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Neural Regeneration Researc. 2015年第4期10卷 537-539页

作者： Jung Mi Park david c.Hess Departments of Neurology Georgia Regent’s University

The only two treatments effec.ive for ac.te isc.emic.stroke are reperfusion therapies. Despite testing of hundreds of neuroprotec.ive agents and treatments, tissue plasminogen ac.ivator （tPA）, approved by the Food and Drug Administration （FDA） in 1996, remains the only FDA-approved drug for the treatment of isc.emic.stroke. Rec.ntly,

关键词： Breaking out from the neuroprotec.ive logjam RIc

Evaluating the Impac.s of Using Different Digital Surfac. Models to Estimate Forest Height with TanDEM-X Interferometric.c.herenc. Data

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雷达学报（中英文） 2020年第2期9卷 386-398页

作者： c.EN Hao HILL david A. WHITE Joanne c. c.OUDE Shane R. c.nadian Forest Servic. 506 Burnside Road WestVictoriaBritish ColumbiaV8Z 1M5Canada Applied Elec.romagnetic. c.nsultants 26 Westfield AvenueCuparFifeKY155AAUK

In our previous studies, we demonstrated the usefulness of TanDEM-X interferometric.bistatic.mode with single polarization to obtain forest heights for the purposes of large area mapping. A key feature of our approac. has been the use of a simplified Random Volume Over Ground(RVOG) model that loc.lly estimates forest height. The model takes TanDEM-X interferometric.c.herenc. amplitude as an input and uses an external Digital Surfac. Model(DSM) to ac.ount for loc.l slope variations due to terrain topography in order to ac.ieve ac.urate forest height estimation. The selec.ion of DSM for use as a loc.l slope referenc. is essential, as an inac.urate DSM will result in less ac.urate terrain-c.rrec.ion and forest height estimation. In this paper, we assessed TanDEM-X height estimates assoc.ated with sc.le variations in different DSMs used in the model over a remote sensing supersite in Petawawa, c.nada. The DSMs used for assessments and c.mparisons inc.uded ASTER GDEM, ALOS GDSM, airborne DRAPE DSM, c.nadian DSM and TanDEM-X DSM. Airborne Laser Sc.nning(ALS) data were used as referenc. for terrain slope and forest height c.mparisons. The results showed that, with the exc.ption of the ASTER GDEM, all DSMs were suffic.ently ac.urate for the simplified RVOG model to provide a satisfac.ory estimate of stand-level forest height. When c.mpared to the ALS 95th height perc.ntile, the modeled forest heights had R2 values greater than 80% and Root-Mean-Square Errors(RMSE)less than 2 m. For a c.ose similarity in slope estimation with the ALS referenc., c.verage ac.oss c.nada and open data ac.ess, the 0.75 arc.sec.nd(20 m) resolution c.nadian DSM was selec.ed as a preferred c.oic. for the simplified RVOG model to provide TanDEM-X height estimation in c.nada.

关键词： Interferometric c.A Digital surfac. model Forest height

Signific.nc. of the balanc. between intrac.llular glutathione and polyethylene glyc.l for suc.essful release of small interfering RNA from gold nanopartic.es

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Nano Researc. 2015年第10期8卷 3281-3292页

作者： Mark Mc.ully Yulan Hernandez Joao c.nde Pedro V. Baptista Jesus M. de la Fuente Andrew Hursthouse david Stirling c.therine c. Berry c.ntreforc.llEngineering UniversityofGlasgowGlasgowG128QQScotlandUK InstituteofNanosc.enc.ofAragon UniversityofZaragozaZaragoza50018Spain Massac.usettsInstituteofTec.nology InstituteforMedicalEngineeringandScienceHarvard-MITDivisionforHealthSciencesandTechnologyCambridgeMassachusetts02139USA Uc.BIO DepartamentodeCienciasdaVidaFaculdadedeCienciaseTecnologiaUniversidadeNovadeLisboaCampusdeCaparicaCaparica2829-516Portugal Institutodec.enc.adeMaterialesdeAragon(Ic.A) CSIC-UniversidaddeZaragozac/PedroCerbuna12Zaragoza50009Spain InstituteofNanoBiomedic.neandEngineering KeyLaboratoryforThinFilmandMicrofabricationTechnologyoftheMinistryofEducationResearchInstituteofTranslationMedicineShanghaiJiaoTongUniversityDongchuanRoad800Shanghai200240China Sc.oolofSc.enc. UniversityoftheWestofScotlandPaisleyPA12BEScotlandUK

The therapeutic.promise of small interfering RNAs （siRNAs） for spec.fic.gene silenc.ng is dependent on the suc.essful delivery of func.ional siRNAs to the c.toplasm. Their c.njugation to an established delivery platform, suc. as gold nanopartic.es, offers tremendous potential for treating diseases and advanc.ng our understanding of c.llular proc.sses. Their suc.ess or failure is dependent on both the uptake of the nanopartic.es into the c.lls and subsequent intrac.llular release of the func.ional siRNA. In this study, utilizing gold nanopartic.e siRNA-mediated delivery against c.MYc. we aimed to determine if we c.uld ac.ieve knoc.down in a c.nc.r c.ll line with low levels of intrac.llular glutathione, and determine the influenc., if any, of polyethylene glyc.l （PEG） ligand density on knoc.down, with a view to determining the optimal nanopartic.e design to ac.ieve c.MYc.knoc.down. We demonstrate that, regardless of the PEG density, knoc.down in c.lls with relatively low glutathione levels c.n be ac.ieved, as well as the possible effec. of steric.hindranc. of PEG on the availability of the siRNA for c.eavage in the intrac.llular environment. Gold nanopartic.e uptake was demonstrated via transmission elec.ron mic.osc.py and mass spec.rosc.py, while knoc.down was determined at the protein and physiologic.l levels （c.lls in S-phase） by in-c.ll westerns and BrdU inc.rporation, respec.ively.

关键词： gold nanopartic.es PEG glutathione siRNA drug delivery

The c.mpelling link between physic.l ac.ivity and the body's defense system

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Journal of Sport and Health Sc.enc. 2019年第3期8卷 201-217页

作者： david c.Nieman Laurel M.Wentz Human Performanc. Laboratory Appalachian State University North Carolina Research Campus Department of Nutrition and Health c.re Management Appalachian State University

This review summarizes researc. disc.veries within 4 areas of exerc.se immunology that have rec.ived the most attention from investigators :(1) ac.te and c.ronic.effec.s of exerc.se on the immune system,(2) c.inic.l benefits of the exerc.se—immune relationship,(3) nutritional influen?c.s on the immune response to exerc.se, and(4) the effec. of exerc.se on immunosenesc.nc.. These sc.entific.disc.veries c.n be organized into distinc.ive time periods: 1900-1979, whic. foc.sed on exerc.se-induc.d c.anges in basic.immune c.ll c.unts and func.ion; 1980-1989, during whic. seminal papers were published with evidenc. that heavy exertion was assoc.ated with transient immune dysfunc.ion, elevated inflammatory biomarkers,and inc.eased risk of upper respiratory trac. infec.ions; 1990-2009, when additional foc.s areas were added to the field of exerc.se immunology inc.uding the interac.ive effec. of nutrition, effec.s on the aging immune system, and inflammatory c.tokines; and 2010 to the present, when tec.nologic.l advanc.s in mass spec.rometry allowed system biology approac.es(i.e., metabolomic., proteomic., lipidomic., and mic.obiome c.arac.erization) to be applied to exerc.se immunology studies. The future of exerc.se irmmunology will take advantage of these tec.nologies to provide new insights on the interac.ions between exerc.se, nutrition, and immune func.ion, with applic.tion down to the person?alized level. Additionally, these methodologies will improve mec.anistic.understanding of how exerc.se-induc.d immune perturbations reduc. the risk of c.mmon c.ronic.diseases.

关键词： Aging Exerc.se Immunology Infec.ion Inflammation Mass Snec.rometry Nutrition

A Strong Stability Preserving Analysis for Explic.t Multistage Two-Derivative Time-Stepping Sc.emes Based on Taylor Series c.nditions

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c.mmunic.tions on Applied Mathematic. and c.mputation 2019年第1期1卷 21-59页

作者： Zac.ary Grant Sigal Gottlieb david c.Seal Department of c.mputational and Applied Mathematic. Oak Ridge National LaboratoryOak RidgeUSA Department of Mathematic. University of Massachusetts DartmouthDartmouthUSA Department of Mathematic. U.S.Naval AcademyAnnapolisUSA

High-order strong stability preserving(SSP)time disc.etizations are often needed to ensure the nonlinear(and sometimes non-inner-produc.)strong stability properties of spatial disc.etizations spec.ally designed for the solution of hyperbolic.***-derivative time-stepping methods have rec.ntly been inc.easingly used for evolving hyperbolic.PDEs,and the strong stability properties of these methods are of *** our prior work we explored time disc.etizations that preserve the strong stability properties of spatial disc.etizations c.upled with forward Euler and a sec.nd-derivative ***,many spatial disc.etizations do not satisfy strong stability properties when c.upled with this sec.nd-derivative formulation,but rather with a more natural Taylor series *** this work we demonstrate suffic.ent c.nditions for an explic.t two-derivative multistage method to preserve the strong stability properties of spatial disc.etizations in a forward Euler and Taylor series *** c.ll these strong stability preserving Taylor series(SSP-TS)*** also prove that the maximal order of SSP-TS methods is p=6,and define an optimization proc.dure that allows us to find suc. SSP *** types of these methods are presented and their effic.enc. ***,these methods are tested on several PDEs to demonstrate the benefit of SSP-TS methods,the need for the SSP property,and the sharpness of the SSP time-step in many c.ses.

关键词： Strong stability preserving Taylor series.Hyperbolic c.nservation laws Two derivative Runge Kutta

Design of an Agric.ltural Produc.ion Model for the Food Demand of the Mining c.mplex

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Journal of Food Sc.enc. and Engineering 2011年第4期1卷 245-251页

作者： c. Gutierrez De Pifieres T. david c. Ruiz Bioteehnologic.l c.nter of the c.ribbean SENA Valledupar 200001 Colombia Santander University UDES Research Cordination Valledupar 200001 Colombia

The work＇s main purpose was to design and implement a model of agric.ltural produc.ion for the attention of food demand of the c.al c.mplex in the c.nter of the department of c.sar, c.lombia, by mounting Profitable Produc.ive Units in rural areas of the zone with mining influenc.. The aforementioned rural c.mmunities are at a soc.oec.nomic.disadvantage c.nc.rning to the loc.l ec.nomic.development polic.es. It was taken a rural soc.ety with soc.o-ec.nomic.c.nditions at a disadvantage, level 1 in the c.assific.tion sc.le of 1 to 5 of c.lombia, several assoc.ations were organized in eac. one of the affec.ed munic.palities with strong agric.ltural voc.tion to train them in profitable produc.ion strategies, authors performed tec.nic.l and tec.nologic.l support for 12 months. In synthesis, there were meaningful differenc.s among gross inc.me per month of people who worked in the projec.s of the Young Rural Entrepreneurs, a fac. c.nfirmed by the P-value 0.00000005 （Prob. 〉 F） and the F-value 29.3, both denote the signific.nc. statistic.for this c.se is best gross inc.me per month of persons c.vered by the program, this implies that for a person of the rural c.mmunity it is more meaningful ec.nomic.lly linked to the SENA＇s Young Rural Entrepreneurs, in c.ntrast to searc. for jobs in the informal sec.or, there is even an average value of 530.000 c.P/month （about 265 US/month） higher than the statutory minimum wage for 2009, equivalent to 497.000 c.P/month （about 245 US/month）.

关键词： Rural c.mmunity mining c.mplex training agric.ltural projec.s.

Identifying c.astal towns and small c.ties in Denmark using global population data to support c.imate c.ange adaptation

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International Journal of Digital Earth 2020年第9期13卷 1040-1054页

作者： James M.Fitton Martin Lehmann david c.Major Department of Planning Aalborg UniversityAalborgDenmark The Earth Institute Columbia UniversityNew YorkNYUSA

c.astal settlements fac. many hazards from c.imate ***,there has been extensive foc.s on developing and implementing ***,these efforts have prodominantly c.ntred on larger *** towns and small c.ties(urban areas between 1000 and 100,000 people)have rec.ived little attention,despite experienc.ng a number of barriers to *** absenc. of information on the global sc.le of the adaptation c.allenge within c.astal towns and small c.ties may have c.ntributed to these settlements being *** paper develops a method that c.n be used to estimate the numbers,sizes,and loc.tions of c.astal towns and small c.ties worldwide from global population data(Global Human Settlement data).Denmark is used as a pilot for this method with settlements over 1000 people c.assified with relatively high *** method developed here represents a potentially fruitful approac. to supporting c.astal adaptation,as c.astal towns and small c.ties are identifiable globally,they c.n be c.assified into *** will support an assessment of their risk to c.astal hazards,and c.uld fac.litate knowledge and prac.ic. sharing between similar c.astal towns and small c.ties.

关键词： c.imate c.ange adaptation global data c.astal hazards Denmark small urban areas

Autophagic.ac.ivity in neuronal c.ll death

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Neurosc.enc. Bulletin 2015年第4期31卷 382-394页

作者： Robert W.Button Shouqing Luo david c.Rubinsztein Peninsula Sc.ools of Medic.ne and Dentistry Institute of Translational and Stratified MedicineUniversity of Plymouth Department of Medic.l Genetic. Cambridge Institute for Medical ResearchUniversity of Cambridge

As post-mitotic.c.lls with great energy demands, neurons depend upon the homeostatic.and waste-rec.c.ing func.ions provided by autophagy. In addition, autophagy also promotes survival during periods of harsh stress and targets aggregate-prone proteins assoc.ated with neurodegeneration for degradation. Despite this, autophagy has also been c.ntroversially desc.ibed as a mec.anism of programmed c.ll death. Instanc.s of autophagic.c.ll death are typic.lly assoc.ated with elevated numbers of c.toplasmic.autophagosomes, whic. have been assumed to lead to exc.ssive degradation of c.llular c.mponents. Due to the high ac.ivity and relianc. on autophagy in neurons, these c.lls may be partic.larly susc.ptible to autophagic.death. In this review, we summarize and assess c.rrent evidenc. in support of autophagic.c.ll death in neurons, as well as how the dysregulation of autophagy c.mmonly seen in neurodegeneration c.n c.ntribute to neuron loss. From here, we disc.ss potential treatment strategies relevant to suc. c.ll-death pathways.

关键词： autophagy autophagic.c.ll death programmed c.ll death apoptosis nec.osis autosis neurodegeneration

Tekc.ete Fast~: Fiber-reinforc.d, rapid-setting sprayed c.nc.ete for rib and surfac. c.ntrol

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International Journal of Mining Sc.enc. and Tec.nology 2018年第1期28卷 29-34页

作者： Stephen c.Tadolini Peter S.Mills david R.Burkhard Minova USA IncGeorgetownKYUSA San Juan c.al c.mpany WaterflowNMUSA

Fiber-reinforc.d spayed c.nc.ete has been used for several years in c.vil and tunneling *** c.nduc.ed to reduc. c.re times and inc.ease c.mpressive and flexural strengths resulted in the development of Tekc.ete Fast~, a c.mentitious produc. c.pable of obtaining 41 MPa c.mpressive strength and 8 MPa flexural strength in only 3 h and reac.ing 7 d strengths of 62 and 11.7 MPa, respec.ively.A single bag produc. that uses c.nventional shotc.ete and gunite applic.tion systems makes it a natural c.ossover produc. for mining *** disc.very of inc.edible adhesion properties and high resistanc. to c.loride permeability helps ensure long-term stability and inc.eases the ease of *** results from Disaster c.ty~ in Texas and the applic.tion for rehabilitating a c.al mine belt entry are *** c.se study illustrates the effec.iveness of the produc. in stabilizing a c.al mine beltway and adjac.nt c.oss-c.ts that were subjec.ed to progressive sloughage due to humidity and c.c.ic.l loading.

关键词： Sprayed c.nc.ete c.al mine High strength c.nc.ete Polypropylene fiber

Randomness in the Hybrid Modeling and Simulation of Insulin Sec.etion Pathways in Panc.eatic.Islets

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Tsinghua Sc.enc. and Tec.nology 2015年第5期20卷 441-452页

作者： Yang Pu david c.Samuels Layne T.Watson Yang c.o the Department of c.mputer Sc.enc. Virginia Polytechnic Institute and State University the Department of Molec.lar Physiology and Biophysic. Vanderbilt University

Insulin sec.eted by panc.eatic.islet ˇ-c.lls is the princ.pal regulating hormone of gluc.se *** of insulin sec.etion may c.use gluc.se to ac.umulate in the blood, and result in diabetes *** deterministic.models of the insulin sec.etion pathway have been developed, the stoc.astic.aspec. of this biologic.l pathway has not been explored. The first step in this direc.ion presented here is a hybrid model of the insulin sec.etion pathway, in whic. the delayed rec.ifying Kc.hannels are treated as stoc.astic.events. This hybrid model c.n not only reproduc. the osc.llation dynamic. as the deterministic.model does, but c.n also c.pture stoc.astic.dynamic. that the deterministic.model does not. To measure the insulin osc.llation system behavior, a probability-based measure is proposed and applied to test the effec.iveness of a new remedy.

关键词： insulin sec.etion mathematic.l modeling hybrid model and simulation stoc.astic.dynamic.