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电子设计技术 EDN CHINA 2012年第3期19卷 42-42,44,46,49页

作者： david gunderson Micro Power Electronics公司

在选择电池充电控制器时，是选微控制器还是专用充电控制IC，要认真做出权衡。

关键词：充电控制器微控制器充电控制IC 可编程控制器

Synthesis and Characterization of Naproxen-Salicylate Derivatives as Potential Dual-Targeted Inhibitors of Dihydrofolate Reductase

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Advances in Biological Chemistry 2024年第4期14卷 87-102页

作者： Syon Schlecht Emily gunderson Ruthie Fowler Takara Aguilar Biotechnology Research and Development Empower College and Career Center Jefferson Georgia

Dihydrofolate reductase (DHFR) is an enzyme that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). Chemotherapy drugs such as methotrexate help to slow the progression of cancer by limiting the ability of dividing cells to make nucleotides by competitively inhibiting DHFR. Nonsteroidal anti-inflammatory drugs (NSAIDs) have been previously reported to exhibit competitive inhibition of DHFR, in addition to their primary action on cyclooxygenase enzymes. This interaction interferes with the enzymatic reduction of dihydrofolate to tetrahydrofolate, thereby impeding the folate metabolism pathway essential for nucleotide synthesis and cell proliferation. This activity stems from their structural resemblance to the p-aminobenzoyl-l-glutamate (pABG) moiety of folate, a substrate of DHFR. It has been established that NSAIDs containing a salicylate group (which has structural similarities to pABG), such as diflunisal, exhibit stronger DHFR-binding activity. In this study, we synthesized salicylate derivatives of naproxen with the aim of exploring their potential as inhibitors of DHFR. The interactions between these derivatives and human DHFR were characterized using a combination of biochemical, biophysical, and structural methods. Through polyacrylamide gel electrophoresis (PAGE) analysis, enzymatic assays, and quantitative ELISA, we investigated the binding affinity and inhibitory potency of the synthesized salicylate derivatives towards DHFR. The findings of this study suggest the potential of salicylate derivatives of naproxen as promising candidates for the inhibition of DHFR, thereby offering novel therapeutic opportunities for modulating the inflammatory process through multiple pathways. Further optimization of these derivatives could lead to the development of more efficacious dual-targeted analogs with enhanced therapeutic benefits.

关键词： Dihydrofolate Reductase DHFR Chemotherapy Nonsteroidal Anti-Inflammatory Drugs NSAIDs Folate Metabolism Pathway Anti-Folate Novel Therapeutic Development

Go to the back before going forward:Addressing psychological responses in anterior cruciate ligament reconstruction rehabilitation

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Journal of Sport and Health Science 2024年第5期13卷 666-669页

作者： Terese L.Chmielewski Adam Meierbachtol Rick Aberman Travis gunderson Jonathon Sikorski Kathleen Cummer TRIA Orthopedic Center BloomingtonMN 55431USA Rehabilitation Science Graduate Program Department of Family Medicine and Community HealthMedical SchoolUniversity of MinnesotaMinneapolisMN 55455USA Optum Inc. Clinical OperationsPhysical Health DivisionEden PrairieMN 55344USA Dr.Rick Aberman Consulting MinnetonkaMN 55305USA Department of Rehabilitation Medicine Division of Physical TherapyUniversity of WashingtonSeattleWA 98195USA

Helping athletes return to sports participation is a primary goal of anterior cruciate ligament(ACL)reconstruction *** facilitate the achievement of this goal,decades of research studies have sought to identify knee impairments that reduce knee function as well as interventions to resolve them.1Yet,over the past 10 years,research pertaining to psychological responses(i.e.,cognitions and emotions)after ACL reconstruction has grown exponentially—a phenomenon that can be visualized by entering the search terms"psychological"and"anterior cruciate ligament reconstruction"into the PubMed search engine.

关键词： ligament return psychological

Visual ＂playback＂ of colorful signals in the field supports sensory drive for signal detectability

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Current Zoology 2018年第4期64卷 493-498页

作者： Alex R. gunderson Leo J. FLEISHMAN Manuel LEAL Department of Integrative Biology University of California Berkeley CA 94720 USA Department of Biology Union College Schenectady NY 12308 USA Division of Biological Sciences University of Missouri 105 Tucker Hall Columbia MO 65211 USA

Colorful visual signals are important systems for investigating the effects of signaling environ ments and receiver physiology on signal evolution as predicted by the sensory drive hypothesis. Support for the sensory drive hypothesis on color signal evolution is mostly based on document ing correlations between the properties of signals and habitat conditions under which the signals are given （i.e., a correlational approach） and less commonly on the use of mathematical models that integrate representations of visual environments, signal properties, and sensory systems （i.e., a functional approach）. Here, we used an experimental approach in the field to evaluate signal efficacy of colorful lizard throat fans called dewlaps that show geographic variation in the lizard Anolis cristatellus. We used a remote controlled apparatus to display ＂fake dewlaps＂ to wild lizards to test for adaptive divergence in dewlap brightness （i.e., perceived intensity） among populations in situ. We found evidence of local adaptation in dewlap brightness consistent with the sensory drive hypothesis. Specifically, dewlaps that had the brightness characteristics of local lizards were more likely to be detected than those with the brightness characteristics of nonlocal lizards. Our findings indicate that simplified mathematical representations of visual environments may allow robust estimates of relative detectability or conspicuousness in natural habitats. We have shown the feasibility of evaluating color signal efficacy experimentally under natural conditions and dem onstrate the potential advantages of presenting isolated components of signals to an intended re ceiver to measure their contribution to signal function.

关键词： Anolis color signal sensory drive signal evolution

Numerical Study of the Impact of Wake Surfing on Inland Bodies of Water

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Journal of Water Resource and Protection 2022年第3期14卷 238-272页

作者： Endicott M. Fay Andrew gunderson Arden Anderson Cotty Fay Marine Design Inc. Bainbridge Island WA USA Mercury Marine Fond du Lac WI USA

In many areas around the world, wake surfing has been cited as one of the major causes of lakeshore erosion and turbidity. This paper quantifies the impact related to turbidity and erosion with the use of computational fluid dynamics (CFD) of boat wakes in shallow water and the build-up of wind driven waves. The energy, type and direction of the boat’s wake are described quantitatively and a table for predicting wind driven waves over varying fetches, depth and wind speeds is provided. The CFD simulation shows that if a wake surf boat is operated 200 ft from shore and in at least 10 ft of water, the environmental impact is minimal.

关键词： CFD Erosion Waves Wakes Wind Driven Waves

Burden of bone disease in chronic pancreatitis:A systematic review and meta-analysis

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World Journal of Gastroenterology 2023年第8期29卷 1374-1394页

作者： Ankit Chhoda Maria Jose Hernandez-Woodbine Nana Afua Akkya Addo Syed Alishan Nasir Alyssa Grimshaw Craig gunderson Awais Ahmed Steven D.Freedman Sunil G.Sheth Department of Gastroenterology Beth Israel Deaconess Medical CenterBostonMA 02215United States Department of Medicine Norwalk HospitalYale School of MedicineNorwalkCT 06850United States Cushing/Whitney Medical Library Yale UniversityNew HavenCT 06510United States General Internal Medicine Yale School of MedicineNew HavenCT 06510United States

BACKGROUND Bone disease is an under-recognized cause of morbidity in chronic pancreatitis(CP).Over the past decade,publications of original studies on bone disease in CP has warranted synthesis of the evidence to ascertain the true burden of the *** To quantify the prevalence of osteopenia,osteoporosis,and fragility fractures in CP patients and investigate the associated clinical features and *** A systematic search identified studies investigating bone disease in CP patients from Cochrane Library,Embase,Google Scholar,Ovid Medline,PubMed,Scopus,and Web of Science,from inception until October *** outcomes included prevalence of osteopenia,osteoporosis,and fragility fractures,which were metaanalyzed using a random-effects model and underwent metaregression to delineate association with baseline clinical *** Twenty-one studies were included for systematic review and 18 studies were included for *** pooled prevalence of osteopenia and osteoporosis in CP patients was 41.2%(95%CI:35.2%-47.3%)and 20.9%(95%CI:14.9%-27.6%),*** pooled prevalence of fragility fractures described among CP was 5.9%(95%CI:3.9%-8.4%).Metaregression revealed significant association of pancreatic enzyme replacement therapy(PERT)use with prevalence of osteoporosis[coefficient:1.7(95%CI:0.6-2.8);P<0.0001].We observed no associations with mean age,sex distribution,body mass index,alcohol or smoking exposure,diabetes with prevalence of osteopenia,osteoporosis or fragility *** of data on systemic inflammation,CP severity,and bone mineralization parameters precluded a formal *** This meta-analysis confirms significant bone disease in patients with *** than PERT use,we observed no patient or study-specific factor to be significantly associated with CP-related bone *** studies are needed to identify confounders,at-risk population,and to understand the mechanisms of CP-related bone disease an

关键词： Chronic pancreatitis Fractures Osteoporosis Osteopenia Bone disease

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灵活的分立式冷却机组

现代塑料 2012年第10期 48-48,51页

作者： Jon gunderson Advantage Engineering公司

当考虑要替代中央冷却系统耐，通常会想起所谓的“便携式”冷却机组，它是一种被安装在脚轮上的相对较小的设备，可以在车间里从一个应用移动到另一个应用。但是，该类冷却机组并不总是可以便携的。也许，对它们而言，更恰当的名称应该... 详细信息

当考虑要替代中央冷却系统耐，通常会想起所谓的“便携式”冷却机组，它是一种被安装在脚轮上的相对较小的设备，可以在车间里从一个应用移动到另一个应用。但是，该类冷却机组并不总是可以便携的。也许，对它们而言，更恰当的名称应该是“分立式”冷却机组。

关键词：中央冷却系统分立式机组便携式应用

Dysfunctional stem and progenitor cells impair fracture healing with age

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World Journal of Stem Cells 2019年第6期11卷 281-296页

作者： Diane R Wagner Sonali Karnik Zachary J gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li Department of Mechanical and Energy Engineering Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202United States Department of Medicinal Chemistry and Molecular Pharmacology Purdue UniversityWest LafayetteIN 47907United States Department of Physical Therapy Indiana University- Purdue University IndianapolisIndianapolisIN 46202United States Division of Biomedical Science Marian University College of Osteopathic MedicineIndianapolisIN 46222United States Department of Chemistry Purdue UniversityWest LafayetteIN 47907 United States Richard L. Roudebush VA Medical Center IndianapolisIN 46202United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States Department of Biology Indiana University-Purdue University IndianapolisIndianapolisIN 46202United States

Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly.

关键词： Fracture healing Aging Bone Angiogenesis Mesenchymal stem cells Endothelial progenitor cells

Essential neural anatomy for creating a clinically translatable osseointegrated neural interface for prosthetic control in sheep

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Plastic and Aesthetic Research 2023年第1期10卷 600-614页

作者： Kirsten A.gunderson Scott K.Odorico Zeeda H.Nkana Lucas Sears Grant Seils Rashea L.Minor Weifeng Zeng Samuel O.Poore Aaron M.Dingle Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53792USA University of Wisconsin-Madison School of Veterinary Medicine MadisonWI 53706USA

Aim:Ovine models for osseointegrated prosthetics research are well established,but do not consider neural control of advanced *** validity of interfacing technologies,such as the Osseointegrated Neural Interface(ONI),in their ability to provide communication between native nerves and advanced prosthetics is required,necessitating a stable,longitudinal large animal model for *** objective of this study is to provide a detailed anatomic description of the major nerves distal to the carpal and tarsal joints,informing the creation of a chronic ONI for prosthetic control in ***:Six pelvic and six thoracic cadaveric limbs from mature female,non-lactating sheep were *** were obtained to determine average bone length,medullary canal diameter,and cortical bone *** dissection was performed to discern topographical neuroanatomy and average circumferences of the major nerves of the pelvic and thoracic *** analysis was performed.A surgical approach for the creation of ONI was ***:Average metacarpal and metatarsal length was 15.0 cm(±0.0)and 19.7 cm(±1.0),*** intramedullary canal diameter was 12.91 mm(±3.69)for forelimbs and 12.60 mm(±3.69)for *** thoracic limb nerves consisted of one dorsal and three ventral nerves,with an average circumference of 5.14 mm(±2.00)and 5.05 mm(±1.06),*** limb nerves consisted of two dorsal and one ventral nerve with an average circumference of 6.27 mm(±1.79)and 5.40 mm(±0.53),***:These anatomic data inform the surgical approach and manufacture of a sensory ONI for chronic testing in awake,freely ambulating animals for future clinical translation.

关键词： Amputation prosthesis prostheses neural interface clinical translation large animal osseointegration neuroprosthesis

中年肥胖与远期患痴呆症的危险:一项随访27年的纵向人群研究

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英国医学杂志中文版 2005年第5期8卷 277-280页

作者： Rachel A Whitmer Erica P gunderson Erica P gunderson obesity epidemiologist Elizabeth Barrett-Connor Charles P Quesenberry Jr Kristine Yaffe 袁涛 Division of Research KaiserPermanente OaklandCA 94612 USA gerontological epidemiologist Division of Research KaiserPermanente OaklandCA 94612 USA Department of Epidemiology University of CaliforniaLa Jolla CA USABarrett-Connorprofessor Division of Research KaiserPermanente OaklandCA 94612 USA gerontological epidemiologistseniorbiostatisician Department of Psychiatry University ofCaliforniaSan FranciscoCA USAassociate professor

目的评价中年肥胖与远期患痴呆症危险性之间的关系,以体重指数(BMI)和皮褶厚度代表肥胖程度。设计前瞻性分析一个多种族人群的系列研究资料。背景北加利福尼亚州Kaiser长期医疗组是一个健康保护组织。参加者在1964至1973年间当时年龄在4... 详细信息

目的评价中年肥胖与远期患痴呆症危险性之间的关系,以体重指数(BMI)和皮褶厚度代表肥胖程度。设计前瞻性分析一个多种族人群的系列研究资料。背景北加利福尼亚州Kaiser长期医疗组是一个健康保护组织。参加者在1964至1973年间当时年龄在40～45岁间的男女共10276人参加详细健康检查者,在1994年仍参加该健康检查项目的成员。主要结局测定1994年1月至2003年4月确诊的痴呆症患者。确诊时间由Cox比例危险模型分析,从年龄、性别、种族、教育情况、吸烟、饮酒、婚姻状况、糖尿病、高血压、高脂血症、卒中和缺血性心脏病等方面进行了校正。结果在所有入选者中有713例(6.9%)诊断痴呆症。肥胖者(BMI≥30)患痴呆症的危险增加74%(危险比例1.74,95%可信区间1.34～2.26),而超重者(BMI25.0～29.9)患痴呆症的危险与那些正常体重者(BMI18.6～24.9)相比增加35%。以肩胛下或三头肌皮褶厚度的分布情况来评价,在第5百分位以下者与第95百分位以上者相比患痴呆症的危险分别增加72%和59%,数值分别为(1.72,1.36～2.18和1.59,1.24～2.04)。结论中年肥胖独立于其他因素增加远期患痴呆症的危险。

关键词：肥胖程度痴呆症人群研究中年三头肌皮褶厚度随访 Kaiser 加利福尼亚州缺血性心脏病种族人群