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Double-Blind, Parallel Group Study to Compare the Clinical Effectiveness of Calcium Dobesilate 500 mg BID vs. Calcium Dobesilate LP 1 g OD, in Patients with Chronic Venous Insufficiency of the Lower Limbs

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International Journal of Clinical medicine 2024年第5期15卷 211-223页

作者： Ramón téllez méndez maria González Yibirin david rincón m.t.te Centro Clnico Prevaler Pampatar Nueva Esparta Venezuela Grupo Leti Guarenas Miranda Venezuela

Background: Chronic venous insufficiency (CVI) describes a condition that affects the venous system of the lower extremities due to venous hypertension (VH. the prevalence is between 5% - 30%. CVI is associated with older age, smoking, lower extremity trauma, presence of an arteriovenous shunt, and elevated estrogen levels. All patients should be initially treated with conservative management. Venoactive drugs like calcium dobesilate are useful. Objectives: the primary objective compared the clinical improvement in patients with CVI, grades 0 - 3 of the CEAP classification of chronic venous disease, produced by two formulations of calcium dobesilate: calcium dobesilate LP 1 g OD vs calcium dobesilate 500 mg BID, immediate release. the secondary objective assessed the side effects of both formulations. method: All patients took one tablet and one capsule at 7 am, and one capsule at 7 pm, for 8 weeks. One group received dobesilate 1 g OD and the other group received dobesilate 500 md BID. they were evaluated after 15, 30 and 60 days of treatment, using the symptom evaluation scale. Results: In both groups, there was a significant decrease in the symptom score after 15 days. Four patients in the Dobesilate OD group: had adverse effects, which did not require suspension of treatment. In the BID dobesilate group, there was one therapeutic failure, and one case of gastric discomfort. Conclusions: Prolonged-release Calcium dobesilate 1 g OD is as effective as calcium dobesilate 500 mg BID for the treatment of patients with chronic venous insufficiency.

关键词： Chronic Venous Insufficiency (CVI) Calcium Dobesilate CEAP Classification Adverse Effects treatment Adherence

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Late Ordovician mass Extinction: Earth, fire and ice

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national Science Review 2024年第1期11卷 51-65页

作者： david A.t.Harper Palaeoecosystems Group Department of Earth SciencesDurham University

the Late Ordovician mass Extinction was the earliest of the ‘big’ five extinction events and the earliest to affect the trajectory of metazoan life. two phases have been identified near the start of the Hirnantian period and in the middle. It was a massive taxonomic extinction, a weak phylogenetic extinction and a relatively benign ecological extinction. A rapid cooling, triggering a major ice age that reduced the temperature of surface waters, prompted a drop in sea level of some 100 m and introduced toxic bottom waters onto the shelves. these symptoms of more fundamental planetary processes have been associated with a range of factors with an underlying driver identified as volcanicity. Volcanic eruptions, and other products, may have extended back in time to at least the Sandbian and early Katian, suggesting the extinctions were more protracted and influential than hitherto documented.

关键词： Ordovician LOmE paleoecology palaeobiogeography biotas

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Pharmacodynamic Study of Parallel Groups Comparing the Effect of Rivaroxaban 20 mg (Laboratorios Leti, S.A.V.) vs Rivaroxaban 20 mg (Bayer Laboratories) on Prothrombin time

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International Journal of Clinical medicine 2024年第3期15卷 123-133页

作者： Elsy Rodriguez de Roa maría Gonzalez Yibirin david rincón m.t.te Carolina Aguilera Centro médico Uslar Distrito Capital Caracas Venezuela Investigación Clínica Grupo Leti Guarenas Venezuela

Background: the prevalence of both atrial fibrillation (FA) and diabetes mellitus (Dm) is increasing and they often occur together and constitute a high risk of thrombosis. Rivaroxaban is a Factor Xa inhibitor with a rapid onset and disappearance of action after oral administration;it acts by inhibiting the active form of the coagulation factor. In order to reflect the effect of the action of Rivaroxaban, we used the prothrombin time (Pt);however, it′s not the most accurate, but it is the one available in our community. methods: this was a prospective, randomized, analyst-blinded, parallel group clinical study to verify the efficacy of Rivaroxaban Leti 20 mg (RL) (12 volunteers vs Rivaroxaban Bayer 20 mg (RB) (13 volunteers). the variables were determination of Pt and Partial thromboplastin time (aPtt) at baseline and at 24, 48 and 72 hours after administering a daily dose of 20 mg for three days. the determination was carried out with the IDG method (Integrated Diagnostics Group Sanzay Corporation) with an International Sensitivity Index (ISI) of 1.17 Pt and aPtt were taken before the first dose, and then, every day during the next 3 days, three hours after the ingestion of their daily dose at 7 am. Results: the 25 healthy volunteers were similar in age, BmI, and SBP/DBP level with a greater number of men in the Bayer group. the efficacy of rivaroxaban was similar in both groups with prolongation of Ptt to the 2nd day of treatment with Pt, and percentage changes from baseline (14.46 ± 0.97 for RB vs 14.17 ± 0.94 RL p: 0.45), Ptt results and percentage changes from the base (RB: 34 ± 4.53 RL: 33.46 ± 2.82). the safety of rivaroxaban was good in both groups with no serious adverse events. the equivalence in the logarithmically transformed Pt result (ln) on day two, mean and CI (90%) 99.2 (94.4-104) and 100 (99.5-100.8);neither the means nor the 90% confidence intervals of the Pt variable transformed logarithmically to ensure its normality, were far from the 80%-125%

关键词： Pharmacodynamic Study Rivaroxaban Clinical trial Pt aPtt

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targeting muscle to treat Charcot-marie-tooth disease

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neural Regeneration Research 2024年第8期19卷 1653-1654页

作者： david Villarroel-Campos James n.Sleigh Department of neuromuscular Diseases and UCL Queen Square motor neuron Disease Centre UCL Queen Square Institute of NeurologyUniversity College LondonLondonUK UK Dementia Research Institute University College LondonLondonUK

Charcot-marie-tooth disease(Cmt)is a hereditary peripheral neuropathy causing muscle weakness/wasting and sensory dysfunction predominantly in limb *** patients display gait abnormalities,foot deformities,loss of sens... 详细信息

关键词： marie sensation neuropathy

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the role of n-glycosylation in cancer

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1098-1110页

作者： Yu Lin david m.Lubman Department of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer *** play an important role in medicine and are involved in various human disease conditions including ***-moieties participate in fundamental cancer processes like cell signaling,invasion,angiogenesis,and *** n-glycosylation significantly impacts cancer processes and targeted therapies in ***,understanding n-glycosylation in a tumor is essential for comprehending disease progression and discovering anti-cancer targets and biomarkers for therapy monitoring and *** review presents the fundamental process of protein n-glycosylation and summarizes glycosylation changes in tumor cells,including increased terminal sialylation,n-glycan branching,and ***,the role of n-glycosylation in tumor signaling pathways,migration,and metabolism are *** and glycopeptides as potential biomarkers for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteome,along with its role in medicine,implication in cancer and other human diseases,highlights the significance of n-glycosylation in tumor processes,necessitating further research for potential anticancer targets and biomarkers.

关键词： n-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers

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Role of climatic variability in shaping intraspecific variation of thermal tolerance in mediterranean water beetles

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Insect Science 2024年第1期31卷 285-298页

作者： Susana Pallarés david Garoffolo Belén Rodríguez david Sánchez-Fernández Department of Zoology University of SevilleSevilleSpain Faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

the climatic variability hypothesis(CVH)predicts that organisms in more thermally variable environments have wider thermal breadths and higher thermal plasticity than those from more stable ***,due to evolutionary trade-offs,taxa with greater absolute thermal limits may have little plasticity of such limits(trade-off hypothesis).the CVH assumes that climatic variability is the ultimate driver of thermal tolerance variation across latitudinal and altitudinal gradients,but average temperature also varies along such *** explored intraspecific variation of thermal tolerance in three typical mediterranean saline water beetles(families Hydrophilidae and Dytiscidae).For each species,we compared two populations where the species coexist,with similar annual mean temperature but contrasting thermal variability(continental *** population).We estimated thermal limits of adults from each population,previously acclimated at 17,20,or 25℃.We found species-specific patterns but overall,our results agree with the CVH regarding thermal ranges,which were wider in the continental(more variable)*** the two hydrophilid species,this came at the cost of losing plasticity of the upper thermal limit in this population,supporting the trade-off hypothesis,but not in the dytiscid *** results support the role of local adaptation to thermal variability and trade-offs between basal tolerance and physiological plasticity in shaping thermal tolerance in aquatic ectotherms,but also suggest that intraspecific variation of thermal tolerance does not fit a general pattern among aquatic *** such intraspecific variation could lead to inaccurate predictions of the vulnerability of aquatic insects to global warming.

关键词： acclimation capacity aquatic insects climate change heat coma temperature supercooling point thermal plasticity

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Cognitive function among military veterans with Stem occupations

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military medical Research 2024年第2期11卷 308-310页

作者： Justin t.mcDaniel Kevin n.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda m.Weidhuner Harvey Henson david L.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA Stem Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,there is limited research on the relationship between science,technology,engineering,and mathematics(Stem)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(Stem) Animal fluency test Dementia

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Evaluation of hand infections in the emergency department using point-of-care ultrasound

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World Journal of Emergency medicine 2024年第4期15卷 283-288页

作者： david Ahmad Haidar david mintz Brandon m Wubben Omar Rizvi Srikar Adhikari Department of Emergency medicine Michigan MedicineAnn Arbor 48109-1382USA University of Arizona College of medicine Tucson 85724USA Department of Emergency medicine University of IowaIowa City 52242-1009USA Department of Surgery University of Arizona College of MedicineTucson 85724USA Department of Emergency medicine University of Arizona College of MedicineTucson 85724USA

BACKGROUnD:We aimed to evaluate the utility of point-of-care ultrasound(POCUS)in the assessment of hand infections that present to the emergency department(ED)and its impact on medical decision making and patient ***:We conducted a retrospective review of patients who presented to two urban academic EDs with clinical presentations concerning for skin and soft tissue infections(SStI)of the hand between December 2015 and December *** trained POCUS fellowship physicians reviewed an ED POCUS database for POCUS examinations of the *** then reviewed patients’electronic health records(EHR)for demographic characteristics,history,physical examination findings,ED course,additional imaging studies,consultations,impact of POCUS on patient care and final ***:We included a total of 50 cases(28 male,22 female)in the final *** most common presenting symptoms and exam findings were pain(100%),swelling(90%),and erythema(74%).the most common sonographic findings were edema(76%),soft tissue swelling(78%),and fluid surrounding the tendon(57%).POCUS was used in medical decision making 68%of the time(n=34),with the use of POCUS leading to changes in management 38%of the time(n=19).POCUS use led to early antibiotic use(11/19),early consultation(10/19),and led to the performance of a required procedure(8/19).the POCUS diagnosis was consistent with the discharge diagnosis of flexor tenosynovitis 8/12 times,abscess 12/16 times,and cellulitis 14/20 ***:POCUS is beneficial for evaluating of hand infections that present to the ED and can be used as an important part of medical decision making to expedite patient care.

关键词： Ultrasound Point-of-care ultrasound Cellulitis Abscess Flexor tenosynovitis

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Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

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Journal of Energy Chemistry 2024年第4期91卷 99-110页

作者： marwan Laqdiem Julio García-Fayos Laura Almar Alfonso J.Carrillo Álvaro Represa Josém.López nieto Sonia Escolástico david Catalán-martinez Jose m.Serra Instituto de tecnología Química(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(Otms)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,Otms could provide oxygen from different sources(air,water,CO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,Otms can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional Otm material(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the Otm is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.the O_(2)permeation flux reached for the electrified membranes was~3.7 nmL min^(-1)cm^(-2),corresponding to the flux obtained with an Otm non-electrified at 900℃.the influence of depositing a porous Ce_(0.8)tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(CmR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect mixed ionic-electronic conductors Catalytic membrane reactors

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mitochondrial recruitment in myelin:an anchor for myelin dynamics and plasticity?

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neural Regeneration Research 2024年第7期19卷 1401-1402页

作者： Jean-david m.Gothié timothy E.Kennedy Department of neurology and neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optimal propagation of neuronal electrical impulses depends on the insulation of axons by myelin,produced in the central nervous system by *** is an extension of the oligodendrocyte plasma membrane,which wraps around an axon to form a compact multi-layered *** is composed of a substantially higher proportion of lipids compared to other biological membranes and enriched in a small number of specialized proteins.

关键词： plasticity insulation dynamics

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