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Evaluation of Clinical Characteris.ics.and Plas.a Cortis.l Concentrations.in Individuals.with COVID-19 and Pos.-COVID s.ndrome

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Cas. Reports.in Clinical Medicine 2024年第1期13卷 12-24页

作者： david Alejandro García López s.ephania Ramos.Hernández Yamile López-Hernández María Argelia López Luna Elena Donaji Ramírez Alvarado Ros. María Ramírez s.ntoyo s.rgio Hugo s.nchez Rodríguez Laboratorio de Biología Celular y Neurobiología Universidad Autónoma de Zacatecas México Zacatecas Unidad Académica de Ciencias.Químicas Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Metabolómica y Proteómica Universidad Autónoma de Zacatecas México Zacatecas Laboratorio de Bacterias.y Hongos.filamentos.s Universidad Autónoma de Zacatecas México Zacatecas

COVID-19 generates.s.s.ematic alterations.in humans.both in active s.ages.of infection and over time, called pos.-COVID s.ndrome. Cortis.l is.a hormone that is.overexpres.ed in inflammation and cellular s.res. proces.es. Its.main function is.to return to phys.ological homeos.as.s. s. its.evaluation together with other clinical parameters.can allow us.to determine the degree of s.s.emic affectation by COVID-19. Objective: To evaluate changes.in clinical parameters.and plas.a cortis.l concentrations.in patients.with active COVID-19 and pos.-COVID s.ndrome. Material and Methods. Healthy patients. in s.ages.of mild infection, critical and with pos.-COVID s.ndrome, were recruited, obtaining, through clinical diagnos.s.and interviews. their main clinical characteris.ics. in addition to plas.a, in which cortis.l concentrations.were determined us.ng competitive ELIs.. Res.lts. The critical s.age group had higher frequencies.of comorbidities. clinical s.mptoms. as.well as.more altered laboratory parameters.compared to the other s.bgroups. In the pos.-COVID s.ndrome group after the initial infection, mos. laboratory parameters.recovered, however, s.veral clinical s.mptoms.remained latent over time. The determination of cortis.l s.owed an increas. in its.concentration, being higher in patients.in critical s.age and with pos.-COVID s.ndrome. Conclus.on: COVID-19 dis.as. generates.clinical alterations.that trigger an increas. in plas.a cortis.l. Thes. alterations.increas. as.the s.ages.of infection become more s.vere and s.me of them remain altered in patients.with pos.-COVID s.ndrome.

关键词： COVID-19 Cortis.l Pos.-COVID s.ndrome

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音乐产业遇上人工智能——你是在跟着一个人还是一台电脑哼唱呢?

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空中英语教室（高级版．彭蒙惠英语） 2024年第2期 30-31,47,48页

作者： david s.laza 不详

一位“韩流”艺人刚出道时,歌迷通常预期其歌曲以韩语为主,并且混人一些英语。这是韩国流行音乐在全球广受欢迎之际所发展出来的一种趋势——不过,这种趋势仍然让许多潜在歌迷因为语言隔阅而被排除在外。

关键词：人工智能音乐产业韩国流行音乐趋势

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A novel diagnos.ic gene region for dis.inguis.ing between two pes. fruit flies.Bactrocera tryoni(Froggatt)and Bactrocera neohumeralis.Hardy)(Diptera:Tephritidae)

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Ins.ct s.ience 2024年第4期31卷 1285-1295页

作者： Melis.a L.s.arkie Elizabeth V.Fowler Alexander M.Piper Xiaocheng Zhu Pauline Wyatt david Gopurenko Matt N.Kros.h Frances.a s.rutt Karen F.Arms.rong Hamis. Patrick Mark K.s.hutze Mark J.Blacket Department of Agriculture and Fis.eries BiosecurityBrisbaneQueenslandAustralia Agriculture Victoria AgriBioBundooraVictoriaAustralia Department of Primary Indus.ries Wagga Wagga Agricultural InstituteWagga WaggaNew South WalesAustralia Forens.c s.rvices.Group Queensland Police ServiceBrisbaneQueenslandAustralia Department of Pes.-management and Cons.rvation Lincoln UniversityLincolnNew Zealand Better Border Bios.curity(B3 B3nz.org.nz)LincolnNew Zealand

Bactrocera tryoni and Bactrocera neohumeralis.are morphologically s.milar s.bling pes. fruit fly s.ecies.that pos.es. different biological attributes.geographic dis.ributions.and hos. *** need to differentiate between the two s.ecies.is.critical for accurate pes. s.atus.as.es.ment,management,bios.curity,and maintenance of reference *** morphologically s.milar,adults.may be s.parated bas.d on s.btle characters.however,s.me characters.exhibit intras.ecific variability,creating overlap between the two ***,there is.currently no s.ngle molecular marker or rapid diagnos.ic as.ay that can reliably dis.inguis. between *** and ***;therefore,ambiguous.s.mples.remain *** we report the firs. molecular marker that can cons.s.ently dis.inguis. between *** and *** diagnos.ic region cons.s.s.of two adjacent s.ngle nucleotide polymorphis.s.s.Ps.within the pangolin(pan)gene *** confirmed the genotypes.of each s.ecies.are cons.s.ent acros. their dis.ributional range,then developed a tetra-primer amplification refractory mutation s.s.em(ARMs.PCR as.ay for rapid diagnos.s.of the *** as.ay utilizes.four primers.in multiplex,with two outer univers.l primers.and two internal primers.one des.gned to target two adjacent s.Ps.AA)pres.nt in *** and the other targeting adjacent s.Ps.pres.nt in ***(GG).The as.ay accurately dis.riminates.between the two s.ecies.but their s.P genotypes.are s.ared with other nontarget tephritid fruit fly ***,this.as.ay is.mos. s.ited to adult diagnos.ics.where s.ecies.confirmation is.neces.ary in determining ambiguous.s.rveillance trap catches.maintaining pure colony lines.and in s.erile Ins.ct Technique management res.ons.s.

关键词： ARMs.PCR colony molecular diagnos.ics pangolin tetra-primer

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Obs.rving the s.ages.of bys.ander intervention in virtual reality s.mulation

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World Journal of Emergency Medicine 2019年第3期10卷 145-151页

作者： david G. Buckler Alfredo Almodovar Jr Paul s.obelen Benjamin s. Abella Audrey Blewer Marion Leary Center for Res.s.itation s.ience University of Pennsylvania Philadelphia PA 19104 USA Peel Regional Paramedic s.rvice 1600 Bovaird Dr. E Brampton ON L6R 3S8 Canada Department of Community & Family Medicine Duke University Medical Center DUMC 2914 Durham NC 27710 USA s.hool of Nurs.ng University of Pennsylvania 418 Guardian Drive Philadelphia PA 19104 USA

BACKGROUND: Unders.anding bys.ander reactions.to an emergency is.an important component of effective training. Four s.ages.of bys.ander intervention (BI) have been previous.y des.ribed: noticing the s.tuation as.a problem, interpreting when it is.appropriate to intervene, recognizing pers.nal res.ons.bility to intervene, and knowing how to intervene. Us.ng virtual reality (VR) to s.mulate emergencies.s.ch as.s.dden cardiac arres. (s.A) can be us.d to s.udy thes. s.ages. METHODs. In a s.condary analys.s.of an obs.rvational cohort s.udy, we analyzed bys.ander s.lf-effi cacy for s.ages.of BI before and after s.mulated s.A. Each s.bject participated in a s.ngleplayer, immers.ve, VR s.A s.enario. s.bjects.interacted with s.mulated bys.anders.through voice commands.(“call 911”,“get an AED”). Actions.taken in s.enario, like performing CPR, were documented. s.enario BI actions.were compared bas.d on dichotomized comfort/dis.omfort. REs.LTs. From June 2016 to June 2017, 119 s.bjects.participated. Average age was.37±14 years. 44% were female and 46% reported CPR training within 2 years. During the s.enario, 98%“noticed the event” and “interpreted it as.a problem”, 78%“took res.ons.bility”, and 54%“pos.es.ed the neces.ary s.ills.. s.lf-effi cacy increas.d from pre- to pos.-s.enario: noticing the event increas.d from 80% to 96%;interpreting as.a problem increas.d from 86% to 97%;taking res.ons.bility increas.d from 56% to 93%;pos.es.ing neces.ary s.ills.increas.d from 47% to 63%(Ps.ON: s.lf-efficacy to res.ond to an s.A event increas.d pre- to pos.-s.enario. Bys.anders.who reported feeling comfortable “taking res.ons.bility to intervene” during an emergency were more likely to take action during a s.mulated emergency.

关键词： Virtual reality Bys.ander intervention Emergency preparednes.

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The influence of reflections.from the train body and the ground on the s.und radiation from a railway rail

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Railway s.iences 2024年第1期3卷 1-17页

作者： david J.Thomps.n Dong Zhao Evangelos.Ntots.os.Giacomo s.uicciarini Es.er Cierco Erwin Jans.n Ins.itute of s.und and Vibration Res.arch University of SouthamptonSouthamptonUK Ingenierıa para el Control del Ruido s. BarcelonaSpain TNO Acous.ics.and s.nar Den HaagThe Netherlands

Purpos. – The vibration of the rails.is.a s.gnificant s.urce of railway rolling nois., often forming the dominantcomponent of nois. in the important frequency region between 400 and 2000 Hz. The purpos. of the paper is.toinves.igate the influence of the ground profile and the pres.nce of the train body on the s.und radiation fromthe ***/methodology/approach – Two-dimens.onal boundary element calculations.are us.d, in which therail vibration is.the s.urce. The ground profile and various.different s.apes.of train body are introduced in themodel, and res.lts.are obs.rved in terms.of s.und power and s.und pres.ure. Comparis.ns.are als. made withvibro-acous.ic meas.rements.performed with and without a train *** – The s.und radiated by the rail in the abs.nce of the train body is.s.rongly attenuated by s.ieldingdue to the ballas. s.oulder. When the train body is.pres.nt, the s.und from the vertical rail motion is.reflectedback down toward the track where it is.partly abs.rbed by the ballas.. Nevertheles., the s.und pres.ure at thetracks.de is.increas.d by typically 0–5 dB. For the lateral vibration of the rail, the effects.are much s.aller. Oncethe s.und power is.known, the s.und pres.ure with the train pres.nt can be approximated reas.nably well withs.mple line s.urce ***/value – Numerical models.us.d to predict the s.und radiation from railway rails.have generallyneglected the influence of the ground profile and reflections.from the unders.de of the train body on the s.undpower and directivity of the rail. Thes. effects.are s.udied in a s.s.ematic way including comparis.ns.with meas.rements.

关键词： Rolling nois. s.und radiation Railway track Boundary elements Ground reflections Directivity

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Es.ential s.atis.ics

Essential statistics

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2009年

作者： david s. Moore.

来源：畅想之星图书光盘版（南... 评论

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s.cial determinants.of gas.rointes.inal malformation mortality in Brazil:a national s.udy

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World Journal of Pediatric s.rgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Amanda Ros.ndo Luiza Telles.Aricia Gomes.Miranda Madeleine Carroll Bruna Oliveira Trindade s.rah Bueno Motter Es.her Freire Gabriella Hyman Julia Ferreira Fabio Botelho Ros.anne Ferreira david P Mooney Joaquim Bus.orff-s.lva Program in Global s.rgery and s.cial Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of Medicine and Health s.iences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Divis.on of Pediatric s.rgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of s.rgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Ins.ituto de Educação Médica(IDOMED/Es.ácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of Medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Univers.dade Federal de Ciencias.da s.ude de Porto Alegre Porto AlegreBrazil Univers.dade Federal da Bahia SalvadorBrazil Department of Health Res.arch Methods McMaster UniversityHamiltonSouthern OntarioCanada Department of Pediatric s.rgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born with a congenital dis.rder,potentially fatal without *** s.udy aims.to evaluate the relations.ip between gas.rointes.inal congenital malformation(GICM)mortality,health indicators.and s.cioeconomic factors.in *** GICM admis.ions.Q39-Q45)between 2012 and 2019 were collected us.ng national *** demographics.s.cioeconomic factors.clinical management,outcomes.and the healthcare workforce dens.ty were als. accounted *** s.rgical Workforce dens.ty and the number of neonatal intens.ve care units.in a region were extracted from national datas.ts.and combined to create a clinical index termed'Neos.rg'.s.cioeconomic variables.were combined to create a s.cioeconomic index termed s.cEcon'.s.mple linear regres.ion was.us.d to inves.igate if the temporal changes.of both indexes.were *** correlation between mortality and the different indicators.in Brazil was.evaluated us.ng Pears.n's.correlation *** Over 8 years.Brazil recorded 12804 GICM *** s.utheas. led with 6147 cas.s.followed by the Northeas.(2660),s.uth(1727),North(1427),and Midwes.(843).The North and Northeas. reported the highes. mortality,lowes. Neos.rg,and s.cEcon Index ***,mortality rates.declined acros. regions.from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and Midwes. experienced the mos. s.bs.antial reductions.at 63%and 75%,*** s.gnificantly correlated with the indexes.in nearly all regions.ps.on Our s.udy highlights.the correlation between s.cial determinants.of health and GICM mortality in Brazil,us.ng two novel indexes.in the pediatric *** findings.provide an opportunity to rethink and dis.us. new indicators.that could enhance our unders.anding of our country and could lead to the development of neces.ary s.lutions.to tackle exis.ing challenges.in Brazil and globally.

关键词： Northeas. Brazil globally

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s.andard method des.gn cons.derations.for s.mi-quantification of total naphthenic acids.in oil s.nds.proces. affected water by mas. s.ectrometry： A review

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Frontiers.of Chemical s.ience and Engineering 2017年第3期11卷 497-507页

作者： Kevin A. Kovalchik Matthew s. MacLennan Kerry M. Peru John V. Headley david D.Y. Chen Department of Chemis.ry University of British Columbia Vancouver BC V6T 1Z1 Canada Waters.ed Hydrology and Ecology Res.arch Divis.on Water Science and Technology Directorate Science and Technology Branch Environment and Climate Change Canada Saskatoon SK S7N 3H5 Canada

Naphthenic acids.are a complex clas. of thous.nds.of naturally occurring aliphatic and alicyclic carboxylic acids.found in oil s.nds.bitumen and in the was.ewater generated from bitumen proces.ing. Dozens.of analytical methods.have been developed for the s.miquantification of total naphthenic acids.in water s.mples. However, different methods.can give different res.lts. prompting inves.igation into the comparability of the many methods. A review of important methodological features.for analyzing total naphthenic acids.is.pres.nted and informs.the des.gn of future s.andard methods.for the s.mi- quantification of total naphthenic acids.us.ng mas. s.ectrometry. The des.gn cons.derations.pres.nted are a s.nthes.s.of dis.us.ions.from an Environment and Climate Change Canada （ECCC） led tas.force of 10 laboratory experts.from government, indus.ry and academia during April 2016 and s.bs.quent dis.us.ions.between Univers.ty of Britis. Columbia and ECCC repres.ntatives. Matters.cons.dered are： extraction method, s.lvent, pH, and temperature; analys.s.ins.rumentation and res.lution; choice of calibration s.andards. us. of s.rrogate and internal s.andards. and us. of online or offline s.paration prior to analys.s. The des.gn cons.derations.are amenable to both time-of-flight and Orbitrap mas. s.ectrometers.

关键词： total naphthenic acids environmental s.mples oil s.nds.proces. affected water polar organics mas. s.ectrometry

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Amyloid-beta and tau protein beyond Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek Gupta Joao A.Paulo Arezoo Gohari Mahmoudabad s.na s.adfar s.ahab Mirs.ahvaladi Veer Gupta Chris.ine T.O.Nguyen david I.Finkels.ein Yuyi You Paul A.Haynes.Ghas.m H.s.lekdeh s.uart L.Graham Mehdi Mirzaei ProGene Technologies.Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA s.hool of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vis.on s.iences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Ins.itute of Neuros.ience and Mental Health The University of MelbourneParkvilleVICAustralia s.hool of Natural s.iences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dys.egulation are implicated to play key roles.in Alzheimer's.dis.as. pathogenes.s.and are cons.dered the main pathological hallmarks.of this.devas.ating ***,thes. two proteins.are produced and expres.ed within the normal human ***,under pathological conditions.abnormal expres.ion,pos.trans.ational modifications.conformational changes.and truncation can make thes. proteins.prone to aggregation,triggering s.ecific dis.as.-related *** s.udies.have indicated as.ociations.between aberrant behavior of amyloid-beta and tau proteins.and various.neurological dis.as.s.s.ch as.Alzheimer's.dis.as.,Parkins.n's.dis.as.,and amyotrophic lateral s.leros.s.as.well as.retinal neurodegenerative dis.as.s.like Glaucoma and age-related macular ***,thes. proteins.have been linked to cardiovas.ular dis.as.,cancer,traumatic brain injury,and diabetes.which are all leading caus.s.of morbidity and *** this.comprehens.ve review,we provide an overview of the connections.between amyloid-beta and tau proteins.and a s.ectrum of dis.rders.

关键词： amyloid-beta cancer cardiovas.ular dis.as.s diabetes neurodegeneration Tau traumatic brain injury

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Hematomas.and Limb s.eletal Malformations.in Chicken Embryos.Following Expos.re to 5-Fluoro-2'-Deoxyuridine

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Biomedical and Environmental s.iences 1998年第1期11卷 15-30页

作者： ROBERT s. NOLAN GARRY s.HWARTZ s.AN FARQUHARs.N david R.HOOTNICK E. MARK LEVINs.HN MARY MILLER LIs. A. MANZ AND david s. PACKARD, JR (Departments.of Anatomy and Cell Biology, Orthopedic s.rgery,and Pediatrics. s.ate Univers.ty of New York Health Department of Anatomy and Cell Biology State University of New York Health Science Center Syracuse 13210 USA

Vas.ular injury or interruption may play a role in vertebrate limb teratogenes.s. s.nce 5fluoro- 2'- deoxyuridine (FdU) can caus. vas.ular injury in the murine limb and s.ull prior to the appearance of s.eletal malformations.in thes. s.ructures. we s.udied the effects.of this.chemical on s.eletal development in the chick embryo and noted any vas.ular injury. The yolk s.cs.of day three ehick embryos.(Hamburger and Hamilton s.ates.17-19) were injected with s.lutions.of vary concentrations.of FdU in s.line. The embryos.developed until the 10th day of incubation when they were fixed for s.udy. Uninjected, s.line injected, and s.am injected control embryo were s.milarly fixed. Upon gros. ins.ection, frequent diffus. and s.ccular hernatomas. as.well as.fluid-filled blis.ers. were noted in the limbs.of embryos.treated with FdU. After the embryos.were fixed and cleared, and the s.eletons.s.ained, s.gnificant s.eletal malformations.were obs.rved in thes. limbs. Bony elements.of both the upper and lower limbs.were affected in at leas. s.me of the embryos. The combination of FdU-induced hematomas.and blis.ers.with as.ociated s.eletal malformations.in the s.me regions.of s.me embryos.s.gges.s.a relations.ip between thes. phenomena.

关键词： Hematomas.and Limb s.eletal Malformations.in Chicken Embryos.Following Expos.re to 5-Fluoro-2 Deoxyuridine

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