检索结果-南通市图书馆

East meets West:ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and caucasians

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of cancer 2011年第5期30卷 287-292页

作者： Wei Zhou david c. christiani Molecular Epidemiology Research Global Outcomes Research Pfizer Oncology Collegeville PA 19426 USA Departments of Epidemiology and Environmental Health Harvard School of Public Health Boston MA 02115 USA Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA 02115 USA

Lung cancer is the leading cause of cancer death worldwide,with large variation of the incidence and mortality across *** the mortality of lung cancer has been decreasing,or steady in the US,it has been increasing in Asia for the past two *** is the leading cause of lung cancer,and other risk factors such as indoor coal burning,cooking fumes,and infections may play important roles in the development of lung cancer among Asian never smoking *** median age of diagnosis in Asian patients with lung cancer is generally younger than caucasian patients,particularly among *** and caucasians may have different genetic susceptibilities to lung cancer,as evidenced from candidate polymorphisms and genome-wide association *** epidemiologic studies and clinical trials have shown consistently that Asian ethnicity is a favorable prognostic factor for overall survival in non-small cell lung cancer(NScLc),independent of smoking *** with caucasian patients with NScLc,East Asian patients have a much higher prevalence of epidermal growth factor receptor(EGFR) mutation(approximately 30% vs.7%,predominantly among patients with adenocarcinoma and never-smokers),a lower prevalence of K-Ras mutation(less than 10% vs.18%,predominantly among patients with adenocarcinoma and smokers),and higher proportion of patients who are responsive to EGFR tyrosine kinase *** ethnic differences in epidemiology and clinical behaviors should be taken into account when conducting global clinical trials that include different ethnic populations.

关键词：非小细胞肺癌临床试验种族差异流行病学亚洲人中西文化行为白种人

中国留学生在美国的师生互动压力:以美国某大学为例

在线全文

学校读者我要写书评

暂无评论

复旦教育论坛 2011年第1期9卷 77-82页

作者：阎琨 david c Berliner 清华大学教育研究院 college of Education Arizona State UniversityTempeAZ 85287-2411USA

本文从师生互动的维度解析了中国留学生在美国大学中的学业压力因素。四种因素构成了中国学生和美国教授互动的主要压力因素:语言功力不足、缺少对学业的自治和自主引领、言语表达的被动性、交流模式的非直接性。中国学生的压力是中美... 详细信息

本文从师生互动的维度解析了中国留学生在美国大学中的学业压力因素。四种因素构成了中国学生和美国教授互动的主要压力因素:语言功力不足、缺少对学业的自治和自主引领、言语表达的被动性、交流模式的非直接性。中国学生的压力是中美两种文化模式和教育模式碰撞合力作用的结果。这为反思中国教育的问题提供了有效切入点。本文从英语语言教育和转变人才培养观念两个方面为中国教育提出了相应的建议。并指出中国学生应进行"深层结构性社会文化转化",充分适应美国大学的学术文化,与美国教授形成良性互动,最终减缓跨文化所带来的压力。

关键词：压力因素师生互动中国留学生美国

Successful aspiration and ethanol sclerosis of a large,symptomatic, simple liver cyst:case presentation and review of the literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第18期12卷 2949-2954页

作者： Wojciech c Blonski Mical S campbell Thomas Faust david c Metz Division of Gastroenterology University of PennsylvaniaPhiladelphiaPAUnited States and Department of Gastroenterology and HepatologyWroclaw Medical UniversityPoland Division of Gastroenterology University of PennsylvaniaPhiladelphiaPAUnited States

Simple liver cysts are congenital with a prevalence of 2.5%-4.25%. Imaging, whether by US, cT or MRI, is accurate in distinguishing simple cysts from other etiologies, including parasitic, neoplastic, duct-related, and traumatic cysts. Symptomatic simple liver cysts are rare, and the true frequency of symptoms is not known. Symptomatic simple liver cysts are predominantly large （〉 4 cm）, right-sided, and more common in women and older patients. The vast majority of simple hepatic cysts require no treatment or follow-up, though large cysts （〉 4 cm） may be followed initially with serial imaging to ensure stability. Attribution of symptoms to a large simple cyst should be undertaken with caution, after alternative diagnoses have been excluded. Aspiration may be performed to test whether symptoms are due to the cyst; however, cyst recurrence should be expected. Limited experience with both laparoscopic deroofing and aspiration, followed by instillation of a sclerosing agent has demonstrated promising results for the treatment of symptomatic cysts. Here, we describe a patient with a large, symptomatic, simple liver cyst who experienced complete resolution of symptoms following cyst drainage and alcohol ablation, and we present a comprehensive review of the literature.

关键词： Simple hepatic cyst Alcohol sclerosis Laparoscopic deroofing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

氮化镓功率晶体管三电平驱动技术

电工技术学报 2013年第5期28卷 202-207页

作者：任小永 david Reusch 季澍穆明凯 Fred c Lee 南京航空航天大学江苏省新能源发电与电能变换重点实验室南京210016 VirginiaPolytechnicInstituteandStateUniversityBlacksburgVA24061

作为第三代半导体材料的典型代表,宽禁带半导体氮化镓(GaN)材料具有许多硅材料所不具备的优异性能,是高频、高压、高温和大功率应用的优良半导体材料,无论在民用或是军事领域都具有广阔的应用前景。随着GaN技术的进步,大直径硅(Si)基Ga... 详细信息

作为第三代半导体材料的典型代表,宽禁带半导体氮化镓(GaN)材料具有许多硅材料所不具备的优异性能,是高频、高压、高温和大功率应用的优良半导体材料,无论在民用或是军事领域都具有广阔的应用前景。随着GaN技术的进步,大直径硅(Si)基GaN外延技术逐步成熟并向商用化方向发展。2010年以来,多家国际著名半导体厂商相继推出GaN功率晶体管器件。与硅半导体功率器件一样,合理的驱动方式也是GaN功率晶体管优越性能得以体现的重要保障。本文将以GaN功率器件在同步整流Buck变换器中的应用为例,提出一种三电平的驱动方式,以充分发挥GaN功率晶体管器件的优越性。实验结果表明,本文提出的三电平驱动方式可以有效提高变换器的效率。

关键词：氮化镓 GaN 三电平驱动方式

Elevated plasma levels of N-terminal pro-brain natriuretic peptide in patients with chronic hepatitis c during interferon-based antiviral therapy

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第36期12卷 5875-5877页

作者： Jrg Bojunga christoph Sarrazin Georg hess Stefan Zeuzem Internal Medicine Ⅱ Saarland University Hospital 66421 Homburg/Saar Germany Roche Diagnostics 68305 Mannheim Germany

AIM: To investigate plasma levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), an established marker of cardiac function, in patients with chronic hepatitis c during interferon-based antiviral therapy. METHODS: Using a sandwich immunoassay, plasma levels of NT-proBNP were determined in 48 patients with chronic hepatitis c at baseline, wk 24 and 48 during antiviral therapy and at wk 72 during ***: Plasma NT-proBNP concentrations were significantly increased (P compared to the baseline values. NT-proBNP concentrations at baseline and wk 24 were closely correlated (r = 0.8; P concentrations above 200 ng/L compared to 1 (2%) patient at baseline (P = 0.059). Six of these 7 patients had been treated with high-dose IFN-α induction therapy. In multiple regression analysis, NT-proBNP was not related to other clinical parameters, biochemical parameters of liver disease or virus load and response to ***: Elevated levels of NT-proBNP during and after interferon-based antiviral therapy of chronic hepatitis c may indicate the presence of cardiac dysfunction, which may contribute to the clinical symptoms observed in patients during therapy. Plasma levels of NT-proBNP may be used as a diagnostic tool and for guiding therapy in patients during interferon-based antiviral therapy.

关键词： Hepatitis c N-terminal pro-brain natriuretic peptide Interferon cardiomyopathy Treatment side effects

The diagnostic and prognostic utility of the dual-task tandem gait test for pediatric concussion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2021年第2期10卷 131-137页

作者： Katie A.Van Deventer corrine N.Seehusen Gregory A.Walker Julie c.Wilson david R.Howell University of colorado School of Medicine AuroraCO 80045USA Sports Medicine center Children’s Hospital ColoradoAuroraCO 80045USA Department of Orthopedics University of Colorado School of MedicineAuroraCO 80045USA Department of Pediatrics University of Colorado School of MedicineAuroraCO 80045USA

Background:The tandem gait test has gained interest recently for assessment of concussion *** purpose of our study was to determine the prognostic and diagnostic use of the single-and dual-task tandem gait test,alongside other clinical measures,within 10 days of pediatric ***:We assessed 126 patients post-concussion(6.3§2.3 days post-injury,mean§SD)at a pediatric sports medicine clinic and compared them to 58 healthy controls(age:15.6§1.3 years;43%female).We also compared the 31 patients with concussion who developed persistent post-concussion symptoms(PPcS)(age=14.9§2.0 years;48%female)to the 81 patients with concussion who did not develop PPcS following the initial assessment(age:14.1§3.0 years;41%female).All subjects completed a test battery,and concussion patients were monitored until they experienced concussion-symptom *** test battery included tandem gait(single-task,dual-task(performing tandem gait while concurrently completing a cognitive test)conditions),modified Balance Error Scoring System(mBESS),and concussion symptom assessment(Health and Behavior Inventory).We defined PPcS as symptom resolution time>28 days post-concussion for the concussion *** outcomes included tandem gait time(single-and dual-task),dual-task cognitive accuracy,mBESS errors(single/double/tandem stances),and symptom ***:The concussion group completed the single-task(mean difference=9.1 s,95%confidential interval(95%cI):6.1-12.1)and dual-task(mean difference=12.7 s,95%cI:8.716.8)tandem gait test more slowly than the control *** to those who recovered within 28 days of concussion,the PPcS group had slower dual-task tandem gait test times(mean difference=7.9 s,95%cI:2.0-13.9),made more tandem-stance mBESS errors(mean difference=1.3 errors,95%cI:0.2-2.3),and reported more severe symptoms(mean difference=26.6 Health and Behavior Inventory rating,95%cI:21.1-32.6).conclusion:Worse dual-task tandem gait test time and mB

关键词： Adolescent Balance Mild traumatic brain injury Postural stability Prognosis

在线全文

学校读者我要写书评

暂无评论

cc趋化因子偶联受体信号途径(英文)

Acta Biochimica et Biophysica Sinica 2003年第9期35卷 779-788页

作者： NEW david c.,WONG Yung H. 香港科技大学生物化学系香港科技大学生物化学系九龙清水湾香港九龙清水湾香港

The isolation and characterization of multiple cc chemokine receptors (ccRs) in a wide range of tissues and cells signifies the functional diversity of cc chemokines. The realization that multiple chemokines activate individual receptors and that some chemokines are functional at several different ccRs, indicates that interplay between a complex network of intracellular pathways is required for the full expression of the physiological function of each ligand. In different cellular environments, chemokines can regulate distinct second messengers or even positively or negatively regulate the same signal transduction pathway. The specific interactions between many signalling molecules have been discerned in an increasing number of cellular systems and this information is being used to explain the physiological actions of chemokines. This review will attempt to summarize recent research by many groups that has revealed numerous subtleties of the cc chemokine-coupled signalling pathways.

关键词： cc chemokine receptor (ccR) chemokines chemotaxis G protein G protein-coupled receptor (GPcR)

convergent adaptation of the genomes of woody plants at the land–sea interface

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2020年第6期7卷 978-993页

作者： Ziwen He Shaohua Xu Zhang Zhang Wuxia Guo Haomin Lyu cairong Zhong david E.Boufford Norman c.Duke The International Mangrove consortium Suhua Shi State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant Resources Key Laboratory of Biodiversity Dynamics and Conservation of Guangdong Higher Education Institutes School of Life Sciences Sun Yat-Sen University Hainan Dongzhai Harbor National Nature Reserve Administration Harvard University Herbaria centre for Tropical Water and Aquatic Ecosystem Research James Cook University the consortium of 26 Institutions

Sequencing multiple species that share the same ecological niche may be a new frontier for genomic *** such studies should shed light on molecular convergence, genomic-level analyses have been unsuccessful, due mainly to the absence of empirical controls. Woody plant species that colonized the global tropical coasts, collectively referred to as mangroves, are ideal for convergence studies. Here, we sequenced the genomes/transcriptomes of 16 species belonging in three major mangrove clades. To detect convergence in a large phylogeny, a ccS+ model is implemented, extending the more limited ccS method(convergence at conservative sites). Using the empirical control for reference, the ccS+ model reduces the noises drastically, thus permitting the identification of 73 convergent genes with Ptrue(probability of true convergence) > 0.9. Products of the convergent genes tend to be on the plasma membrane associated with salinity tolerance. Importantly, convergence is more often manifested at a higher level than at amino-acid(AA) sites. Relative to >50 plant species, mangroves strongly prefer 4 AAs and avoid 5 others across the genome. AA substitutions between mangrove species strongly reflect these tendencies. In conclusion, the selection of taxa, the number of species and, in particular, the empirical control are all crucial for detecting genome-wide convergence. We believe this large study of mangroves is the first successful attempt at detecting genome-wide site convergence.

关键词： convergent evolution genome mangrove adaptive evolution woody plants

clinical outcomes of isolated renal failure compared to other forms of organ failure in patients with severe acute pancreatitis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第29期23卷 5431-5437页

作者： Amir Gougol Mohannad Dugum Anwar Dudekula Phil Greer Adam Slivka david c Whitcomb Dhiraj Yadav Georgios I Papachristou Division of Gastroenterology Hepatology and Nutrition Department of Medicine University of Pittsburgh

To assess differences in clinical outcomes of isolated renal failure (RF) compared to other forms of organ failure (OF) in patients with severe acute pancreatitis (SAP). METHODSUsing a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ (2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded. Differences in clinical outcomes after development of isolated RF in comparison to other forms of OF were determined using independent t and Mann-Whitney U tests for continues variables, and χ2 test for discrete variables. RESULTSAmong 500 patients with acute pancreatitis, 111 patients developed persistent OF: mean age was 54 years, and 75 (67.6%) were male. Forty-three patients had isolated OF: 17 (15.3%) renal, 25 (21.6%) respiratory, and 1 (0.9%) patient with cardiovascular failure. No differences in demographics, etiology of acute pancreatitis, systemic inflammatory response syndrome scores, or development of pancreatic necrosis were seen between patients with isolated RF vs isolated respiratory failure. Patients with isolated RF were less likely to require nutritional support (76.5% vs 96%, P = 0.001), IcU admission (58.8% vs 100%, P = 0.001), and had shorter mean IcU stay (2.4 d vs 15.7 d, P compared to isolated respiratory failure. None of the patients with isolated RF or isolated respiratory failure died. cONcLUSIONAmong patients with SAP per the Revised Atlanta classification, approximately 15% develop isolated RF. This subgroup seems to have a less protracted clinical course compared to other forms of OF. Isolated RF might be weighed less than isolated respiratory failure in risk predictive modeling of acute pancreatitis.

关键词： Renal failure Respiratory failure Organ failure Acute pancreatitis clinical outcomes