检索结果-南通市图书馆

维普期刊数据库博看期刊

基于网络药理学探讨畲药十二时辰镇痛作用机制

在线全文

学校读者我要写书评

暂无评论

海峡药学 2024年第1期36卷 1-6页

作者：陈懿冲沈廷明陈艳柠黄春情颜于露杨成梓福建中医药大学药学院福建福州350122 福建省宁德市中医院福建宁德352100 福建省级中药原料质量监测技术服务中心福建福州350122

目的通过网络药理学方法探究畲药“十二时辰”镇痛作用的有效成分及可能的作用机制。方法利用TCMSP数据库对十二时辰已知化学成分进行活性筛选并收集对应的相关靶点,利用GeneCards数据库和DisGeNET数据库收集疼痛相关靶点,利用Venny... 详细信息

目的通过网络药理学方法探究畲药“十二时辰”镇痛作用的有效成分及可能的作用机制。方法利用TCMSP数据库对十二时辰已知化学成分进行活性筛选并收集对应的相关靶点,利用GeneCards数据库和DisGeNET数据库收集疼痛相关靶点,利用Venny网站筛选出二者的交集基因,作为十二时辰镇痛作用的潜在靶点;利用Cytoscape软件构建活性成分-靶点网络、利用STRING数据库构建PPI网络、利用david 6.8数据库对十二时辰潜在靶点进行GO功能和KEGG通路富集分析,利用Cytoscape软件构建十二时辰成分-靶点-信号通路网络。结果网络分析确定十二时辰中11个化合物与24个靶点基因与镇痛作用有关,蛋白互作网络的核心基因是ACTB、NOS3、CASP3、PTGS2、RELA和PPARA,通过KEGG确定核心通路主要包括非酒精性脂肪肝、心肌细胞的肾上腺素能信号传导、流体剪切应力与动脉粥样硬化等。结论十二时辰可能通过多靶点、多信号途径的相互作用对炎症、癌症引起的疼痛及神经性疼痛起到镇痛作用。可为下一步实验研究提供依据。

关键词：畲药十二时辰镇痛网络药理学作用机制

China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2020年第3期5卷 211-239页

作者： Yong-Jun Wang zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong david Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Neurology and Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouGuangdongChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA 不详

China faces the greatest challenge from stroke in the *** death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in *** ranked third among the leading causes of death behind malignant tumours and heart *** age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,*** to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in *** absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in *** main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over *** on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco *** those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during *** those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age

关键词： admitted smoke insurance

基于生物信息学的hsa-miR-155-5p通过PTEN调控中央记忆T细胞/辅助T细胞对肝细胞癌免疫微环境的影响研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

医学信息 2024年第9期37卷 7-15页

作者：张珍珍刘一妍舒悦刘滋煜王钰王佳露颜学兵徐州医科大学附属医院东院感染及肝病科昆明医科大学第三附属医院神经外科

目的运用生物信息学方法预测人类miR-155-5p靶基因，进一步探索其在肝细胞癌（HCC）中的功能。方法通过starBase数据库筛选出hsa-miR-155-5p靶基因，david和Reactome数据库进行功能富集分析。蛋白-蛋白相互作用网络分析靶基因之间的... 详细信息

目的运用生物信息学方法预测人类miR-155-5p靶基因，进一步探索其在肝细胞癌（HCC）中的功能。方法通过starBase数据库筛选出hsa-miR-155-5p靶基因，david和Reactome数据库进行功能富集分析。蛋白-蛋白相互作用网络分析靶基因之间的相互关系，cytohubba插件获得关键基因。Kaplan-Meier生存分析进一步筛选关键基因，ssGSEA算法分析HCC免疫浸润情况，Spearman相关系数分析关键基因与免疫浸润的相关性。结果共筛选出1493个hsa-miR-155-5p靶基因；靶基因GO富集分析集中于调控转录、蛋白质分解代谢过程、细胞周期的调节；KEGG生物通路主要富集于AMPK信号通路、PI3K-Akt信号通路和FoxO信号通路、以及子宫内膜癌、胰腺癌和肝细胞癌等疾病通路。利用蛋白互作网络共获得30个关键基因，与HCC信号通路基因取交集获得GSK3B、PTEN、PIK3R1、EGFR、CCND1、SMAD2、PIK3CA、RPS6KB1、KRAS、SOS1等10个关键基因。生存分析显示，PTEN高表达的HCC患者的预后优于低表达患者。PTEN表达量与中央记忆T细胞、辅助T细胞的免疫浸润均呈现较强的正相关性。结论 hsa-miR-155-5p通过下游靶基因PTEN调控中央记忆T细胞、辅助T细胞，进而影响HCC免疫浸润微环境，或可为HCC发生机制和临床治疗的探索提供帮助。

关键词：肝细胞癌 hsa-miR-155-5p 生物信息学 PTEN 中央记忆T细胞辅助T细胞

The PPR protein RARE1-mediated editing of chloroplast accD transcripts is required for fatty acid biosynthesis and heat tolerance in Arabidopsis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2023年第1期4卷 217-227页

作者： Chao Huang Dan Liu zi-Ang Li david P.Molloy Zhou-Fei Luo Yi Su Hai-Ou Li Qing Liu Ruo-Zhong Wang Lang-Tao Xiao College of Bioscience and Biotechnology Hunan Agricultural UniversityChangsha 410128China Department of Biochemistry and Molecular Biology School of Basic Medical ScienceChongqing Medical UniversityChongqing 400016China

It has been reported that Arabidopsis chloroplast accD transcripts undergo RNA editing and that loss of accD-C794 RNA editing does not affect plant growth under normal *** date,the exact biological role of accD-C794 editing has remained ***,we reveal an unexpected role for accD-C794 editing in response to heat *** of accD-C794 editing results in a yellow and dwarf phenotype with decreased chloroplast gene expression under heat stress,and artificial improvement of C794-edited accD gene expression enhances heat tolerance in *** data suggest that accD-C794 editing confers heat tolerance in *** also found that treatment with the product of acetyl coenzyme A carboxylase(ACCase)could allay mutant phenotypic characteristics and showed that a mutation in the CAC3 gene for the a-subunit of ACCase was associated with dwarfism under heat *** observations indicate that defective accD-C794 editing may be intrinsic to reduced ACCase activity,thereby contributing to heat *** catalyzes the committed step of de novo fatty acid(FA)*** content analysis revealed that unsaturated oleic(C18:1)and linoleic acids(C18:2)were low in the accD-C794 editing-defective mutant but high in the C794-edited accD-overexpressing plants compared with the wild *** exogenous C18:1 and C18:2 could rescue the mutant phenotype,suggesting that these FAs play an essential role in tolerance to heat *** electron microscopy observations showed that heat stress seriously affected the membrane architecture in accD editing-defective mutants but not in accD-overexpressing *** results provide the first evidence that accD-C794 editing regulates FA biosynthesis for maintenance of membrane structural homeostasis under heat stress.

关键词： chloroplast RNA editing RARE1 accD fatty acid heat stress

西部多民族地区民众政治认同的影响因素——基于对贵州民族地区调查数据的分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

贵州民族研究 2014年第8期35卷 1-5页

作者：陈自强华中师范大学政治学研究院湖北武汉430079 贵州民族大学贵州贵阳550025

借鉴伊斯顿提出的政治支持理论框架,政治认同可划分为二元分析框架,即普遍性政治认同、特定性政治认同,运用不同的量表去考察这两个维度,得到普遍性政治认同高而特定性政治认同低的结论。为了探究其背后的影响因素,对问卷数据进行了相... 详细信息

借鉴伊斯顿提出的政治支持理论框架,政治认同可划分为二元分析框架,即普遍性政治认同、特定性政治认同,运用不同的量表去考察这两个维度,得到普遍性政治认同高而特定性政治认同低的结论。为了探究其背后的影响因素,对问卷数据进行了相关性分析,从社会人口属性、高政治取向、低政治取向三个层面的社会政治因素分别考察了对两类政治认同的影响,明晰了具体社会政治因素所起的作用。

关键词：民族地区政治认同影响因素

Near-infrared and mid-infrared semiconductor broadband light emitters

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2017年第1期6卷 63-69页

作者： Chun-Cai Hou Hong-Mei Chen Jin-Chuan Zhang Ning Zhuo Yuan-Qing Huang Richard A Hogg david TD Childs Ji-Qiang Ning Zhan-Guo Wang Feng-Qi Liu zi-Yang Zhang Key Lab of Nanodevices and Applications Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China School of Engineering The University of GlasgowGlasgow G128LTUK Vacuum Interconnected Nanotech Workstation Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Semiconductor broadband light emitters have emerged as ideal and vital light sources for a range of biomedical sensing/imaging applications,especially for optical coherence tomography *** near-infrared broadband light emitters have found increasingly wide utilization in these imaging applications,the requirement to simultaneously achieve both a high spectral bandwidth and output power is still challenging for such *** to the relatively weak amplified spontaneous emission,as a consequence of the very short non-radiative carrier lifetime of the inter-subband transitions in quantum cascade structures,it is even more challenging to obtain desirable mid-infrared broadband light *** have been great efforts in the past 20 years to pursue high-efficiency broadband optical gain and very low reflectivity in waveguide structures,which are two key factors determining the performance of broadband light *** we describe the realization of a high continuous wave light power of 420 mW and broadband width of 4130 nm with near-infrared broadband light emitters and the first mid-infrared broadband light emitters operating under continuous wave mode at room temperature by employing a modulation p-doped InGaAs/GaAs quantum dot active region with a‘J’-shape ridge waveguide structure and a quantum cascade active region with a dual-end analogous monolithic integrated tapered waveguide structure,*** work is of great importance to improve the performance of existing near-infrared optical coherence tomography systems and describes a major advance toward reliable and costeffective mid-infrared imaging and sensing systems,which do not presently exist due to the lack of appropriate low-coherence mid-infrared semiconductor broadband light sources.

关键词： broadband light emitters optical coherence tomography quantum cascade structure quantum dot

Mechanism prediction analysis of an epidemic prevention sachet in preventing new coronavirus pneumonia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Toxicology Research 2020年第2期2卷 50-60页

作者： Xin-Zhe Zhao zi-Qi Jin Yao Yang Guo-Wei Zhang College of Traditional Chinese Medicine Hebei UniversityBaoding 071000China

Objective:To explore the prevention mechanism of an anti-epidemic sachet on the new coronavirus pneumonia(COVID-19)based on the network pharmacology and molecular docking ***:The chemical constituents and action targets of wormwood leaves,white peony,borneol,Rhizoma atracylodis,and Herba pogostemonis in the epidemic-preventive sachet were retrieved in TCMSP *** the genes of targets through the Uniprot database,and then use Cytoscape 3.7.2 software to build a medicinal drugs-active ingredients-targets(genes)network for *** we used david to perform gene ontology(GO)function enrichment analysis and genome encyclopedia(KEGG)pathway analysis to predict the mechanisms of *** histograms and bubble charts for visualization with Excel software and Omicshare *** crystal structure of ACE2 was searched in the RCSB PDB database,and the compounds and proteins were molecularly docked with the help of PyMOL,AutoDockTool,and Vina ***:Sixty-seven effective chemical components in the anti-epidemic sachet were screened and a drugs-chemical components-targets network was constructed to obtain 948 targets,and 18 core targets and 28 core target pathways were predicted.6 compounds in Folium artemisiae argyi,13 compounds in Radix angelicae dahuricae,3 compounds in Rhizoma atracylodis,4 compounds in Fructus tsaoko,8 compounds in Herba pogostemonis,and 3 compounds in Rhizoma acori talarinowii have less binding energy with 1R42 than the ***:It is predicted that the anti-epidemic sachet has prevention effects on new coronavirus pneumonia.

关键词： Epidemic prevention sachet New coronavirus pneumonia COVID-19 Mechanisms of action Network pharmacology Molecular docking

聚合物/表面活性剂二元驱采出水稳定机理研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

应用化工 2021年第S2期50卷 150-154页

作者：杨萍萍汤梓仟郑帅 david Jiang 曾玉彬中油(新疆)石油工程有限公司新疆克拉玛依834000 武汉大学流体机械与动力工程装备技术湖北省重点实验室湖北武汉430072 武汉英中高级中学湖北武汉430000

由于含有聚合物和表面活性剂,二元驱采出水水质复杂,油水乳化严重,悬浮物含量高且长期稳定,处理难度大。研究聚合物、表面活性剂在油田采出水中的相互作用,探索二元驱采出水的稳定机理,对发展高效二元驱采出水脱稳技术和水处理工艺具有... 详细信息

由于含有聚合物和表面活性剂,二元驱采出水水质复杂,油水乳化严重,悬浮物含量高且长期稳定,处理难度大。研究聚合物、表面活性剂在油田采出水中的相互作用,探索二元驱采出水的稳定机理,对发展高效二元驱采出水脱稳技术和水处理工艺具有重要意义。研究了聚合物、表面活性剂等因素对二元驱采出水稳定性的影响,结果表明:聚合物增大了粘度和浊度,并降低颗粒物的zeta电位;表面活性剂增大了粘度和浊度,降低zeta电位,减小平均粒径;聚合物/表面活性剂共存使粘度和浊度增大,zeta电位减小,平均粒径呈现先增大后减小的趋势。

关键词：二元驱油田采出水聚合物表面活性剂稳定性

认知行为治疗改善精神分裂症患者生活质量的随机单盲对照试验

在线全文

学校读者我要写书评

暂无评论

中国心理卫生杂志 2012年第11期26卷 801-807页

作者：马云李占江徐子燕郭志华屈英王向群 KINGDON david 首都医科大学附属北京安定医院临床心理学系精神疾病诊断与治疗北京市重点实验室北京100088 北京回龙观医院精神医学研究中心北京100096 北京大学精神卫生研究所卫生部精神卫生学重点实验室(北京大学)北京100191 英国南安普顿大学

目的:探讨认知行为治疗对精神分裂症患者生活质量的效果及相关因素,为寻找有效改善精神分裂症患者生活质量的方法提供依据。方法:本研究为单盲随机对照临床试验。选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)中精神分裂症诊断标准... 详细信息

目的:探讨认知行为治疗对精神分裂症患者生活质量的效果及相关因素,为寻找有效改善精神分裂症患者生活质量的方法提供依据。方法:本研究为单盲随机对照临床试验。选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)中精神分裂症诊断标准的医院门诊和住院患者共120例,随机分配到认知行为治疗组(CBT组,n=60)和支持性心理治疗组(ST组,n=60),在药物治疗基础上分别接受15次认知行为治疗和支持性心理治疗。在基线采用世界卫生组织生存质量量表简表(WHOQOL-BREF)、阳性和阴性症状量表(PANSS)、应付方式问卷(CSQ)、非理性信念量表(IBS)及自编药物副反应问卷对两组患者进行盲法评定。第12周、24周采用WHOQOL-BREF和自编药物副反应问卷对患者进行随访评估。结果:第12周,CBT组患者WHOQOL-BREF总分各因子分均高于基线[(77.0±13.9)vs.(73.1±13.8),(22.4±4.5)vs.(21.5±4.7),(18.9±4.1)vs.(17.8±4.3),(9.3±2.2)vs.(8.9±2.3),(26.4±5.0)vs.(24.7±5.3),均P0.05)。第24周,两组在WHOQOL-BREF的社会关系和环境因子分上组间效应显著(F=6.77,7.21,均P<0.05),CBT组得分均高于ST组。Logis-tic回归分析发现,基线应对方式分数较低、接受CBT及男性对患者的生活质量有正性预测作用(B=-0.25,2.31,-1.64,均P<0.05)。结论:认知行为治疗能够有效改善精神分裂症患者的生活质量,且基线应对方式得分相对更低、能接受认知行为治疗及男性患者更容易从治疗中获得生活质量的改善。

关键词：精神分裂症认知行为治疗生活质量随机对照试验盲法