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Genes & Diseases 2022年第3期9卷 820-825页

作者： Andrew t.turk Dario Garcia-Carracedok david t.kent Elizabeth Philipone Juana Maria Garcia-Pedrero Salvatore M.Caruana Lanny G.Close Gloria H.Su Department of Pathology and Cell Biology and Columbia UniversityNew YorkNY 10032USA Department of Otolaryngology Columbia UniversityNew YorkNY 10032USA Department of Otolaryngology Vanderbilt UniversityNashvilleTN 37232USA Department of Otolaryngology Hospital Universitario Central de Asturias and Instituto Universitario de Oncologia Del Principado de AsturiasOviedo 33006Spain

In order to assess Stathmin as an immunohistochemical(IHC)indicator of phosphatidylinositol 3-kinase(PI3K)pathway activity in HPV-negative head&neck squamous cell carcinoma(HNSCC),we compared Stathmin IHC to expression of other pathway *** also evaluated the relationship between Stathmin IHC and the mutational status of four key pathway ***,we ascertained whether Stathmin IHC correlates with tumor grade or primary *** exists between high Stathmin expression and high pAKt1 expression,indicating a role for Stathmin IHC as a marker of pathway *** analysis did not show correlation between Stathmin IHC and mutation of the four genes *** also observed an association between high Stathmin expression and oropharyngeal primary *** results suggest utility of Stathmin IHC as an indicator of PI3K pathway activity,and thereby demonstrate potential relevance of Stathmin IHC in the context,of HNSCC.

关键词： Cancer Head&neck squamous cell carcinoma Pathology Stathmin

Late Ordovician Mass Extinction: Earth, fire and ice

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National Science Review 2024年第1期11卷 51-65页

作者： david A.t.Harper Palaeoecosystems Group Department of Earth SciencesDurham University

the Late Ordovician Mass Extinction was the earliest of the ‘big’ five extinction events and the earliest to affect the trajectory of metazoan life. two phases have been identified near the start of the Hirnantian period and in the middle. It was a massive taxonomic extinction, a weak phylogenetic extinction and a relatively benign ecological extinction. A rapid cooling, triggering a major ice age that reduced the temperature of surface waters, prompted a drop in sea level of some 100 m and introduced toxic bottom waters onto the shelves. these symptoms of more fundamental planetary processes have been associated with a range of factors with an underlying driver identified as volcanicity. Volcanic eruptions, and other products, may have extended back in time to at least the Sandbian and early Katian, suggesting the extinctions were more protracted and influential than hitherto documented.

关键词： Ordovician LOME paleoecology palaeobiogeography biotas

Risk profiles and outcomes of patients receiving antibacterial cardiovascular implantable electronic device envelopes:A retrospective analysis

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World Journal of Cardiology 2022年第3期14卷 177-186页

作者： david A Woodard Grace Kim kent R Nilsson Department of Cardiology Piedmont Heart InstituteAthensGA 30606United States Department of Medicine Augusta University-University of Georgia Medical PartnershipAthensGA 30606United States

BACKGROUND Cardiovascular implantable electronic devices(CIEDs)are implanted in an increasing number of patients each year,which has led to an increase in the risk of CIED *** CIED envelopes locally deliver antibiotics to the implant site over a short-term period and have been shown to reduce the risk of implant site *** envelopes are derived from either biologic or nonbiologic *** is a paucity of data examining patient risk profiles and outcomes from using these envelope materials in the clinical setting and comparing these results to patients receiving no envelope with their CIED *** to evaluate risk profiles and outcomes of patients who underwent CIED procedures with an antibacterial envelope or no *** After obtaining Internal Review Board approval,the records of consecutive patients who underwent a CIED implantation procedure by a single physician between March 2017 and December 2019 were retrospectively collected from our hospital.A total of 248 patients within this period were identified and reviewed through 12 mo of follow *** CIED procedures used either no envelope(n=57),a biologic envelope(CanGaroo®,Aziyo Biologics)that was pre-hydrated by the physician with vancomycin and gentamicin(n=89),or a non-biologic envelope(tyrx^(tM),Medtronic)that was coated with a resorbable polymer containing the drug substances rifampin and minocycline by the manufacturer(n=102).Patient selection for receiving either no envelope or an envelope(and which envelope to use)was determined by the treating *** analyses were performed between the 3 groups(CanGaroo,tyrx,and no envelope),and also between the No Envelope and Any Envelope groups by an independent,experienced *** On average,patients who received any envelope(biologic or non-biologic)were younger(70.7±14.0 vs 74.9±10.6,P=0.017),had a greater number of infection risk factors(81.2%vs 49.1%,P<0.001),received more high-

关键词： Cardiovascular implantable electronic device envelope Defibrillator Extracellular matrix Implantable cardioverter-defibrillator Infection Pacemaker

Combining innovative science and policy to improve air quality in cities with refining and chemicals manufacturing： the case study of Houston, texas, USA

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Frontiers of Chemical Science and Engineering 2017年第3期11卷 293-304页

作者： david t. Allen University of texas Austin Department of Chemical Engineering and Center for Energy and Environmental Resources Austin TX 78759 USA

In Houston, a combination of urban emissions from a city of 4 million people, coupled with emissions from extensive petroleum refining and chemical manufacturing, leads to conditions for photochemistry that are unique in the United States, and historically, the city had experienced some of the highest ozone concentrations recorded in the United States. Large air quality field studies （the texas Air Quality Studies or texAQS I and II） were conducted to determine root causes of the high ozone concentrations. Hundreds of air quality investigators, from around the world, deployed instruments on aircraft, on ships, and at fixed ground sites to make extensive air quality measurements; detailed photochemical modeling was used to interpret and assess the implications of the measurements. the texas Air Quality Studies revealed that both continuous and episodic emissions of light alkenes, which came to be called highly reactive volatile organic compounds, played a critical role in the formation of ozone and other photochemical oxidants in the region. Under- standing and quantifying the role of these emissions in regional air quality required innovations in characterizing emissions and in photochemical modeling. Reducing emissions required innovative policy approaches. these coupled scientific and policy innovations are described, and the result, substantially cleaner air for Houston, is documented. the lessons learned from the Houston air quality experience are relevant to cities with similar population and industrial profiles around the world.

关键词： ozone air quality highly reactive volatile organic compounds Houston

Experimental tomographic methods for analysing flow dynamics of gas-oil- water flows in horizontal pipeline

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Journal of Hydrodynamics 2016年第6期28卷 1018-1021页

作者： Qiang WANG Jiri POLANSKY Bishal KARKI Mi WANG kent WEI Changhua QIU Asaad KENBAR david MILLINGtON University of Leeds Leeds LS2 9JT UK Industrial tomography System plc Manchester M3 3JZ UK NEL Glasgow G75 0QF UK

Gas-oil-water three phase flow is of practical significance in oil and gas industries. An insight into the dynamics of such multiphase flows is significantly valuable to obtain optimal design parameters and operational conditions. Since flow patterns are sensitive to pipe geometry, flow conditions and thermophysical properties of fluid, it is extremely challenging to provide a universal solution for visualisation of three phase horizontal flows. this study deals with a fully developed, turbulent three phase flow and presents the outcomes of electrical tomographic imaging techniques to visualise gas-oil-water flows in a horizontal pipeline.

关键词： multiphase flow regimes electrical tomography bubbly flow mapping Boolean logic recognition proper orthogonal decomposition method

Regulation of proprietary traditional Chinese medicines in Australia

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Chinese Journal of Natural Medicines 2017年第1期15卷 12-14页

作者： david t. Graham ISO technical committee 249 (1SO/tC 249) 7-C Shuguang Building 189 Pu 'an Road Shanghai 200021 China

this review article describes the regulation of proprietary Chinese medicines for the Australian market, which may permit many medicines used in traditional Chinese Medicine to have a simplified process of market acce... 详细信息

关键词： Regulation Australia Chinese medicines

Influence of incubation temperature on sea turtle hatchling quality

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Integrative Zoology 2017年第5期12卷 352-360页

作者： david t.BOOtH School of Biological Sciences The University of QueenslandSt LuciaQueenslandAustralia

Since the 1980s it has been known that incubation temperature influences the sex ratio of sea turtle hatchlings emerging from their nests,and there has been much speculation on how global climate change might threaten sea turtle populations by raising nest temperatures and causing highly female-biased hatchling sex *** recently,studies have indicated that incubation temperature can also influence the size and locomotor performance of sea turtle *** I review recent studies that have explored the influence of incubation temperature on sea turtle hatchling quality in terms of hatchling morphology and locomotor performance.I also discuss the likely underlying mechanisms responsible for incubation temperature-induced differences in hatchling locomotor performance,and how an increase in nest temperature associated with global warming might affect recruitment of sea turtle hatchlings.

关键词： locomotor performance nest temperature phenotype sea turtle hatchling

Seed Plant Species Pools：the Development of Species Richness in Eastern Asia and North America

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生物多样性 1994年第B11期2卷 18-29页

作者： kent t. ADAIR SHIYOU LI Henry M. Rockwell Professor of Forestry Henry M. Rockwell Postdoctoral Fellow The Tucker Center Stephen F. Austin State University Nacogdoches Texas 75962 USA

Maximum Species Richness： Where Is It？

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生物多样性 1995年第B6期3卷 30-35页

作者： SHIYOU LI kent t. ADAIR the tucker Center. Stephen F. Austin State University. Nacogdoches. texas 75962. USA

Colorectal cancer and dysplasia in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第17期14卷 2662-2669页

作者： timothy L Zisman david t Rubin Clinical Research Fellow in Gastro-enterology the University of Chicago Medical Center the University of Chicago Medical Center

Both ulcerative colitis and Crohn’s disease carry an increased risk of developing colorectal cancer. Established risk factors for cancer among patients with inflammatory bowel disease (IBD) include the younger age at diagnosis, greater extent and duration of disease, increased severity of inflammation, family history of colorectal cancer and coexisting primary sclerosing cholangitis. Recent evidence suggests that current medical therapies and surgical techniques for inflammatory bowel disease may be reducing the incidence of this complication. Nonetheless heightened vigilance and a careful, comprehensive approach to prevent or minimize the complications of invasive cancer are warranted in this unique cohort of patients. Current guidelines for the prevention and early detection of cancer in this high risk population are grounded in the concept of an inflammation-dysplasia- carcinoma sequence. A thorough understanding of the definition and natural history of dysplasia in IBD, as well as the challenges associated with detection and interpretation of dysplasia are fundamental to developing an effective strategy for surveillance and prevention, and understanding the limitations of the current approach to prevention. this article reviews the current consensus guidelines for screening and surveillance of cancer in IBD, as well as presenting the evidence and rationale for chemoprevention of cancer and a discussion of emerging technologies for the detection of dysplasia.

关键词： Cancer Dysplasia Inflammatory Bowel Disease Ulcerative Colitis Crohn's Disease Chemoprevention