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World journal of Diabetes 2024年第8期15卷 1820-1823页

作者： Kira j Szulborski david j ramsey Department of Ophthalmology Tufts University School of MedicineBostonMA 02111United States Lahey Department of Surgery Division of OphthalmologyUMass Chan Medical SchoolUniversity of MassachusettsBurlingtonMA 01805United States Graduate Faculty New England College of OptometryBostonMA 02115United States

The utilization of non-mydriatic fundus photography-assisted telemedicine to screen patients with diabetes mellitus for diabetic retinopathy provides an accurate,efficient,and cost-effective method to improve early detection of *** has also been shown to correlate with increased participation of patients in other aspects of diabetes *** particular,patients who undergo teleretinal imaging are more likely to meet Comprehensive Diabetes Care Healthcare Effectiveness Data and Information Set metrics,which are linked to preservation of quality-adjusted life years and additional downstream healthcare savings.

关键词： Diabetes Diabetic retinopathy Telemedicine Tele-ophthalmology Nonmydriatic fundus photography-assisted telemedicine Vision screening Preventative health services Health policy

Keeping an eye on the diabetic foot: The connection between diabetic eye disease and wound healing in the lower extremity

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World journal of Diabetes 2022年第12期13卷 1035-1048页

作者： david j ramsey james T Kwan Arjun Sharma Department of Ophthalmology Lahey Hospital and Medical CenterBurlingtonMA 01805United States Department of Ophthalmology Tufts University School of MedicineBostonMA 02111United States

Diabetic eye disease is strongly associated with the development of diabetic foot ulcers(DFUs).DFUs are a common and significant complication of diabetes mellitus(DM)that arise from a combination of micro-and macrovascular *** and associated metabolic dysfunction in DM lead to impaired wound healing,immune dysregulation,peripheral vascular disease,and diabetic neuropathy that predisposes the lower extremities to repetitive injury and progressive tissue damage that may ultimately necessitate *** retinopathy(DR)is caused by cumulative damage to the retinal microvasculature from hyperglycemia and other diabetes-associated *** severity of DR is closely associated with the development of DFUs and the need for lower extremity revascularization procedures and/or *** the lower extremity,the eye may also suffer end-organ damage from macrovascular compromise in the form of cranial neuropathies that impair its motility,cause optic neuropathy,or result in partial or complete ***,poor perfusion of the eye can cause ischemic retinopathy leading to the development of proliferative diabetic retinopathy or neovascular glaucoma,both serious,visionthreatening ***,diabetic corneal ulcers and DFUs share many aspects of impaired wound healing resulting from neurovascular,sensory,and immunologic ***,alterations in serum biomarkers,such as hemoglobin A1c,ceruloplasmin,creatinine,low-density lipoprotein,and highdensity lipoprotein,are associated with both DR and *** these parameters can aid in prognosticating long-term outcomes and shed light on shared pathogenic mechanisms that lead to end-organ *** frequent cooccurrence of diabetic eye and foot problems mandate that patients affected by either condition undergo reciprocal comprehensive eye and foot evaluations in addition to optimizing diabetes management.

关键词： Foot ulcer Diabetic Wound healing Diabetes complications Amputation Diabetic retinopathy Corneal ulcer

Efficacy of a Topical Aromatic Rub (Vicks VapoRub<sup>®</sup>)-Speed of Action of Subjective Nasal Cooling and Relief from Nasal Congestion

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Open journal of Respiratory Diseases 2015年第1期5卷 10-18页

作者： Ron Eccles Martez jawad david L. ramsey j. david Hull Common Cold and Nasal Research Centre Cardiff School of Biosciences Cardiff University Cardiff UK The Procter & Gamble Company Mason Business Centre Mason OH USA Procter & Gamble Technical Centres Ltd. Whitehall Lane Egham Surrey UK

Vicks VapoRub® (VVR) is a pharmaceutical preparation containing a combination of levomenthol, eucalyptus oil, turpentine oil and camphor as active ingredients, and thymol, cedarwood oil, and white soft paraffin as excipients. VVR is a petrolatum-based ointment to be either applied topically to the chest, throat, and back or added to hot water and the aromatic vapours inhaled. When used topically, the actives are evaporated by body temperature and inspired. The main therapeutic effects are the feeling of relief from nasal congestion and relief from cough. These were primarily experienced by patients as the trigeminal and olfactory impact of the aromatics and were hypothesized to be experienced within minutes. This was a randomized, single-(Investigator) blind, controlled, 2-arm (VVR vs. petrolatum), parallel design pilot study in 50 otherwise healthy adult patients suffering from common cold and experiencing nasal congestion. Speed to detection of a sensation of nasal cooling and nasal decongestion was assessed following application of the recommended amount of product. The time to first experience of a sensation of nasal cooling was significantly (p ® as directed experienced significant differences from control for sensation of nasal cooling in 12 seconds and the sensation of nasal decongestion in 62 seconds.

关键词： VapoRub Common Cold Flu Topical Decongestion Nasal Decongestion

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3779-3790页

作者： Gundala Venkata Naveen Kumar Keito Hoshitsuki Sanjay Rathod Manda j.ramsey Lauren Kokai Erin E.Kershaw Wen Xie Christian A.Fernandez Department of Pharmaceutical Sciences and Center for Pharmacogenetics University of Pittsburgh School of PharmacyPittsburghPA 15261USA Division of General Internal Medicine University of Pittsburgh School of MedicinePittsburghPA 15261USA Department of Plastic Surgery University of Pittsburgh and the McGowan Institute for Regenerative MedicinePittsburghPA 15261USA University of Pittsburgh Division of EndocrinologyDepartment of MedicinePittsburghPA 15261USA

PEGylated-L-asparaginase(PEG-ASNase)is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia(ALL).Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis,with obesity and older age considered risk factors of the *** study aims to elucidate the mechanism of PEG-ASNase-induced liver *** received 1500 U/kg of PEG-ASNase and were sacrificed 1,3,5,and 7 days after drug *** triglycerides were quantified,and plasma bilirubin,ALT,AST,and non-esterified fatty acids(NEFA)were *** mRNA and protein levels of genes involved in hepatic fatty acid synthesis,β-oxidation,very low-density lipoprotein(VLDL)secretion,and white adipose tissue(WAT)lipolysis were *** developed hepatic steatosis after PEG-ASNase,which associated with increases in bilirubin,ALT,and *** hepatic genes Ppara,Lcad/Mcad,Hadhb,Apob100,and Mttp were upregulated,and Srebp-1 c and Fas were downregulated after *** plasma NEFA,WAT loss,and adipose tissue lipolysis were also observed after ***,we found that PEG-ASNase-induced liver injury was exacerbated in obese and aged mice,consistent with clinical studies of ASNase-induced liver *** data suggest that PEG-ASNase-induced liver injury is due to drug-induced lipolysis and lipid redistribution to the liver.

关键词： Liver injury Leukemia Asparaginase Lipolysis Adverse drug reaction Adipose tissue Hepatic steatosis Amino acid response

GREENHOUSE GAS AND AMMONIA EMISSION MITIGATION PRIORITIES FOR UK POLICY TARGETS

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Frontiers of Agricultural Science and Engineering 2023年第2期10卷 268-280页

作者： Sarah BUCKINGHAM Cairistiona F.E.TOPP Pete SMITH Vera EORY david R.CHADWICK Christina K.BAXTER joanna M.CLOY Shaun CONNOLLY Emily C.COOLEDGE Nicholas j.COWAN julia DREWER Colm DUFFY Naomi jFOX Asma jEBARI Becky jENKINS Dominika j.KROL Karina A.MARSDEN Graham A.MCAULIFFE Steven j.MORRISON Vincent O'FLAHERTY Rachael ramsey Karl G.RICHARDS Rainer ROEHE jo SMITH Kate SMITH Taro TAKAHASHI Rachel E.THORMAN john WILLIAMS jeremy WILTSHIRE Robert M.REES Scotland’s Rural College EdinburghEH93JGUK Institute of Biological&Environmental Sciences AberdeenAB243UUUK School of Natural Sciences Bangor UniversityBangorGwyneddLL572DGUK Agricultural Development and Advisory Service(ADAS) BoxworthCambridgeCB234NNUK School of Biological and Chemical Sciences University of GalwayH91 TK33Ireland Centre for Ecology and Hydrology Bush EstateMidlothianEH260QBUK The james Hutton Institute DundeeDD25DAUK Rothamsted Research North WykeOkehamptonDevonEX202SBUK Ricardo Energy&Environment HarwellOxonOX110QRUK Environment Soils and Land Use DepartmentTeagascCounty WexfordY35 TC97Ireland Agri-food and Biosciences Institute HillsboroughCounty DownBT266DRUK Bristol Veterinary School University of BristolSomersetBS405DUUK

Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed.

关键词： agriculture ammonia greenhouse gas mitigation net zero

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美国俄勒冈州印第安神话传说

美国俄勒冈州印第安神话传说

丛书名：民间文学资料丛刊

1983年

作者：（美）拉姆齐（ramsey j.）编史昆李务生译

本书收集了112个有趣味性和有一定民间文学研究价值的美国俄勒冈州印第安神话传说故事内容

ISBN: (纸本)10229·0046

本书收集了112个有趣味性和有一定民间文学研究价值的美国俄勒冈州印第安神话传说故事内容

关键词：文学美洲文学

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具有可变触发延迟的引信激励系统

探测与控制学报 1989年第3期17卷 38-48页

作者： Edgar j.Abt Arlie A.ramsey 邵伟春

本发明一般与引信激励系统有关,尤其是与配有可变触发延迟定时器的引信激励系统有关。在设计触发作用的弹丸引信时,理想的是在目标内起爆弹丸。例如在飞机机内而不是一接触到目标就起爆弹丸。这可通过多种方法来实现。

关键词：反相器激励系统多谐振荡器解脱保险双稳态分频器选通脉冲电源接通解除保险时钟脉冲

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振动与工人健康的最新研究

振动.测试与诊断 1986年第3期 39-41页

作者： M.Y.Beshir j.D.ramsey 高铁生

本文结合振动环境对人体健康产生不同影响提出了新的见解。同时也介绍了如何诊断和分析由于振动而带来的疾病以及有关的知识。

关键词：全身振动血管系统神经系统振动工具工人解剖学工资劳动者局部振动振动环境骨胳社会活动指尖手指

米索前列醇阴道给药与催产素浓缩液和PGE_2阴道给药对妊娠中期引产作用的比较

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 41-42页

作者： ramsey P.S. Savage K. Lincoln T. Owen j. 刘亦恒 Dr.Department of Obstetrics/Gynecology Ctr. for Research in Women's Health University of Alabama 619 19th Street South Birmingham AL 35249-7333 United States

OBjECTIVE: To compare the efficacy, side effects, and complications of high-dose vaginal misoprostol with concentrated intravenous oxytocin plus low-dose vaginal prostaglandin (PGE2) for second-trimester labor induction. METHODS: One hundred twenty-six consenting women with maternal or fetal indications for pregnancy termination and no prior cesarean delivery were randomly assigned to receive either vaginal misoprostol 600 μg1 ×, 400 μg every 4 hours 5×.(misoprostol group, n = 60) or escalating-dose concentrated oxytocin infusions (277-1,667 mU/min) plus vaginal PGE2 10 mg every 6 hours 4×. (oxytocin group, n = 66). Both groups received concurrent extra-amniotic saline infusion for cervical ripening. Women who failed their assigned regimen received 20 mg of PGE2 suppositories every 4 hours until delivery. Analysis was by intent to treat. RESULTS: Demographic characteristics were similar between study groups. Median induction-to-delivery interval was significantly shorter in the misoprostol group (12 hours) than in the oxytocin group (17 hours; P < .001). There was a higher induction success rate at 24 hours in the misoprostol group (95%) than in the oxytocin group (85%; P = .06), although this difference did not reach statistical significance. The incidence of live birth (25%versus 17%), chorioamnionitis (5%versus 2%), and postpartum hemorrhage greater than 500 mL (3%versus 3%) were similar between the misoprostol and oxytocin groups, respectively. Diarrhea (2%versus 11%; P = .04), nausea/emesis (25%versus 42%; P = .04), and retained placenta requiring curettage (2%versus 15%; P = .008) were significantly less common in the misoprostol group when compared with the oxytocin group, respectively. Isolated intrapartum fever, however, was more frequent in the misoprostol group (67%) than in the oxytocin group (21%; P < .001). CONCLUSION: Compared with concentrated oxytocin plus low-dose vaginal PGE2, high-dose vaginal misoprostol is associated with significantly shorter

关键词：中期引产 PGE2 浓缩液阴道给药宫颈成熟引产成功率终止妊娠羊膜腔活产率绒毛膜羊膜炎

妊娠中期羊水中基质金属蛋白酶-8的水平高于第90百分位数可预测随后的早产胎膜早破

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 13-14页

作者： Biggio jr. j.R. ramsey P.S. Cliver S.P. 高雪莲 Ctr. for Research in Women’ s Health Division of Maternal- Fetal Medicine Dept. Obstet. Gy5necol. Univ. A. Birmingham AL United States Dr.

We sought to determine whether midtrimester amniotic fluid levels of matrix metalloproteinase- 8 were associated with subsequent preterm premature rupture of membranes. We conducted a case- control study examining 57 asymptomatic women who underwent genetic amniocentesis from 14 to 21 weeks’ gestation and subsequently had preterm premature rupture of membranes (justment for maternal age, race, parity, gestational age, and year of amniocentesis (odds ratio 3.4, 95% CI 1.2- 9.9; P =. 03). The overall distribution of midtrimester amniotic fluid matrix metalloproteinase- 8 levels did not differ between women who had preterm premature rupture of membranes and those delivered at term. However, marked elevations of midtrimester amniotic fluid matrix metalloproteinase- 8 were highly associated with subsequent preterm premature rupture of membranes, suggesting that the pathophysiologic processes that contribute to preterm premature rupture of membranes may begin in early pregnancy.

关键词：早产胎膜早破妊娠中期百分位数基质金属蛋白酶羊膜腔穿刺足月分娩染色体检查妊娠早期基质蛋白周和