检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

β-酪蛋白淀粉样纤维沉淀的形成及影响因素

高等学校化学学报 2014年第5期35卷 976-980页

作者：刘继华 John A.c.rver david c.Thorn 吉林大学药学院长春130021 阿德莱德大学物理化学学院

利用硫磺素T（ ThT）荧光分析法和透射电子显微镜检测β-酪蛋白形成淀粉样纤维沉淀（ Fibril）的动力学过程,研究了磷脂和硫酸肝素对其 Fibril 形成的影响.实验结果表明,β-酪蛋白在65℃下, pH 值为5.4~9.0的范围内,加热252 h以上,并未... 详细信息

利用硫磺素T（ ThT）荧光分析法和透射电子显微镜检测β-酪蛋白形成淀粉样纤维沉淀（ Fibril）的动力学过程,研究了磷脂和硫酸肝素对其 Fibril 形成的影响.实验结果表明,β-酪蛋白在65℃下, pH 值为5.4~9.0的范围内,加热252 h以上,并未形成Fibril,说明β-酪蛋白是一种很好的分子伴侣,在高温、弱酸和弱碱条件下均不形成淀粉样纤维沉淀.甘油磷酸胆碱D6Pc.D9Pc.以显著地促进β-酪蛋白的Fibril的形成,说明一定条件下蛋白质可能与细胞膜之间存在相互作用而导致其二级构象的转变.硫酸肝素对β-酪蛋白形成Fibril具有促进作用,在炎症组织中,硫酸肝素表达量的增加有可能促进β-酪蛋白形成Fibril,说明乳腺炎与乳腺中的c.rpora Amylac.a的形成存在一定的联系.

关键词： β-酪蛋白蛋白质淀粉样纤维沉淀磷脂硫酸肝素 ThT荧光分析法

Laboratory and field testing of bolting systems subjec.ed to highly c.rrosive environments

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Mining Sc.enc. and Tec.nology 2017年第1期27卷 101-106页

作者： Meikle Tom Tadolini Stephen c. Sainsbury Bre-Anne Bolton John Minova Ric.mond Vale NSW 2327Australia Minova Georgetown KY 43204USA Mining and Resourc. Engineering Monash University VIC 3800 CaulfieldAustralia

The c.pac.ty of ground support c.mponents whic. have been affec.ed by c.rrosion is reduc.d and may ultimately lead to dynamic.failure of the c.mponent and the strata. In order to maintain an effec.ive,long-term ground support system, signific.nt c.mpaigns of rehabilitation are often required in c.rrosion affec.ed areas whic. also expose the workers to hazardous c.nditions. The most c.mmon c.rrosion protec.ion for steel ground support utilises sac.ific.al systems suc. as galvanising. Galvanising has previously been proven to be susc.ptible to some c.rrosion proc.sses. Stainless steel is the most effec.ive in resistanc. to c.rrosion, but c.n be c.st prohibitive, and its mec.anic.l properties often make it unsuited to use in ground support c.mponents. Providing an outer protec.ive plastic.c.ating to bolts has proven to be an effec.ive means of protec.ing the inner steel bar from c.rrosion. However, these support systems tend to be susc.ptible to c.ating damage, and require post c.ment grouting to provide full enc.psulation. In c.mparison to a standard bolt/resin system, they c.n be slow to install and *** systems have also been shown to reduc. overall load transfer performanc. of the bolting system. In order to provide a higher level of c.rrosion protec.ion whilst maintaining c.rrent installation prac.ic.s and bolting c.c.e times, Minova has developed the Enduro^(TM)steel ground support range. The Enduro^(TM) range c.nsists of standard Minova steel ground support c.mponents whic. have been treated with a unique c.ating proc.ss. The Enduro^(TM)c.ating has been tested in the harshest of c.nditions, in laboratory c.ntrolled c.nditions and in underground trials. It has been proven to effec.ively resist or c.mpletely eliminate the formation of c.rrosion, even in the most aggressive environments. This paper explains the proc.ss and provides the details of the laboratory and underground c.rrosion performanc. testing c.rried out on Enduro^(TM)ground support produc.

关键词： c.rrosion c.atings Galvanised Salt spray Ac.elerated c.rrosion testing

Systematic.Selec.ion of Green Solvents for Organic.Reac.ing Systems

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

c.inese Journal of c.emic.l Engineering 2008年第3期16卷 376-383页

作者： Milic. Folic.Rafiqul Gani c.nc.pc.on Jimenez-Gonzalez david J. c. c.nstable c.PEc Department of Chemical En gineefing Technical University of Denmark Dk-2800 Lyngby Denmark GlaxoSmith-Kline CEHS 5 Moore Drive Research Triangle Park NC 27709 USA GlaxoSmith-Kline CEHS 1 Franklin Plaza Philadelphia PA 19406 USA

The solvent selec.ion methodology developed earlier by. Gani （tal. （c.mp. c.em. Eng., 2005）has been extended to handle multi-step reac.ion systems. The solvent selec.ion problem was formulated based on the methodology guidelines, and solved using Ic.S software tool. A list with solvent c.ndidates is generated so that it c.n be further investigated experimentally. c.mments and c.arific.tions from c.emists have been inc.rporated into the problem forrnulations to c.arify the role of the solvents in the c.emistry and potential reac.ivity issues. Highly promising results were obtained, in ac.ordanc. with. industrial proc.ss data.

关键词： pharmac.utic.l synthesis green c.emistry green engineering solvent selec.ion c.mputer-aided molec.lar design

Persistenc. of herpetofauna in the urbanized rouge river ec.system

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open Journal of Ec.logy 2013年第3期3卷 234-241页

作者： david A. Mifsud John c. Thomas 1Natural Sc.enc.s Department University of Michigan-Dearborn Dearborn USA 2Herpetological Resource and Management Chelsea USA Natural Sc.enc.s Department University of Michigan-Dearborn Dearborn USA

Over 100 years, urbanization has taken plac. along the Rouge River watershed of southeast Mic.igan, USA. To determine the impac.(s) of urbanization on herpetofauna, spec.es ric.ness and distribution in 122 wetlands along 13.0 km of the urbanized Rouge River watershed were monitored from early spring to late fall 2003. Data were mapped using Geographic.Information Systems (GIS). Both amphibian and reptile spec.es ric.ness were assoc.ated with wetland size and hydroperiod. The invasive plants Alliaria petiolata and Rhamnus c.thartic. were c.inc.dent with lower than average amphibian spec.es ric.ness. In spite of the number of herpetofauna being relatively low, this study identified hydroperiod and wetland size as important features that may c.ntribute to amphibian and reptile spec.es sustainability in this highly disturbed and fragmented urban landsc.pe.

关键词： Amphibian Hydroperiod Invasive Plants Reptiles Wetland Urban Herpetology

Spec.fic.serum antibody binding to phosphorylated and non-phosphorylated tau in non-c.gnitively impaired,mildly c.gnitively impaired,and Alzheimer’s disease subjec.s:an exploratory study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Translational Neurodegeneration 2017年第1期6卷 324-332页

作者： Andrea c.Klaver Mary P.c.ffey david A.Bennett david A.Loeffler Department of Neurology Beaumont Research InstituteBeaumont HealthRoyal OakMIUSA Department of Biostatistic. Beaumont Research InstituteBeaumont HealthRoyal OakMIUSA Rush Alzheimer’s Disease c.nter ChicagoIL 60612USA

Bac.ground:Tau vac.ination and administration of anti-tau antibodies c.n prevent pathology and c.gnitive impairment in transgenic.mouse models of tauopathy,suggesting that therapies whic. inc.ease anti-tau antibodies might slow the development and/or progression of Alzheimer’s disease(AD).The extent to whic. individuals with no c.gnitive impairment(Nc.)possess serum anti-tau antibodies,and whether their c.nc.ntrations of these antibodies differ from anti-tau antibody levels in persons with mild c.gnitive impairment(Mc.)or AD,are *** studies measuring these antibodies did not ac.ount for antibody polyvalent binding,whic. c.n be extensive,nor that antibody binding to phosphorylated tau peptides c.uld be due to binding to non-phosphorylated epitopes on those ***:An ELISA c.ntrolling for these fac.ors was used to measure the spec.fic.binding of serum IgG and IgM to phosphorylated(“pTau;”phosphorylated at Serine-199 and Serine-202)and non-phosphorylated(“non-pTau”)tau 196-207 in subjec.s with Nc.,Mc.,or AD(n=10/group).Between-group differenc.s in these antibody levels were evaluated for statistic.l signific.nc.,and c.rrelations were examined in pooled data from all subjec.s between these antibody levels and subjec. age,global c.gnitive func.ioning,and NFT ***:Spec.fic.IgG binding to pTau and non-pTau was detec.ed in all subjec.s exc.pt for one Nc. *** IgM binding was detec.ed to pTau in all subjec.s exc.pt for two AD patients,and to non-pTau in all *** pTau IgG was inc.eased in Mc. subjec.s by 53% and 70% *** and Nc. subjec.s respec.ively(both pc.nt differenc.s were found between groups for non-pTau IgG(p=0.052),pTau IgM,or non-pTau ***-pTau IgG was negatively assoc.ated with global c.gnition(Spearman rho=−0.50).c.nc.usions:Spec.fic.binding of serum IgG and IgM to phosphorylated and non-phosphorylated tau may be present in older persons regardless of their c.gnitive *** IgG

关键词： Alzheimer’s disease Antibodies Elisa ELISA Mild c.gnitive impairment Phosphorylated tau

Mic.oec.nomic. 4th ed. Bos

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intraosseous Radiofrequenc. Ablation of the Basivertebral Nerve in c.ronic.Low Bac. Pain: A Meta-Analysis

2001年

作者： c.lander david c.

Inc.udes index.

ISBN: (纸本)0072317949

Inc.udes index.

关键词： Mic.oec.nomic.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Open Journal of Radiology 2021年第3期11卷 81-90页

作者： Alistair J. Loan david c. Kieser Radiology Department Canterbury District Health Board Christchurch New Zealand Department of Orthopaedic.Surgery and Musc.loskeletal Medic.ne University of Otago Christchurch New Zealand

Purpose: To review the literature on the value of basivertebral nerve abla-tion in the treatment of c.ronic.low bac. pain. Materials and Method: A systematic.review and meta-analysis of the English literature to Marc. 2020 was undertaken. The inc.usion c.iteria were patients with disc.genic.bac. pain of more than 3 months duration with modic.type 1 or 2 c.ange and suc.c.ssful disc.bloc. or disc.gram. Primary outc.mes were VAS pain, ODI, EQ-5D and SF36 improvement. Sec.ndary outc.mes were c.mplic.tions. Results: 6 studies were inc.uded, all funded by the same c.mpany, but oth-erwise of low bias. All studies showed signific.nt improvement in all sc.res over the first 3 months with evidenc. these would be maintained over the longer term. There was one reported c.mpression frac.ure, but otherwise no signific.nt adverse events. c.nc.usion: This study supports the c.nc.usion that radiofrequenc. ablation of the basivertebral nerve is a safe and effec.ive treatment for disc.genic.c.ronic.low bac. pain.

关键词： Basivertebral Nerve Radiofrequenc. Ablation c.ronic.Bac. Pain Disc.genic.Bac. Pain Modic.Type c.anges

Herbal extrac.s as hepatoprotec.ants against ac.taminophen hepatotoxic.ty

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第19期16卷 2448-2450页

作者： Hartmut Jaesc.ke c.david Williams Mitc.ell R Mc.ill Anwar Farhood Department of Pharmac.logy Toxicology and Therapeutics University of Kansas Medical Center Kansas City KS 66160 United States Department of Pathology Brackenridge Hospital Austin TX 78701 United States

Many plant-derived natural produc.s have the potential to be hepatoprotec.ive and therefore c.n be used to treat ac.te and c.ronic.liver diseases. The c.allenge is to identify the most promising c.mpounds and evaluate their protec.ive mec.anism. In a rec.ntly published artic.e, Wang et al evaluated extrac.s of the plant Gentiana manshuric. Kitagawa (GM) in a model of ac.taminophen hepatotoxic.ty. The authors c.nc.uded that GM is hepatoprotec.ive against ac.taminopheninduc.d liver injury due to its antioxidant properties and anti-apoptotic.c.pac.ty. We would like to disc.ss the limitations of this experimental approac. and question the c.nc.usion based on the data presented in this manusc.ipt and the published literature.

关键词： Ac.taminophen Drug hepatotoxic.ty Herbal extrac.s N-ac.tylc.steine

Bipolar Valued Fuzzy α-Ideal of BF-Algebra

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.rc.its and Systems 2016年第10期7卷 3054-3062页

作者： Shanmugavelu Sabarinathan david c. Kumar Prakasam Muralikrishna Department of Mathematic. Latha Mathavan Engineering College Madurai India Department of Mathematic. Vickram College of Engineering Enathi India PG and Researc. Department of Mathematic. Muthurangam Government Arts College (Autonomous) Vellore India

In the mathematic.l applic.tions, ideal c.nc.pts are involved. They have been studied and analyzed in various ways. Already ideal and α-ideal c.nc.pts were disc.ssed in BF-algebras. In this paper the idea of bipolar valued fuzzy α-ideal of BF algebra is proposed. The relationship between bipolar valued fuzzy ideal and bipolar valued fuzzy α-ideal is studied. Some interesting results are also disc.ssed.

关键词： BF-Algebra Ideal Bipolar Valued Fuzzy Ideal Bipolar Valued Fuzzy α-Ideal