检索结果-南通市图书馆

A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers

World Journal of Gastroenterology 2010年第46期16卷 5779-5789页

作者： Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo david p carbone Kohzoh Imai Yasuhisa Shinomura First Department of Internal Medicine Sapporo Medical University Department of Internal Medicine Sapporo Shirakabadai Hospital Vanderbilt-Ingram Cancer Center and Departments of Medicine and Cell Biology Vanderbilt University

Advances in molecular research in cancer have brought new therapeutic strategies into clinical *** new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) *** concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new *** I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human *** this review,we focus on this promising therapeutic target,*** IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI *** studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer *** results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and *** also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical *** mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single *** summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug ***,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcino

关键词： Dominant negative Gastrointestinal cancer Insulin like growth factor-I receptor Monoclonal anti-body Tyrosine kinase inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

液体活检在肺癌管理中新技术的发展和临床应用的拓展

引用

Science Bulletin 2024年第10期69卷 1556-1568页

作者：陈克终何越王文香袁晓秋 david p.carbone 杨帆 Department of Thoracic Surgery Peking University People’s HospitalBeijing 100044China peking University people’s Hospital Thoracic Oncology Institute&Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer Beijing 100044China peking University Health Science Center Beijing 100191China Thoracic Oncology Center Ohio State UniversityColumbus 43026USA

Lung cancer is an exceedingly malignant tumor reported as having the highest morbidity and mortality of any cancer worldwide,thus posing a great threat to global *** the growing demand for precision medicine,current methods for early clinical detection,treatment and prognosis monitoring in lung cancer are hampered by certain *** have found that during the formation and development of a tumor,molecular substances carrying tumor-related genetic information can be released into body *** biopsy(LB),a method for detecting these tumor-related markers in body fluids,maybe a way to make progress in these *** recent years,LB technology has undergone rapid ***,this review will provide information on technical updates to LB and its potential clinical applications,evaluate its effectiveness for specific applications,discuss the existing limitations of LB,and present a look forward to possible future clinical ***,this paper will introduce technical updates from the prospectives of engineering breakthroughs in the detection of membrane-based LB biomarkers and other improvements in sequencing ***,it will summarize the latest applications of liquid biopsy for the early detection,diagnosis,treatment,and prognosis of lung *** will present the interconnectedness of clinical and laboratory issues and the interplay of technology and application in LB today.

关键词： Liquid biopsy techniques Lung cancer Circulating tumor cells Circulating tumor DNA Sequencing technology Clinical application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

RANBp9 as potential therapeutic target in non-small cell lung cancer

引用

Journal of Cancer Metastasis and Treatment 2020年第1期6卷 177-187页

作者： Anna Tessari Shimaa H.A.Soliman Arturo Orlacchio Marina Capece Joseph M.Amann Rosa Visone david p.carbone Dario palmieri Vincenzo Coppola Department of Cancer Biology and Genetics College of MedicineThe Ohio State University and Arthur G.James Comprehensive Cancer CenterColumbusOH 43210USA Department of Medicine Dentistry and BiotechnologyG.d’Annunzio University of ChietiChieti 66100Italy Current address:Department of Biochemistry and Molecular Genetics Northwestern University Feinberg School of MedicineChicagoIL 60611USA Division of Medical Oncology Department of Internal MedicineCollege of MedicineThe Ohio State University and Arthur G.James Comprehensive Cancer CenterColumbusOH 43210USA

Non-small cell lung cancer(NSCLC)remains the leading cause of cancer-related deaths in the Western *** progress made with targeted therapies and immune checkpoint inhibitors,the vast majority of patients have to undergo chemotherapy with platinum-based *** increase efficacy and reduce potential side effects,a more comprehensive understanding of the mechanisms of the DNA damage response(DDR)is *** have shown that overexpressby live cell imaging Incuyion of the scaffold protein RAN binding protein 9(RANBp9)is pervasive in *** importantly,patients with higher levels of RANBp9 exhibit a worse outcome from treatment with platinum-based ***,RANBp9 exists as a target and an enabler of the ataxia telangiectasia mutated(ATM)kinase ***,the depletion of RANBp9 in NSCLC cells abates ATM activation and its downstream targets such as pby live cell imaging Incuy53 ***9 knockout cells are more sensitive than controls to the inhibition of the ataxia and telangiectasia-related(ATR)kinase but not to ATM *** absence of RANBp9 renders cells more sensitive to drugs inhibiting the poly(ADp-ribose)-polymerase(pARp)resulting in a“BRCAness-like”*** summary,as a result of increased sensitivity to DNA damaging drugs conferred by its ablation in vitro and in vivo,RANBp9 may be considered as a potential target for the treatment of *** article aims to report the results from past and ongoing investigations focused on the role of RANBp9 in the response to DNA damage,particularly in the context of *** review concludes with future directions and speculative remarks which will need to be addressed in the coming years.

关键词： RANBp9 RANBp10 Scorpins DNA damage DNA repair DNA damage response CTLH complex cisplatin non-small cell lung cancer pARp BRCAness-like phenotype

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

液体活检在肺癌管理中新技术的发展和临床应用的拓展（英文）

引用

Science Bulletin 2024年第10期 1556-1568页

作者：陈克终何越王文香袁晓秋 david p.carbone 杨帆 Department of Thoracic Surgery Peking University People's Hospital peking University people's Hospital Thoracic Oncology Institute&Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer peking University Health Science Center Thoracic Oncology Center Ohio State University

Lung cancer is an exceedingly malignant tumor reported as having the highest morbidity and mortality of any cancer worldwide, thus posing a great threat to global health. Despite the growing demand for precision medicine, current methods for early clinical detection, treatment and prognosis monitoring in lung cancer are hampered by certain bottlenecks. Studies have found that during the formation and development of a tumor, molecular substances carrying tumor-related genetic information can be released into body fluids. Liquid biopsy(LB), a method for detecting these tumor-related markers in body fluids, maybe a way to make progress in these bottlenecks. In recent years, LB technology has undergone rapid advancements. Therefore, this review will provide information on technical updates to LB and its potential clinical applications, evaluate its effectiveness for specific applications, discuss the existing limitations of LB, and present a look forward to possible future clinical applications. Specifically, this paper will introduce technical updates from the prospectives of engineering breakthroughs in the detection of membrane-based LB biomarkers and other improvements in sequencing technology. Additionally, it will summarize the latest applications of liquid biopsy for the early detection, diagnosis, treatment,and prognosis of lung cancer. We will present the interconnectedness of clinical and laboratory issues and the interplay of technology and application in LB today.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

GREEN BUILDING MATERIALS:A REVIEW OF STATE OF THE ART STUDIES OF INNOVATIVE MATERIALS

引用

Journal of Green Building 2017年第4期12卷 141-161页

作者： p.De Luca I.carbone J.B.Nagy Department of Ingegneria per l’Ambiente ed il Territorio ed Ingegneria Chimica University of CalabriaRendeItaly Department of Ingegneria Civile University of CalabriaRendeItaly

***is paper presents a comprehensive survey of the latest international publications(2012-2017)regarding innovative and environmentally sustainable materials that reduce the production of *** is recognised that world construction is responsible for substantial amounts of harmful *** particular,the survey collected data on new sustainable solutions and innovative materials,such as cement,wood,glass and ceramics that are essential to minimize the environmental impact of buildings on the ecosystem and to reduce the consumption of natural resources.erefore,the paper’s intent is to give an overview of the current state of the art and research in theeld of bio-building,gathering information on the environmental impacts of these innovative materials and listing the benets that can be obtained with their *** findings of this study support the growing importance of grecn building as a componcnt of the whole construction market and provide a benchmark against which to mcasure futurc changes in the industry over time.

关键词： innovative materials sustainable materials bio-building green building

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

potential physiological and pathological roles for axonal ryanodine receptors

引用

Neural Regeneration Research 2023年第4期18卷 756-759页

作者： david p.Stirling Kentucky Spinal Cord Injury Research Center and Departments of Neurological Surgery Anatomical Sciences and NeurobiologyMicrobiology and ImmunologyUniversity of LouisvilleSchool of MedicineLouisvilleKYUSA

Clinical disability following trauma or disease to the spinal cord often involves the loss of vital white matter elements including axons and *** excessive Cais an established driver of axonal degeneration,therapeutically targeting externally sourced Cato date has had limited success in both basic and clinical *** factors that may underlie this limited success include the complexity of the many potential sources of Caentry and the discovery that axons also contain substantial amounts of stored Cathat if inappropriately released could contribute to axonal *** Castorage is largely accomplished by the axoplasmic reticulum that is part of a continuous network of the endoplasmic reticulum that provides a major sink and source of intracellular Cafrom the tips of dendrites to axonal ***“neuron-within-a-neuron”is positioned to rapidly respond to diverse external and internal stimuli by amplifying cytosolic Calevels and generating short and long distance regenerative Cawaves through Cainduced *** review provides a glimpse into the molecular machinery that has been implicated in regulating ryanodine receptor mediated Carelease in axons and how dysregulation and/or overstimulation of these internodal axonal signaling nanocomplexes may directly contribute to Ca-dependent axonal *** ryanodine receptors expressed in dendrites,soma,and axonal terminals have been implicated in synaptic transmission and synaptic plasticity,but a physiological role for internodal localized ryanodine receptors remains largely *** physiological roles for internodal ryanodine receptors and such an elaborate internodal binary membrane signaling network in axons will also be discussed.

关键词： axomyelinic synapse axon axoplasmic reticulum calcium ryanodine receptor secondary axonal degeneration spinal cord injury voltage-gated calcium channel white matter injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gradient microstructure and enhanced mechanical performance of magnesium alloy by severe impact loading

引用

Journal of Materials Science & Technology 2020年第1期36卷 45-49页

作者： Maryam Jamalian david p.Field School of Mechanical and Materials Engineering.Washington State University PullmanUSA

Subjecting a workpiece to a surface treatment with severe impact loading is a novel severe plastic deformation procedure to fabricate gradient microstructures through the thickness and longitudinal *** performance is a function of twin density and the newly-formed grain size gradients.{1012}tensile twins created from processing without excessive grain refinement lead to strength enhancement with retained *** of residual strain by a single impact results in a significant reduction in time and cost of the *** paper investigates the effect of applying severe impact loading on mechanical and microstructural properties of magnesium for various impact velocities.

关键词： Surface modification Twinning Magnesium alloys Mechanical properties Severe impact loading(SIL)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Statistical analysis of physico-mechanical parameters of sandstones occurring in orogenic settings

引用

Journal of Mountain Science 2024年第4期21卷 1388-1402页

作者： pAppALARDO Giovanna carbone Serafina MONACO Carmelo ZOCCO Giordana MINEO Simone Dipartimento Di Scienze Biologiche Geologiche E AmbientaliUniversitàDegli Studi Di CataniaCorso Italia 5795129 CataniaItaly

In northeastern Sicily(Italy),sandstone rock masses widely crop out as cover deposits over crystalline terrains belonging to the orogenic *** being part of the same geological formation,these sandstones are characterized by highly different features in terms of texture and physico-mechanical *** poses a scientific question on the possibility of tracing these rocks to a single statistical model,which could be representative of their main engineering geological ***,it is worth investigating on the possible reasons of such differences,that should be searched either in the current geographical sandstone distribution or in the rock *** this study,sandstone samples were collected from different sites and were analyzed at both the hand and thin section *** sandstone types were recognized,characterized by a different ***,the laboratory characterization allowed estimating their main physico-mechanical and ultrasonic properties,such as porosity,density,mechanical strength,deformability,and ultrasonic *** rock mechanical strength proved linked to the rock compactness and to the presence of lithic fragments,while pores and a pseudo-matrix between grains represent weakening *** data were also statistically analyzed by grouping the specimens according to a geographical criterion,with respect to their sampling area,but no link was found between location and rock ***,with the aim of achieving mathematical laws that could be used to predict some rock properties from others,useful for practical purposes when dealing with such a high property variability,single and multiple regression analyses were carried *** show that the Uniaxial Compressive Strength,porosity,and p-wave velocity are the best predictors for a quick,indirect estimation of the main physico-mechanical *** methodological approach developed for this research can be taken as reference to study other world

关键词： Sandstone Laboratory test Uniaxial Compressive Strength porosity Rocks

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contemporary coronary artery bypass grafting

引用

Frontiers of Medicine 2014年第4期8卷 395-398页

作者： david p. Taggart Nuffield Department of Surgery University of Oxford John Radcliffe Hospital Oxford OX3 9DU UK

Current evidence clearly demonstrates that coronary artery bypass grafting （CABG） remains the ＂gold standard＂ treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.

关键词： coronary artery bypass grafting (CABG) coronary artery disease left main arterial grafts internal mammary artery off-pump CABG

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Direct-to-indirect mapping for optimal low-thrust trajectories

引用

Astrodynamics 2024年第1期8卷 27-46页

作者： david Ottesen Ryan p.Russell Department of Aerospace Engineering and Engineering Mechanics The University of Texas at AustinAustinTexas78712USA

Optimal,many-revolution spacecraft trajectories are challenging to solve.A connection is made for a class of models between optimal direct and indirect *** transfers that minimize thrust-acceleration-squared,primer vector theory maps direct,many-impulsive-maneuver trajectories to the indirect,continuous-thrust-acceleration *** mapping algorithm is independent of how the direct solution is obtained and requires only a solver for a boundary value problem and its partial derivatives.A Lambert solver is used for the two-body problem in this *** mapping is simple because the impulsive maneuvers and co-states share the same linear space around an optimal *** numerical results,the direct coast-impulse solutions are demonstrated to converge to the indirect continuous solutions as the number of impulses and segments *** two-body design space is explored with a set of three many-revolution,many-segment examples changing semimajor axis,eccentricity,and *** first two examples involve a small change to either semimajor axis or eccentricity,and the third example is a transfer to geosynchronous *** a single processor,the optimization runtime is seconds to minutes for revolution counts of 10 to 100,and on the order of one hour for examples with up to 500 *** of these thrust-acceleration-squared solutions are good candidates to start a homotopy to a higher-fidelity minimization problem with practical constraints.

关键词： direct optimization indirect optimization impulsive maneuvers Lambert's problem two-body dynamics primer vectortheory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：