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DEVELOPING AN ENERGY BENCHMARKING SYSTEM FOR HOTEL BUILDINGS USING THE STATISTICAL METHOD AND THE SIMULATION-BASED APPROACH

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Journal of Green Building 2019年第3期14卷 3-22页

作者： Anh Tuan Nguyen david rockwood the Faculty of Architecture University of Science and Technology–The University of DanangViet Nam School of Architecture University of HawaiiU.S.A

Due to increased tourist activity,many cities now have a large number of hotel *** is necessary to establish measures to evaluate energy use intensity to effectively manage energy consumption in this *** study uses a combined strategy to establish an energy benchmark for hotel buildings in ***,a survey and analysis of actual building stock data of 50 hotels in Danang,Vietnam,was *** survey-based benchmark and its related data was then used to build a reference energy model to estimate an energy benchmark for other climatic regions in Vietnam by using the energy simulation *** results reveal that the average energy use intensity for hotels in Danang was 87.4 kWh/*** or 8628.6 kWh/***,this study proposes that because of the differing expectations of comfort standards,hotels of different grades should have separate *** study also proposes an energy intensity-based rating scale,including 7 grades from the least energy intensive(grade A)to the most energy intensive(grade G),which can be used to manage,label,or encourage sustainable energy use in hotel *** relationship between the energy use intensity and the occupancy rate of the hotels was reported,compared,and *** was found that occupancy rate has no significant impact on the energy use *** the survey result,some predictive models were developed to estimate annual energy consumption of hotel buildings based on their *** simulated benchmarks for other regions were also *** results demonstrate many potential applications in the management,design and construction,and renovation of this building type.

关键词： energy benchmarking hotel energy use intensity energy labeling energy rating scale simulation-based benchmarking

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Studies on sustainable features of vernacular architecture in different regions across the world:A comprehensive synthesis and evaluation

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Frontiers of Architectural Research 2019年第4期8卷 535-548页

作者： Anh Tuan Nguyen Nguyen Song Ha Truong david rockwood Anh Dung Tran Le Faculty of Architecture the University of Danang-University of Science and TechnologyDa NangViet Nam School of Architecture University of Hawaii at ManoaUSA Laborotoire des Technologies Innovantes(LTI) Universite de Picardie Jules VerneFrance

Due to the increasing pressure brought by recent global environmental problems,building designers are embracing regionalism and the knowledge of traditional structures,arguing that these structures are energy efficient and highly *** observe clear evidence of the increasing interest in vernacular architecture among the research *** study therefore aims to clarify the contents and issues raised in the studies on vernacular architecture and the knowledge and recommendations that can be derived from them.A database of the research is established by collecting many studies from primary *** data is carefully refined and categorized into a table where synthesized information is *** results of this study show an uneven geographic and climatic distribution of the studies;the trend in selecting research objectives and research objects;the choice of research methods with a clear shift towards quantitative research methods,and the generic findings from the database of the *** results can support diverse inquiries about vernacular architecture across the world and be used as a resource or an orientation to support numerous subsequent studies.

关键词： Vernacular architecture Traditional architecture Sustainable feature Research method Building design

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The role of XPC protein deficiency in tobacco smoke-induced DNA hypermethylation of tumor suppressor genes

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Open Journal of Genetics 2013年第4期3卷 285-293页

作者： Gan Wang Le Wang Vanitha Bhoopalan Yue Xi Deepak K. Bhalla david Wang Xiaoxin S. Xu Department of Pharmaceutical Sciences School of Pharmacy and Health Sciences Wayne State University Detroit USA Institute of Environmental Health Sciences Wayne State University Detroit USA Lafeyatte High School Rockwood USA

DNA hypermethylation of tumor suppressor genes has been frequently observed in cancer patients, and therefore, may provide a valuable biomarker for cancer prevention and treatment. DNA hypermethylation may also provide an important mechanism in cancer progression. Lung cancer is strongly associated with exposure to environmental carcinogens, especially tobacco smoke. DNA damage generated by tobacco smoke is believed to play an important role in lung cancer development. XPC is a DNA damage recognition protein required for DNA repair and other DNA damage responses and attenuated XPC protein levels have been detected in many lung cancer patients. We studied the role of XPC protein deficiency in tobacco smoke-caused DNA hypermethylation of important tumor suppressor genes. Using both normal human fibroblasts (NF) and XPC-deficient hu man fibroblasts (XPC), our DNA methylation studies demonstrated that the XPC deficiency caused elevated levels of DNA hypermethylation in both Brca1 and Mlh1 tumor suppressor genes following exposure to tobacco smoke condensate (TSC). The results of our ChIP studies revealed that the XPC deficiency led to an increased binding of DNA methyltransferase 3A (DNMT3A) at the promoter region CpG island-containing sequences of these genes under the TSC treatment;however, this increase was partially diminished with prior treatment with caffeine. The results of our immuno-precipitation (IP) studies demonstrated a protein-protein interaction of the ATR with DNMT3A. Our western blots revealed that the XPC deficiency caused an increase in TSC-induced ATR phosphorylation at serine 428, an indicator of ATR activation. All these results suggest that XPC deficiency causes an accelerated DNA hypermethylation in important tumor suppressor genes under tobacco smoke exposure and activation of the ATR signaling pathway is involved in this DNA hypermethylation process.

关键词： DNA Hypermethylation Tumor Suppressors XPC Tobacco Smoke DNA Damage DNA Repair Deficiency ATR DNMT3A

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骨科教程不易修复性肩袖破裂：如何做和何时做；医生的困惑

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骨科动态 2007年第1期3卷 58-64页

作者： david M. DINES DANIEL P. MOYNIHAN JOSHUA S. DINES PETER MCCANN 钱不凡（译） An Instructional Course Lecture American Academy of Orthopaedic Surgeons 上海市伤骨科研究所 200025

不易修复性肩袖破裂虽不常见，但是一种不能用常规方法修复的大型明确定位的病损。rockwood及其他学者认为．根据其破裂的尺寸及回缩程度的特点采用常规游离及软组织松解的方法不能一期把它们的支点重新安放到结节上。Goutallier等根据C... 详细信息

不易修复性肩袖破裂虽不常见，但是一种不能用常规方法修复的大型明确定位的病损。rockwood及其他学者认为．根据其破裂的尺寸及回缩程度的特点采用常规游离及软组织松解的方法不能一期把它们的支点重新安放到结节上。Goutallier等根据CT显示的肌肉萎缩及脂肪浸润程度，对肩袖破裂进行分类。这种破裂因常合并盂肱关节炎，而使其治疗更为复杂。

关键词：肩袖破裂修复性骨科教程医生软组织松解盂肱关节炎浸润程度肌肉萎缩

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