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Recent advances towards single biomolecule level understanding of protein adsorption phenomena unique to nanoscale polymer surfaces with chemical variations

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Nano Research 2020年第5期13卷 1295-1317页

作者： david H.cho Tian Xie Johnson Truong Andrew c.Stoner Jong-in Hahm Department of chemistry Georgetown University37th&O Sts.NW.WashingtonDC 20057USA

Protein adsorption onto polymer surfaces is a very complex and ubiquitous phenomenon whose integrated process impacts essential applications in our daily lives such as food packaging materials,health devices,diagnostic tools,and medical ***,novel polymer materials with greater chemical intricacy and reduced dimensionality are used for various applications involving adsorbed proteins on their ***,the nature of protein-surface interactions to consider is becoming much more complicated than before.A large body of literature exists for protein ***,most of these investigations have focused on collectively measured,ensemble-averaged protein behaviors that occur on macroscale and chemically unvarying polymer surfaces instead of direct measurements at the single protein or sub-protein *** addition,interrogations of protein-polymer adsorption boundaries in these studies were typically carried out by indirect methods,whose insights may not be suitably applied for explaining individual protein adsorption processes occurring onto nanostructured,chemically varying polymer ***,an important gap in our knowledge still exists that needs to be systematically addressed via direct measurement means at the single protein and sub-protein *** efforts will require multifaceted experimental and theoretical approaches that can probe multilength scales of protein adsorption,while encompassing both single proteins and their collective ensemble behaviors at the length scale spanning from the nanoscopic all the way to the macroscopic *** this review,key research achievements in nanoscale protein adsorption to date will be ***,protein adsorption studies involving polymer surfaces with their defining feature dimensions and associated chemical partitions comparable to the size of individual proteins will be discussed in *** this regard,recent works bridging the crucial knowledge gap in protein adso

关键词： nanoscale protein adsorption nanoscale protein assembly protein self-assembly on polymer protein nanopatterning protein-nanosurface interaction

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Filling the Disaster Data Gap:Lessons from cataloging Singapore’s Past Disasters

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International Journal of Disaster Risk Science 2021年第2期12卷 188-204页

作者： Yolanda c.Lin Feroz Khan Susanna F.Jenkins david Lallemant Department of Geography and Environmental Studies University of New MexicoAlbuquerqueNM87131USA Asian School of the Environment Nanyang Technological UniversitySingapore639798Singapore Earth Observatory of Singapore Singapore639798Singapore Disaster Resilience Leadership Academy Tulane UniversityNew OrleansLA70112USA

International disaster databases and catalogs provide a baseline for researchers,governments,communities,and organizations to understand the risk of a particular place,analyze broader trends in disaster risk,and justify investments in *** because Singapore is routinely identified as one of the safest countries in the world,Singapore’s past disasters have not been studied extensively with few events captured in major global databases such as *** this article,we fill the disaster data gap for postwar Singapore(1950–2020)using specified metrics through an archival search,review of literature,and analysis of secondary *** present four key lessons from cataloging these ***,we expand Singapore’s disaster catalog to 39 events in this time period and quantify the extent of this data ***,we identify the mitigating actions that have followed past events that contribute to Singapore’s present-day ***,we discuss how these past events uncover continuities among vulnerability bearers in ***,we identify limitations of a disaster catalog when considering future *** expanding the disaster catalog,this case study of Singapore supports the need for comprehensive understanding of past disasters in order to examine current and future disaster resilience.

关键词： catalog Database Data gap Disasters Resilience Singapore

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Predisposing factors’effects on mortality of oak (Quercus) and hickory (carya) species in mature forests undergoing mesophication in Appalachian Ohio

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Forest Ecosystems 2021年第1期8卷 81-94页

作者： Don c.Radcliffe david M.Hix Stephen N.Matthews School of Environment and Natural Resources The Ohio State University2021 Coffey RoadColumbus OH 43210USA School of Environmental and Forest Sciences University of WashingtonBox 352100Seattle WA 98195-2100USA

Background:Mature oak(Quercus spp.)and hickory(carya spp.)trees are gradually being replaced by more shadetolerant tree species across the eastern U.S.,likely due to fire suppression and increased *** and hickories are highly valuable to wildlife;therefore,studying their mortality patterns can provide information on the longevity of habitat quality for many animal *** mortality has most often been studied following large oak decline events,but background mortality rates in forests with aging oak and hickory canopies warrant equal attention,especially in the context of widespread oak and hickory regeneration ***:We studied background mortality rates of five oak and one hickory species over a 23–25 year time period(1993–1995 to 2018),using 821/20th hectare permanent plots on the Marietta Unit of the Wayne National Forest in southeastern *** calculated mortality rates based on remeasurement of individual trees for white oak(Quercus alba),chestnut oak(Quercus montana),northern red oak(Quercus rubra),black oak(Quercus velutina),scarlet oak(Quercus coccinea),and pignut hickory(carya glabra).For each of these species other than scarlet oak,we also modeled the relationships of mortality probability with a priori topographic,soil,stand structural,and individual tree covariates,using a mixed-effects logistic regression ***:The species with the highest mortality rate was scarlet oak(61.3%),followed by northern red oak(41.4%),black oak(26.7%),pignut hickory(23.9%),white oak(23.4%),and chestnut oak(19.1%).In our models,northern red oak mortality was associated with more mesic slope positions,shallower solums,more acidic soils,and older stand *** hickory and chestnut oak mortality rates were associated with higher basal areas on the plot,while white oak mortality showed the opposite ***:Our data suggest that red oak subgenus trees in mature forests of our area will become increasingly uncommon relative t

关键词： Mortality Quercus carya Mesophication Wildlife habitat

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抛开计划重新排序

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商学院 2009年第6期 71-72页

作者： david court 麦肯锡达拉斯分公司

在以往的经济低迷时期，许多营销商在规模大、历史盈利水平较高的客户、地区和细分市场上加倍下工夫。如今，这种方法可能不再有效，因为，世界经济不景气以出乎意料而又极其特殊的方式影响着客户和市场。因此，营销商应抛弃那些基于历... 详细信息

在以往的经济低迷时期，许多营销商在规模大、历史盈利水平较高的客户、地区和细分市场上加倍下工夫。如今，这种方法可能不再有效，因为，世界经济不景气以出乎意料而又极其特殊的方式影响着客户和市场。因此，营销商应抛弃那些基于历史的预期，而专注于新兴的客户赢利点。

关键词：排序细分市场经济不景气经济低迷盈利水平营销商客户赢利点

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每月麦肯锡经济低迷下的营销商新规则

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商学院 2009年第2期 62-66页

作者： david court 麦肯锡道格拉斯分公司

衰退时期的老规则这次不再适用。目前的经济低迷的性质,以及营销和销售环境从2001～2002年的衰退以来所经历的变化的性质似乎表明,遵循低迷时期老一套的生存法则的人这次是在冒险,把赌注押在了错误的市场、客户、广告手段或销售方法上面。

关键词：经济低迷营销商销售环境生存法则销售方法性质冒险市场

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Multicenter,randomized study to optimize bowel for colon capsule endoscopy

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World Journal of Gastroenterology 2017年第48期23卷 8615-8625页

作者： david Kastenberg Wilmot c Burch Jr david P Romeo Pankaj K Kashyap david c Pound Neophytos Papageorgiou Ignacio Fernández-Urien Sainz carly E Sokach Douglas K Rex Division of Gastroenterology Thomas Jefferson University Franklin Gastroenterology PLLC Dayton Gastroenterology Inc. Pinnacle Research Group LLc Indianapolis Gastroenterology and hepatology Department of Gastroenterology American Medical Center Department of Gastroenterology Servicio de Digestivohospital de Navarra Sidney Kimmel Medical college at Thomas Jefferson University Indiana University hospital

AIM To assess the cleansing efficacy and safety of a new colon capsule endoscopy(ccE) bowel preparation *** This was a multicenter,prospective,randomized,controlled study comparing two ccE regimens. Subjects were asymptomatic and average risk for colorectal cancer. The second generation ccE system(Pill cam? cOLON 2;Medtronic,Yoqneam,Israel) was utilized. Preparation regimens differed in the 1 st and 2 nd boosts with the Study regimen using oral sulfate solution(89 m L) with diatrizoate meglumine and diatrizoate sodium solution("diatrizoate solution")(boost 1 = 60 m L,boost 2 = 30 m L) and the control regimen oral sulfate solution(89 m L) alone. The primary outcome was overall and segmental colon cleansing. Secondary outcomes included safety,polyp detection,colonic transit,ccE completion and capsule excretion ≤ 12 h. RESULTS Both regimens had similar cleansing efficacy for the whole colon(Adequate: Study = 75.9%,control = 77.3%;P = 0.88) and individual segments. In the Study group,ccE completion was superior(Study = 90.9%,control = 76.9%;P = 0.048) and colonic transit was more often control = 4%;P = 0.0073). More Study regimen subjects experienced adverse events(Study = 19.4%,control = 3.4%;P = 0.0061),and this difference did not appear related to diatrizoate solution. Adverse events were primarily gastrointestinal in nature and no serious adverse events related either to the bowel preparation regimen or the capsule were observed. There was a trend toward higher polyp detection with the Study regimen,but this did not achieve statistical significance for any size category. Mean transit time through the entire gastrointestinal tract,from ingestion to excretion,was shorter with the Study regimen while mean colonic transit times were similar for both study *** A ccE bowel preparation regimen using oral sulfate solution and diatrizoate solution as a boost agent is effective,safe,and achieved superior ccE completion.

关键词： Bowel preparation Purgative capsule endoscopy Endoscopy capsule colonoscopy Large intestine

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Two-Factor cancelable Biometrics Authenticator

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Journal of computer Science & Technology 2007年第1期22卷 54-59页

作者：彭颖涵 Andrew T. B. J david N. c. L Faculty of Information Science and Technology Multimedia University dalan Ayev Keroh Lama 75450 Melaka Malaysia

Biometrics-based authentication system offers advantages of providing high reliability and accuracy. However the contemporary authentication system is impuissance to compromise. If a biometrics data is compromised, it cannot be replaced and rendered unusable. In this paper, a cancelable biometrics-based authenticator is proposed to solve this irrevocability issue. The proposed approach is a two-factor authentication system, which requires both of the random data and facial feature in order to access the system. In this system, tokenized pseudo-random data is coupled with momentbased facial feature via inner product algorithm. The output of the product is then discretized to generate a set of private binary code, coined as 2factor-Hashing code, which is acted as verification key. If this biometrics-based verification key is compromised, a new one can be issued by replacing a different set of random number via token replacement. Then, the compromised one is rendered completely useless. This feature offers an extra protection layer against biometrics fabrication since the verification code is replaceable. Experimental results demonstrate that the proposed system provides zero Equal Error Rate in which there is a clear separation in between the genuine and the imposter distribution populations.

关键词： cancelable biometrics face recognition Geometric moments,pseudo Zernike moment

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Integrating flood depth and plant resistance with chlorantraniliprole seed treatments for management of rice water weevil, Lissorhoptrus oryzophilus （coleoptera： curculionidae）

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Insect Science 2015年第5期22卷 679-687页

作者： Srinivas K. Lanka david c. Blouin Michael J. Stout Department of Entomology Louisiana State University Agricultural Center Baton Rouge LA 70803 USA

chlorantraniliprole seed treatments in rice provide effective suppression of rice water weevil populations in the United States; however, heavy reliance on prophylac- tic insecticide treatments as a sole strategy could destabilize management programs for this insect. The present research evaluated the compatibility of seed treatments with two other potential management tactics--plant resistance and shallow flooding-by conducting two split-plot experiments in 2009 and 2011. In both experiments, no substantial antago- nism was found among the 3 different tactics. Statistical interactions in these experiments arose from the strong and persistent effects of chlorantraniliprole on larval densities rather than incompatibility of tactics. In 2009, weevil densities differed among varieties and were significantly lower on the cultivar ＂Jefferson.＂ In 2011, weevil densities were reduced sig- nificantly in shallow-flooded plots compared to deep-flooded plots. Significant reductions in weevil numbers by chlorantraniliprole seed treatments, even at application rates 5 fold lower than commercially recommended rates, demonstrated the potential to reduce appli- cation rates of this highly potent larvicide. These latter results suggest that future studies on the relationship between chlorantraniliprole seed treatment rate and weevil fitness are warranted.

关键词： chlorantraniliprole compatibility integrated management plant resistance rice water weevil seed treatments

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carboalumination-Epoxide Ring Opening for the Formation of 1,4-Disubstituted （Z）-3,6-Alkadienols

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chinese Journal of chemistry 2013年第6期31卷 773-778页

作者： Quan Zhang Yuhuan Jing david c. Myles Yong Li Yue chen college of Pharmacy State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Molecular Drug Research Nankai University Tianjin 300071 China Kosan Biosciences Inc. 3832 Bay Center Place Hayward California 94545 USA

Allylalumination of alkynes （i.e. forming Negishi＇s （Z）-alkenyl dialkylalane） followed by alkenylation of epoxides provides 1,4-disubstituted （Z）-3,6-alkadienols. The alkenylation can be facilitated by the presence of a neighbouring coordinating group in the epoxides. This ＂one-pot＂ approach has been successfully applied in the large-scale production of c 10--c 15 fragment of 9,10-didehydroepothilone D （a synthetic epothilone analog as an anti-cancer agent in phase 2 clinical trials）.

关键词： carboalumination-epoxide ring opening 1,4-disubstituted (Z)-3,6-alkadienols

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Primary Non-HFE Hemochromatosis:A Review

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Journal of clinical and Translational Hepatology 2023年第4期11卷 925-931页

作者： Alla Turshudzhyan david c.Wu George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Iron homeostasis is a complex process in which iron uptake and use are tightly *** Type 1 or HFE hemochromatosis results from homozygous mutations in the gene that encodes human homeostatic iron regulator(known as human factors engineering,HFE)protein,a regulator of hepcidin,and makes up approximately 90%of all hemochromatosis ***,four types of hemochromatosis do not involve the HFE *** are non-HFE hemochromatosis type 2A(HFE2,encoding HJV),type 2B(HAMP,encoding hepcidin),type 3(TFR2,encoding transferring receptor-2),and types 4A and B(SLc40A1,encoding *** hemochromatosis is extremely *** allele frequencies have been estimated to be 74/100,000 for type 2A,20/100,000 for type 2B,30/100,000 for type 3,and 90/100,000 for type 4 *** guidelines recommend that the diagnosis be made by ruling out HFE mutations,history,physical examination,laboratory values(ferritin and transferrin saturation),magnetic resonance or other imaging,and liver biopsy if *** less common,non-HFE hemochromatosis can cause iron overload as severe as the HFE *** most cases,treatment involves phlebotomy and is successful if started before irreversible damage *** diagnosis and treatment are important because it prevents chronic liver *** review updates the mutations and their pathogenetic consequences,the clinical picture,diagnostic guidelines,and treatment of hemochromatosis.

关键词： Non-HFE Hemochromatosis cirrhosis Iron homeostasis

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