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Journal of Forensic Science and Medicine 2024年第3期10卷 171-175页

作者： Clinton david Orupabo Joshua Oghenemiro Chijioke department of Human Anatomy Faculty of Basic Medical SciencesCollege of Medical SciencesRivers State UniversityPort HarcourtNigeria

Background:Human bone analysis is a useful tool in assessing and identifying skeletal *** make this easier,newer and modified approaches have often being *** and Objectives:The aim of this study is to analyze the histomorphometric features of various bone segments and its relevance in forensic case *** and Methods:The human bones used were that of cadaveric bone samples harvested from three adult male *** proximal,midshaft and distal segments of the femur,tibia,and humerus were utilized for the *** bone sections were subjected to processing using Frost’s rapid manual preparation of ground sections *** evaluation studied the number of primary osteons,secondary osteons,and osteon fragments,as well as the Haversian canal diameter(HCd).Results:The primary osteons,secondary osteons,osteon fragments,and HCd in each of the segments of the long bones show that the F values are less than the F critical for an alpha level of *** shows that there is no statistically significant(p>0.05)variation in the histomorphometric pattern for the various segments of the bones *** differences in the haversian canal diameter of the various segments of the long bones shows statistically significant variation(pdings have laid to rest the challenges with using the only available bone fragment for forensic case investigation as no notable variations exist across various segments.

关键词： Bone comparative histology forensic anthropology haversian canals osteons

ApIR:Aggregating Universal proteomics database Search Algorithms for peptide Identification with FdR Control

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Genomics, proteomics & Bioinformatics 2024年第2期22卷 171-187页

作者： Yiling Elaine Chen Xinzhou Ge kyla Woyshner MeiLu Mcdermott Antigoni Manousopoulou Scott B.Ficarro Jarrod A.Marto kexin Li Leo david Wang Jingyi Jessica Li department of Statistics and data Science University of CaliforniaLos AngelesCA 90095USA department of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA department of Quantitative and Computational Biology University of Southern CaliforniaLos AngelesCA 90089USA department of Cancer Biology and Blais proteomics Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA department of pediatrics City of Hope National Medical CenterDuarteCA 91010USA Bioinformatics Interdepartmental program University of CaliforniaLos AngelesCA 90095USA department of Human Genetics University of CaliforniaLos AngelesCA 90095USA department of Computational Medicine University of CaliforniaLos AngelesCA 90095USA department of Biostatistics University of CaliforniaLos AngelesCA 90095USA

Advances in mass spectrometry(MS)have enabled high-throughput analysis of proteomes in biological *** state-of-the-art MS data analysis relies on database search algorithms to quantify proteins by identifying peptide–spectrum matches(pSMs),which convert mass spectra to peptide *** database search algorithms use distinct search strategies and thus may identify unique ***,no existing approaches can aggregate all user-specified database search algorithms with a guaranteed increase in the number of identified peptides and a control on the false discovery rate(FdR).To fill in this gap,we proposed a statistical framework,Aggregation of peptide Identification Results(ApIR),that is universally compatible with all database search ***,under an FdR threshold,ApIR is guaranteed to identify at least as many,if not more,peptides as individual database search algorithms *** of ApIR on a complex proteomics standard dataset showed that ApIR outpowers individual database search algorithms and empirically controls the *** data studies showed that ApIR can identify disease-related proteins and post-translational modifications missed by some individual database search *** ApIR framework is easily extendable to aggregating discoveries made by multiple algorithms in other high-throughput biomedical data analysis,e.g.,differential gene expression analysis on RNA sequencing *** ApIR R package is available at https://***/yiling0210/ApIR.

关键词： Shotgun proteomics peptide–spectrum match peptide identification Aggregation of lists FdR control

A system for probing Casimir energy corrections to the condensation energy

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Microsystems & Nanoengineering 2020年第1期6卷 1-12页

作者： diego perez-Morelo Alexander Stange Richard W.Lally Lawrence k.Barrett Matthias Imboden Abhishek Som david k.Campbell Vladimir A.Aksyuk david J.Bishop department of ECE Boston UniversityBostonMA 02215USA physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Institute for Research in Electronics and Applied physics&Maryland NanoCenter University of MarylandCollege ParkMD 20742USA division of MSE Boston UniversityBostonMA 02215 USA 54k-MEMS Sarl Rue des Lavannes 172072 St BlaiseSwitzerland department of physics Boston UniversityBostonMA 02215USA department of ME Boston UniversityBostonMA 02215USA department of BME Boston UniversityBostonMA 02215USA

In this article,we present a nanoelectromechanical system(NEMS)designed to detect changes in the Casimir *** Casimir effect is a result of the appearance of quantum fluctuations in an electromagnetic *** experiments have used nano-or microscale parallel plate capacitors to detect the Casimir force by measuring the small attractive force these fluctuations exert between the two *** this new set of experiments,we aim to directly detect the shifts in the Casimir energy in a vacuum due to the presence of the metallic parallel plates,one of which is a superconductor.A change in the Casimir energy of this configuration is predicted to shift the superconducting transition temperature(T_(c))because of the interaction between it and the superconducting condensation *** our experiment,we take a superconducting film,carefully measure its transition temperature,bring a conducting plate close to the film,create a Casimir cavity,and then measure the transition temperature *** expected shifts are smaller than the normal shifts one sees in cycling superconducting films to cryogenic temperatures,so using a NEMS resonator in situ is the only practical way to obtain accurate,reproducible *** a thin pb film and opposing Au surface,we observe no shift in T_(c)>12µk down to a minimum spacing of~70 nm at zero applied magnetic field.

关键词： cycling energy film

Wild Nutrition’s Food-Grown® Magnesium Supplementation Increases Sleep Quality and Sleep duration and Reduces Stress in a Healthy Adult population: A double-Blind, Randomised, placebo-Controlled Study

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Food and Nutrition Sciences 2024年第7期15卷 509-523页

作者： david Briskey Jane Erickson Chelsie Smith Amanda Rao School of Human Movement and Nutrition Sciences University of Queensland Brisbane Australia RdC Clinical Brisbane Australia

Background: Magnesium, an essential mineral crucial for various bodily functions, has been shown to positively influence sleep patterns. This study aimed to evaluate the efficacy of Food-Grown® magnesium in enhancing sleep quality and duration, as well as overall well-being. Methods: Eighty participants were randomly assigned to receive either 80 mg of Food-Grown® magnesium or a placebo (microcrystalline cellulose) daily for 8 weeks. participants completed questionnaires assessing sleep quality, daytime drowsiness, quality of life, anxiety, and stress levels. Additionally, participants maintained daily sleep diaries and wore wrist-worn actigraphy devices. The primary outcome measured was the change in sleep quality and duration. Results: Seventy-one participants fulfilled all study requirements (35 in the active group and 36 in the placebo group). Magnesium supplementation significantly improved reported sleep quality, with the active group showing a 32% increase compared to 16% in the placebo group (p = 0.034). Moreover, magnesium supplementation led to a decrease in reported stress scores at week 8 compared to the placebo group (3.7 ± 2.6 vs. 5.5 ± 3.1, respectively). Both the magnesium and placebo groups exhibited significant increases in reported sleep duration and reductions in time to fall asleep, sleep disturbance, sleep latency, sleep medication usage, and total pittsburgh Sleep Quality Index score at week 8 compared to baseline. Conclusion: Magnesium supplementation notably enhanced sleep quality and reduced stress levels compared to the placebo group. These findings highlight the potential of magnesium as a beneficial supplement for improving sleep quality and overall well-being.

关键词： Magnesium Sleep Quality Sleep duration Stress Food-Grown

Risk of colon cancer in hereditary non-polyposis colorectal cancer patients as predicted by fuzzy modeling:Influence of smoking

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World Journal of Gastroenterology 2006年第28期12卷 4485-4491页

作者： Rhonda M Brand david d Jones Henry T Lynch Randall E Brand patrice Watson Ramesh Ashwathnayaran Hemant k Roy department of Internal Medicine Evanston Northwestern Healthcare and Feinberg School of Medicine at Northwestern UniversityEvanston ILUinted States department of Biological Systems Engineering University of Nebraska-LincolnLincoln NEUinted States Hereditary Cancer Institute Creighton UniversityUinted States

AIM： To investigate whether a fuzzy logic model could predict colorectal cancer （CRC） risk engendered by smoking in hereditary non-polyposis colorectal cancer （HNpCC） patients. METHOdS： Three hundred and forty HNpCC mismatch repair （MMR） mutation carriers from the Creighton University Hereditary Cancer Institute Registry were selected for modeling. Age-dependent curves were generated to elucidate the joint effects between gene mutation （hMLH1 or hMSH2）, gender, and smoking status on the probability of developing CRC. RESULTS： Smoking significantly increased CRC risk in male hMSH2 mutation carriers （p 〈 0.05）. hMLH1 mutations augmented CRC risk relative to hMSH2 mutation carriers for males （p 〈 0.05）. Males had a significantly higher risk of CRC than females for hMLH1 non smokers （p 〈 0.05）, hMLH1 smokers （p 〈 0.1） and hMSH2 smokers （p 〈 0.1）. Smoking promoted CRC in a dose-dependent manner in hMSH2 in males （p 〈 0.05）. Females with hMSH2 mutations and both sexes with the hMLH1 groups only demonstrated a smoking effect after an extensive smoking history （p 〈 0.05）. CONCLUSION： CRC promotion by smoking in HNpCC patients is dependent on gene mutation, gender and age. These data demonstrate that fuzzy modeling may enable formulation of clinical risk scores, thereby allowing individualization of CRC prevention strategies.

关键词： Hereditary non-polyposis colorectal cancer Lynch syndrome Smoking Colorectal cancer Fuzzy modeling Risk assessment

Microbial and size characterization of airborne particulate matter collected on sticky tapes along US–Mexico border

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Journal of Environmental Sciences 2017年第3期29卷 207-216页

作者： Amir Gonzalez-delgado Manoj k.Shukla david W.duBois Juan p.Flores-Mdrgez Joel A.Hernandez Escamilla Evangelina Olivas plant and Environmental Sciences department New Mexico State UniversityMSC 3Q Skeen Hall Room N 127P.O.Box 30003Las CrucesNM 88003-8003USA Universidad Autonoma de Ciudad Judrez UACJAv.Plutarco Elias Calles 1020Fovisste ChamizalCiudad JudrezChihuahua C.P.32310Mexico

particulate matter （pM） emissions from various sources can affect significantly human health and environmental quality especially in the Chihuahuan desert region along US- Mexico border. The objective of this study was to use the low-cost sticky tape method to collect airborne pM for size characterization and identification of fungal spores. Sticky tape samplers were placed at 1.0 and 2.0 m above the ground surface at experimental sites in Ciudad Ju＆ez, Mexico and at 0.6, 1.2 and 1.8 m at New Mexico sites, USA. Soil samples were collected in both countries to determine fungal diversity, texture and moisture content. dust particles collected from all of the experimental sites had a dominant texture of clay （〈0.002 mm）. The dominant textures identified from soil samples collected from the US and Mexican sites were loam and sandy clay loam, respectively. Alternaria, penicillium and Fusarium were frequently found funguses in the US sites while Alternaria and Aspergillus were commonly observed in the Mexican sites. The sticky tapes also showed a similar diversity of fungal microorganisms present in the airborne pM at both Mexico and US sites. Alternaria, penicillium and Aspergillus were the three groups of airborne fungal microorgan- isms consistently present in the US and Mexican sites. The low-cost sticky tape method has the potential to be used for characterizing different airbome microorganisms and dust particles.

关键词： Fungal sporesSticky tapeparticle sizeMicroorganismdust

Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity

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World Journal of Gastroenterology 2024年第4期30卷 332-345页

作者： Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah p Eckel douglas I Walker damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell david V Conti Lida Chatzi department of population and public Health Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90032United States Barcelona Institute of Global Health Barcelona Institute of Global HealthBarcelona 08036Spain department of Environmental Health Sciences Mailman School of Public HealthColumbia UniversityNew YorkNY 10032United States Gangarosa department of Environmental Health Rollins School of Public HealthEmory UniversityAtlantaGA 30329United States department of Environmental Medicine and public Health Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States department of Environmental Toxicology University of CaliforniaDavisCA 95616United States department of Surgery Lurie Children’s Hospital of ChicagoChicagoIL 60611United States Northwestern University Feinberg School of Medicine Northwestern UniversityChicagoIL 60611United States division of Biostatistics and Epidemiology Cincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States department of pediatrics University of Cincinnati College of MedicineCincinnatiOH 45229United States department of pediatrics Children’s Nutrition Research Center USDA/ARSBaylor College of MedicineHoustonTX 77030United States department of Gastroenterology Children’s Hospital Los AngelesLos AngelesCA 90027United States division of Gastroenterology Hepatology and NutritionCincinnati Children's Hospital Medical CenterCincinnatiOH 45229United States

BACkGROUNd Nonalcoholic fatty liver disease(NAFLd)is one of the most common chronic liver diseases in children and *** ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with *** microRNA(miRNA)levels have been suggested to be altered in NAFLd,but the extent to which miRNA are related to NAFLd features remains *** analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLd in *** To investigate the relationship between plasma miRNA expression and NAFLd features among adolescents with *** This study included 81 adolescents diagnosed with NAFLd and 54 adolescents without NAFLd from the Teen-Longitudinal Assessment of Bariatric Surgery ***-operative core liver biopsies were collected from participants and used to characterize histological features of *** samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq *** examined associations of plasma miRNAs and NAFLd features using logistic regression after adjusting for age,sex,race,and other key *** pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of *** We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with ***,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,***,16 miRNAs were associated with two or more histological features of *** those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and posi

关键词： MicroRNA Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Liver fibrosis Lobular inflammation Ballooning degeneration

Fatal gastrointestinal histoplasmosis 15 years after orthotopic liver transplantation

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World Journal of Gastroenterology 2017年第43期23卷 7807-7812页

作者： Nikita Agrawal david EJ Jones Jessica k dyson Tim Hoare Sharon A Melmore Stephanie Needham Nick p Thompson department of Gastro-enterology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom Faculty of Medical Sciences Newcastle UniversityNewcastle Upon Tyne NE7 7DNUnited Kingdom department of Radiology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom department of Histopathology Newcastle Hospitals NHS Foundation TrustNewcastle Upon Tyne NE7 7DNUnited Kingdom

We report a case of ileo-colonic Histoplasmosis without apparent respiratory involvement in a patient who had previously undergone an orthotopic liver transplant(OLT) for primary biliary cholangitis 15 years earlier. The recipient lived in the United kingdom,a non-endemic region for Histoplasmosis. However,she had previously lived in rural southern Africa prior to her OLT. The patient presented with iron deficiency anaemia,diarrhoea,abdominal pain and progressive weight loss. She reported no previous foreign travel,however,it later became known that following her OLT she had been on holiday to rural southern Africa. On investigation,a mild granulomatous colitis primarily affecting the right colon was identified,that initially improved with mesalazine. Her symptoms worsened after 18 mo with progressive ulceration of her distal small bowel and right colon. Mycobacterial,Yersinia,cytomegalovirus and human immunodeficiency virus infections were excluded and the patient was treated with prednisolone for a working diagnosis of Crohn's disease. despite some early symptom improvement following steroids,there was subsequent deterioration with the patient developing gram-negative sepsis and multi-organ failure,leading to her death. post-mortem examination revealed that her ileo-colonic inflammation was caused by Histoplasmosis.

关键词： Histoplasmosis Orthotopic liver transplant primary biliary cholangitis primary biliary cholangitis

Change in Functional Status from preoperative to One Year postoperative in patients Who Have Undergone Elective Open-Heart Surgery: A Repeated-Measures Study

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World Journal of Cardiovascular diseases 2024年第6期14卷 421-433页

作者： A. kate Macphedran david Barker Mark Marbey kieran Fogarty physical Therapy program Morosky College of Health Professions and Sciences Gannon University Erie PA USA Interdisciplinary Health Sciences phd program College of Health and Human Sciences Western Michigan University Kalamazoo MI USA Organizational Learning and Leadership phd program College of Humanities Education and Social Sciences Gannon University Erie PA USA Cardiac Surgery Services AHN Saint Vincent Health Center Erie PA USA

purpose: Although patient-related factors affect surgical outcomes, preoperative functional status is not measured by any cardiac risk score. Functional status can, however, be objectively measured using validated outcome tools such as the Late-Life Function and disability Instrument (LLFdI). The purpose of this study was to determine 1) if there was a change over time in functional status, as measured by the LLFdI, in patients who underwent elective cardiac surgery, and if so, 2) what specific aspect(s) of functional status changed. Methods: A prospective longitudinal study of one year was conducted on elective cardiac surgery patients (n = 43) using the self-reported LLFdI, which measures disability Frequency (frequency of participation in social tasks), disability Limitation (ability to participate in social tasks) and Function Total (ease in performing routine activities). Higher scores indicate increased function and decreased disability. LLFdI scores were compared at three times (preoperative, six-week and one-year postoperative) using repeated measures ANOVA. post hoc pairwise comparison was conducted for specific interactions. Results: Both Function Total and disability Frequency significantly changed over time (p = 0.047 and p = 0.013, respectively). Specifically, patients’ function level was significantly higher one-year postoperative compared to preoperative (M difference = +3.48, SE = 1.48, p = 0.026). Likewise, disability Frequency scores were significantly higher (i.e. more active) at one-year postoperative versus preoperative (M difference= +5.98, SE = 2.19, p = 0.033). disability Limitation scores were not significantly different between any time points (p > 0.05). Conclusion: By one-year postoperative, patients demonstrated increased ease in their routine physical activities and were more participatory in social life tasks. Individuals who underwent elective cardiac surgery took more than six weeks to detect notable improvement in functional status,

关键词： Functional Status Elective Cardiac Surgery Late-Life Function and disability Instrument

persistent Abdominal pain Associated with Splenic Lymphangioma in An Adult patient: A Case presentation

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Journal of Biosciences and Medicines 2024年第9期12卷 82-88页

作者： david Fernando Ortiz pérez Janne Jorgeth Fabregas Ramirez Mario Enrique Montoya Jaramillo Juan José Iles Bravo John Sebastián Osorio Muñoz Manuel Fernando Chavarro Muñoz daniel de Jesús González Villarreal Manuel Esteban Ortiz pérez department of Internal Medicine Cartagena del Mar Clinical Center Cartagena Colombia

Splenic lymphangioma is a rare benign lesion, predominantly seen in the pediatric population and exceptionally in adults. It is usually associated with lymphatic system malformations caused by secondary lymphangiectasia due to abnormal communication between lymphatic ducts. It often coexists with complex clinical syndromes, such as klippel-Trenaunay syndrome, congenital epithelial cysts, or, in less frequent conditions, infectious or post-traumatic triggering events. It typically presents in the neck or axillae, with intra-abdominal cases accounting for less than 5% of all cases. We present the clinical case of a 44-year-old male patient who presented with a clinical course of approximately one month, characterized by progressive abdominal pain associated with nausea, multiple episodes of emesis, anorexia, and involuntary weight loss. A diagnostic laparoscopy was performed, revealing a poorly differentiated lesion in the splenic topography, for which a biopsy was performed, leading to the definitive diagnosis. In this scenario, splenic lymphangioma should be considered among the differential diagnoses of persistent abdominal pain, and definitive interventions should be determined based on clinical characteristics.

关键词： Lymphangioma Neoplasms Splenic Neoplasms Laparoscopy Adulthood