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Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex david J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Making bridges between preclinical and clinical insights into age-related cognitive decline

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Neural Regeneration Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio Nóbrega Algarve Biomedical Center-Research Institute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Center-(ABC) Campus GambelasFaroPortugal Faculty of Medicine and Biomedical sciences(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people living longer,the societal impact of age-related cognitive decline is becoming more pronounced(Crimmins,2015).Thus,it is increasingly important to comprehend the cognitive shifts linked to aging-whether th... 详细信息

关键词： bridges becoming insight

Current state-of-the-art review of footwear–ground friction

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Friction 2024年第10期12卷 2188-2204页

作者： david REBENDA Tomáš sÁHA Footwear Research Centre University InstituteTomas Bata University in ZlinZlin 76001Czech Republic Faculty of Mechanical Engineering Brno University of TechnologyBron 61600Czech Republic

The most important role of footwear is to ensure safe,functional walking,and foot *** the proper functionality of not only the work shoes,the anti-slip behavior of the shoe under various conditions and environments plays an important role in the prevention of slips,trips,falls,and consequent *** article is intended to review the current understanding of the frictional mechanisms between shoe outsoles and various counterfaces that impact the evaluation of outsole *** research focuses on the mechanisms driving outsole friction on different ground surfaces or the definition and description of parameters that influence outsole ***,the review discusses the effect of various surface contaminants on footwear ***,challenges and outlooks in the field of footwear outsoles are briefly mentioned.

关键词： shoe outsole composite slipperiness coefficient of friction(COF) adhesion safe walk

Toward a neurobiology of auditory object perception： What can we learn from the songbird forebrain？

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Current Zoology 2011年第6期57卷 671-683页

作者： Kai LU, david s. VICARIO Department of Psychology Rutgers University Piscataway NJ 08854 USA

In the acoustic world, no sounds occur entirely in isolation; they always reach the ears in combination with other sounds. How any given sound is discriminated and perceived as an independent auditory object is a challenging question in neu- roscience. Although our knowledge of neural processing in the auditory pathway has expanded over the years, no good theory ex- ists to explain how perception of auditory objects is achieved. A growing body of evidence suggests that the selectivity of neurons in the auditory forebrain is under dynamic modulation, and this plasticity may contribute to auditory object perception. We propose that stimulus-specific adaptation in the auditory forebrain of the songbird （and perhaps in other systems） may play an important role in modulating sensitivity in a way that aids discrimination, and thus can potentially contribute to auditory object perception.

关键词： songbird Object perception Auditory scene analysis Neural selectivity Plasticity stimulus-specific adaptation

strategies to avoid a missed diagnosis of co-occurring concussion in post-acute patients having a spinal cord injury

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Neural Regeneration Research 2015年第6期10卷 859-861页

作者： david s.Kushner Department of Physical Medicine & Rehabilitation University of Miami Miller School of Medicine

Research scientists and clinicians should be aware that missed diagnoses of mild-moderate traumatic brain injuries in post-acute patients having spinal cord injuries may approach 60-74% with certain risk factors, potentially causing clinical consequences for patients, and confounding the results of clinical research studies. Factors leading to a missed diagnosis may include acute trauma-related life-threatening issues, sedation/intubation, subtle neuropathology on neuroimaging, failure to collect Glasgow Coma scale scores or duration of posttraumatic amnesia, or lack of validity of this information, and overlap in neuro-cognitive symptoms with emotional responses to spinal cord injuries. strategies for avoiding a missed diagnosis of mild-moderate traumatic brain injuries in patients having a spinal cord injuries are highlighted in this perspective.

关键词： traumatic brain injury spinal cord injuries dual diagnosis diagnosis complications rehabilitation post-concussion syndrome brain concussion

The basic practice of statistics / david s. Moore. 2nd ed.

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Role of climatic variability in shaping intraspecific variation of thermal tolerance in Mediterranean water beetles

2000年

作者： david s. Moore.

A gift of the Asia Bridge.

ISBN: (纸本)0716736276

A gift of the Asia Bridge.

关键词： statistics.

来源：畅想之星图书光盘版（南... 评论

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Insect science 2024年第1期31卷 285-298页

作者： susana Pallarés david Garoffolo Belén Rodríguez david sánchez-Fernández Department of Zoology University of SevilleSevilleSpain Faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The climatic variability hypothesis(CVH)predicts that organisms in more thermally variable environments have wider thermal breadths and higher thermal plasticity than those from more stable ***,due to evolutionary trade-offs,taxa with greater absolute thermal limits may have little plasticity of such limits(trade-off hypothesis).The CVH assumes that climatic variability is the ultimate driver of thermal tolerance variation across latitudinal and altitudinal gradients,but average temperature also varies along such *** explored intraspecific variation of thermal tolerance in three typical Mediterranean saline water beetles(families Hydrophilidae and Dytiscidae).For each species,we compared two populations where the species coexist,with similar annual mean temperature but contrasting thermal variability(continental *** population).We estimated thermal limits of adults from each population,previously acclimated at 17,20,or 25℃.We found species-specific patterns but overall,our results agree with the CVH regarding thermal ranges,which were wider in the continental(more variable)*** the two hydrophilid species,this came at the cost of losing plasticity of the upper thermal limit in this population,supporting the trade-off hypothesis,but not in the dytiscid *** results support the role of local adaptation to thermal variability and trade-offs between basal tolerance and physiological plasticity in shaping thermal tolerance in aquatic ectotherms,but also suggest that intraspecific variation of thermal tolerance does not fit a general pattern among aquatic *** such intraspecific variation could lead to inaccurate predictions of the vulnerability of aquatic insects to global warming.

关键词： acclimation capacity aquatic insects climate change heat coma temperature supercooling point thermal plasticity

Bone–cartilage crosstalk:a conversation for understanding osteoarthritis

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Bone Research 2016年第3期4卷 121-132页

作者： david M Findlay Julia s Kuliwaba Discipline of Orthopaedics and Trauma The University of Adelaide

Although cartilage degradation is the characteristic feature of osteoarthritis （OA）, it is now recognized that the whole joint is involved in the progression of OA. In particular, the interaction （crosstalk） between cartilage and subchondral bone is thought to be a central feature of this process. The interface between articular cartilage and bone of articulating long bones is a unique zone, which comprises articular cartilage, below which is the calcified cartilage sitting on and intercalated into the subchondral bone plate. Below the subchondral plate is the trabecular bone at the end of the respective long bones. In OA, there are well- char described *** destructive tges in the ~cular cartilage, which parallel characteristic changes in the underlying hone, This review examines the evidence that biochemical and biomechanical signaling between these tissue compartments is important in OA disease progression and asks whether such signaling might provide possibilities for therapeutic intervention to halt or slow disease development.

关键词： OA Bone

New Generations: sequencing Machines and Their Computational Challenges

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Journal of Computer science & Technology 2010年第1期25卷 3-9页

作者： david C. schwartz Michael s. Waterman Laboratory for Molecular and Computational Genomics Departme4nt of Chemistry and Laboratory of Genetics University of Wisconsin-Madison Department of Biological sciences University of Southern California Department of Automation Tsinghua University

New generation sequencing systems are changing how molecular biology is practiced. The widely promoted $1000 genome will be a reality with attendant changes for healthcare, including personalized medicine. More broadly the genomes of many new organisms with large samplings from populations will be commonplace. What is less appreciated is the explosive demands on computation, both for CPU cycles and storage as well as the need for new computational methods. In this article we will survey some of these developments and demands.

关键词： genome sequencing new generation sequencing read mapping optical mapping sequence assembly Eulerian graphs