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3 TMR引导下经直肠前列腺穿刺活检:基于前列腺影像报告和数据系统(PI-RADS)第2版诊断前列腺癌

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国际医学放射学杂志 2017年第3期 346-346页

作者： N.Tan w.C.Lin P.Khoshnoodi N.H.Asvadi j.Yoshida D.j.Margolis 张单霞 The UCLA Prostate Imaging Research Group Department of Radiologyand Department of Pathology.David Geffen School of Medicine at UCLARonald Reagan UCLA Medical Center

摘要目的依据PI-RADS第1版和第2版判断在3 T MR引导下前列腺活检的诊断率。材料与方法本研究符合HIPAA并经机构伦理委员会批准。对106例男性病人行3 T MR引导下前列腺穿刺活检,获得134个活检组织。入组标准:1以往未行前列腺活检者,2以... 详细信息

摘要目的依据PI-RADS第1版和第2版判断在3 T MR引导下前列腺活检的诊断率。材料与方法本研究符合HIPAA并经机构伦理委员会批准。对106例男性病人行3 T MR引导下前列腺穿刺活检,获得134个活检组织。入组标准:1以往未行前列腺活检者,2以前前列腺活检阴性,但前列腺特异性抗原(PSA)水平升高者,或3具有前列腺癌病史且PSA水平升高者。临床采用3 T MR对前列腺进行引导穿刺活检并搜集病理资料。对每例病人及每个活检组织进行

关键词：穿刺活检前列腺癌 PI-RADS

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PPAR Signaling Pathw.y may be an Important Predictor of Breast Cancer Response to Neoadj.vant Chemotherapy

作者：大卫·G. 威尔金斯(david G. w.lkins) 伯纳德·舒尔茨(Bernard Schultz) 凯瑟琳·M. 林嘉琳(Katheryn M. Linduff)

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PPAR Signaling Pathway may be an Important Predictor of Brea...

踝关节脱位是导致旋后外旋型踝关节骨折预后不良的危险因素

首届浙赣两省肿瘤研究交流会

作者： Y.Z.Chen j.Y.Xue C.M.Chen B.L.Yang G.Y.Liu Z.Z.Shen Z.M.Shao j.w. Q.H.Xu F.w. F.Liu X.Ye X.Meng Department of Breast Surgery Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical CollegeFudan University Department of Oncology Surgery First Affiliated Hospital of Wenzhou Medical College2 Fu Xue Lane Fudan University Shanghai Cancer Center-Institut Mérieux Laboratory Fudan University Shanghai Cancer Center

Purpose Neoadj.vant chemotherapy for advanced breast cancer may improve the radicality for a subset of patients,but others may suffer from severe adverse drug reactions w.thout any *** predict the responses to chemotherapy,w. performed a phaseⅡtrial of neoadj.vant chemotherapy using a w.ekly PCb regimen[paclitaxel (Taxol) plus carboplatin]for stageⅡ/Ⅲbreast cancer and assessed the correlation betw.en baseline gene expression and the tumor response to treatment. Methods A total of 61 patients w.th stage II-Ⅲbreast cancer w.re included and administered four cycles of preoperative *** performed a gene expression analysis using Affymetrix HG-U133 Plus 2.0 GeneChip arrays in 31 breast cancer *** expressed genes(DEGs) w.re identified by the Significance Analysis of Microarrays(SAM) program using a false discovery rate(FDR) of *** Functional Annotation Tool in the david Bioinformatics Resources w.s used to perform the gene functional enrichment *** other 30 patients(15 pCR and 15 non-pCR patients) w.re available as an independent validation set to test the selected DEGs by quantitative real-time PCR analysis(qRT-PCR). Results By analyzing six pathological complete response(pCR) patients and 25 patients w.th non-pCR,300 probes(231 genes) w.re identified as differentially expressed betw.en pCR and residual disease by the SAM program w.en the fold change w.s>*** gene functional enrichment analysis revealed 15 prominent gene categories that w.re different betw.en pCR and non-pCR patients,most notably the genes involved in the PPAR(Peroxisome Proliferator Activated Receptor),DNA repair and ER signal pathw.ys and in the immune-related gene *** qRT-PCR analysis results for the genes in the PPAR pathw.y(LPL,SORBSl,PLTP,SCD5,MMPl and CSTA) in independent validation set w.re consistent w.th the results from the microarray data analysis. Conclusion In the present study,w. identified a number of gene categories pertinent to the ther

关键词： Neoadj.vant Gene expression Chemotherapy response PPAR pathw.y DNA repair

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实用骨科杂志 2016年第10期22卷 960-960页

作者： Peter K.Sculco Lionel E.Lazaro Milton M.Little Marschall B.Berkes Stephen j.w.rner david L.Helfet Dean G.Lorich 王勇卓(整理) 张民(整理) 不详山西医科大学第二医院骨科

旋后外旋型骨折是踝关节骨折中最为常见的类型。其中SER四型骨折由于造成踝关节不稳,所以需要手术治疗。SER四型骨折部分会造成踝关节脱位。踝关节骨折脱位意味着关节软骨和关节周围软组织的严重损伤,但目前还缺乏脱位对围手术期并发症... 详细信息

旋后外旋型骨折是踝关节骨折中最为常见的类型。其中SER四型骨折由于造成踝关节不稳,所以需要手术治疗。SER四型骨折部分会造成踝关节脱位。踝关节骨折脱位意味着关节软骨和关节周围软组织的严重损伤,但目前还缺乏脱位对围手术期并发症、放射学及临床疗效影响的研究。本研究的目的是探讨脱位是否会增加SER四型踝关节骨折（内踝骨折或三角韧带断裂）切口并发症或深部感染发生率、是否会增加骨折复位不良的风险、是否与经过至少随访1年后的关节功能不良有关。2004-2010年由同一医生治疗的SER四型旋后外旋型踝关节骨折共178例，经过选择后共有108例纳入本研究中。

关键词：踝关节骨折踝关节脱位外旋型旋后内踝骨折四型关节软骨围手术期并发症下胫腓联合切口并发症

大肠埃希菌临床分离株对喹诺酮类抗菌药的质粒介导耐药

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中国感染与化疗杂志 2006年第4期6卷 217-221页

作者：王明贵 j.hnH.Tran GeorgeA.j.coby 张婴元汪复 davidC.Hooper 复旦大学附属华山医院抗生素研究所上海200040 美国哈佛医学院麻省总医院感染科美国Lahey医学中心感染科

目的了解近年来发现的质粒介导耐药机制在大肠埃希菌临床株对喹诺酮类耐药中所起的作用。方法78株环丙沙星耐药菌株分离自上海5所教学医院。以克隆斑点杂交及Southern杂交方法筛选质粒介导耐药基因qnr；以接合试验了解喹诺酮耐药的可转... 详细信息

目的了解近年来发现的质粒介导耐药机制在大肠埃希菌临床株对喹诺酮类耐药中所起的作用。方法78株环丙沙星耐药菌株分离自上海5所教学医院。以克隆斑点杂交及Southern杂交方法筛选质粒介导耐药基因qnr；以接合试验了解喹诺酮耐药的可转移性；对qnr基因进行序列分析,以引物步移法对qnr周边质粒DNA进行测序、分析。结果78株大肠埃希菌中,6株(7．7%)qnr检测阳性。在6株阳性菌中,喹诺酮耐药性均可通过质粒转移,接合子对环丙沙星的MIC较受体菌上升16～250倍。qnr基因与最早报道的序列一致,qnr位于In4族的Ⅰ类整合子上,本研究中的2个新整合子命名为In36及In37。结论与qnr相关的质粒介导喹诺酮类耐药性在大肠埃希菌临床分离株中有一定程度流行,这可能是我国细菌对喹诺酮类耐药性上升迅速的原因之一。

关键词：大肠埃希菌质粒介导耐药喹诺酮类 qnr

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青年与老年直肠癌患者生存率有无差异?

世界核心医学期刊文摘（胃肠病学分册） 2005年第6期1卷 22-23页

作者： O’Connell j.B. Maggard M.A. 王志宇 Department of Surgery David Geffen School of Medicine Univ. of California Los Angeles 10833 Le Conte Avenue Los Angeles CA 90095 United States Dr.

PURPOSE: Although it is generally believed that young patients w.th rectal cancer have w.rse survival rates, no comprehensive analysis has been reported. This study uses a national-level, population-based cancer registry to compare rectal cancer outcomes betw.en young vs. older populations. METHODS: All patients w.th rectal carcinoma in the Surveillance, Epidemiology, and End Results cancer database from 1991 to 1999 w.re evaluated. Young (range, 20-40 years; n = 466) and older groups (range, 60-80 years; n = 11,312) w.re compared for patient and tumor characteristics, treatment patterns, and five-year overall and stage-specific survival. Cox multivariate regression analysis w.s performed to identify predictors of survival. RESULTS: Mean ages for the groups w.re 34.1 and 70 years. The young group w.s comprised of more black and Hispanic patients compared w.th the older group (P w.re more likely to present w.th late-stage disease (young vs. older: Stage III, 27 vs. 20 percent respectively, P w.rse grade tumors (poorly differentiated 24.3 vs. 14 percent respectively, P j.rity of both groups received surgery (85 percent for each), significantly more young patients received radiation (P w.re similar for both groups (P = not significant). CONCLUSIONS: Although previous studies have found young rectal cancer patients to have poorer survival compared w.th older patients, this population-based study show. that young rectal cancer patients seem to have equivalent overall and stage-specific survival.

关键词：老年直肠癌肿瘤分级肠癌患者多变量回归年龄层有直中所

心脏移植后血管重构的3年连续血管内超声研究

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 33-34页

作者： Tanaka K. Oeser B. j.M. Tobis 郭俊 Department of Medicine(Division of Cardiology) University of California Los Angeles David Geffen School of Medicine 10833 Le Conte Avenue Los Angeles CA 90095 United States

Aims: To assess the time-course of intimal hyperplasia and vascular remodelling, and their relative contributions on luminal narrow.ng in transplant coronary artery disease(TCAD) by a 3-year serial intravascular ultrasound(IVUS) study. Methods and results: Serial IVUS examinations w.re performed in 90 cardiac transplant recipients at 1.4±0.6 months after transplantation and again annually thereafter for 3 years. From 90 arteries, 304 sites w.re matched from baseline to the third year posttransplant. Based on the change in external elastic membrane(EEM) area±10%at 1 year, 304 sites w.re divided into three groups: sites w.th no remodelling(52%); early constrictive remodelling(26%); and early compensatory enlargement(22%). Greater intimal grow.h w.s seen at 1 year in sites w.th early compensatory enlargement, w.ereas there w.s no change in intimal area in sites w.th early constrictive remodelling. Over 3 years, the cumulative lumen loss w.s greater in sites w.th early constrictive remodelling than in sites w.th early compensatory enlargement or no remodelling(Pw.en luminal narrow.ng occurred for each annual interval, the contribution from the decrease in EEM area w.s greater than that due to intimal thickening(Pw.h occurs in the first year,mostly in sites w.th early compensatory enlargement. The contribution to luminal loss in TCAD is greater from constrictive remodelling than from intimal hyperplasia. The type of remodelling pattern that occurs in transplanted coronary arteries w.thin the first year post-transplant may be a predictor of the progression of luminal narrow.ng during subsequent years.

关键词：血管内超声血管重构内膜增生

非复杂下呼吸道感染的抗生素处方策略及不良结局：前瞻性咳嗽并发症队列（3C）研究

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英国医学杂志中文版 2017年第12期20卷 681-681页

作者： Paul Little Beth Stuart Sue Smith Matthew.j.Thompson Kyle Knox Annvanden Bruel Mark Low. Michael Moore david Mant 王雯王峰 University of Southampton Primary Care Medical Group PCPS Unit Aldermoor Health Centre Southampton S0 16 5ST UK Nuffield Department of Primary Health Care Sciences University of OxfordRadcliffe Observatory Quarter Oxford UK University of w.shington Seattle WA USA 首都医科大学附属北京朝阳医院呼吸与危重症医学科

目的旨在评估16岁及以上的下呼吸道感染患者中，不同抗生素处方策略对不良结局的影响。

关键词：非复杂下呼吸道感染抗生素处方策略

β受体阻滞剂（普萘洛尔）治疗复杂的面部血管瘤

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中国美容整形外科杂志 2012年第3期23卷 I0016-I0016页

作者： j.gpal S. Arnej. Peggy N. Pappas Tor A. Shw.yder Marc L. Cullen Cristie j. Becker Fasahat H. Hamzavi j.hn D. Roarty david N. Madgy j.hn D. Baker 魏峰高景恒张晨加拿大卑诗省温哥华卑诗省儿童医院整形外科中心血管畸形门诊；美国密歇根州底特律密歇根州儿童医院血管畸形门诊《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

【结论】为检测β受体阻滞剂治疗血管瘤远期效果的安全性和有效性，将其与其他药物进行前瞻性对照研究显然是有必要的。采用皮质类固醇治疗复杂的血管瘤，可能无反应或产生有害后遗症，因此，需要把注意力放到非传统疗法上。然而，这并... 详细信息

【结论】为检测β受体阻滞剂治疗血管瘤远期效果的安全性和有效性，将其与其他药物进行前瞻性对照研究显然是有必要的。采用皮质类固醇治疗复杂的血管瘤，可能无反应或产生有害后遗症，因此，需要把注意力放到非传统疗法上。然而，这并不是对已报道的采用传统治疗标准的成功案例的否定。口服皮质类固醇仍是目前可以接受的药物治疗标准；然而，此类药物既不是完全良性，也不是普遍有效。

关键词： β受体阻滞剂面部血管瘤治疗标准普萘洛尔皮质类固醇类药物远期效果传统疗法