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利用超声疗法来治疗人类阿尔兹海默病或可行

生物医学工程与临床 2024年第3期28卷 353-353页

作者： Leinenga g

据Leinenga g 2024年3月18日(Mol Pshchiatry,2024 Mar 18. doi:10.1038/s41380-024-02509-5.)报道,澳大利亚昆士兰大学等机构的研究人员通过研究发现,在治疗人类神经退行性疾病时,采用超声波技术改善认知功能,并不需要特意针对大脑中... 详细信息

据Leinenga g 2024年3月18日(Mol Pshchiatry,2024 Mar 18. doi:10.1038/s41380-024-02509-5.)报道,澳大利亚昆士兰大学等机构的研究人员通过研究发现,在治疗人类神经退行性疾病时,采用超声波技术改善认知功能,并不需要特意针对大脑中的淀粉样斑块。这项研究强调了超声波频率的选择、认知功能的改善与β淀粉样蛋白清除的独立性,这对于规划未来针对人类阿尔兹海默病的临床试验至关重要。

关键词：超声波频率阿尔兹海默病神经退行性疾病澳大利亚昆士兰 β淀粉样蛋白超声波技术超声疗法临床试验

Adaptive Weighted Flow Net Algorithm for Human Activity Recognition Using Depth Learned Features

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Computer Systems Science & Engineering 2023年第8期46卷 1447-1469页

作者： g.Augusta Kani P.geetha Department of Information Science and Technology Anna UniversityChennai600025TamilnaduIndia

Human Activity Recognition(HAR)from video data collections is the core application in vision tasks and has a variety of utilizations including object detection applications,video-based behavior monitoring,video classification,and indexing,patient monitoring,robotics,and behavior *** many techniques are available for HAR in video analysis tasks,most of them are not focusing on behavioral ***,a new HAR system analysis the behavioral activity of a person based on the deep learning approach proposed in this *** most essential aim of this work is to recognize the complex activities that are useful in many tasks that are based on object detection,modelling of individual frame characteristics,and communication among ***,this work focuses on finding out the human actions from various video resolutions,invariant human poses,and nearness of multi ***,we identify the key and essential frames of each activity using histogram ***,Discrete Wavelet Transform(DWT)is used in this system to extract coefficients from the sequence of key-frames where the activity is localized in ***,an Adaptive Weighted Flow Net(AWFN)algorithm is proposed in this work for effective video activity ***,the proposed algorithm has been evaluated by comparing it with the existing Visual geometry group(Vgg-16)convolution neural networks for making performance *** work focuses on competent deep learning-based feature extraction to discriminate the activities for performing the classification *** proposed model has been evaluated with Vgg-16 using a combination of regular UCF-101 activity datasets and also in very challenging Low-quality videos such as *** these investigations,it is proved that the proposed AWFN approach gives higher detection accuracy of 96%.It is approximately 0.3%to 7.88%of higher accuracy than state-of-art methods.

关键词： Activity classification discrete wavelet object detection AWFN

A literature review of cost-effectiveness of intravenous recombinant tissue plasminogen activator for treating acute ischaemic stroke

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Stroke & Vascular Neurology 2017年第2期2卷 73-83页

作者： Heesoo Joo guijing Wang Mary g george Division for Heart Disease and Stroke Prevention CDCIHRC Inc.AtlantaGeorgiaUSA Division for Heart Disease and Stroke Prevention CDCAtlantaGeorgiaUSA

Background Intravenous recombinant tissue plasminogen activator(IV rtPA)is recommended treatment for patients with acute ischaemic stroke,but the cost-effectiveness of IV rtPA within different time windows after the onset of acute ischaemic stroke is not well *** To conduct a literature review of the cost-effectiveness studies about IV rtPA by treatment *** of review A literature search was conducted using MEDLINE,EMBASE,CINAHL and Cochrane Library,with the keywords acute ischemic stroke,tissue plasminogen activator,cost,economic benefit,saving and incremental cost-effectiveness *** review is limited to original research articles published during 1995-2016 in English-language peer-reviewed *** found 16 studies meeting our criteria for this *** of them were cost-effectiveness studies of IV rtPA treatment within 0-3 hours after stroke onset,2 studies within 3-4.5 hours,3 studies within 0-4.5 hours and 2 studies within 0-6 *** rtPA is a cost-saving or a cost-effectiveness strategy from most of the study *** one study showed incremental cost-effectiveness ratio of IV rtPA within 1 year was marginally above US$50000 per quality-adjusted life year *** rtPA within 0-3 hours after stroke led to cost savings for lifetime or 30 years and IV rtPA within 3-4.5 hours after stroke increased costs but still was *** The literature generally showed that IV rtPA was a dominant or a cost-effective strategy compared with traditional treatment for patients with acute ischaemic stroke without IV *** findings from the literature lacked generalisability because of limited data and various assumptions.

关键词： acute cost treatment

Evolution of fracture permeability due to co-colloidal bacterial transport in a coupled fracture-skin-matrix system

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geoscience Frontiers 2012年第4期3卷 503-514页

作者： N.Natarajan g.Suresh Kumar EWRE Division Department of Civil EngineeringIndian Institute of TechnologyMadrasChennai 600036India Department of Ocean Engineering Indian Institute of TechnologyMadrasChennai 600036India

A numerical model is developed for investigating the evolution of fracture permeability in a coupled fracture-matrix system in the presence of fracture-skin with simultaneous colloidal and bacte- rial transport, by taking into account the effects of thermal stress and silica precipitation/dissolution, which is computed using linear reaction kinetics. The non-linear coupled equations are numerically modeled using the fully implicit finite difference method and a constant continuous source is adopted while modeling thermal, contaminant, colloidal and bacterial transport. Due to co-colloid bacterial trans- port under non-isothermal conditions, in a coupled fracture-skin-matrix system, the fracture apertures vary spatially, with a corresponding pressure variation for a constant discharge. A series of numerical experiments were conducted for analyzing the spatial variation of fracture aperture in response to the combined effects of thermal stress, silica precipitation/dissolution, and simultaneous colloidal and bacte- rial transport in the presence of the fracture-skin. The simulation results suggest that temperature and contaminant concentration of the mobile fluid within the fracture increases with reduction in initial frac- ture aperture. The pattern of variation followed by the fracture aperture is nearly the same in the presence and absence of bacterial transport but the magnitude of the fracture aperture is low under the influence of bacterial transport. The variation in the fracture aperture resulting from precipitation-dissolution and thermoelastic stress is significant when the fracture aperture is very low and reduces with increment in fracture aperture. The variation in fracture aperture and pressure remains the same for both undersaturated and supersaturated fluid entering the fracture due to the influence of bacterial transport at the inlet of the fracture.

关键词： Bacterial transport Colloidal transport Fracture permeability Fracture skin Precipitation-dissolution

Opportunistic Routing with Multi-Channel Cooperative Neighbour Discovery

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Intelligent Automation & Soft Computing 2023年第2期35卷 2367-2382页

作者： S.Sathish Kumar g.Ravi AVS College of Technology Salem636106India Sona College of Technology Salem636005India

Due to the scattered nature of the network,data transmission in a dis-tributed Mobile Ad-hoc Network(MANET)consumes more energy resources(ER)than in a centralized network,resulting in a shorter network lifespan(NL).As a result,we build an Enhanced Opportunistic Routing(EORP)protocol architecture in order to address the issues raised *** proposed routing protocol goal is to manage the routing cost by employing power,load,and delay to manage the routing energy consumption based on theﬂooding of control pack-ets from the target *** to the goal of the proposed protocol techni-que,it is possible to manage the routing cost by applying power,load,and *** proposed technique also manage the routing energy consumption based on theﬂooding of control packets from the destination node in order to reduce the routing *** packet exchange between the target and all the nodes,on the other hand,is capable of having an inﬂuence on the overall efﬁciency of the *** EORP protocol and the Multi-channel Cooperative Neighbour Discovery(MCCND)protocol have been designed to detect the cooperative adja-cent nodes for each node in the routing route as part of the routing path discovery process,which occurs during control packet *** control packet transmission is taking place during the routing path discovery process,the EORP protocol and the Multi-channel Cooperative Neighbour Discovery(MCCND)protocol have been designed to detect the cooperative adjacent nodes for each node in the *** included is a simulation of these protocols in order to evaluate their performance across a wide range of packet speeds using Constant Bit Rate(CBR).When the packet rate of the CBR is 20 packets per second,the results reveal that the EORP-MCCND is 0.6 s quicker than the state-of-the-art protocols,according to theﬁ*** that the CBR packet rate is 20 packets per second,the EORP-MCCND achieves 0.6 s of End 2 End Delay,0.05 s of Routing Overhea

关键词： Macro-addressable network power-and load-aware routing deterministic and opportunistic routing gradient routing multi-channel cooperative neighbor discovery

Novel treatment options for perforations of the upper gastrointestinal tract:Endoscopic vacuum therapy and over-the-scope clips

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World Journal of gastroenterology 2014年第24期20卷 7767-7776页

作者： Rudolf Mennigen Norbert Senninger Mike g Laukoetter Department of general and Visceral Surgery University Hospital MuensterD-48149 MuensterGermany

Endoscopic management of leakages and perforations of the upper gastrointestinal tract has gained great importance as it avoids the morbidity and mortality of surgical *** the past years,covered selfexpanding metal stents were the mainstay of endoscopic ***,two new techniques are now available that enlarge the possibilities of defect closure:endoscopic vacuum therapy(EVT),and over-the-scope clip(OTSC).EVT is performed by mounting a polyurethane sponge on a gastric tube and placing it into the *** suction is applied via the tube resulting in effective drainage of the cavity and the induction of wound healing,comparable to the application of vacuum therapy in cutaneous *** system is changed every 3-5 *** overall success rate of EVT in the literature ranges from 84%to 100%,with a mean of 90%;only few complications have been *** are loaded on a transparent cap which is mounted on the tip of a standard *** bringing the edges of the perforation into the cap,by suction or by dedicated devices,such as anchor or twin grasper,the OTSC can be placed to close the *** acute endoscopy associated perforations,the mean success rate is 90%(range:70%-100%).For other types of perforations(postoperative,other chronic leaks and fistulas)success rates are somewhat lower(68%,and59%,respectively).Only few complications have been *** first reports are promising,further studies are needed to define the exact role of EVT and OTSC in treatment algorithms of upper gastrointestinal perforations.

关键词： Upper gastrointestinal Perforation Fistula Endoscopy Over-the-scope clip Endoscopic vacuum therapy

INFORMATION CHARACTERIZATION OF COMMUNICATION CHANNELS FOR SYSTEM IDENTIFICATION

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Journal of Systems Science & Complexity 2007年第2期20卷 251-261页

作者： Le Yi WANg g. george YIN Department of Electrical and Computer Engineering Wayne State University Detroit Michigan 48202 USA Department of Mathematics Wayne State University Detroit Michigan 48202 USA

This paper studies identification of systems in which the system output is quantized, transmitted through a digital communication channel, and observed afterwards. The concept of the CR Ratio is introduced to characterize impact of communication channels on identification. The relationship between the CR Ratio and Shannon channel capacity is discussed. Identification algorithms are further developed when the channel error probability is unknown.

关键词： Communication channel efficient estimation system identification

Abnormal Crowd Behavior Detection Using Optimized Pyramidal Lucas-Kanade Technique

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Intelligent Automation & Soft Computing 2023年第2期35卷 2399-2412页

作者： g.Rajasekaran J.Raja Sekar Department of information technology mepco schlenk engineering collegesivakasi626005india Department of computer science and engineering mepco schlenk engineering collegesivakasi626005india

Abnormal behavior detection is challenging and one of the growing research areas in computer *** main aim of this research work is to focus on panic and escape behavior detections that occur during unexpected/uncertain *** this work,Pyramidal Lucas Kanade algorithm is optimized using EME-HOs to achieve the *** stage,OPLKT-EMEHOs algorithm is used to generate the opticalﬂow from *** stage,the MIIs opticalﬂow is applied as input to 3 layer CNN for detect the abnormal crowd *** of Minnesota(UMN)dataset is used to evaluate the proposed *** experi-mental result shows that the proposed method provides better classiﬁcation accu-racy by comparing with the existing *** method provides 95.78%of precision,90.67%of recall,93.09%of f-measure and accuracy with 91.67%.

关键词： Crowd behavior analysis anomaly detection Motion Information

Secondary endoresection for previously treated choroidal melanomas with a non-responsive course and persistent exudative retinal detachment

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 276-283页

作者： Ahmet Kaan gündüz Ibadulla Mirzayev Department of Ophthalmology Ankara University Faculty of MedicineAnkara 06590Turkey Private Eye Clinic Ankara 06590Turkey Department of Ophthalmology Dünyagoz HospitalAnkara 06540Turkey

AIM:To evaluate the results and complications of secondary endoresection via pars plana vitrectomy for choroidal melanoma and review the previously reported endoresection studies on the treatment of choroidal ***:The medical records of 6 patients with choroidal melanoma who underwent secondary endoresection between March 2012 and March 2020 were retrospectively *** indications for secondary endoresection were progressive or recurrent tumor and severe exudative retinal detachment after previous treatment with plaque radiotherapy/Cyberknife radiosurgery/transpupillary thermotherapy(TTT).RESULTS:Before endoresection,2 eyes had Iodine-125 plaque radiotherapy and TTT,1 eye had Ruthenium-106 plaque radiotherapy and TTT,1 eye had Cyberknife radiosurgery and TTT,1 eye had Cyberknife radiosurgery,and 1 eye had TTT *** visual acuity ranged from 20/63 to 20/1600(Snellen) and from 0.5 to 1.9(mean:1.1) on the log MAR *** mean tumor base diameters were 9.5×8.7 mm and the mean tumor thickness was 5.4 *** secondary endoresection,transient vitreous hemorrhage developed in 2(33.3%) eyes and retinal detachment in 1(16.7%) *** examination revealed epithelioid cell melanoma in 4(66.7%) eyes and mixed cell melanoma in 1(16.7%).Melanoma cell type was not specified in 1(16.7%) *** a mean follow-up of 49.6 mo(range:16-90 mo),mean visual acuity did not improve and 1 eye was enucleated due to tumor *** visual acuity ranged from 20/63 to 20/1600(Snellen) and from 0.5 to 1.9(mean:1.2) on the log MAR *** patients with choroidal melanoma developed metastasis and eventually ***:Secondary endoresection seems to be an effective treatment option for globe salvage in choroidal melanoma not responsive to conventional treatment and displaying persistent exudative retinal *** was no visual acuity increase among the treated eyes but globe salvage was possible in most cases in this study.

关键词： endoresection choroidal melanoma metastasis pars plana vitrectomy recurrence