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古生态学概念与应用 1

Hospital management in China in a time of change

1989年

作者：（美）j.Robert Dodd AND ROBERT j.stanton jR. 徐珊红钱文龙王雪等译

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Chinese Medical journal 2002年第11期115卷 1716-1726页

作者：裴丽昆 david Legge Pauline stanton School of Public Health La Trobe University Bundoora Victoria 3083 Australia

Chinese hospitals face complex challenges: allocating resources equitably and efficiently whilst moving to greater reliance on market mechanisms; maintaining quality despite declining government funding; exercising responsibility in some areas whilst tight government controls remain in others; and generating more revenue from user charges whilst ensuring access to care for the poor.

关键词： Hospital Administration China Financial Management, Hospital Health Policy Hospital Information Systems Humans Problem Solving Quality of Health Care

Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro

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Asian journal of Andrology 2016年第4期18卷 620-626页

作者： Mark j McCabe Caroline FH Foo Marcel E Dinger Peter M Smooker Peter G stanton Male Fertility Regulation Laboratory Hudson Institute of Medical Research Monash Medical Centre Clayton Victoria 3168 Australia School of Applied Sciences Royal Melbourne Institute of Technology University Bundoora Victoria 3088 Australia Kinghorn Centre for Clinical Genomics Garvan Institute of Medical Research Darlinghurst New South Wales 2010 Australia St Vincent's Clinical School UNSW Sydney New South Wales 2052 Australia.

The Sertoli cell tight junction （T j） is the key component of the blood-testis barrier, where it sequesters developing germ cells undergoing spermatogenesis within the seminiferous tubules. Hormonally regulated claudin-11 is a critical transmembrane protein involved in barrier function and its murine knockout results in infertility. We aimed to assess quantitatively the significance of the contribution of claudin-11 to Tj function, in vitro, using siRNA-mediated gene silencing. We also conducted an analysis of the contribution of occludin, another intrinsic transmembrane protein of the Tj. Silencing of claudin-11 and/or occludin was conducted using siRNA in an immature rat Sertoli cell culture model. Transepithelial electrical resistance was used to assess quantitatively Tj function throughout the culture. Two days after siRNA treatment, cells were fixed for immunocytochemical localization of junction proteins or lyzed for RT-PCR assessment of mRNA expression. Silencing of claudin-11, occludin, or both resulted in significant decreases in Tj function of 55% （P 〈 0.01）, 51% （P 〈 0.01）, and 62% （P 〈 0.01）, respectively. Data were concomitant with significant decreases in mRNA expression and marked reductions in the localization of targeted proteins to the Sertoli cell Tj. We provide quantitative evidence that claudin-11 contributes significantly （P 〈 0.01） to Sertoli cell Tj function in vitro. Interestingly, occludin, which is hormonally regulated but not implicated in infertility until late adulthood, is also a significant （P 〈 0.01） contributor to barrier function. Our data are consistent with in vivo studies that clearly demonstrate a role for these proteins in maintaining normal Tj barrier structure and function.

关键词： blood-testis barrier claudin-11 occludin Sertoli cell tight junction siRNA

Zinc in plants:Integrating homeostasis and biofortification

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Molecular Plant 2022年第1期15卷 65-85页

作者： Camilla stanton Dale Sanders Ute Krämer Dorina Podar john Innes Centre Colney LaneNorwichNR47UHUK Molecular Genetics and Physiology of Plants Ruhr University Bochum44801 BochumGermany Department of Molecular Biology and Biotechnology and Centre for Systems Biology Biodiversity and BioresourcesBabes-Bolyai University400084 Cluj-NapocaRomania

Zinc plays many essential roles in *** a strong Lewis acid that lacks redox activity under environ-mental and cellular conditions,the Zn2+cation is central in determining protein structure and catalytic function of nearly 10%of most eukaryotic *** specific functions of zinc have been elucidated at a molecular level in a number of plant proteins,wider issues abound with respect to the acquisition and distribution of zinc by *** important challenge is to understand how plants balance between Zn supply in soil and their own nutritional requirement for zinc,particularly where edaphic factors lead to a lack of bioavailable zinc or,conversely,an excess of zinc that bears a major risk of *** are the ultimate source of zinc in the human diet,and human Zn deficiency accounts for over 400000 deaths ***,we review the current understanding of zinc homeostasis in plants from the molecular and physiological *** provide an overview of approaches pursued so far in Zn biofortification of ***,we outline a"push-pull"model of zinc nutrition in plants as a simplifying *** summary,this review discusses avenues that can potentially deliver wider bene-fits for both plant and human Zn nutrition.

关键词： zinc biofortification Zn homeostasis cereals Arabidopsis barley wheat rice

Heat Shock Protein 90.1 Plays a Role in Agrobacterium- Mediated Plant Transformation

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Molecular Plant 2014年第12期7卷 1793-1796页

作者： So-Yon Park Xiaoyan Yin Kaixuan Duan stanton B. Gelvin Zhanyuan j. Zhang Plant Transformation Core Facility University of Missouri Columbia MO 65211 USA Department of Plant Pathology Physiology and Weed Science Virginia Tech Blacksburg VA 24061 USA Department of Biological Sciences Purdue University West Lafayette IN 47907–1392 USA

Dear Editor, ManybacterialproteinsareinvolvedinAgrobacterium- mediated plant transformation. By contrast, relatively little is known about plant proteins that play key roles in transformation. Some of these host proteins interact with Virulence effector proteins, including VirE2, that are transferred from Agrobacterium to plants （Gelvin, 2010; Pitzschke and Hirt, 2010）. A recent study indicated that the plant protein SUPPRESSOR OF G2 ALLELE OF SKP1 （SGT1）, a co-chaperone of heat shock protein 90 （HSP90）, is required for Agrobacterium-mediated transformation （Anand et al., 2012）. These studies suggested the involvement of HSPg0 in Agrobacterium-mediated transformation.

关键词： BACTERIA -- Heat shock proteins PLANT genetic transformation AGROBACTERIUM

Limosilactobacillus mucosae FZjTZ26M3 prevents NAFLD in mice through modulation of lipid metabolism and gut microbiota dysbiosis

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Food Science and Human Wellness 2024年第3期13卷 1589-1601页

作者： Danting Dang Bowen Li Mengfan Ding RPaul Ross Catherine stanton jianxin Zhao Bo Yang Wei Chen State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China International joint Research Center for Probiotics&Gut Health Jiangnan UniversityWuxi 214122China APC Microbiome Ireland University College CorkCork T12 YT20Ireland Teagasc Food Research Centre MooreparkFermoyCork T12 YT20Ireland National Engineering Research Center for Functional Food Jiangnan UniversityWuxi 214122China

Lactobacillus are considered promising therapeutic methods for nonalcoholic fatty liver disease(NAFLD).The effects of two strains of Ltmosilactobacillus mucosae on NAFLD were investigated in this ***-old male C57BL/6j mice were divided into 4 groups(n=8 per group,Control,Model,FZjTZ26M3,FGSYC17L3).*** FZjTZ26M3 reduced the mice 's body weight,liver weight,and adipose tissue weight after 12 weeks of *** to serum analysis,total cholesterol,triacylglycerol,and low-density lipoprotein cholesterol significantly decreased after *** FZjTZ26M3 *** pathology showed that *** FZjTZ26M3 was effective to ameliorate lipid deposition in NAFLD ***,the expression of the gene related to lipid metabolism in the liver and adipose tissue was analyzed,and the results indicated that *** FZjTZ26M3 could alleviate NAFLD by regulating lipid ***,the results of 16S rRNA gene sequencing revealed a drop in the relative abundance of Ruminococcaceae,which is linked to inflammation,but the relative abundance of a potential probiotic Akkermansia significantly increased after *** FZjTZ26M3 ***,*** FZjTZ26M3 could be a candidate to prevent NAFLD.

关键词： Limosilactobacillus mucosae Nonalcoholic fatty liver disease(NAFLD) Probiotic Lipid metabolism Gut microbiota

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Biological Parts for Plant Biodesign to Enhance Land-Based Carbon Dioxide Removal

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BioDesign Research 2021年第1期2021卷 17-38页

作者： Xiaohan Yang Degao Liu Haiwei Lu david j.Weston jin-Gui Chen Wellington Muchero stanton Martin Yang Liu Md Mahmudul Hassan Guoliang Yuan Udaya C.Kalluri Timothy j.Tschaplinski julie C.Mitchell Stan D.Wullschleger Gerald A.Tuskan Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The Center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomicsand Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Academic Education Central Community College-HastingsHastingsNE 68902USA Environmental Sciences Division and Climate Change Science Institute Oak Ridge National LaboratoryOak RidgeTN 37831USA

A grand challenge facing society is climate change caused mainly by rising CO_(2) concentration in Earth’s *** plants are linchpins in global carbon cycling,with a unique capability of capturing CO_(2) via photosynthesis and translocating captured carbon to stems,roots,and soils for long-term ***,many researchers postulate that existing land plants cannot meet the ambitious requirement for CO_(2) removal to mitigate climate change in the future due to low photosynthetic efficiency,limited carbon allocation for long-term storage,and low suitability for the *** address these limitations,there is an urgent need for genetic improvement of existing plants or construction of novel plant systems through biosystems design(or biodesign).Here,we summarize validated biological parts(e.g.,protein-encoding genes and noncoding RNAs)for biological engineering of carbon dioxide removal(CDR)traits in terrestrial plants to accelerate land-based decarbonization in bioenergy plantations and agricultural settings and promote a vibrant ***,we first summarize the framework of plant-based CDR(e.g.,CO_(2) capture,translocation,storage,and conversion to value-added products).Then,we highlight some representative biological parts,with experimental evidence,in this ***,we discuss challenges and strategies for the identification and curation of biological parts for CDR engineering in plants.

关键词： dioxide roots locating

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电炉jetBOx^(TM)技术的发展

钢铁 2007年第1期42卷 31-34,38页

作者： Christopher Farmer Val Shver Mac Coburn Dave stanton Tom Gahagan 工艺技术国际有限公司

美国PTI公司发明的专利技术jetBOxTM超音速氧枪喷射系统被证明是一种能有效提高电弧炉产量同时又能减少电炉改造成本的技术。通过在各个炼钢电炉上使用这种独特而有效的化学能输入方式从而获得了良好的效果。由于每个电炉的jetBOxTM系... 详细信息

美国PTI公司发明的专利技术jetBOxTM超音速氧枪喷射系统被证明是一种能有效提高电弧炉产量同时又能减少电炉改造成本的技术。通过在各个炼钢电炉上使用这种独特而有效的化学能输入方式从而获得了良好的效果。由于每个电炉的jetBOxTM系统都是专门设计,能满足每个炼钢车间的不同要求,因此已经被成功地应用在用料篮加料的普通电炉、Consteel电炉、使用DRI/HBI的电炉以及热装铁水的电炉上,同样都获得了良好的运行效果。自2001年以来jetBOxTM系统已经在全世界超过60台不同的电炉上安全而有效地运行着,满足了不同钢厂的要求。

关键词：氧-燃料超音速烧嘴

Towards interruption of schistosomiasis transmission in sub-Saharan Africa:developing an appropriate environmental surveillance framework to guide and to support‘end game’interventions

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Infectious Diseases of Poverty 2017年第1期6卷 78-88页

作者： j.Russell Stothard Suzy j.Campbell Mike Y.Osei-Atweneboana Timothy Durant Michelle C.stanton Nana-Kwadwo Biritwum david Rollinson Dieudonne R.Eloundou Ombede Louis-Albert Tchuem-Tchuente Department of Parasitology Liverpool School of Tropical MedicinePembroke PlaceLiverpool L35QAUK Department of Environmental Biology and Health Council for Scientific and Industrial Research-Water Research InsituteP.O.Box M 32AccraGhana Neglected Tropical Diseases Programme Ghana Health ServicesAccraGhana Department of Life Sciences Natural History MuseumCromwell RoadLondon SW75BDUK Centre for Schistosomiasis and Parasitology YaoundeCameroon Laboratory of Parasitology and Ecology Faculty of SciencesUniversity of YaoundeIYaoundeCameroon National Programme for the Control of Schistosomiasis and Intestinal Helminthiasis Ministry of Public HealthYaoundeCameroon

Schistosomiasis is a waterborne parasitic disease in sub-Saharan Africa,particularly common in rural populations living in impoverished *** the scale-up of preventive chemotherapy,national campaigns will transition from morbidity-to transmission-focused interventions thus formal investigation of actual or expected declines in environmental transmission is needed as‘end game’scenarios ***,there are no international or national guidelines to do so in sub-Saharan *** article therefore provides an introduction to key practicalities and pitfalls in the development of an appropriate environmental surveillance *** this context,we discuss how strategies need to be adapted and tailored to the local level to better guide and support future interventions through this *** detection of egg-patent infection in people becomes rare,careful sampling of schistosome larvae in freshwater and in aquatic snails with robust species-specific DNA assays will be *** metrics,derived from observed prevalence(s)as compared with predetermined thresholds,could each provide a clearer insight into contamination-and exposure-related *** could be twofold,first to certify areas currently free from schistosomiasis transmission or second to red-flag recalcitrant locations where extra effort or alternative interventions are needed.

关键词： Environmental monitoring Freshwater snails eDNA WASH Zoonosis