林天宝吕志强画水君鑫家庭农场浙江东阳322102 浙江省农业科学研究院蚕桑与茶叶研究所浙江杭州310021

本文运用网络药理学方法探讨桑椹的主要活性成分、靶点,初步研究其治疗便秘的药理学作用机制,为进一步深入探讨其药理学作用提供新线索。通过检索数据库的方法筛选出桑椹的主要活性成分、靶点及便秘相关靶点,构建成分-靶点-疾病数据库,... 详细信息

本文运用网络药理学方法探讨桑椹的主要活性成分、靶点,初步研究其治疗便秘的药理学作用机制,为进一步深入探讨其药理学作用提供新线索。通过检索数据库的方法筛选出桑椹的主要活性成分、靶点及便秘相关靶点,构建成分-靶点-疾病数据库,导入Cytoscape软件构建网络,获取靶点信息。筛选出关键靶点,利用String进行蛋白相互作用(protein-protein interaction,PPI)网络构建,利用david系统进行GO富集和通路富集分析。从TCMSP数据库中筛选得到桑椹活性成分12种,其作用靶点共370个;从Gene Cards和OMIM疾病相关靶点数据库中检索得到便秘相关靶点452个,取交集后得到桑椹治疗便秘作用靶点共211个。这些靶点主要涉及锌离子结合、氧化还原酶活性、液泡、药物反应与炎症应答等生物学过程,和PPAR信号通路、酒精性肝病、糖尿病并发症AGR受体信号通路、脂质与动脉粥样硬化及流体剪切应力与动脉粥样硬化多条信号通路。本研究发现,网络药理学方法初步揭示了桑椹治疗便秘的主要药理学机制。

关键词：桑椹便秘网络药理学通路分析