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Successful transjugular intrahepatic portal-systemic shunt in an ineligible liver transplant patient with primary biliary cirrhosis with refractory ascites and aplastic anemia

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Open Journal of Gastroenterology 2013年第1期3卷 1-4页

作者： Christopher M. Moore George Behrens Hector Ferral david H. van Thiel Section of Hepatology Department of Medicine Rush University Medical Center Chicago USA Section of Interventional Radiology Department of Radiology Rush University Medical Center Chicago USA

A transjugular intrahepatic portal-systemic shunt (TIPS) is a standard way to decompress the portal system in cirrhotic patients as a bridge to orthotopic liver transplantation (OLT). Traditionally, TIPS has been indicated for certain portal hypertensive sequelae such as refractory ascites, varices treatment and even hepato-hydrothorax. Herein is a case report on the efficacy of TIPS in an OLT ineligible patient with primary biliary cirrhosis and aplastic anemia who had developed refractive ascites requiring serial paracentesis and esophageal varices. He survived 2.5 years post-TIPS placement and died from complications related to severe leucopenia and the development of sepsis.

关键词： Aplastic Anemia Ascites Liver Transplantation Paracentesis TIPS

Macrophages are the primary effector cells in IL-7-induced arthritis

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Cellular & Molecular Immunology 2020年第7期17卷 728-740页

作者： Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi david A.Fox Nadera Sweiss Shiva Shahrara Division of Rheumatology Jesse Brown VAMedical CenterChicagoIL 60612USA Department of Medicine Division of RheumatologyUniversity of Illinois at ChicagoChicagoIL 60612USA Department of Microbiology and Immunology Chicago College of Osteopathic MedicineMidwestern UniversityDowners GroveIL 60515USA Pulmonary Critical Care and Sleep MedicineOhio State University Wexner Medical CenterDavis Heart and Lung Research InstituteColumbusOH 43210USA Division of Allergy Clinical Immunology and RheumatologyThe University of Kansas Medical CenterKansas CityKS 66160USA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMI 481096USA

Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine *** local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ ***, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity.

关键词： myeloid elevated inflammation

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烟道吸附剂多重污染物干涸、导管注入技术

烟道吸附剂多重污染物干涸、导管注入技术

High-throughput calculations of charged point defect properties with semi-local density functional theory— performance benchmarks for materials screening applications

中美工业锅炉先进技术研讨会

作者： Sid Nelson Jr. Richard Oehlberg Ronald Landreth david van Stone

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npj Computational Materials 2023年第1期9卷 1628-1639页

作者： Danny Broberg Kyle Bystrom Shivani Srivastava Diana Dahliah Benjamin A.D.Williamson Leigh Weston david O.Scanlon Gian-Marco Rignanese Shyam Dwaraknath Joel Varley Kristin A.Persson Mark Asta Geoffroy Hautier Materials Sciences Division Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Physics An-Najah National UniversityNablusPalestine Institute of Condensed Matter and Nanosciences UniversitéCatholique de LouvainChemin desÉtoiles 8B-1348 Louvain-la-NeuveBelgium Department of Materials Science and Engineering NTNU Norwegian University of Science and TechnologyTrondheimNorway Energy Technologies Area Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Department of Chemistry University College London20 Gordon StreetLondon WC1H 0AJUK Thomas Young Centre University College LondonGower StreetLondon WC1E 6BTUK Diamond Light Source Ltd. Diamond HouseHarwell Science and Innovation CampusDidcotOxfordshire OX110DEUK Lawrence Livermore National Laboratory LivermoreCA 94550USA Molecular Foundry Lawrence Berkeley National Laboratory1 Cyclotron RoadBerkeleyCA 94720USA Thayer School of Engineering Dartmouth CollegeHanoverNH 03755USA

Calculations of point defect energetics with Density Functional Theory(DFT)can provide valuable insight into several optoelectronic,thermodynamic,and kinetic *** calculations commonly use methods ranging from semi-local functionals with a-posteriori corrections to more computationally intensive hybrid functional *** applications of DFT-based high-throughput computation for data-driven materials discovery,point defect properties are of interest,yet are currently excluded from available materials *** work presents a benchmark analysis of automated,semi-local point defect calculations with a-posteriori corrections,compared to 245“gold standard”hybrid calculations previously *** consider three different a-posteriori correction sets implemented in an automated workflow,and evaluate the qualitative and quantitative differences among four different categories of defect information:thermodynamic transition levels,formation energies,Fermi levels,and dopability *** highlight qualitative information that can be extracted from high-throughput calculations based on semi-local DFT methods,while also demonstrating the limits of quantitative accuracy.

关键词： properties defect correction

Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2015年第37期21卷 10621-10635页

作者： Vikas Gupta Xian-Jun Mah Maria Carmela Garcia Christina Antonypillai david van der Poorten Department of Gastroenterology and Hepatology Division of MedicineUniversity of Sydney at Westmead Hospital

Rates of non-alcoholic fatty liver disease(NAFLD) are increasing worldwide in tandem with the metabolic syndrome, with the progressive form of disease, nonalcoholic steatohepatitis(NASH) likely to become the most common cause of end stage liver disease in the not too distant future. Lifestyle modification and weight loss remain the main focus of management in NAFLD and NASH, however, there has been growing interest in the benefit of specific foods and dietary components on disease progression, with some foods showing protective properties. This article provides an overview of the foods that show the most promise and their potential benefits in NAFLD/NASH, specifically; oily fish/fish oil, coffee, nuts, tea, red wine, avocado and olive oil. Furthermore, it summarises results from animal and human trials and highlights potential areas for future research.

关键词： Non-alcoholic fatty liver disease Nonalcoholic ste

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个体化循证医学:异质性治疗效应的预测方法

英国医学杂志中文版 2019年第5期22卷 266-280页

作者： david M Kent Ewout Steyerberg david van Klaveren 周齐张静怡罗旭飞(译) 吕萌(译) 陈耀龙杨克虎(校) 张越伦(校) Predictive Analytics andComparative Effectiveness Center Institute for Clinical Research andHealth Policy StudiesTufts MedicalCenterBostonMA 02111USA Department of Biomedical DataSciences Leiden University MedicalCenterEinthovenweg 202333 ZCLeidenNetherlands 兰州大学循证医学中心兰州大学公共卫生学院北京协和医院中心实验室

使用来自临床试验的证据去支持个体患者决策是“参考类别预测”的一种形式:对个体的隐含预测是基于使用替代疗法治疗的“相似”患者参考类别的结果。循证医学普遍强调有资格的广泛参考类别患者参加试验。然而,试验(和临床实践)中的患者... 详细信息

使用来自临床试验的证据去支持个体患者决策是“参考类别预测”的一种形式:对个体的隐含预测是基于使用替代疗法治疗的“相似”患者参考类别的结果。循证医学普遍强调有资格的广泛参考类别患者参加试验。然而,试验(和临床实践)中的患者在许多方面彼此不同,这些可能影响主要的结局和潜在的获益。个体化医学各种形式的核心目标是缩小参考类别,以产生更多的患者特异性效应估计,从而支持更多个体化的临床决策。本文将回顾结果风险预测和治疗效应异质性(HTE)的基本概念问题,以及常规(单变量)亚组分析的局限性。讨论几种不同的基于回归的“预测性”HTE分析方法,包括基于“风险模型”(例如根据主要结局的风险或严重治疗相关危害的风险对试验人群进行分层)和“效应模型”的分析(其中包含相对效应的修饰)。用临床实例说明这些方法,并讨论它们各自的优势与不足。

关键词：个体化医学风险预测治疗效应循证医学异质性临床试验风险模型临床实践

Review of the impact of heat stress on reproductive performance of sheep

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Journal of Animal Science and Biotechnology 2021年第3期12卷 859-876页

作者： William H.E.J.van Wettere Karen L.Kind Kathryn L.Gatford Alyce M.Swinbourne Stephan T.Leu Peter T.Hayman Jennifer M.Kelly Alice C.Weaver david O.Kleemann Simon K.Walker The University of Adelaide School of Animal and Veterinary SciencesDavies Livestock Research CentreRoseworthy CampusMudla Wirra RdRoseworthySouth Australia 5371Australia The University of Adelaide Robinson Research InstituteAdelaide Medical SchoolNorth TerraceAdelaideSouth Australia 5000Australia The University of Adelaide School of AgricultureFood and WineWaite Research InstituteUrrbraeSouth Australia 5064Australia South Australian Research and Development Institute Primary Industries and Regions SAGovernment of South AustraliaClimate ApplicationsWaite Research PrecinctUrrbraeSouth Australia 5064Australia South Australian Research and Development Institute Primary Industries and Regions SAReproductive BiologyLivestock SciencesTurretfield Research Centre129 Holland RdRosedaleSouth Australia 5350Australia

Heat stress significantly impairs reproduction of sheep,and under current climatic conditions is a significant risk to the efficiency of the meat and wool production,with the impact increasing as global temperatures *** from field studies and studies conducted using environmental chambers demonstrate the effects of hot temperatures(≥32℃)on components of ewe fertility(oestrus,fertilisation,embryo survival and lambing)are most destructive when experienced from 5 d before until 5 d after *** controlled studies also demonstrate that ram fertility,as measured by rates of fertilisation and embryo survival,is reduced when mating occurs during the period 14 to 50 d ***,the contribution of the ram to heat induced reductions in flock fertility is difficult to determine *** primarily on temperature controlled studies,it is clear that sustained exposure to high temperatures(≥32℃)during pregnancy reduces lamb birthweight and will,therefore,decrease lamb survival under field *** is concluded that both ewe and ram reproduction is affected by relatively modest levels of heat stress(≥32℃)and this is a concern given that a significant proportion of the global sheep population experiences heat stress of this magnitude around mating and during *** this,strategies to limit the impacts of the climate on the homeothermy,behaviour,resource use and reproduction of extensively grazed sheep are limited,and there is an urgency to improve knowledge and to develop husbandry practices to limit these impacts.

关键词： Fertility Heat stress Oogenesis Pregnancy Sheep Spermatogenesis

Global Locate LTO技术的过去、现在与未来——GPS辅助数据技术

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电子与电脑 2006年第9期6卷 90-96页

作者： david Lundgren Frank van Diggelen Global Locate

本文介绍Global Locate的长期轨道（Long Term Orbit ,LTO）技术，有时又称为“扩充式星历表”（extended ephemeris）技术，LTO是一种GPS辅助数据，不需无线连接到辅助性全球定位系统（Assisted GPS,A-GPS）服务器就能提供辅助数据给A-... 详细信息

本文介绍Global Locate的长期轨道（Long Term Orbit ,LTO）技术，有时又称为“扩充式星历表”（extended ephemeris）技术，LTO是一种GPS辅助数据，不需无线连接到辅助性全球定位系统（Assisted GPS,A-GPS）服务器就能提供辅助数据给A-GPS装置。传统A-GPS系统虽然大幅改善GPS效能，但是A-GPS装置几乎每小时都要连接到A-GPS服务器以便下载最新的辅助数据。LTO数据则可透过因特网获得，而且有效期限长达数天，这使得连接需求大幅降低。

关键词： A-GPS LTO技术数据技术辅助数据全球定位系统无线连接 Orbit

High-Dose Intra-Dermal Hepatitis B Vaccine in a Liver Transplant Patient Who Failed Prior Intramuscular Vaccination: A Brief Case Report

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World Journal of Vaccines 2013年第1期3卷 16-18页

作者： Sonu Dhillon Kartik Sampath Christopher M. Moore Anil Dosanjh david H. van Thiel Division of Gastroenterology and Hepatology Saint Francis Medical Center Peoria USA Divison of Digestive Diseases Rush University Medical Center Chicago USA University of California Davis USA

Hepatitis B virus (HBV) chronic infection represents a significant cause of morbidity and mortality worldwide. While traditional intramuscular (IM) HBV vaccination is an excellent method for robust and sustained seroconversion in healthy individuals, its efficacy in chronic liver disease is sub-optimal and scant data exists in the post-liver transplant state. Importantly, HBV complications are even more severe in these same immunocompromised populations. Intra-dermal (ID) vaccination has shown initial promise as a successful alternative to achieving HBV seroconversion in patients refractory to standard vaccination protocols. Herein is a case report of a 61 year-old female who underwent liver transplantation for chronic HBV infection and achieved HBsAg seroconversion with a robust HSsAb titer with ID vaccination after having failed both standard and double dose IM vaccination.

关键词： Hepatitis B Virus Intra-Dermal Vaccination Orthotopic Liver Transplant