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Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical Sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

On water security, sustainability, and the water-food-energy-climate nexus

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Frontiers of Environmental Science & Engineering 2013年第5期7卷 626-639页

作者： Michael Bruce BECK Rodrigo villarroel WALKER Wamell School of Forestry and Natural Resources University of Georgia Athens GA 30602-2152 USA

The role of water security in sustainable development and in the nexus of water, food, energy and climate interactions is examined from the starting point of the definition of water security offered by Grey and Sadoff. Much about the notion of security has to do with the presumption of scarcity in the resources required to meet human needs. The treatment of scarcity in mainstream economics is in turn examined, therefore, in relation to how each of us as individuals reconciles means with ends, a procedure at the core of the idea of sustainable development. According to the Grey-Sadoff definition, attaining water security amounts to achieving basic, single- sector water development as a precursor of more general, self-sustaining, multi-sectoral development. This is con- sistent with the way in which water is treated as ＂first among equals＂, i.e. privileged, in thinking about what is key in achieving security around the nexus of water, food, energy and climate. Cities, of course, are locations where demands for these multiple resource-energy flows are increasingly being generated. The paper discusses two important facets of security, i.e., diversity of access to resources and services （such as sanitation） and resilience in the behavior of coupled human-built-natural systems. Eight quasi-operational principles, by which to gauge nexus security with respect to city buildings and infrastructure, are developed.

关键词： cities as forces for good diversity energy and nutrient recovery green economy infrastructure failure,resilience

Nexus security： governance, innovation and the resilient city

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Frontiers of Environmental Science & Engineering 2013年第5期7卷 640-657页

作者： Michael Bruce BECK Rodrigo villarroel WALKER Wamell School of Forestry and Natural Resources University of Georgia Athens GA 30602-2152 USA

Nexus security is a compound mix of ideas： reconciling human needs and wants with access to multiple resources; diversity of access to those resources and services; resilience in the face of weather- and climate- related variability; resilience likewise in the face of infrastructure failure; and the personal, individual sense of belonging. At the level of Systems Thinking there is a very close relationship between resilience in the behavior of natural （ecological） systems and resilience in the social dynamics of governance within communities, where such resilience establishes the viability of these communities over centuries, which in turn entails successful stewardship of the man-environment relationship. We use insights from this cross-system mapping -- across natural, built, and human systems -- to assess, first, the role of city governance in achieving nexus security （or not） and, second, the role of technological innovations in serving the same purpose. More specifically, eight principles, covering resilience and diversity of access to resources and services, are used to gauge security-enhancing features of city buildings and infrastructure. Case studies include new designs of resilient office blocks, nutrient （nitrogen and phosphorus） recovery systems for sanitation and waste- water treatment, and the reconstruction of urban parks for the provision of ecosystem services. Throughout the paper, matters of risk in the face of meteorological variability are prominent. We do not conclude, however, that the presence of risk implies nexus insecurity.

关键词： cities as forces for good climate variability,ecosystem services energy and nutrient recovery infrastructure failure urban metabolism

Wind-farm and hydrogen-storage co-location system optimization for dynamic frequency response in the UK

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Clean Energy 2023年第1期7卷 157-173页

作者： Fulin Fan Shanay Skellern david campos-Gaona John Nwobu Department of Electronic and Electrical Engineering University of StrathclydeGlasgowUK 2Offshore Renewable Energy CatapultGlasgowUK

The continuous development of hydrogen-electrolyser and fuel-cell technologies not only reduces their investment and operating costs but also improves their technical performance to meet fast-acting requirements of electrical grid balancing services such as frequency-response *** order to project the feasibility of co-locating a hydrogen-storage system with a wind farm for the dynamic regulation frequency-response provision in Great Britain,this paper develops a modelling framework to coordinate the wind export and frequency responses to the main grid and manage the interaction of the electrolyser,compressor,storage tank and fuel cell within the hydrogen-storage system by respecting the market mechanisms and the balance and conversion of power and hydrogen *** the revenue of frequency-response service provision and a variety of costs induced by the hydrogen-storage system are translated into the net profit of the co-location system,which is maximized by optimizing the capacities of hydrogen-storage-system components,hydrogen-storage levels that guide the hydrogen restoration via operational baselines and the power interchange between a wind-farm and hydrogen-storage system,as well as the capacities tendered for low-and high-frequency dynamic regulation *** developed modelling framework is tested based on a particular 432-MW offshore wind farm in Great Britain combined with the techno-economics of electrolysers and fuel cells projected for 2030 and 2050 *** optimized system configuration and operation are compared between different operating scenarios and discussed alongside the prospect of applying hydrogen-storage systems for frequency-response provision.

关键词： dynamic regulation frequency response hydrogen-storage system techno-economic optimization UK perspective wind farm

Glacier reconstruction of La Covacha Massif in Sierra de Gredos(central Spain) during the Last Glacial Maximum

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Journal of Mountain Science 2019年第6期16卷 1336-1352页

作者： Néstor campos david PALACIOS Luis M.TANARRO Department of Geography Complutense University of Madrid

A paleoglacier reconstruction during the Last Glacial Maximum(LGM) is presented for a high mountain area of La Covacha massif in Sierra de Gredos(Iberian Central System) in central Spain. The moraines that, according with the previous literature, had formed during the global LGM, were mapped through photo interpretation of digital aerial photographs and 3D images and detailed field surveys. The topography of the paleoglaciers was estimated using a simple steady-state model that assumed a perfectly plastic ice rheology, reconstructing the theoretical ice profiles and obtaining the ice thickness of the glaciers during the LGM. The reconstruction of the glaciers was carried out using automated and semi-automated physically-based models, obtaining more realistic results with semi-automated models. According to our study, the paleoglaciers in the study area covered an area of 34.79 km^2 during the global LGM, with a maximum ice thickness of 366 meters in La Vega gorge, a total volume of 34.25 × 108 m^3 and a mean paleoELA of 1932 meters. Most of the ice(~82%) was in paleoglaciers facing north, and the rest was in paleoglaciers with other orientations. This emphasizes the importance of orientation in relation to glacier dynamics and ice accumulation. The results obtained in the calculation of paleoELAs during the global LGM in Gredos are average compared to the Iberian mountains of the Northwest where the values were much lower, and with respect to those of the Southwest, much higher. This demonstrates the importance of the exposure of Mediterranean mountains to the humidity sources coming from the NW during the global LGM, as is the case at present.

关键词： Glacier reconstruction Paleoglacier Ice thickness Equilibrium line altitude Iberian Central System

FeedEfficiencyService: An architecture for the comparison of data from multiple studies related to dairy cattle feed efficiency indices

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Information Processing in Agriculture 2022年第3期9卷 378-396页

作者： Heitor Magaldi Linhares Regina Braga Wagner Antonio Arbex Mariana Magalhaes campos Fernanda campos Jose Maria N.david Victor Stroele Programa de Pos-Graduacao em Ciencia da Computacao Universidade Federal de Juiz de ForaCampus UniversitarioRua JoseLourenco Kelmers/n-Sao PedroJuiz de ForaMinas Gerais 36036-900Brasil Brazilian Agricultural Research Corporation-Embrapa Av.Eugenio do Nascimento610-AeroportoJuiz de Fora-MGMinas Gerais 36038-330Brasil

The increased demand for food worldwide,the reduced land availability for livestock pro-duction,the increasing cost of animal feed and the need for mitigating livestock-related greenhouse gas emissions have driven the search for animal feeding systems that proves more *** tackle this problem,we propose the use of computational support to help researchers compare data on feed efficiency,therefore improving economic and environ-mental *** a solution,we present an integrative architecture capable of combining heterogeneous data from multiple experiments related to dairy cattle feed efficiency *** proposed architecture,called FeedEfficiencyService,classifies animals according to feed efficiency indices and allows visualizations through ontologies and inference *** results obtained from a case study with researchers from the Brazilian Agri-cultural Research Corporation–Dairy Cattle(EMBRAPA)demonstrate that this architecture is a supporting tool in their daily work *** researchers highlighted the importance of the proposed architecture as it allows analyzing animal data,comparing experiments,having reliable data analyses,and standardizing and organizing data from *** novelty of our approach is the use of ontologies and inference engines to enable the discovery of new knowledge and new relationships between data from feed efficiency-related *** store such data,relationships,and analyses of results in an inte-grated *** solution ensures unified access to the processing history and data from diverse experiments,including those conducted at external research centers.

关键词： Dairy Cattle

Water and nutrient and energy systems in urbanizing watersheds

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Frontiers of Environmental Science & Engineering 2012年第5期6卷 596-611页

作者： Rodrigo villarroel WALKER Michael Bruce BECKl, Jim W. HALL Warnell School of Forestry & Natural Resources University of Georgia Athens GA 30602-2152 USA Environmental Change Institute University of Oxford Oxford University Centre for the Environment South Parks Road Oxford OXI 3QY UK

Driven by considerations of sustainability, it has become increasingly difficult over the past 15-20 years -- at least intellectually -- to separate out the water infrastructure and water metabolism of cities from their intimately inter-related nutrient and energy metabolisms. Much of the focus of this difficulty settles on the wastewater component of the city＇s water infrastructure and its associated fluxes of nutrients （N, P, C, and so on）. Indeed, notwithstanding the massive volumes of these materials flowing into and out of the city, the notion of an urban nutrient infrastructure is conspicuous by its absence. Likewise, we do not tend to discuss, or conduct research into, ＂soilshed＂ agencies, or soilshed management, or Integrated Nutrient Resources Management （as opposed to its most familiar companion, Integrated Water Resources Management, or IWRM）. The paper summarizes some of the benefits （and challenges） deriving from adopting this broader, multi-sectoral ＂systems＂ perspective on addres- sing water-nutrient-energy systems in city-watershed settings. Such a perspective resonates with the growing interest in broader policy circles in what is called the ＂water-food-energy security nexus＂. The benefits and challenges of our Multi-sectoral Systems Analysis （MSA） are illustrated through computational results from two primary case studies： Atlanta, Georgia, USA; and London, UK. Since our work is part of the International Network on Cities as Forces for Good in the Environment （CFG; see ***）, in which other case studies are currently being initiated -- for example, on Kath- mandu, Nepal we close by reflecting upon these issues of water-nutrient-energy systems in three urban settings with quite different styles and speeds of development.

关键词： cities climate change energy sector nutrientsector systems analysis resource recovery water-food-energy security

Logarithmic Regge pole

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Chinese Physics C 2020年第10期44卷 41-50页

作者： S.D.campos Applied Mathematics Laboratory-CCTS/DFQM Federal University of Sâo CarlosSorocabaSão Paulo CEP 18052780Brazil

This work presents the subtraction procedure and the Regge cut in the logarithmic Regge pole *** subtraction mechanism leads to the same asymptotic behavior as previously obtained in the non-subtraction *** Regge cut,in contrast,introduces a clear role to the non-leading contributions for the asymptotic behavior of the total *** these results,some simple parameterization is introduced to fit the experimental data for the proton-proton and antiproton-proton total cross-section above some minimum value up to the *** fit parameters obtained are used to present predictions for the ρ(s)-parameter as well as to the elastic slope B(s)at high energies.

关键词： Regge pole double pomeron ρ-parameter total cross section