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Relationship between Serum Leptin and Adiponectin Levels in Obese Nigerians with Type 2 Diabetes Subjects

Journal of Diabetes Mellitus 2023年第3期13卷 248-256页

作者： Rosemary Temidayo Ikem Ugochukwu Rosemary Mosanya Gbadebo Oladimeji david Ajani Okechukwu Obumneme Ezekpo david olubukunmi soyoye Department of Medicine Obafemi Awolowo University Ile Ife Nigeria Department of Orthopaedic Surgery & Traumatology Obafemi Awolowo University Teaching Hospitals Complex Ile Ife Nigeria Department of Medicine Afe Babalola University Ado Ekiti & Federal Medical Teaching Hospital Ido Ekiti Nigeria Department of Medicine Afe Babalola University & Multi-System Hospital Ado Ekiti Nigeria

Background: Obesity is rising globally, independent of ethnicity, race and age, and is associated with increased risk of cardiovascular mortality and morbidity especially in persons living with diabetes. The effect of adipokines such as leptin, resistin and adiponectin which are secreted by adipose tissue factors has been linked to the increased risk of the cardiovascular mortality and morbidity. Aim: This study aims to assess the levels of serum leptin and serum adiponectin in obese type 2 diabetes subjects, and their relationship with cardio-metabolic component (using lipid profile). Method: This is a cross-sectional comparative hospital-based study in which one hundred and fifty participants grouped into 60 obese, 60 non-obese none diabetic and 30 non-obese non-diabetic adults with similar age from the Endocrinology outpatient’s clinic, General outpatient department (GOPD) and staff clinic of Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC). Anthropometric parameters and other relevant clinical details of all subjects were obtained. Fasting venous blood samples were taken from all subjects for the determination of fasting plasma glucose (FPG), fasting lipid profile, glycosylated haemoglobin levels (HbA1C), fasting serum insulin, leptin, and adiponectin. Data was analysed using the Statistical Package of Social Sciences (SPSS) version 23.0. Results: Twenty-eight (46.7%)) subjects were males while 32 subjects (53.3%) were females (in obese groups). There was no statistical difference between these two groups for both sexes (p = 1.000). The age range for all subjects was 34 to 64 years with their mean age being 52 ± 7.3 years, and for type 2 subjects and the obese non-diabetic 50.7 ± 7.3 years respectively. The mean body mass index of the non-obese and non-diabetic was 23.7 ± 4 Kg/m2 while the anthropometric measurements of the obese two groups were similar. The lipid profile, serum leptin and adiponectin in both the obese groups

关键词： Obesity Type 2 DM Leptin Adipokines

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Diabetes and peripheral artery disease:A review

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World Journal of Diabetes 2021年第6期12卷 827-838页

作者： david olubukunmi soyoye Olugbenga Olusola Abiodun Rosemary Temidayo Ikem Babatope Ayodeji Kolawole Anthony Olubunmi Akintomide Department of Medicine Obafemi Awolowo UniversityIle-Ife 220282Osun StateNigeria Department of Medicine Obafemi Awolowo University Teaching HospitalIle-Ife 220282Osun StateNigeria Department of Medicine Federal Medical CentreJabi 900211AbujaNigeria

Peripheral arterial disease(PAD)refers to partial or complete occlusion of the peripheral vessels of the upper and lower *** usually occurs as part of systemic atherosclerosis in the coronary and cerebral *** prevalence of PAD is expected to continue to increase in the foreseeable future owing to the rise in the occurrence of its major risk *** ulcers,limb amputation and physical disability are some of its major *** mellitus(DM)remains a major risk for PAD,with DM patients having more than two-fold increased prevalence of PAD compared with the general *** clinical presentation in people with DM also differs slightly from that in the general *** addition,PAD in DM may lead to diabetic foot ulcers(DFUs),which precipitate hyperglycaemic emergencies and result in increased hospital admissions,reduced quality of life,and *** the epidemiological and clinical importance of PAD,it remains largely under diagnosed and hence undertreated,possibly because it is largely *** has been placed on neuropathy as a cause of DFUs,however PAD is equally *** review examines the epidemiology,pathophysiology and diagnosis of lower limb PAD in people with diabetes and relates these to the general *** also highlights recent innovations in the management of PAD.

关键词： Diabetes Peripheral arterial disease Diabetic foot ulcers Lower limb complications

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