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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Software, Software Engineering and Software Engineering Research: Some Unconventional Thoughts

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Journal of Computer Science & Technology 2009年第2期24卷 189-197页

作者： david Notkin Computer Science and Engineering University of Washington Seattle

Software engineering is broadly discussed as falling far short of expectations. Data and examples are used to justify how software itself is often poor, how the engineering of software leaves much to be desired, and how research in software engineering has not made enough progress to help overcome these weaknesses. However, these data and examples are presented and interpreted in ways that are arguably imbalanced. This imbalance, usually taken at face value, may be distracting the field from making significant progress towards improving the effective engineering of software, a goal the entire community shares. Research dichotomies, which tend to pit one approach against another, often subtly hint that there is a best way to engineer software or a best way to perform research on software. This, too, may be distracting the field from important classes of progress.

关键词： software engineering/general software engineering process/life cycle

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

The functional properties of synapses made by regenerated axons across spinal cord lesion sites in lamprey

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Neural Regeneration Research 2022年第10期17卷 2272-2277页

作者： david Parker Department of Physiology Developmentand NeuroscienceUniversity of CambridgeCambridgeUK

While the anatomical properties of regenerated axons across spinal cord lesion sites have been studied extensively,little is known of how the functional properties of regenerated synapses compared to those in unlesioned *** study aims to compare the properties of synapses made by regenerated axons with unlesioned axons using the lamprey,a model system for spinal injury research,in which functional locomotor recovery after spinal cord lesions is associated with axonal regeneration across the lesion *** synapses below the lesion site did not differ from synapses from unlesioned axons with respect to the amplitude and duration of single excitatory postsynaptic *** also showed the same activity-dependent depression over spike ***,regenerated synapses did differ from unlesioned synapses as the estimated number of synaptic vesicles was greater and there was evidence for increased postsynaptic quantal *** axons above the lesion site,the amplitude and duration of single synaptic inputs also did not differ significantly from unlesioned ***,in this case,there was evidence of a reduction in release probability and inputs facilitated rather than depressed over spike *** inputs from single regenerated axons below the lesion site thus do not increase in amplitude to compensate for the reduced number of descending axons after functional ***,the postsynaptic input was maintained at the unlesioned level using different synaptic ***,the facilitation from the same initial amplitude above the lesion site made the synaptic input over spike trains functionally *** may help to increase propriospinal activity across the lesion site to compensate for the lesion-induced reduction in supraspinal *** animal experiments were approved by the Animal Ethics Committee of Cambridge University.

关键词： electrophysiology lamprey plasticity regeneration reticulospinal axon spinal cord spinal injury synapse

Conversion of Solar Energy to Fuels by Inorganic Heterogeneous Systems

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催化学报 2011年第6期32卷 879-890页

作者： Kimfung LI david MARTIN Department of Chemical Engineering University College LondonTorrington PlaceLondonWC1E 7JEUK

Over the last several years,the need to find clean and renewable energy sources has increased rapidly because current fossil fuels will not only eventually be depleted,but their continuous combustion leads to a dramatic increase in the carbon dioxide amount in *** of the Sun's radiation can provide a solution to both *** fuel can be generated by using solar energy to split water,and liquid fuels can be produced via direct CO2 *** would create an essentially free carbon or at least carbon neutral energy *** this tutorial review,the current progress in fuels' generation directly driven by solar energy is *** mechanisms are discussed with suggestions for future research.

关键词：固体超强碱氧化钙硝酸钾氧化铝氧化锆氢氧化钾硝酸钙

Experimental Study of An Aquaculture Net Cage in Waves and Current

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China Ocean Engineering 2015年第3期29卷 325-340页

作者： david KRISTIANSEN Pal LADER Фsten JENSEN david FREDRIKSSON SINTEF Fisheries and Aquaculture United States Naval Academy

Model experiments of a floating fish cage subjected to waves and current have been performed. The objective was to study the dynamic behaviour of the fish cage model in waves and current. The fish cage model was composed of a model net, a flexible floating collar of the circular plastic type and a weight system. It was found that there are many wave periods in which cancellation of the wave-induced forces on the model occur. These cancellation wave periods are within the range of dimensioning wave periods commonly used for testing of fish farm structures and hence are important to be aware of. Large deformations of the net under realistic wave and current conditions were observed, where contact between the net and other parts of the structure were identified. This may cause damages to the net due to abrasion.

关键词： aquaculture structure hydrodynamic loads hydroelasticity

The use of mathematics in software quality assurance

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Frontiers of Computer Science 2012年第1期6卷 3-16页

作者： david Lorge PARNAS Middle Road Software Inc. Ottawa K1V 1V5 Canada

The use of mathematics for documenting, in- specting, and testing software is explained and illus- trated. Three measures of software quality are described and discussed. Then three distinct complementary approaches to software quality assurance are presented. A case study, the testing and inspection of a safety-critical system, is discussed in detail.

关键词： software quality assurance documentationbased inspection documentation based testing

Late Ordovician Mass Extinction: Earth, fire and ice

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National Science Review 2024年第1期11卷 51-65页

作者： david A.T.Harper Palaeoecosystems Group Department of Earth SciencesDurham University

The Late Ordovician Mass Extinction was the earliest of the ‘big’ five extinction events and the earliest to affect the trajectory of metazoan life. Two phases have been identified near the start of the Hirnantian period and in the middle. It was a massive taxonomic extinction, a weak phylogenetic extinction and a relatively benign ecological extinction. A rapid cooling, triggering a major ice age that reduced the temperature of surface waters, prompted a drop in sea level of some 100 m and introduced toxic bottom waters onto the shelves. These symptoms of more fundamental planetary processes have been associated with a range of factors with an underlying driver identified as volcanicity. Volcanic eruptions, and other products, may have extended back in time to at least the Sandbian and early Katian, suggesting the extinctions were more protracted and influential than hitherto documented.

关键词： Ordovician LOME paleoecology palaeobiogeography biotas