检索结果-南通市图书馆

NetPrune:A sparklines visualization for network pruning

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Visual Informatics 2023年第2期7卷 85-99页

作者： Luc-Etienne Pommé Romain Bourqui Romain Giot Jason Vallet david auber Univ.Bordeaux CNRSBordeaux INPINRIALaBRIUMR 5800F-33400 TalenceFrance

Current deep learning approaches are cutting-edge methods for solving classification *** transfer learning techniques allows applying large generic model to simple tasks whereas simpler models could be *** models raise the major problem of their memory consumption and processor usage and lead to a prohibitive ecological *** that paper,we present a novel visual analytics approach to interactively prune those networks and thus limit that *** technique leverages a novel sparkline matrix visualization technique as well as a novel local metric which evaluates the discriminatory power of a filter to guide the pruning process and make it *** assess the well-founded of our approach through two realistic case studies and a user *** both of them,the interactive refinement of the model led to a significantly smaller model having similar prediction accuracy than the original one.

关键词： Explainable pruning Guided Fine-tuning Visualization Deep learning

Making bridges between preclinical and clinical insights into age-related cognitive decline

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Women in visual neural regeneration research

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Toward automatic comparison of visualization techniques:Application to graph visualization

在线全文

学校读者我要写书评

暂无评论

Visual Informatics 2020年第2期4卷 86-98页

作者： L.Giovannangeli R.Bourqui R.Giot D.auber LaBRI UMR CNRS 5800 University of BordeauxFrance

Many end-user evaluations of data visualization techniques have been run during the last *** results are cornerstones to build efficient visualization ***,designing such an evaluation is always complex and time-consuming and may end in a lack of statistical evidence and *** believe that modern and efficient computer vision techniques,such as deep convolutional neural networks(CNNs),may help visualization researchers to build and/or adjust their evaluation *** basis of our idea is to train machine learning models on several visualization techniques to solve a specific *** assumption is that it is possible to compare the efficiency of visualization techniques based on the performance of their corresponding *** current machine learning models are not able to strictly reflect human capabilities,including their imperfections,such results should be interpreted with ***,we think that using machine learning-based preevaluation,as a pre-process of standard user evaluations,should help researchers to perform a more exhaustive study of their design ***,it should improve their final user evaluation by providing it better test *** this paper,we present the results of two experiments we have conducted to assess how correlated the performance of users and computer vision techniques can *** study compares two mainstream graph visualization techniques:node-link(NL)and adjacency-matrix(AM)*** two well-known deep convolutional neural networks,we partially reproduced user evaluations from Ghoniem et *** from Okoe et al..These experiments showed that some user evaluation results can be reproduced automatically.

关键词： Visualization Machine learning Deep learning Automatic evaluation Graph drawing

Transformation of leather waste into microwave-activated and N-doped carbon for Li-S batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

新型炭材料(中英文) 2025年

作者： Carolina Pano-Azucena Roberto Rosas-Rangel Miguel Olvera-Sosa david Salvador González-González Rene Rangel-Mendez Luis Felipe Chazaro-Ruiz Miguel Avalos-Borja Javier Antonio Arcibar-Orozco CIATEC.Center for Applied Innovation in Competitive Technologies Tecnologico de Monterrey School of Engineering and Sciences Instituto Potosino de Investigación Científica y Tecnológica Universidad Autónoma de Coahuila Facultad de SistemasCiudad Universitaria

The use of carbon from waste biomass has the potential to buffer the drawbacks of Li-S batteries and improve their overall performance. Chrome-Tanned-LeatherShavings(CTLS) are undesirable wastes, highly available for transformation into porous carbon. Microwave activation is an efficient state-of-the-art procedure to obtain unique porous structures and nitrogen incorporation can improve the performance of porous carbons. This study proposes the transformation of CTLS into a microwave activated porous carbon, and then was modified to introduce nitrogen. A microporous activated carbon with a specific surface area of 556 m2g-1 with honeycomb-like structure was obtained. Both urea thermal decomposition and ethanolamine impregnation improves the nitrogen and amine presence of surface groups. However,the results indicated that only urea treatment was effective in improving the initial capacity of the cell(1363 mAhg-1), which is probably linked with the sorption of long-chain polysulfides. This investigation confirms that it is possible to obtain carbon materials from CTLS, for use as sulfur-host cathodes in Li-S batteries, and improve their performance with urea thermal decomposition. Furthermore, a Radial basis function neural network was fitted to provide statistical support to the experimental results. The trained model corroborated the importance of nitrogen content of the carbons in the discharge capacity of the cells.

关键词：

Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl LászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller david Hercher Department Life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria Ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGCs). However, the use of tNGCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). Given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGCs and compared the various features of these improved silk^(+) tNGCs with the tubes without holes(silk^(–) tNGCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNGCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Hybrid de novo genome assembly of red gromwell(Lithospermum erythrorhizon)reveals evolutionary insight into shikonin biosynthesis

在线全文

学校读者我要写书评

暂无评论

Horticulture Research 2020年第1期7卷 1651-1665页

作者： Robert P.auber Thiti Suttiyut Rachel M.McCoy Manoj Ghaste Joseph W.Crook Amanda L.Pendleton Joshua R.Widhalm Jennifer H.Wisecaver Department of Biochemistry Purdue UniversityWest LafayetteIN 47907USA Purdue Center for Plant Biology Purdue UniversityWest LafayetteIN 47907USA Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN 47907USA

Lithospermum erythrorhizon(red gromwell;zicao)is a medicinal and economically valuable plant belonging to the Boraginaceae *** from *** have been used for centuries based on the antiviral and woundhealing properties produced from the bioactive compound shikonin and its *** recently,shikonin,its enantiomer alkannin,and several other shikonin/alkannin derivatives have collectively emerged as valuable natural colorants and as novel drug *** several transcriptomes and proteomes having been generated from ***,a reference genome is still *** has limited investigations into elucidating the shikonin/alkannin pathway and understanding its evolutionary and ecological *** this study,we obtained a de novo genome assembly for *** using a combination of Oxford Nanopore long-read and Illumina short-read sequencing *** resulting genome is∼367.41 Mb long,with a contig N50 size of 314.31 kb and 27,720 predicted protein-coding *** the *** genome,we identified several additional phydroxybenzoate:geranyltransferase(PGT)homologs and provide insight into their evolutionary *** analysis of prenyltransferases suggests that PGTs originated in a common ancestor of modern shikonin/alkanninproducing Boraginaceous species,likely from a retrotransposition-derived duplication event of an ancestral prenyltransferase ***,knocking down expression of LePGT1 in *** hairy root lines revealed that LePGT1 is predominantly responsible for shikonin production early in culture *** together,the reference genome reported in this study and the provided analysis on the evolutionary origin of shikonin/alkannin biosynthesis will guide elucidation of the remainder of the pathway.

关键词： insight collective evolutionary

Redox physiology in animal function:The struggle of living in an oxidant environment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Zoology 2010年第6期56卷 687-702页

作者： david COSTANTINI Division of Ecology and Evolutionary Biology Faculty of Biomedical and Life SciencesUniversity of Glasgow

A strong focus of ecological research for several decades has been to understand the factors underlying the variation in animal life-histories. In recent times, ecological studies have begun to show that oxidative stress may represent another important modulator of competitive trade-offs among fitness traits or of positively integrated patterns of traits. Therefore, incorporating mechanisms underlying oxidative physiology into evolutionary ecology has the potential to help understand variation in life-history strategies. In this review, I provide a general overview of oxidative stress physiology, and subsequently focus on topics that have been neglected in previous ecological reviews on oxidative stress. Specifically, I introduce and discuss the adaptations that animals have evolved to cope with oxidative stress; the environmental stressors that can generate changes in oxidative balance; the role of reactive species in transduction of environmental stimuli and cell signaling; and the range of hormetic responses to oxidative stress [Current Zoology 56 （6）： 687-702, 2010].

关键词： Antioxidants Free radicals Life-history Oxidative stress Stress response Vertebrates