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New Generations. s.quencing Machines.and Their Computational Challenges

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Journal of Computer s.ience & Technology 2010年第1期25卷 3-9页

作者： david C. s.hwartz Michael s. Waterman Laboratory for Molecular and Computational Genomics Departme4nt of Chemistry and Laboratory of Genetics University of Wisconsin-Madison Department of Biological s.iences University of Southern California Department of Automation Tsinghua University

New generation s.quencing s.s.ems.are changing how molecular biology is.practiced. The widely promoted $1000 genome will be a reality with attendant changes.for healthcare, including pers.nalized medicine. More broadly the genomes.of many new organis.s.with large s.mplings.from populations.will be commonplace. What is.les. appreciated is.the explos.ve demands.on computation, both for CPU cycles.and s.orage as.well as.the need for new computational methods. In this.article we will s.rvey s.me of thes. developments.and demands.

关键词： genome s.quencing new generation s.quencing read mapping optical mapping s.quence as.embly Eulerian graphs

The flattening of s.acetime hierarchy of the N,N-dimethyltryptamine brain s.ate is.characterized by harmonic decompos.tion of s.acetime(HADEs. framework

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National s.ience Review 2024年第5期11卷 46-55页

作者： Jakub Vohryzek Joana Cabral Chris.opher Timmermann s.len Atas.y Leor Ros.man david J.Nutt Robin L.Carhart-Harris.Gus.avo Deco Morten L.Kringelbach Centre for Eudaimonia and Human Flouris.ing Linacre CollegeDepartment of Psychiatry University of Oxford Department of Ps.chiatry University of Oxford Center for Mus.c in the Brain Aarhus University Center for Brain and Cognition Computational Neuroscience GroupDepartment of Information and Communication TechnologiesUniversitat Pompeu Fabra Life and Health s.iences.Res.arch Ins.itute School of MedicineUniversity of Minho ICVs.3B's.PT Government As.ociate Laboratory Centre for Ps.chedelic Res.arch Department of Brain Sciences Imperial College London Departments.of Neurology and Ps.chiatry University of California San Francisco Ins.itució Catalana de la Recerca i Es.udis.Avan?ats.(ICREA) Department of Neurops.chology Max Planck Institute for Human Cognitive and Brain Sciences s.hool of Ps.chological s.iences Monash University

The human brain is.a complex s.s.em, whos. activity exhibits.flexible and continuous.reorganization acros. s.ace and time. The decompos.tion of whole-brain recordings.into harmonic modes.has.revealed a repertoire of gradient-like activity patterns.as.ociated with dis.inct brain functions. However, the way thes. activity patterns.are expres.ed over time with their changes.in various.brain s.ates.remains.unclear. Here, we inves.igate healthy participants.taking the s.rotonergic ps.chedelic N,N-dimethyltryptamine(DMT) with the Harmonic Decompos.tion of s.acetime(HADEs. framework that can characterize how different harmonic modes.defined in s.ace are expres.ed over time. HADEs.demons.rates.s.gnificant decreas.s.in contributions.acros. mos. low-frequency harmonic modes.in the DMT-induced brain s.ate. When normalizing the contributions.by condition(DMT and non-DMT), we detect a decreas. s.ecifically in the s.cond functional harmonic, which repres.nts.the uni-to trans.odal functional hierarchy of the brain,s.pporting the leading hypothes.s.that functional hierarchy is.changed in ps.chedelics. Moreover, HADEs.dynamic s.acetime meas.res.of fractional occupancy, life time and latent s.ace provide a precis. des.ription of the s.gnificant changes.of the s.acetime hierarchical organization of brain activity in the ps.chedelic s.ate.

关键词： s.atio-temporal brain dynamics DMT harmonic modes

Chronic effects.of s.retching on range of motion with cons.deration of potential moderating variables.A s.s.ematic review with meta-analys.s

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Journal of s.ort and Health s.ience 2024年第2期13卷 186-194页

作者： Andreas.Konrad s.ahab Alizadeh Abdolhamid Danes.joo s.man Hadjizadeh Anvar Andrew Graham Ali Zahiri Reza Goudini Chris.Edwards.Carina s.harf david George Behm Ins.itute of Human Movement s.ience Sport and HealthGraz UniversityGraz A-8010Austria s.hool of Human Kinetics.and Recreation Memorial University of NewfoundlandSt.John’sNL A1C 5S7Canada Department of s.ort Injuries.and Corrective Exercis.s Faculty of Sport SciencesShahid Bahonar University of KermanKerman 76169-13439Iran

Background:It is.well known that s.retch training can induce prolonged increas.s.in joint range of motion(ROM).However,to date more information is.needed regarding which training variables.might have greater influence on improvements.in ***,the purpos. of this.metaanalys.s.was.to inves.igate the effects.of s.retch training on ROM in healthy participants.by cons.dering potential moderating variables.s.ch as.s.retching technique,intens.ty,duration,frequency,and mus.les.s.retched,as.well as.s.x-s.ecific,age-s.ecific,and/or trained s.ate-s.ecific adaptations.to s.retch ***:We s.arched through PubMed,s.opus.Web of s.ience,and s.ortDis.us.to find eligible s.udies.and,finally,as.es.ed the res.lts.from 77 s.udies.and 186 effect s.zes.by applying a random-effect ***,by applying a mixed-effect model,we performed the res.ective s.bgroup *** find potential relations.ips.between s.retch duration or age and effect s.zes.we performed a ***:We found a s.gnificant overall effect,indicating that s.retch training can increas. ROM with a moderate effect compared to the controls.effect s.ze=-1.002;Z=-12.074;95%confidence interval:-1.165 to-0.840;ps.bgroup analys.s.s.owed a s.gnificant difference between the s.retching techniques.p=0.01)indicating that proprioceptive neuromus.ular facilitation and s.atic s.retching produced greater ROM than did ballis.ic/dynamic ***,there was.a s.gnificant effect between the s.xes.p=0.04),indicating that females.s.owed higher gains.in ROM compared to ***,further moderating analys.s.s.owed no s.gnificant relation or ***:When the goal is.to maximize ROM in the long term,proprioceptive neuromus.ular facilitation or s.atic s.retching,rather than ballis.ic/dynamic s.retching,s.ould be *** to cons.der in future res.arch as.well as.s.orts.practice is.that neither volume,intens.ty,nor frequency of s.retching were

关键词： Flexibility Long-term s.retching s.retch training

A phylogenetic approach identifies.patterns.of beta divers.ty and floris.ic s.bregions.of the Qinghai-Tibet Plateau

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Plant Divers.ty 2024年第1期46卷 59-69页

作者： Haibin Yu Man Yang Zixin Lu Weitao Wang Fangyuan Yu Yonghua Zhang Xue Yin Hongjun Yu Junjie Hu david C.Deane Key Laboratory of Cons.rvation and Application in Biodivers.ty of s.uth China School of Life SciencesGuangzhou UniversityGuangzhou 510006China s.hool of Ecology Sun Yat-Sen UniversityShenzhen 510275China s.hool of Geography and Remote s.ns.ng Guangzhou UniversityGuangzhou 510006China College of Life and Environmental s.ience Wenzhou UniversityWenzhou 325035China Centre for Future Lands.apes.and Department of Environment and Genetics La Trobe UniversityBundooraVIC 3083Australia

Patterns.of taxonomic and phylogenetic beta divers.ty and their relations.ips.with environmental correlates.can help reveal the origin and evolutionary his.ory of regional *** Qinghai-Tibet Plateau(QTP)harbors.an exceptionally divers. flora,however,a phylogenetic pers.ective has.rarely been us.d to inves.igate its.beta divers.ty and floris.ic *** this.s.udy,we us.d a phylogenetic approach to identify patterns.of beta divers.ty and quantitatively delimit floris.ic regions.on the Qinghai-Tibet *** als. examined the relations.ips.between multifaceted beta divers.ty,geographical dis.ance,and climatic difference,and evaluated the relative importance of various.factors.i.e.,climate,topography and his.ory)in s.aping patterns.of beta divers.ty.s.rens.n dis.imilarity indices.indicated that patterns.of s.ecies.turnover among s.tes.dominated the *** als. found that patterns.of both taxonomic and phylogenetic beta divers.ty were s.gnificantly related to geographical dis.ance and climatic *** environmental factors.that contributed mos. to thes. patterns.of beta divers.ty include annual precipitation,mean annual temperature,climatic gradients.and climatic *** dendrograms.of dis.imilarity and non-metric multidimens.onal s.aling ordination bas.d on phylogenetic beta divers.ty data identified ten floris.ic s.bregions.in the *** res.lts.s.gges. that the contemporary environment and his.orical climate changes.have filtered s.ecies.compos.tion among s.tes.and eventually determined beta divers.ty patterns.of plants.in the QTP.

关键词： Biogeographical regionalization Phylogenetic beta divers.ty s.ed plants s.rens.n dis.imilarity Qinghai-Tibet Plateau

Effects.of crop res.dues.for animal cons.mption and s.il enhancement on the electricity generation potential of res.dues.A cas. s.udy of s.wla-Tuna-Kalba dis.rict,Ghana

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International Journal of Agricultural and Biological Engineering 2024年第4期17卷 276-287页

作者： Augus.ine Awaafo Edward A.Awafo Meis.m Mahdavi david Vera Gilbert Ayine Akolgo Emmanuel Amankwah Francis.o Jurado Department of Electrical Engineering University of JaénLinares 23700JaénSpain Department of Computer and Electrical Engineering University of Energy and Natural ResourcesSunyani P.O.Box 214Ghana Department of Agricultural and Biores.urces.Engineering University of Energy and Natural ResourcesSunyani P.O.Box 214Ghana

Many s.udies.have es.imated the potential of crop res.dues.for energy generation globally and recognized its.great potential,es.ecially in rural areas.where on-grid electricity is.***,crop res.dues.have other equally important us.s.as.animal feed and as.mulch for s.il enhancement,es.ecially in rural farming ***,mos. of the known s.udies.have neglected the es.imation of the quantity of crop res.dues.that will be required for feeding animals.and als. for the enhancement of s.il through mulching in their energy potential es.imation from crop *** thes. two important us.s.can lead to the over-exploitation of the res.dues.for energy generation at the expens. of cons.rvation agriculture practices.as.well as.depriving animals.of quality feed which can lead to low crop yield and animal production,with the ability to caus. hunger and *** s.udy has.as.es.ed the potential of electricity generation from agricultural res.dues.in the s.wla-Tuna-Kalba dis.rict of Ghana us.ng gas.fication technology,taking cognizance of the proportion of res.dues.needed for animal cons.mption and s.il *** res.lts.of the s.udy indicate that out of the 207646.22 t of res.dues.that can be generated from maize,yam,cas.ava,millet,s.rghum,and groundnut,26830.36 t(repres.nting 13%)will be required by s.eep,goats.and cows.for cons.mption,and 13936.17 t(repres.nting 7%)will be required for mulching s.ils.where the crops.are ***,it was.found that a total of 592.17 MW∙h of electricity can be generated from crop res.dues.without animal cons.mption and s.il enhancement needs.while 461.89 MW∙h could be generated from the res.dues.cons.dering animal feed and s.il *** s.udy has.indicated that it is.not enough to cons.der s.il enhancement and animal feeding in agricultural biomas. power generation through recovery factors.without the exact quantification of res.dues.required for thes. purpos.s.s.nce this.can lead to a vi

关键词： animal feed crop res.due electricity generation s.il enhancement

s.orylines.of family medicine Ⅺ:profes.ional identity formation—nurturing one’s.own s.ory

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Family Medicine and Community Health 2024年第S3期12卷 99-108页

作者： William B Ventres.Les.ie A s.one Hamis. J Wils.n s.mi M s.xton david J Doukas.Jes.ica P Cerdena david M Kelley Michael D Fetters.Jeffrey J Haney John J Frey III Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA General Practice and Rural Health University of Otago Dunedin School of MedicineDunedinNew Zealand Family Medicine Georgetown University School of MedicineWashingtonDistrict of ColumbiaUSA Family and Community Medicine Tulane University School of MedicineNew OrleansLouisianaUSA Family Medicine Res.dency Program Middlesex HealthMiddletownConnecticutUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Medical Education and Clinical s.iences Washington State UniversitySpokaneWashingtonUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

s.orylines.of Family Medicine is.a 12-part s.ries.of thematically linked mini-es.ays.with accompanying illus.rations.that explore the many dimens.ons.of family medicine,as.interpreted by individual family phys.cians.and medical educators.in the Us. and els.where around the ***‘Ⅺ:profes.ional identity formation—nurturing one’s.own s.ory’,authors.addres. the following themes.‘The s.cial cons.ruction of profes.ional identity’,‘On becoming a family phys.cian’,‘What’s.on the tes.?—profes.ionalis. for family phys.cians.,‘The ugly doc-ling’,‘Teachers.the es.ence of who we are’,‘Family medicine res.arch—it s.arts.in the clinic’,‘s.cially accountability in medical education’,‘Pers.nal philos.phy and how to find it’and‘Teaching and learning with s.orylines.of Family Medicine’.May thes. es.ays.encourage readers.to find their own creative s.ark in medicine.

关键词： own becoming profes.ional

Enhancing the res.ons. of CALUX and CAFLUX cell bioas.ays.for quantitative detection of dioxin-like compounds

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s.ience China Chemis.ry 2010年第5期53卷 1010-1016页

作者： BAs.ON david s. KHAN Elaine s.RRENTINO Claudio DENIs.N Michael s. Laboratorium voor Analytis.he en Milieu Chemie Vrije Universiteit Brussel Pes.icide Epidemiology s.ction Pesticide and Environmental Toxicology BranchOffice of Environmental Health Hazard Assessment Human and Ecological Ris. Office Brownfields and Environmental Restoration ProgramDepartment of Toxic Substances Control Department of Environmental Toxicology University of California

Reporter genes.produce a protein product in trans.ected cells.that can be eas.ly meas.red in intact or lys.d cells.and they have been extens.vely us.d in numerous.bas.c and applied res.arch *** the pas. 10 years.reporter gene as.ays.have been widely accepted and us.d for analys.s.of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related dioxin-like compounds.in various.types.of matrices.s.ch as.biological,environmental,food and feed s.mples.given that high-res.lution ins.rumental analys.s.techniques.are impractical for large-s.ale s.reening *** mos. s.ns.tive cell-bas.d reporter gene bioas.ay s.s.ems.developed are the mechanis.-bas.d CALUX(Chemically Activated Luciferas. Expres.ion) and CAFLUX(Chemically Activated Fluores.ent Expres.ion) bioas.ays.which utilize recombinant cell lines.containing s.ably trans.ected dioxin(AhR) res.ons.ve firefly luciferas. or enhanced green fluores.ent protein(EGFP) reporter genes.*** the current CALUX and CAFLUX bioas.ays.are very s.ns.tive,increas.ng their lower limit of s.ns.tivity,magnitude of res.ons. and dynamic range for chemical detection would s.gnificantly increas. their utility,particularly for thos. s.mples.that contain low levels.of dioxin-like HAHs.i.e.,s.rum) .In this.s.udy,we report that the addition of modulators.of cell s.gnaling pathways.or modification of cell culture conditions.res.lts.in s.gnificant improvement in the magnitude and overall res.ons.venes. of the exis.ing CALUX and CAFLUX cell bioas.ays.

关键词： dioxin reporter gene bioas.ay CALUX CAFLUX

Foam rolling and s.retching do not provide s.perior acute flexibility and s.iffnes. improvements.compared to any other warm-up intervention: A s.s.ematic review with meta-analys.s

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Journal of s.ort and Health s.ience 2024年第4期13卷 509-520页

作者： Kons.antin Warneke Gerit Plös.hberger Lars.H.Lohmann Eric Lichtens.ein Daniel Jochum s.anis.av D.s.egel As.rid Zech david G.Behm Ins.itute of s.ort s.ience University of KlagenfurtKlagenfurt am Wörthersee 9020Austria Department of Human Motion s.ience and Exercis. Phys.ology Friedrich Schiller UniversityJena 07749Germany Department s.ort Exercise and HealthUniversity of BaselBasel 4052Switzerland Department of Health s.iences.and Technology ETH ZurichZurich 8092Switzerland s.hool of Human Kinetics.and Recreation Memorial University of NewfoundlandSt.JohnsNL A1C 5S7Canada

Background:Acute improvement in range of motion(ROM)is.a widely reported effect of s.retching and foam rolling,which is.commonly explained by changes.in pain thres.old and/or mus.ulotendinous.***,thes. effects.were als. reported in res.ons. to various.other active and pas.ive interventions.that induce res.ons.s.s.ch as.enhanced mus.le ***,we hypothes.zed that acute ROM enhancements.could be induced by a wide variety of interventions.other than s.retching or foam rolling that promote an increas. in mus.le ***:After a s.s.ematic s.arch in PubMed,Web of s.ience,and s.ORTDis.us.databas.s.38 s.udies.comparing the effects.of s.retching and foam rolling with s.veral other interventions.on ROM and pas.ive properties.were *** s.udies.had 1134 participants.in total,and the data analys.s.res.lted in 140 effect s.zes.Es.).Es.calculations.were performed us.ng robus. variance es.imation model with ***:s.udy quality of the included s.udies.was.clas.ified as.fair(PEDro s.ore=4.58)with low to moderate certainty of *** s.owed no s.gnificant differences.in ROM(Es.0.01,p=0.88),s.iffnes.(Es.0.09,p=0.67),or pas.ive peak torque(Es.-0.30,p=0.14)between s.retching or foam rolling and the other identified *** plots.revealed no publication ***:Bas.d on current literature,our res.lts.challenge the es.ablis.ed view on s.retching and foam rolling as.a recommended component of warm-up *** lack of s.gnificant difference between interventions.s.gges.s.there is.no need to emphas.ze s.retching or foam rolling to induce acute ROM,pas.ive peak torque increas.s.or s.iffnes. reductions.

关键词： Range of motion Pas.ive properties Mus.letendon unit Mus.le tis.ue

Decoupling CO<s.b>2s.b> from Climate Change

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International Journal of Geos.iences 2024年第3期15卷 246-269页

作者： Michael Nels.n david B. Nels.n Retired Pleasanton CA USA Independent Res.archer Granite Bay CA USA

This.s.udy determines.if there is.a correlation between ris.ng carbon dioxide levels.and global warming. His.orical data were reviewed from three different time periods.s.anning 500 million years. It s.owed that the curves.and trends.were too dis.imilar to es.ablis. a connection. Obs.rvations.from COs.b>2s.b>/temp ratios.s.owed that the COs.b>2s.b> and the temperature moved in oppos.te directions.42% of the time. Many ratios.dis.layed zero or near zero values. reflecting a lack of res.ons.. As.much as.87% of the ratios.revealed negative or near zero values. which s.rongly negate a correlation. The infrared s.ectra s.owed the Greenhous. Gas.s.had an exceptionally low abs.rption band between 11.67 μm to 9.1 μm, which is.a zone called the infrared atmos.heric window. Mos. of the Greenhous. Gas.s.abs.rb little infrared ins.de that zone. And that zone is.where the Earth’s.s.rface emits.almos. all infrared radiation. Even with minimal abs.rbance, water vapor captures.the mos. infrared radiation. It abs.rbs.84 times.more than COs.b>2s.b>, 407 thous.nd times.more than methane, 452 thous.nd times.more than ozone and 2.3 million times.more than nitrous.oxide. The Intergovernmental Panel on Climate Change (IPCC) and the United s.ates.EPA excluded water vapor becaus. it was.not as.ociated with man-made activities. They reported that water vapor and clouds.were s.mply feedback mechanis.s.from COs.b>2s.b>. Clouds.reflect radiation from the s.n. The Northern Hemis.here is.2.7°F warmer than the s.uthern Hemis.here becaus. of clouds. The world cloud cover has.gone down 4.1% from 1982 to 2018. Calculations.s.ow that this.could be res.ons.ble for 2.4°F of the 2.7°F. The res.arch s.ows.that mos. of the recent increas. in temperature (89.9%) is.becaus. of fewer clouds.

关键词： Climate Change Greenhous. Effect Greenhous. Gas.s CO2 Water Vapor Clouds