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英国医学杂志中文版 2016年第1期19卷 13-17页

作者： Nick Freemantle Daniel Ray david McNuhy david rosser Simon Bennett Bruce E Keogh Domenico Pagano 赵英希 Department of Primary Care and Population Health University College London UK Quality and Outcomes Research Unit University Hospitals Birmingham NHS Foundation Trust Birmingham UK Department of Informatics University Hospitals Birmingham NHS Foundation Trust Farr Institute of Health Informatics Research University College London University Hospitals Birmingham NHS Foundation Trust Medical Directorate NHS England London UK Department of Cardiothoracie Surgery University Hospitals Birmingham NHS Foundation Trust 北京大学医学人文研究院

现代化、高效的医疗保健体系不仅应该防止患者因可治疗的原因过早死亡，改善慢性疾病患者的生活质量，帮助急症患者康复，保证治疗的安全性，同时，还应该尽可能为患者提供良好的医疗照护，因此周末医疗照护减少会对以上各方面产生负面... 详细信息

现代化、高效的医疗保健体系不仅应该防止患者因可治疗的原因过早死亡，改善慢性疾病患者的生活质量，帮助急症患者康复，保证治疗的安全性，同时，还应该尽可能为患者提供良好的医疗照护，因此周末医疗照护减少会对以上各方面产生负面影响。不过，整周的服务组织与额外病死率之间的关系很难通过随机对照试验进行研究，所以医疗服务设计是基于观察得到的证据。

关键词：病死率医疗保健体系患者医疗卫生行业

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Outcomes following liver transplantation in intensive care unit patients

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World Journal of Hepatology 2013年第1期5卷 26-32页

作者： Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G rosser david J Kramer Justin H Nguyen Department of Transplantation Mayo ClinicJacksonvilleFL 32225United States Biostatistics Unit Mayo ClinicJacksonvilleFL 32225United States Departments of Transplantation and Critical Care Medicine Mayo ClinicJacksonvilleFL 32225United States Department of Critical Care Medicine and Internal Medicine Aurora Health CareMilwaukeeWI 53204United States

AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient ***:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December ***:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and *** ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to ***-five ICU patients (64%) required dialysis *** 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU *** survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU *** formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable *** findings were consistent in multivariable *** not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (

关键词： Donor pool Donor outcomes Onor after cardiac death grafts Liver graft survival Patient survival

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MG289 in <i>Mycoplasma genitalium</i>Enhances Microbial Invasion and Bacterial Persistence in Benign Human Prostate Cells

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Open Journal of Urology 2013年第6期3卷 232-245页

作者： Wasia Rizwani Leticia Reyes Jeongsoon Kim Steve Goodison Charles J. rosser Cancer Research Institute MD Anderson Cancer Center Orlando Orlando USA Department of Infectious Disease & Pathology College of Veterinary Medicine University of Florida Gainesville USA

Introduction: Recent studies suggest that infectious organisms may facilitate initiation and metastasis of many human cancers. One infectious organism of interest is Mycoplasma genitalium(Mg), a prevalent organism in humans known to cause sexually transmitted infection, as well as urethritis and prostatitis. Previous studies have demonstrated that benign, non-tumorigenic human prostate cells (BPH-1) chronically exposed to M. genitalium led to the malignant transformation of these cells as demonstrated in in vitro and in vivo models. Based on work from our laboratory, we felt this malignant transformation revolved around a specific M. genitalium’s ABC transporter (MG289) with homology to M. hyorhinis’ ABC transporter, p37. In this study, differences in M. genitalium’s ability to infect and induce a unique proteome conducive to tumoral growth were studied with engineered M. genitalium in which the p37 protein was silent. Materials and Methods: Wild-type M. genitalium (strain 431c, designated as M. genitalium WT) and MG289 deficient M. genitalium mutant (strain 260_3, designated as Mg260_3) were used for this study. We studied the infectivity potential between M. genitalium WT and Mg260_3 upon exposure to BPH-1 cells. Furthermore, we set out to identify a unique proteome in BPH-1 cells exposed to M. genitalium WT that could explain its ability to induce malignant transformation of benign cells. Validation of selected proteomic targets was carried out by Western blot analysis. Results: Both M. genitalium WT and Mg260_3 strains showed somewhat similar growth curve when absorbance at 450nm was matched at day 0. Colony forming units (CFUs) were similar for both strains at the same absorbance. However, the ability to infect BPH-1 cells was greatly reduced in Mg260_3 compared to the M. genitalium WT (p < 0.001). This was evident by infectivity assays and confocal microscopy. Proteomic analysis of BPH-1 cells infected with either M. genitalium WT or Mg260_3 for 8 hr, 24 hr an

关键词： Cancer ER Stress Proteins Infection Mycoplasma genitalium Prostate Proteomics

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Monitoring and modeling of slope movement on rock cliffs prior to failure

Monitoring and modeling of slope movement on rock cliffs pri...

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The Tenth International Symposium on Landslides and Engineered Slopes

作者： N.J. rosser D.N. Petley International Landslide Centre Institute of Hazard and Risk Research Durham University UK

In this paper we examine the use of terrestrial laser scan data for monitoring large rock cliffs in order to assess the dynamics of the slope condition prior to failure. The assessment presented uses a combination of this terrestrial data and air-borne mapping and imagery to explore the degree to which small-scale precursors to slope failure can be identified, and ultimately used to predict failure. The degree to which data is projected from any given perspective which represents the development of the slope is suggested to be critical. Here we present data that has been collected for four years at monthly intervals from over 35,000 m3 of near-vertical coastal rock face. This high-resolution data is used to identify characteristic spatial and temporal patterns in rockfall activity notably in the periods leading to large-slope failures. To date in excess of 60,000 discrete events have been recorded ranging from 0.00001 m3 to 2,500 m3. The patterns in the data show similarity with time-dependant models of failure mechanisms, which may enable the prediction of failure occurrence both in time and in space. This interpretation is only reached however with appropriate and, in terms of survey, unconventional treatment. Analysis of the data derived from the laser scanning suggests that given sufficient measurement precision, precursory behavior can be identified and monitored but that the relative viewing angle of the observation compared to the vector of deformation is critical. In this instance pre-failure deformations are manifest as the rate of rock fall activity prior to failure, in addition to the direct measurement of the accumulation of the strain field across the failing rock face. The monitoring data implies a time-dependent sequence in the occurrence of rock falls in the period leading to the largest failures recorded, often mirroring the hyperbolic increases in movement witnessed in standard displacement monitoring or laboratory simulation prior to failure. The

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Tu diras!

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2006年

作者： Ana Mart?inez-Lage John Guti?errez Harry L. rosser with contributions from Stasie C. Harrington.

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视频游戏“热身活动”对腹腔镜手术操作技能的影响(英文)

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中国微创外科杂志 2013年第4期13卷 289-294页

作者：皇甫玉爽应小燕 James C.rosser Jr. Douglas A.Gentile Kevin Hanigan Omar K.Danner 南京医科大学第二附属医院妇产科南京210011 Morehouse School of Medicine AtlantaGAUSA.

目的腹腔镜技术需要经过专门培训,也已证实确实存在手术失误。已经有研究证明在手术之前先进行"热身活动"可以提高腹腔镜操作技能。本研究主要探讨外科医生在进行腹腔镜部分操作和临床操作之前是否能从选择性视频游戏的"热身运动"中获... 详细信息

目的腹腔镜技术需要经过专门培训,也已证实确实存在手术失误。已经有研究证明在手术之前先进行"热身活动"可以提高腹腔镜操作技能。本研究主要探讨外科医生在进行腹腔镜部分操作和临床操作之前是否能从选择性视频游戏的"热身运动"中获益。方法本研究包括303名外科医生(男249名,女54名)。受试者分成对照组(n=180)和实验组(n=123)。实验组在操作之前先进行3段6分钟已验证的视频游戏。在热身之后立即进行眼镜蛇绳部分操作和缝合练习。结果在所有10个试验中,眼镜蛇绳训练之前进行视频游戏热身的外科医生明显比一开始就直接进行眼镜蛇绳训练的医生速度更快。实验组和对照组的总缝合分数有显著差异(t=2.28,df=288,P<0.05)。精英训练总分数显示,实验组进行腹腔镜操作表现更好。结论本研究表明,在进行腹腔镜操作和临床操作(体内缝合)之前,进行选择性视频游戏"热身"的受试者要比那些没有进行热身的受试者速度快,错误率低。然而,确定这是否能作为一种好的方法应用于临床实践还需要更进一步的研究。

关键词：腹腔镜手术培训视频游戏热身活动外科失误减少

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作者： W.G.V.·罗瑟(W.G.V. rosser)

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准备接受肝移植的患者中胃窦血管扩张的发病率及自然病史

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 53-54页

作者： Ward E.M. Raimondo M. rosser B.G. 赵丽娜 Div. of Gastroenterol. and Hepatol. Mayo Clinic 4500 San Pablo Road Jacksonville FL 32224 United StatesDr.

Goals: To describe the prevalence and natural history of gastric antral vascular ectasia (GAVE) in patients with end-stage liver disease undergoing orthotopic liver transplantation (OLT). Background: GAVE is a well-recognized cause of gastrointestinal hemorrhage. Although 30%of patients with GAVE have liver disease, the prevalence of GAVE in patients with cirrhosis is not known. Study: We reviewed clinical records of patients who underwent OLT at our institution from February 1, 1998 to June 2003. Demographic and clinical details were recorded with attention to findings during upper endoscopy before and after OLT. Results: A total of 597 patients underwent OLT, and 345 were evaluated preoperatively with esophagogastroduodenoscopy (EGD). Eight (2.3%) were found to have GAVE before OLT. Three of these eight underwent EGD after OLT, and GAVE was absent in all three. None of the patients with GAVE experienced gastrointestinal bleeding postoperatively. Conclusions: GAVE was present in nearly 1 in 40 patients with end-stage liver disease who underwent EGD before OLT at our institution and appears to resolve after transplant. These findings are consistent with a previous report documenting resolution of GAVE after OLT.

关键词：肝移植自然病史血管扩张十二指肠镜消化道内镜检查临床记录胃镜检查人口统计学移植术临床资料

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成骨细胞向骨细胞分化后可能表达多种新蛋白

成骨细胞向骨细胞分化后可能表达多种新蛋白

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中华医学会第四次全国骨质疏松和骨矿盐疾病学术会议

作者：张克勤李振华 Jenifer rosser Lynda F．Bonewald 南京医科大学第一附属医院内分泌科 Bone Biology Program School of Dentistry University of Missouri at Kansas CityUSA

成骨细胞(OB)在骨表面不断分泌骨基质后自身被埋于类骨质中,由此立方形的成骨细胞变成了具有树枝状突起的骨细胞,或称骨陷窝细胞(OCY),我们认为在这个转换过程中细胞形态、位置发生了变化,必然导致细胞功能发生变化,这意味着功能执行者...

成骨细胞(OB)在骨表面不断分泌骨基质后自身被埋于类骨质中,由此立方形的成骨细胞变成了具有树枝状突起的骨细胞,或称骨陷窝细胞(OCY),我们认为在这个转换过程中细胞形态、位置发生了变化,必然导致细胞功能发生变化,这意味着功能执行者蛋白质的表达也会发生变化,但到目前为止 OCY与OB相比功能发生哪些变化还知之甚少。

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2008年汶川地震触发滑坡量大于造山作用生长量

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世界地震译丛 2014年第1期45卷 51-59页

作者： R.N.Parker A.L.Densmore N.J.rosser M.de Michele Yong Li Runqiu Huang S.Whadcoat D.N.Petley 许冲邓罡中国地震局地质研究所

浅源地震是山区地壳抬升的主要驱动力（Avouac，2008）。然而，浅源大地震也触发大范围的同震滑坡，造成显著、但在空间上不均匀的侵蚀（Keefer，1994；Malamud et al，2004；Larsen et al，2010）。因此地壳抬升与同震滑坡的分布及规... 详细信息

浅源地震是山区地壳抬升的主要驱动力（Avouac，2008）。然而，浅源大地震也触发大范围的同震滑坡，造成显著、但在空间上不均匀的侵蚀（Keefer，1994；Malamud et al，2004；Larsen et al，2010）。因此地壳抬升与同震滑坡的分布及规模间的相互作用就引发了一个根本的问题，即大地震及其相关的滑坡是创生还是消毁了山区地形。2008年中国四川Mw7．9汶川地震触发了超过56000处滑坡（Dai et al，2011），其空间分布仅仅部分与构造变形样式有关（Shen et al，2009）。通过将滑坡面积一体积标度关系（Larsen et al，2010；Guzzetti et al，2009）应用于高分辨率卫星影像，我们仔细检查了造山方量的潜在变化。我们估计，同震滑坡产生了约5～15km^3的可侵蚀物质，大于2．6±1．2km^3（deMichele et al，2010）的同震地壳抬升净方量。这种差异表明，在可能的2000-4000年的地震复发周期中（Shen et al，2009），即使只有小部分滑坡物质从造山带中运移走，汶川地震也会在龙门山导致物质净亏损。我们的结果对长期以来广泛持有的大倾滑或走滑地震能造山的观点提出了挑战，并希望引起对同震滑移、滑坡量与地形生成之间的关系更多的思考研究。

关键词：地震触发造山作用滑坡汶川生长量高分辨率卫星影像侵蚀物质地壳抬升

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