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Polarization Flipping of Even-Order Harmonics in Monolayer Transition-Metal Dichalcogenides

Ultrafast Science 2021年第1期1卷 39-47页

作者： Yuki Kobayashi Christian Heide Hamed Koochaki Kelardeh Amalya Johnson Fang Liu Tony F.Heinz david A.reis Shambhu Ghimire Stanford PULSE Institute SLAC National Accelerator LaboratoryMenlo ParkCA 94025USA Department of Applied Physics Stanford UniversityStanfordCA 94305USA Max Planck Institute for the Physics of Complex Systems Nöthnitzer Str.3801187 DresdenGermany Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry Stanford UniversityStanfordCA 94305USA Department of Photon Science Stanford UniversityStanfordCA 94305USA

We present a systematic study of the crystal-orientation dependence of high-harmonic generation in monolayer transition-metal dichalcogenides,WS2 and MoSe2,subjected to intense linearly polarized midinfrared laser *** measured spectra consist of both odd-and even-order harmonics,with a high-energy cutoff extending beyond the 15th order for a laser-field strength around~1 V/*** WS2,we find that the polarization direction of the odd-order harmonics smoothly follows that of the laser field irrespective of the crystal orientation,whereas the direction of the even-order harmonics is fixed by the crystal mirror ***,the polarization of the even-order harmonics shows a flip in the course of crystal rotation when the laser field lies between two of the crystal mirror *** numerically solving the semiconductor Bloch equations for a gapped-graphene model,we qualitatively reproduce these experimental features and find the polarization flipping to be associated with a significant contribution from interband *** contrast,high-harmonic signals from MoSe2 exhibit deviations from the laser-field following of oddorder harmonics and crystal-mirror-plane following of even-order *** attribute these differences to the competing roles of the intraband and interband contributions,including the deflection of the electron-hole trajectories by nonparabolic crystal bands.

关键词： polarization harmonics mirror

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Fusobacterium is toxic for head and neck squamous cell carcinoma and its presence may determine a better prognosis

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Cancer Communications 2024年第8期44卷 879-883页

作者： Anjali Chander Jacopo Iacovacci Aize Pellon Radhika Kataria Anita Grigoriadis John Maher Cynthia Sears Gilad Bachrach Teresa Guerrero Urbano Mary Lei Imran Petkar Anthony Kong Tony Ng Ester Orlandi Nicola Alessandro Iacovelli Loris De Cecco Mara Serena Serafini david Moyes Tiziana Rancati Miguel reis Ferreira Centre for Host-Microbiome Interactions King’s College LondonLondonUK Comprehensive Cancer Centre King’s College LondonLondonUK Department of Oncology Guys and St Thomas NHS Foundation TrustLondonUK Data Science Unit Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Medicine Department Johns Hopkins University School of MedicineBaltimoreMarylandUSA Institute of Biomedical and Oral Research The Hebrew University-Hadassah School of Dental MedicineHadassah Ein Kerem CampusJerusalemIsrael Dipartimento di scienze Clinico-Chirurgiche Diagnostiche e PediatricheUniversitàdegli studi di PaviaPaviaItaly Radiation Oncology Department Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Department of Medicine Weill Cornell MedicineNew YorkUSA

Head and neck squamous cell carcinoma(HNSCC)is a devastating *** morbid treatment,5-year survival rates remain poor(28%-67%)[1].There is a significant knowledge gap regarding how the microbiota may impact HNSCC treatment efficacy[2].We used microbiome data from two independent cohorts to test and validate the hypothesis that oral bacteria are associated with HNSCC prognosis and in vitro models to investigate mechanistic *** are detailed in Supplementary Materials.

关键词： prognosis squamous carcinoma

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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

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Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti Sandesh Itani Josédavid Castro Sandra Carvalho Ana Sofia Ramos University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to ***,rapid degradation and inadequate strength limit their *** overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)*** approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising *** leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and *** paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr *** analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all ***,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%*** testing in simulated body fluid(SBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%*** with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/*** synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequentl

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

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Agreement between IOLMaster 500 and Pentacam HR for keratometry assessment in type 2 diabetic and nondiabetic patients

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International Journal of Ophthalmology(English edition) 2020年第6期13卷 920-926页

作者： Joao N Beato Joao Esteves-LeANDro david reis Rita Matos Manuel Falcao Vítor Rosas Angela Carneiro FernANDo Falcao-reis Department of Ophthalmology Sao Joao HospitalPorto 4200-319.Portugal Department of Surgery and Physiology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Faculty of Medicine University of PortoPorto 4200-319Portugal

AIM:To evaluate inter-device agreement of anterior keratometry obtained by the IOLMaster 500 and Pentacam HR in type 2 diabetic and non-diabetic ***:Corneal measurements were sequentially performed in 60 diabetes mellitus(DM)and 48 age and sex-matched controls undergoing cataract *** recorded included flat and steep keratometry,mean keratometry(Km),astigmatism magnitude,axis location,JO and J45 ***-Altman plots and intraclass correlation coefficients were used for examination of *** analyses were performed for astigmatism magnitude,diabetes duration,hemoglobin A1c(HbA1c)levels and diabetic retinopathy(DR)***:Agreement for Km and astigmatism magnitude were considered good and moderate,with 95%limits of agreement(LoA)of-1.09 to 1.23 diopters(D)and-0.83 to 0.86 D in DM group,respectively;and-0.59 to 0.72 D and-0.98 to 0.75 D in non-DM group,*** contrast,the 95%LoA for corneal axis exceeded the clinically relevant margins in both *** the total sample,only 41 eyes(38%)had a smaller than 5-degree *** duration,HbA1c levels and DR stage were not found to significantly affect *** regression showed that higher corneal power(P=0.021)and astigmatism magnitude(P=0.011)were associated with a decreased risk of having a difference in axis location greater than ***:In both groups,IOLMaster and Pentacam agree well for corneal power and moderately for ***,axis location disagreement is frequent in eyes with flatter corneas and small amounts of astigmatism.

关键词： keratometry diabetes mellitus astigmatism cataract diabetic retinopathy

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The cardiovascular aspects of a Ménière’s disease population——A pilot study

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Journal of Otology 2019年第2期14卷 51-56页

作者： Angela reis Rego david Dias Ana Pinto SANDra Sousa e Castro Telma Feliciano Cecília Almeida e Sousa ENT Department Centro Hospitalar e Universitário do Porto Largo do Prof.Abel Salazar

Introduction:MD is considered a rare *** adequate model that explains MD's pathophysiology is not well ***,the vascular theory of the disease has been ***:To characterize a MD population according to its cardiovascular risk and correlate it to the MD clinical ***:In this retrospective chart study the data of 31 MD patients observed between January 2017 and April 2018 in a tertiary university hospital were *** included in the study were diagnosed according to the Barany Society *** follow-ups,patients with autoimmune disease,atopy or allergy,major psychiatric disease and migraine were ***,gender,cardiovascular risk factors,audiometric and vestibular parameters,occurrence of MD attacks in the previous 6 months,vestibular medication in course and time course of MD were recorded and compared between groups(with and without cardiovascular risk factors).Results:31 patients(61.3%females)mean aged 60.3 years(±9.7)were studied.74%of the population had at least one risk factor and 51.6%of patients had attacks in the last 6 *** was a statistically significant difference in the occurrence of MD attacks in the last 6 months(p=0.014)between MD patients with and without risk *** PTA thresholds were higher and speech discrimination was lower in individuals with more cardiovascular risk ***:Treatment of MD focusing on vascular risk factors may allow a better control of symptoms and result in a decreased need for ablative procedures in this disorder.

关键词： Meniere disease Cardiovascular disease Hypertension Prognosis

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Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis

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World Journal of Gastroenterology 2018年第47期24卷 5351-5365页

作者： Marcela Alcantara Proenca Joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel reis david J Hughes Ana Elizabete Silva Department of Biology UNESPUniv. Estadual PaulistaCampus of Sao Jose do Rio PretoSao Jose do Rio PretoSao Paulo 15054-000Brazil Department of Surgery and Orthopedics Faculty of MedicineUNESPUniv. Estadual PaulistaCampus of BotucatuBotucatuSao Paulo 18618-687Brazil Endoscopy Center of Rio Preto Sao Jose do Rio PretoSao Paulo 15015-700Brazil Molecular Oncology Research Center Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Life and Health Sciences Research Institute University of MinhoCampus GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Campus GualtarBraga 4710-057Portugal Cancer Biology and Therapeutics Group UCD Conway InstituteUniversity College DublinDublin D04 V1W8Ireland

AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction *** Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high *** Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4.

关键词： Colorectal cancer Colorectal adenoma Fusobacterium nucleatum Inflammation Cytokines MicroRNAs

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The Quadrennial Ozone Symposium 2016

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Advances in Atmospheric Sciences 2017年第3期34卷 283-288页

作者： Sophie GODIN-BEEKMANN Irina PETROPAVLOSKIKH Stefan reis Paul NEWMAN Wolfgang STEINBRECHT Markus REX Michelle L. SANTEE Richard S. ECKMAN Xiandong ZHENG Matthew B. TULLY david S. STEVENSON Paul YOUNG John PYLE Mark WEBER Johanna TAMMINEN Gina MILLS Alkis F. BAIS Clare HEAVISIDE Christos ZEREFOS Observatoire de Versailles Saint-Quentin en Yvelines Universite de Versailles Saint-Quentin-en-Yvelines CNRS 78280 Guyancourt France CIRES University of Colorado Boulder CO 80309 USA NERC Centre for Ecology & Hydrology Edinburgh EH26 OQB UK Goddard Space Flight Center NASA Greenbelt MD 20771 USA Hohenpeissenberg Meteorological Observatory Deutscher Wetterdienst 82383 Hohenpeissenberg Germany Alfred Wegener Institute 14401 Potsdam Germany Jet Propulsion Laboratory California Institute of Technology CA 91109 USA NASA Headquarters Earth Science Division Washington DC USA Chinese Academy of Meteorological Sciences Beijing 100081 China Bureau of Meteorology Melbourne Victoria 3001 Australia University of Edinburgh School of GeoSciences Edinburgh EH9 3FE UK Lancaster Environment Centre Lancaster University Lancaster LA1 4YQ UK University of Cambridge Department of Chemistry Cambridge CB2 1EW UK University of Bremen Institute of Environmental Physics 28359 Bremen Germany Finnish Meteorological Institute Earth Observation FI-00101 Helsinki Finland NERC Centre for Ecology and Hydrology Bangor Gwynedd LL57 2UW Wales UK Aristotle University of Thessaloniki ELKE AUTH Thessaloniki Greece Public Health England Centre for Radiation Chemical and Environmental Hazards London UK Research Center for Atmospheric Physics & Climatology Academy of Athens Athens 10680 Greece University of Exeter Medical School Truro TR1 3HD UK

1. Overview The 2016 Quadrennial Ozone Symposium （QOS-2016） was held on 4-9 September 2016 in Edinburgh, UK. The Symposium was organized by the International Ozone Commission （IO3C）, the NERC Centre for Ecology ＆ Hydrology and the University of Edinburgh, and was co-sponsored by the International Union of Geodesy and Geophysics, the International Association of Meteorology and Atmospheric Sciences, and the World Meteorological Organization.

关键词： NERC The Quadrennial Ozone Symposium 2016 UK USA

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Isolation of Filamentous Fungi from the Caatinga Region and Production of Amylolytic Enzymes of Great Industrial Interest

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Journal of Biosciences and Medicines 2020年第11期8卷 152-164页

作者： Ingrid Cristina Soares Amorim Gessica Oliveira Marinho Tarcisio Michael Ferreira Soares de Oliveira Juan Pedro Bretas Roa Arlete Barbosa dos reis david Lee Nelson Thiago Machado Pasin Vivian Machado Benassi Instituto de Ciência e Tecnologia Universidade Federal dos Vales dos Jequitinhonha e Mucuri Campus JK Diamantina Brasil Programa de Pós-Graduaç ã o em Biocombustíveis Universidade Federal dos Vales dos Jequitinhonha e Mucuri Campus JK Diamantina Brasil Departamento de Bioquímica e Imunologia Faculdade de Medicina de Ribeir&atilde o Preto Universidade de S&atilde o Paulo Ribeir&atilde o Preto Brasil

The industrial importance and the high cost of the commercial amylase require the study of microorganisms that produce these enzymes. For this reason, the objective of this work was to isolate filamentous fungi from a region of the caatinga and evaluate their potential for the production of amylase. Four soil samples were collected from a deactivated dump located in the city of Diamantina, MG, in a region of the caatinga. The analysis of amylolytic production in a submerged medium at the ideal temperature of each microorganism was performed using the saccharification method, and the reducing sugars formed were quantified by DNS. Fourteen filamentous fungi were isolated, which had different morphological aspects. Regarding amylase production, a mean activity of 0.477 U·mL-1 was obtained with the isolates I 1.2.1 and I 4.4.1. These results bring important information regarding the biodiversity of the caatinga, in addition to the isolation of microorganisms that can be used as biological machinery to obtain metabolites with high biotechnological and industrial potential.

关键词： Amylolytic Enzyme Bioprospecting Filamentous Fungi Industrial Interest

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An Exploratory Behavioral Study in Children of Four Years of Age on the Hypothesis of a Two Streams System in Touch Perception and Language Development

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Psychology Research 2018年第11期8卷 567-571页

作者： david Catela Catarina Silva Joana reis Ana Paula Seabra Polytechnic Institute of Santarém SantarémPortugal

A two streams system seems to exist for tactile *** asked kindergarten children to identify(semantic)and describe the function of grasped unseen instruments of their daily life(fork,knife,spoon,brush,toothbrush,pencil,and scissor),and then,to simulate its use(pragmatic).The capacity to describe the function of the set of instruments was significantly superior to that of identifying them by name,although there was a significant direct association between identification and description of the function in the responses to the set of *** simulation of the instrument function was of two types:(i)use―the child simulated how the instrument is grasped and used;and(ii)incorporation―the child simulated the function of the instrument with her/his own *** results support the hypothesis of a two streams tactile system(semantic and pragmatic),and that kindergarten children have the ability to incorporate functional properties of instruments of their daily life,probably as a support for language development.

关键词： children language development tactile perception tool two streams system

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A Privacy Taxonomy for the Management of Ubiquitous Environments

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通讯和计算机（中英文版） 2013年第12期10卷 1529-1553页

作者： Valderi reis Quietinho Leithardt Guilherme Antonio. Borges Anubis Graciela de Morals Rossetto CarlosOberdan Rolim Claudio Fernando Resin Geyer Luiz Henrique Andrade Correia david Nunes Jorge SaSilva Institute of Technology National Service of lndustrial Training (SENAI) Porto Alegre 91140-000 Brazil Institute of Informatics Group of Parallel and Distributed Processing (GPPD) Federal University of Rio Grande do Sul (UFRGS) Porto Alegre 91509-900 Brazil Federal University of Lavras Lavras 37200-000 Brazil Coimbra University Coimbra 3030-290 Portugal

Pervasive and ubiquitous environments must handle the detection and management of users, devices and services, while guaranteeing the privacy of both the users and the environment itself. Current techniques for handling privacy found in the literature treating the subject in various ways, while concentrating on the device management, communication protocols, user profiles and environmental access. This paper examines a control model for privacy in pervasive environments from the perspective of the environment. A prototype was devised and tested to validate the generic model of privacy which was also used to compare taxonomic concepts in the literature. Moreover, the prototype was devised and tested to validate the generic model of privacy for control and manage various users, devices and environments and so on. The prototype was based on Percontrol (a system for pervasive user management), which was only intended to identify users using Wi-Fi, and now it is capable of managing temperature, luminosity and other preferences, measured by a WSN (wireless sensor network) embedded to Percontrol, and the data treatment is done by an ANN (artificial neural network). Results confirmed the viability of device detection with Wi-Fi, Bluetooth and RFID (radio frequency identification) for an increases slight of the latency in registering new devices on the system.

关键词：设备管理计算环境隐私控制分类用户配置文件无线传感器网络原型设计用户管理系统

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