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Journal of Agricultural Che.istry and e.vironme.t 2019年第3期8卷 115-128页

作者： Kumudini M. Me.pagala Brandon M. Clause. Robe.t D. Johnson david e. wedge Ste.he. O. Duke USDA-ARS Natural Products Utilization Research Unit University MS USA Sally McDonne.l Barksdale.Honors Colle.e University of Mississippi University MS USA

Brachiaria e.uciformis (sm.) Grise., locally known as “signal grass”, is a common we.d in lawns and turfs in Mississippi, USA. During late.spring and e.rly summe. months, le.ve. of B. e.uciformis are.infe.te. with a fungus causing ne.rosis. The.infe.te. le.ve. ultimate.y turn brown and withe.. As part of our se.rch for pote.tial ne. natural product-base. agroche.icals, we.studie. this plant pathoge. in orde. to inve.tigate.phytotoxic and fungitoxic me.abolite. produce. by the.fungus. The.causative.fungus was isolate. from an infe.te. le.f of B. e.uciformis, culture. in potato de.trose.agar plate. and ide.tifie. via mole.ular te.hnique. as Pyricularia grise.. A phytotoxic compound was isolate. from Czape.-Dox broth liquid culture.me.ium and ide.tifie. as pyrichalasin H by spe.troscopic te.hnique.. Pyrichalasin H was toxic to the.fungal plant pathoge. Colle.otrichum fragariae.in a TLC bioautography assay and phytotoxic to two monocot and one.dicot plants. This is the.first re.ort of antifungal activity of pyrichalasin H against phytopathoge.s. Pyrichalasin H isolate. from Pyricularia grise., a pathoge. infe.ting B. e.uciformis (signal grass) was shown to be.phytotoxic and fungicidal to Colle.otrichum fragariae.

关键词： Mycotoxin Brachiaria e.uciformis Phytotoxicity Pyricularia grise. Pyrichalasin H

Dive.sity and Biological Activitie. of e.dophytic Fungi Associate. with Micropropagate. Me.icinal Plant <i>e.hinace. purpure.</i>(L.) Moe.ch

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Ame.ican Journal of Plant Scie.ce. 2012年第8期3卷 1105-1114页

作者： Luiz H. Rosa Nurhayat Tabanca Natascha Te.he. david e. wedge Zhiqiang Pan Ulrich R. Be.nie. Jame. J. Be.ne. Natasha M. Agramonte.Larry A. Walke. Rita M. Morae. Ce.te. for Wate. and We.land Re.ource. The University of Mississippi Field Station Abbeville USA De.artame.to de.Microbiologia Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Minas Gerais Brazil National Ce.te. for Natural Products Re.e.rch Research Institute of Pharmaceutical Sciences School of Pharmacy University of Mississippi Oxford USA USDA-ARS Center for Medical Agricultural and Veterinary Entomology (CMAVE) Gainesville USA USDA-ARS Natural Products Utilization Research Unit (NPURU) University of Mississippi Oxford USA

e.hinace. is one.of the.top te. se.ling me.icinal he.bs in e.rope.and Unite. State.. Comme.cially available.formulations may contain diffe.e.t plant parts of thre. spe.ie. (e.hinace. purpure., e. pallida, and e. angustifolia). Our study e.aluate. the.dive.sity of microbial community associate. with he.lthy e. purpure. clone. and the.r ability to produce.de.e.se.compounds. We.re.ove.e. and ide.tifie. thirty-nine.fungal e.dophyte. through the.mole.ular me.hods in 15 distinct phylotype., which we.e.close.y re.ate. to spe.ie. of the.following ge.e.a Ce.atobasidium, Cladosporium Colle.otrichum, Fusarium, Glome.e.la, and Mycole.todiscus. The.e.taxa we.e.pre.iously re.orte. as de.ompose. and phytopathoge.ic fungi. The.fungal community associate. with two e. purpure. clone. showe. high richne.s and dominance.indice. with diffe.e.t distribution among plant organs. Crude.e.tracts of fungal isolate. we.e.te.te. for antifungal and inse.ticidal biological activitie.. A total of 16 e.tracts (41%) showe. antifungal prope.tie.;while.just the.e.tract of M. indicus e.hibite. larvicidal activity against A. ae.ypti. The.e.re.ults sugge.t that the.symbiosis be.we.n the.e.dophytic fungal community and micropropagate. clone. of e. purpure. was re.e.tablishe. afte. acclimatization to soil and the.e.dophytic fungi produce. compounds against phytopathoge.ic fungi.

关键词： e.dophyte. Biological Activity Me.icinal Plant Symbiosis Botanical Drug Microorganisms

Mitochondrial re.ruitme.t in mye.in:an anchor for mye.in dynamics and plasticity?

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Ne.ral Re.e.e.ation Re.e.rch 2024年第7期19卷 1401-1402页

作者： Je.n-david M.Gothié Timothy e.Ke.ne.y De.artme.t of Ne.rology and Ne.rosurge.y Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of ne.ronal e.e.trical impulse. de.e.ds on the.insulation of axons by mye.in,produce. in the.ce.tral ne.vous syste. by *** is an e.te.sion of the.oligode.drocyte.plasma me.brane.which wraps around an axon to form a compact multi-laye.e. *** is compose. of a substantially highe. proportion of lipids compare. to othe. biological me.brane. and e.riche. in a small numbe. of spe.ialize. prote.ns.

关键词： plasticity insulation dynamics

A syste.atic scoping re.ie. of study me.hodology for randomize. controlle. trials inve.tigating probiotics in athle.ic and physically active.populations

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 61-71页

作者： Ale. e.Mohr david B.Pyne.Ge.vana Silva Fogaça Le.te.De.orah Akins Jamie.Pugh Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85004USA Re.e.rch Institute.for Sport and e.e.cise University of CanberraCanberraACT 2617Australia Laboratory of Functional Fe.me.te. Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil Re.e.rch Institute.for Sport and e.e.cise.Scie.ce. Liverpool John Moores UniversityLiverpool L33AFUK

Background:The.purporte. e.goge.ic and he.lth e.fe.ts of probiotics have.be.n a topic of gre.t intrigue.among re.e.rche.s,practitione.s,and the.lay public *** has also be.n an incre.se. re.e.rch focus within the.re.lm of sports scie.ce.and e.e.cise.me.icine.on the.athle.ic gut ***,compare. to othe. e.goge.ic aids and die.ary supple.e.ts,probiotics pre.e.t unique.study *** obje.tive. of this syste.atic scoping re.ie. we.e.to ide.tify and characte.ize.study me.hodologie. of randomize. controlle. trials inve.tigating supple.e.tation with probiotics in athle.e. and physically active.***:Four database.(Me.LINe.CINAHL,Cochrane.Ce.TRAL,and Cochrane.Database.of Syste.atic Re.ie.s)we.e.se.rche. for randomize. controlle. studie. involving he.lthy athle.e. or physically active.*** inte.ve.tion with probiotics and inclusion of a control and/or place.o group we.e.*** pe.r-re.ie.e. article. in e.glish we.e.conside.e.,and the.e.we.e.no date.*** we.e.e.tracte. and pre.e.te. in tabular form to de.ail study protocols,characte.istics,and *** in randomize. controlle. trials was de.e.mine. with the.RoB 2.0 ***:A total of 45 studie. we.e.include. in the.re.ie.,with 35 using a paralle. group de.ign and 10 using a cross-ove. *** half the.studie. use. a single.probiotic and the.othe. half a multi-strain *** probiotic dose.range. from 2×10^(8)to 1×10^(11)colony forming units daily,and the.le.gth of inte.ve.tion was be.we.n 7 and 150 *** than half the.studie. dire.tly asse.se. gastrointe.tinal symptoms,gut pe.me.bility,or the.gut *** se. ratio of participants was he.vily we.ghte. toward male.,and only 3 studie. e.clusive.y inve.tigate. ***-le.e. adve.se.e.e.ts we.e.re.orte. in only 2 studie.,although the.me.hodology of re.orting varie. *** risk of bias was ge.e.ally low,although de.ails on randomization we.e.lacking in some.s

关键词： e.e.cise e.pe.ime.tal me.hodology Gastrointe.tinal symptoms Gut microbiota Probiotic supple.e.tation

Instance.Se.me.tation of Characte.s Re.ognize. in Palmyre.e.Aramaic Inscriptions

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Compute. Mode.ing in e.gine.ring & Scie.ce. 2024年第9期140卷 2869-2889页

作者： Adéla Hamplová Ale.e. Lyavdansky TomášNovák Ondre. Svojše.david Franc Arnošt Ve.e.ý Cze.h Unive.sity of Life.Scie.ce. in Prague.CULS) Faculty of Economics and ManagementDepartment of Information EngineeringPrague16500Czech Republic National Re.e.rch Unive.sity Highe. School of e.onomics(HSe. Faculty of HumanitiesInstitute for Oriental and Classical StudiesMoscow101000The Russian Federation

This study pre.e.ts a single.class and multi-class instance.se.me.tation approach applie. to ancie.t Palmyre.e.inscriptions,e.ploying two state.of-the.art de.p le.rning algorithms,name.y YOLOv8 and Roboflow *** goal is to contribute.to the.pre.e.vation and unde.standing of historical te.ts,showcasing the.pote.tial of mode.n de.p le.rning me.hods in archae.logical *** re.e.rch culminate. in se.e.al ke. findings and scie.tific *** compre.e.sive.y compare.the.pe.formance.of YOLOv8 and Roboflow 3.0 in the.conte.t of Palmyre.e.characte. se.me.tation—this comparative.analysis mainly focuse. on the.stre.gths and we.kne.se. of e.ch algorithm in this *** also cre.te. and annotate. an e.te.sive.datase. of Palmyre.e.inscriptions,a crucial re.ource.for furthe. re.e.rch in the.*** datase. se.ve. for training and e.aluating the.se.me.tation *** e.ploy comparative.e.aluation me.rics to quantitative.y asse.s the.se.me.tation re.ults,e.suring the.re.iability and re.roducibility of our findings and we.pre.e.t custom visualization tools for pre.icte. se.me.tation *** study advance. the.state.of the.art in se.i-automatic re.ding of Palmyre.e.inscriptions and e.tablishe. a be.chmark for future.*** availability of the.Palmyre.e.datase. and the.insights into algorithm pe.formance.contribute.to the.broade. unde.standing of historical te.t analysis.

关键词： Optical characte. re.ognition instance.se.me.tation Palmyre.e ancie.t language. compute. vision

Ke.oge. Kine.ic Distributions and Simulations Provide.Insights into Pe.role.m Transformation Fraction (TF) Profile. of Organic-Rich Shale.

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Journal of e.rth Scie.ce 2024年第3期35卷 747-757页

作者： david A.Wood DWA e.e.gy Limite. Lincoln LN59JPUnited Kingdom

Two hundre. and fifty single.first-orde. Arrhe.ius re.ctions are.simulate. to ge.e.ate.S2 pyrograms at thre. he.ting rate. 25,15,and 5°C·*** activation e.e.gy(e.and pre.e.pone.tial factor(A)of the.re.ctions simulate. follow a long-e.tablishe. tre.d of those.variable.value. displaye. by shale. and *** characte.istics of the.transformation fraction(TF)profile.(product ge.e.ation window te.pe.ature.)of the.simulate. single.re.ctions are.compare. to the.TF profile. of re.orde. shale.pyrograms ge.e.ate. by multiple.re.ctions with diffe.e.t e.A value. lying ne.r the.de.ine. e.A *** similaritie. and diffe.e.ce. are.obse.ve. be.we.n the.TF profile.value. of the.two *** similaritie. support the.spre.d of e.A value. involve. in shale.pyrogram be.t *** diffe.e.ce. are.most like.y e.plaine. by the.comple.ity of the.multiple.ke.oge. first-orde. and se.ond-orde. re.ctions contributing to the.re.orde. shale.pyrograms ve.sus the.simplicity and crispne.s of the.single.first-orde. re.ctions *** re.ults also justify the.validity of using the.pre.iously de.cribe.“variable.e.A pyrogram-fitting me.hod”of multi-he.ting-rate.shale.pyrograms e.abling optimize.s to choose.multiple.re.ctions from an unlimite. range.of e.A *** contrast,furthe. doubt is cast on the.validity of the.constant-A pyrogram-fitting me.hod use. by the.e.sy%Ro te.hnique.in that a distribution of re.ctions with a single.A value.is unlike.y to re.re.e.t the.comple. varie.y of ke.oge. mace.als obse.ve. in shale.*** profile. ge.e.ate. by the.variable.e.A pyrogram-fitting me.hod lie.close.to the.e.tablishe. e.A tre.d and are.like.y to provide.more.re.listic TF ge.e.ation window te.pe.ature. than TF profile. ge.e.ate. by the.constant-A pyrogram-fitting me.hod.

关键词： transformation fraction profile. simulate. S2 pyrograms multiple.he.ting rate. ke.oge./shale.kine.ics S2 pyrogram fitting te.hnique. ke.oge. pe.role.m re.e.rch.

Proje.te. Change. in e.tre.e.e.e.t Indice. for Alaska

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Atmosphe.ic and Climate.Scie.ce. 2024年第2期14卷 191-209页

作者： John e. Walsh Kyle.Re.illa Norman Shippe. Lukas Che.ng david Bige.ow Ronni Wilcock Inte.national Arctic Re.e.rch Ce.te. University of Alaska Fairbanks Fairbanks USA Stante. Ottawa Canada Stante. Montreal Canada Stante. Calgary Canada Two Be.rs e.vironme.tal Consulting Anchorage USA

As climate.has warme. in re.e.t de.ade., Alaska has e.pe.ie.ce. a varie.y of high-impact e.tre.e.e.e.ts that include.he.t wave., wildfire., coastal storms and fre.zing rain. Be.ause.the.warming is proje.te. to continue. it is e.se.tial to conside. future.change. whe. planning adaptation actions and building re.ilie.ce. In this study, we.synthe.ize.information on future.change. in e.tre.e.e.e.ts in Alaska from an e.se.ble.of re.ional climate.mode. simulations pe.forme. as part of Arctic-CORDe. (Coordinate. Re.ional Climate.Downscaling e.pe.ime.t). A se. of 13 e.tre.e.e.e.t indice., base. on those.de.e.ope. by the.World Climate.Re.e.rch Programme.s e.pe.t Te.m on Climate.Change.De.e.tion and Indice. (e.CCDI), are.e.aluate. from the.Arctic-CORDe. output for Alaska. Of the.13 indice., six pe.tain to te.pe.ature. five.to total pre.ipitation, one.to wind and one.to snow. The.re.ults for locations in se.e. diffe.e.t climate.zone. of Alaska include.large.incre.se. (5˚C - 10˚C) in the.te.pe.ature.thre.holds for the.five.hotte.t and colde.t days of the.ye.r, and large.incre.se. in warm spe.l duration and de.re.se. in cold spe.l duration. Change. in the.cold day te.pe.ature.thre.hold are.ge.e.ally large. than the.change. in the.hot day te.pe.ature.thre.hold, consiste.t with the.proje.tions of a stronge. warming in winte. than in summe. in Alaska ye.rly maximum 1-day and 5-day pre.ipitation amounts as we.l as the.ye.rly numbe. of conse.utive.we. days are.proje.te. to incre.se.at all locations. The.indice. for he.vy snow days and high-wind days show mixe. change., although the.re.ults indicate.incre.se. in he.vy snow days at the.more.northe.n locations and incre.se. in windy days at coastal locations. The.change. in the.e.tre.e.e.e.t indice. continue.through 2100 unde. the.highe.-e.ission (RCP 8.5) e.ission sce.ario, while.the.change. ge.e.ally stabilize.unde. the.lowe.-e.ission (RCP 4.5) sce.ario. .

关键词： e.tre.e.e.e.ts Te.pe.ature Pre.ipitation Alaska Climate

Alloge.ic Ste. Ce.l Transplantation and COVID-19 Antibodie.: Me.hanistic Insights and Re.ipie.t Conce.ns

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Ope. Journal of Immunology 2024年第2期14卷 16-32页

作者： Amna Ume. Asma Ume. Khayam Nasar Khan david Lawre.ce.Gre.ne.Umm e. Habiba Sabiha Shamim Pak-Ame.ican Hospital Pvt. Ltd. Islamabad Pakistan R3 Me.ical Re.e.rch LLC Scottsdale USA Be.lo Bio Labs and The.ape.tics (SMC) Pvt. Ltd. Islamabad Pakistan De.artme.t of Bioche.istry Rawalpindi Medical University Rawalpindi Pakistan Be.lo Bio LLC Scottsdale USA

Colle.ting umbilical cord ste. ce.ls is wide.y practice. due.to its nume.ous be.e.its. Ove. the.past de.ade. umbilical cord ste. ce.ls (UCSCs) have.shown e.fe.tive.e.s in tre.ting various conditions, such as bone.pathologie., ne.ropsychiatry disorde.s, he.e.itary dise.se., and me.abolic disorde.s. Howe.e., factors like.immunization affe.t the.quantity and quality of cord harve.ting. Studie. sugge.t that antibodie. from the.mothe. pass through the.umbilical cord to prote.t the.infant against infe.tions. Cle.ning the.umbilical cord be.ore.ste. ce.l e.traction is crucial to maintain ste.ility and ce.l inte.rity. Vaccinating a fe.ale.donor, including for COVID-19, typically doe. not dire.tly affe.t the.ste. ce.ls. Although vaccine. aim to trigge. an immunological re.ponse. the. ge.e.ally do not affe.t the.donor’s ste. ce.ls.

关键词： Vaccination Ste. Ce.l Alloge.e.c COVID Antibodie.

Association be.we.n base.ine.le.e.s of muscular stre.gth and risk of stroke.in late. life.The.Coope. Ce.te. Longitudinal Study

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 642-649页

作者： Ste.he. W.Farre.l david Le.nard Qing Li Carolyn e.Barlow Ke.e. Shuval Jare.t D.Be.ry Andje.ka Pavlovic Laura F.De.ina Re.e.rch Division The Cooper InstituteDallasTX 75230USA De.artme.t of Inte.nal Me.icine University of Texas at Tyler School of MedicineTylerTX 75799USA

Background:Muscular stre.gth is an important compone.t of physical *** e.aluate. the.re.ationship be.we.n base.ine.muscular stre.gth and risk of stroke.among adults who we.e.age.≥65 ye.rs during ***:We.include. 7627 he.lthy adults(me.n age.43.9 ye.rs,86.0%male.unde.we.t a base.ine.physical e.amination be.we.n 1980 and *** stre.gth was de.e.mine. by 1-re.e.ition maximum me.sure. for be.ch pre.s and le. pre.s and cate.orize. into age.and se.-spe.ific te.tile. for e.ch *** fitne.s(CRF)was asse.se. via a maximal tre.dmill e.e.cise.*** e.rolle. in fe.-for-se.vice.Me.icare.from 1999 to 2019 we.e.include. in the.*** be.we.n base.ine.stre.gth and stroke.outcome. we.e.e.timate. using a modifie. Cox proportional hazards *** a se.ondary analysis,we.e.amine. stroke.risk by cate.orie. of CRF whe.e.Quintile.1=low,Quintile. 2-3=mode.ate.and Quintile. 4-5=high CRF base. on age.and ***:Afte. 70,072 pe.son-ye.rs of Me.icare.follow-up,the.e.we.e.1211 e.rlie.t indications of incide.t *** multivariable.analyse.,the.hazard ratio(95%confide.ce.inte.val(95%CI))for stroke.across be.ch pre.s cate.orie. we.e.1.0(re.e.e.t),0.96(0.83-1.11),and 0.89(0.77-1.04),re.pe.tive.y(p tre.d=0.14).The.tre.d across cate.orie. of le. pre.s was also non-significant(p tre.d=0.79).Adjuste. hazard ratio(95%CI)for stroke.across orde.e. CRF cate.orie. we.e.1.0(re.e.e.t),0.90(0.71-1.13),and 0.72(0.57-0.92)(p tre.de.me.ting public he.lth guide.ine. for muscular stre.gthe.ing activitie. is like.y to improve.muscular stre.gth as we.l as many he.lth outcome. in olde. adults,pe.forming such activitie. may not be.he.pful in pre.e.ting ***,me.ting guide.ine. for ae.obic activity is like.y to improve.CRF and lowe. stroke.risk.

关键词： Cardiore.piratory fitne.s Me.icare Muscular stre.gth Stroke

Role.of climatic variability in shaping intraspe.ific variation of the.mal tole.ance.in Me.ite.rane.n wate. be.tle.

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Inse.t Scie.ce 2024年第1期31卷 285-298页

作者： Susana Pallarés david Garoffolo Be.én Rodrígue. david Sánche.-Fe.nánde. De.artme.t of Zoology University of SevilleSevilleSpain Faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The.climatic variability hypothe.is(CVH)pre.icts that organisms in more.the.mally variable.e.vironme.ts have.wide. the.mal bre.dths and highe. the.mal plasticity than those.from more.stable.***,due.to e.olutionary trade.offs,taxa with gre.te. absolute.the.mal limits may have.little.plasticity of such limits(trade.off hypothe.is).The.CVH assume. that climatic variability is the.ultimate.drive. of the.mal tole.ance.variation across latitudinal and altitudinal gradie.ts,but ave.age.te.pe.ature.also varie. along such *** e.plore. intraspe.ific variation of the.mal tole.ance.in thre. typical Me.ite.rane.n saline.wate. be.tle.(familie. Hydrophilidae.and Dytiscidae..For e.ch spe.ie.,we.compare. two populations whe.e.the.spe.ie. coe.ist,with similar annual me.n te.pe.ature.but contrasting the.mal variability(contine.tal *** population).We.e.timate. the.mal limits of adults from e.ch population,pre.iously acclimate. at 17,20,or 25℃.We.found spe.ie.-spe.ific patte.ns but ove.all,our re.ults agre. with the.CVH re.arding the.mal range.,which we.e.wide. in the.contine.tal(more.variable.*** the.two hydrophilid spe.ie.,this came.at the.cost of losing plasticity of the.uppe. the.mal limit in this population,supporting the.trade.off hypothe.is,but not in the.dytiscid *** re.ults support the.role.of local adaptation to the.mal variability and trade.offs be.we.n basal tole.ance.and physiological plasticity in shaping the.mal tole.ance.in aquatic e.tothe.ms,but also sugge.t that intraspe.ific variation of the.mal tole.ance.doe. not fit a ge.e.al patte.n among aquatic *** such intraspe.ific variation could le.d to inaccurate.pre.ictions of the.vulne.ability of aquatic inse.ts to global warming.

关键词： acclimation capacity aquatic inse.ts climate.change he.t coma te.pe.ature supe.cooling point the.mal plasticity