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New hypertension and diabetes diagnoses following the Affordable Care Act Medicaid expansion

Family Medicine and Community Health 2020年第4期8卷 84-89页

作者： Heather Angier Nathalie Huguet david ezekiel-herrera Miguel Marino Teresa Schmidt Beverly B Green Jennifer E DeVoe Family Medicine Oregon Health&Science UniversityPortlandOregonUSA Biostatistics Group Oregon Health&Science University-Portland State University School of Public HealthPortlandOregonUSA Research OCHINPortlandOregonUSA Kaiser Permanente Washington Health Research Institute SeattleWashingtonUSA

Objective To assess the Affordable Care Act(ACA)Medicaid expansion’s impact on new hypertension and diabetes diagnoses in community health centres(CHCs).Design Rates of new hypertension and diabetes diagnoses were computed using generalised estimating equation Poisson models and we tested the difference-in difference(DID)pre-ACA versus post-ACA in states that expanded Medicaid compared with those that did *** We used electronic health record data(pre-ACA:1 January 2012-31 December 2013-post-ACA:1 January 2014-31 December 2016)from the Accelerating Data Value Across a National Community Health Center Network clinical data *** included clinics with≥50 patients contributing to person-time at risk in each study *** Patients aged 19-64 with≥1 ambulatory visit in the study period were *** then excluded patients who were pregnant during the study period(N=127530).For the hypertension outcome,we excluded individuals with a diagnosis of hypertension prior to the start of the study period,those who had a hypertension diagnosis on their first visit to a clinic or their first visit after 3 years without a visit,and those who had a diagnosis more than 3 years after their last visit(pre-ACA non-expansion N=130973;expansion N=193198;post-ACA non-expansion N=186341;expansion N=251015).For the diabetes analysis,we excluded patients with a diabetes diagnosis prior to study start,on their first visit or first visit after inactive patient status,and diagnosis while not an active patient(pre-ACA non-expansion N=145435;expansion N=198558;post-ACA non-expansion N=215039;expansion N=264644).Results In non-expansion states,adjusted hypertension diagnosis rates saw a relative decrease of 6%,while in expansion states,the adjusted rates saw a relative increase of 7%(DID 1.14,95%CI 1.11 to 1.18).For diabetes diagnosis,adjusted rates in non-expansion states experienced a significant relative increase of 28%and in expansion states the relative increase was 25%

关键词： diagnosis hypertension expansion

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Nigerian antimalarial plants and their anticancer potential:A review

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Journal of Integrative Medicine 2020年第2期18卷 92-113页

作者： Kayode ezekiel Adewole Department of Biochemistry Faculty of Basic Medical SciencesUniversity of Medical SciencesOndoOndo State 234Nigeria

Cancer is a leading cause of death globally, while malaria is the leading cause of death from parasitic diseases in Nigeria. Historically, plant remedies have been used to manage both cancer and ***, the possibility of treating cancer with antimalarial remedies has long been reported, even though the two diseases appear to have little in common. However, a body of research has indicated the potential anticancer activity of both synthetic and nature-derived antimalarials. In Nigeria, over 100 plants are used for the management of malaria, but little is known for their potential role in combatting cancer. Therefore, this review is to highlight the documented anticancer activities of plants used to treat malaria in Nigeria, with the goal of supporting anticancer drug discovery. Scientific databases were used to search for antimalarial plants using selected keywords. Of over 100 plants used to treat malaria in Nigeria, 56 have documented anticancer properties, containing alkaloids, flavonoids, tannins, terpenes,terpenoids, quinones, anthraquinones, saponins, steroids, sterols, organosulfur compounds and other polyphenols as the major bioactive components. The major mechanisms of anticancer activity include induction of apoptosis and autophagy, arrest of cell growth, generation of reactive oxygen species and inhibition of angiogenesis. However, mechanistic and clinical investigations of the anticancer properties of most of these plants are still lacking. Notwithstanding, the huge anticancer potential uncovered by the in vitro or in vivo studies and a few clinical studies, Nigerian antimalarial plants may provide a valuable resource, ready to be harnessed for anticancer drug development.

关键词： Anticancer Cytotoxicity Antimalarial Medicinal plants Nigeria

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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

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Impact of climate factors on contact rate of vector-borne diseases： Case study of malaria

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International Journal of Biomathematics 2017年第1期10卷 77-97页

作者： ezekiel Dangbe Antoine Perasso Damakoa Irepran david Bekol1e The University Institute of Technology University of Ngaoundere UMR6249 Chrono-Environment Laboratory University of Franche-Comte The Faculty of Sciences University of Ngaoundere P. O. Boz 454 Ngaoundere Cameroon

Climate change influences more and more of our activities. These changes led to envi- ronmental changes which has in turn affected the spatial and temporal distribution of the incidence of vector-borne diseases. To establish the impact of climate on contact rate of vector-borne diseases, we examine the variation of prevalence of diseases according to season. In this paper, the goal is to establish that the basic reproductive number R0 depends on the duration of transmission period and the date of the first conta- mination case that was declared （to） in the specific ease of malaria. We described the dynamics of transmission of malaria by using non-autonomous differential equations. We analyzed the stability of endemic equilibrium （EE） and disease-free equilibrium （DFE）. We prove that the persistence of disease depends on minimum and maximum values of contact rate of vector-borne diseases.

关键词： SIR models vector-borne disease impact of climate factors malaria.

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Multiaxially-stretchable kirigami-patterned mesh design for graphene sensor devices

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Nano Research 2020年第5期13卷 1406-1412页

作者： Hyo Chan Lee ezekiel YHsieh Keong Yong SungWoo Nam Department of Mechanical Science and Engineering University of Illinois at Urbana–ChampaignUrbanaIllinois 61801USA Department of Materials Science and Engineering University of Illinois at Urbana–ChampaignUrbanaIllinois 61801USA Materials Research Laboratory University of Illinois at Urbana–ChampaignUrbanaIllinois 61801USA Micro and Nanotechnology Laboratory University of Illinois at Urbana–ChampaignUrbanaIllinois 61801USA Carle Illinois College of Medicine University of Illinois at Urbana–ChampaignChampaignIllinois 61820USA

In wearable electronics,significant research has gone into imparting stretchability and flexibility to otherwise rigid electronic components while maintaining their electrical *** far,this has been achieved through various geometric modifications of the rigid conductive components themselves,such as with microcracked,buckled,or planar meander ***,strategic placement of these resulting components within the overall devices,such as embedding them at the neutral plane,has been found to further enhance mechanical stability under ***,these strategies are still limited in performance,failing to achieve fully strain-insensitive electrical performance under biaxial stretching,twisting,and mixed strain ***,we developed a new platform for wearable,motion artifact-free sensors using a graphene-based multiaxially stretchable kirigami-patterned mesh *** normalized resistance change of the electrodes and graphene embedded in the structure is smaller than 0.5%and 0.23%under 180°torsion and 100%biaxial strain,***,the resistance change is limited to 5%under repeated stretching-releasing cycles from 0%to 100%biaxial *** addition,we investigated the deformation mechanisms of the structure with finite element *** on the simulation results,we derived a dimensionless geometric parameter that enables prediction of stretchability of the structure with high ***,as a proof-of-concept,we demonstrated a biaxially-stretchable graphene-based sensor array capable of monitoring of temperature and glucose level with minimized motion-artifacts.

关键词： kirigami mesh strain-insensitive wearable graphene glucose

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Evaluation of methyl ester sulphonate spacer fluid additive for efficient wellbore clean-up

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Energy Geoscience 2022年第1期3卷 73-79页

作者： Henry Elochukwu ezekiel Samansu Douglas Aja Ogboo Chikere Department of Petroleum Engineering Curtin UniversityMiriSarawakMalaysia Department of Mechanical Engineering Curtin UniversityMiriSarawakMalaysia

Oil-based drilling fluid(OBDF)is used to drill through high permeable pay zone to prevent possible damage to the ***,the oil based drilling fluid leaves behind filter cake residue and oilwet surfaces which hinder cement *** fluid is usually introduced to clean up the wellbore prior to cementing *** work presents a spacer fluid designed with environment-friendly anionic methyl ester sulphonate(MES)surfactant and evaluated through a series of experimental tests to ascertain its effectiveness to clean *** of methyl ester sulphonate to confected waterbased drilling fluid at high amount(0.15 g and 0.20 g)showed good rheological properties,compatibility with OBDF and cement and low contact angle on steel and sandstone in the range of 21.9°-34.7°.Furthermore,results show that it requires less amount of MES spacer fluid to revert oil-wet OBDF aqueous phase to water external continuous phase,validating the low contact angle *** efficiencies for two best performing MES spacer fluids achieved 83.27%and 94.3%*** bond strength were measured to be 1.3 MPa and 1.05 MPa for steel and sandstone respectively,above the minimum allowable shear bond strength for oil well ***,MES spacer fluid can be used to clean up wellbores in high permeable formations and in well completion,where strong cement bonding is required.

关键词： Methyl ester sulphonate Spacer fluid Cleaning efficiency Bond strength

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Comment on "Vortex of Fluid Field as Viewed from Curvature" [Commun. Theor. Phys. 43 (2005) 604]

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Communications in Theoretical Physics 2010年第1期53卷 43-44页

作者： Blas herrera Gerard Fortuny Departament d'Enginyeria Informàtica i Matemàtiques Universitat Rovira i Virgili

Here, we make comments to the conclusions of the paper： LIU Shi-Da, Sill Shao-Ying, LIU Shi-Kuo, et al., ＂Vortex of Fluid Field as Viewed from Curvature＂ [Commun. Theor. Phys. 43 （2005） 604].

关键词： curvature vortex

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CO2 geological storage into a lateral aquifer of an offshore gas field in the South China Sea： storage safety and project design

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Frontiers of Earth Science 2015年第2期9卷 286-299页

作者： Liang ZHANG Dexiang LI Justin ezekiel Weidong ZHANG Honggang MI Shaoran REN School of Petroleum Engineering China University of Petroleum (Huadong) Qingdao 266580 China Zhanjiang Branch Company of China National Offshore Oil Corporation Zhanjiang 524000 China

The DFI-1 gas South China Sea, contains thus there is great concern field, located in the western a high concentration of CO2, about the need to reduce the CO2 emissions. Many options have been considered in recent years to dispose of the CO2 separated from the natural gas stream on the Hainan Island. In this study, the feasibility of CO2 storage in the lateral saline aquifer of the DF 1-1 gas field is assessed, including aquifer selection and geological assessment, CO2 migration and storage safety, project design, and economic analysis. Six offshore aquifers have been investigated for CO2 geological storage. The lateral aquifer of the DFI-1 gas field has been selected as the best target for CO2 injection and storage because of its proven sealing ability, and the large storage capacity of the combined aquifer and hydrocarbon reservoir geological structure. The separated CO2 will be dehydrated on the Hainan Island and transported by a long- distance subsea pipeline in supercritical or liquid state to the central platform of the DFI-1 gas field for pressure adjustment. The CO2 will then be injected into the lateral aquifer via a subsea well-head through a horizontal well. Reservoir simulations suggest that the injected CO2 will migrate slowly upwards in the aquifer without disturbing the natural gas production. The scoping economic analysis shows that the unit storage cost of the project is approximately US$26-31/ton CO2 with the subsea pipe- line as the main contributor to capital expenditure （CAPEX）, and the dehydration system as the main factor of operating expenditure （OPEX）.

关键词： DFI-1 gas field C02 storage lateral salineaquifer storage safety project design

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A review on the consumption of vended fruits: microbial assessment, risk, and its control

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Food Quality and Safety 2020年第2期4卷 77-81页

作者： Oluwakemi Osarumwense Igiehon Ademola ezekiel Adekoya Anthony Temitope Idowu Department of Microbiology Faculty of Life ScienceUniversity of BeninEdo StateNigeria Department of Thai Traditional Medicine Prince of Songkla UniversitySongkhla Department of Food Technology Faculty of Agro-IndustryPrince of Songkla UniversitySongkhlaThailand

Fruits are very beneficial to health and their consumption has been recommended in daily ***,when fresh fruits are harvested and processed into sliced ready-to-eat or vended forms for sale,hygienic procedures are ***,they are easily infested by *** addition,uneducated vendors who sell these fruits often display or hawk them on the streets in contaminated containers,utensils,or dirty *** poses a great threat to the health of *** the light of this realization,some microbial assessments have been carried out to ascertain the safety of these vended fruits,thus making it a necessity to exploit the outcomes of some of these microbial assessments on vended fruits in order to sensitize the consumers on the effect of their consumption and mitigate risk by improving their *** will assist to lower certain health concerns,an outbreak of diseases,and death.

关键词： vended fruits microbial assessment risk control and consumption

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