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Diabetic cardio.yo.athy:Impo.tance o. direct evidence to.suppo.t the ro.es o. No.-like recepto. pro.ein 3 inflammaso.e and pyro.to.is

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Wo.ld Jo.rnal o. Diabetes 2024年第8期15卷 1659-1662页

作者： Lu Cai Yi Tan md Shahidul Islam Michael Ho.o.itz Kupper A Wintergerst Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States Department o. Bio.hemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Department o. Medicine University of AdelaideAdelaide 5005Australia Pediatric Research Institute Division of EndocrinologyDepartment of PediatricsWendy Novak Diabetes InstituteNorton Children’s HospitalUniversity of LouisvilleLouisvilleKY 40202United States

Recently,the ro.es o. pyro.to.is,a fo.m o. cell death induced by activated No.like recepto. pro.ein 3(NLRP3)inflammaso.e,in the patho.enesis o. diabetic cardio.yo.athy(DCM)have been extensively ***,mo.t studies have fo.used mainly o. whether diabetes increases the NLRP3 inflammaso.e and asso.iated pyro.to.is in the heart o. type 1 o. type 2 diabetic ro.ent mo.els,and whether vario.s medicatio.s and natural pro.ucts prevent the develo.ment o. DCM,asso.iated with decreased levels o. cardiac NLRP3 inflammaso.e and *** direct link o. NLRP3 inflammaso.e and asso.iated pyro.to.is to.the patho.enesis o. DCM remains unclear based o. the limited evidence derived fro. the available studies,with the appro.ches o. NLRP3 gene silencing o. pharmaceutical applicatio. o. NLRP3 specific *** thus emphasize the requirement fo. mo.e systematic studies that are designed to.pro.ide direct evidence to.suppo.t the link,given that several studies have pro.ided bo.h direct and indirect evidence under specific *** edito.ial emphasizes that the current investigatio. sho.ld be circumspect in its co.clusio.,i.e.,no. o.eremphasizing its ro.e in the patho.enesis o. DCM with the fact o. o.ly significantly increased expressio. o. activatio. o. NLRP3 inflammaso.e and pyro.to.is in the heart o. diabetic ro.ent *** clear-cut evidence-based causative ro.es o. NLRP3 inflammaso.e and pyro.to.is in the patho.enesis o. DCM can help to.develo. effective and safe medicatio.s fo. the clinical management o. DCM,targeting these bio.arkers.

关键词： Diabetic cardio.yo.athy Nucleo.ide o.igo.erizatio. do.ain No.-like recepto. pro.ein 3 inflammaso.e Cardiac cell death Pyro.to.is

A multi-mechanistic appro.ch to.the o.l reco.ery study o. a family o. amphiphilic po.ysaccharides

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Petro.eum Research 2024年第2期9卷 238-249页

作者： Funsho.Afo.abi Syed MMahmo.d Lunech Mario.Nur Asyraf md Akhir Bennett Tackie-o.o. Hamid Sharifigaliuk Center o. Research in Enhanced o.l Reco.ery Universiti Teknologi PETRONASSeri IskandarMalaysia Center fo. Subsurface Imaging Universiti Teknologi PETRONASSeri IskandarMalaysia Research Institute o. Petro.eum Industry(RIPI) TehranIran

Chemical enhanced o.l reco.ery(cEo.)remains o.e o. the mo.t po.ent tertiary reco.ery ***,it is expensive and rarely enviro.mentally ***-based amphiphilic po.ymers have been suggested as an alternative to.eradicating the challenges o. co.ventio.al cEo. because o. co.t-effectiveness,and ***,few in-depth studies exist in the literature to.investigate the pro.pects o. these materials.A new family o. amphiphilic po.ysaccharides was synthesized by hydro.ho.ic mo.ificatio. o. cellulo.e sulphate,and the Eo. functio.alities were *** no.el bio.o.ymers exhibited the ability to.alter ro.k wetting *** terms o. reco.ery,o.e o. the variants o. the synthesized bio.amphiphilic po.ymer(D-I)was able to.reduce residual o.l saturatio. to.12%at harsh co.ditio.s o. 60,000 ppm salinity at 75℃.Micro.o.el visual analysis revealed that the perfo.mance o. the no.el materials was due to.the co.binatio. o. mo.ility co.tro.,IFT lo.ering and emulsificatio.,wettability alteratio.,and *** a perfo.mance co.mensurate to.that o. a co.mercial hydro.ho.ically mo.ified po.ymer,it can be said that the no.el amphiphilic po.ysaccharides can stand as a viable cEo. agent fo. o.lfield applicatio.s.

关键词： Bio.based po.ymers Amphiphilic po.ysaccharides Eo. Cellulo.e sulphate Enviro.mental sustainability

Adaptive Clo.d Intrusio. Detectio. System Based o. Pruned Exact Linear Time Technique

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Co.puters, Materials & Co.tinua 2024年第6期79卷 3725-3756页

作者： Widad Elbakri Maheyzah md.Siraj Bander Ali Saleh Al-rimy Sultan No.an Qasem Tawfik Al-Hadhrami Faculty o. Co.puting Universiti Teknologi MalaysiaJohor BahruJohor81310Malaysia Co.puter Science Department College of Computer and Information SciencesImam Mohammad Ibn Saud Islamic University(IMSIU)Riyadh11432Saudi Arabia Scho.l o. Science and Techno.o.y Nottingham Trent UniversityNottinghamNG118NSUK

Clo.d co.puting enviro.ments,characterized by dynamic scaling,distributed architectures,and co.plex wo.k-lo.ds,are increasingly targeted by malicio.s *** threats enco.pass unautho.ized access,data breaches,denial-o.-service attacks,and evo.ving malware *** security so.utio.s o.ten struggle with the dynamic nature o. clo.d enviro.ments,highlighting the need fo. ro.ust Adaptive Clo.d Intrusio. Detectio. Systems(CIDS).Existing adaptive CIDS so.utio.s,while o.fering impro.ed detectio. capabilities,o.ten face limitatio.s such as reliance o. appro.imatio.s fo. change po.nt detectio.,hindering their precisio. in identifying *** can lead to.missed attacks o. an abundance o. false alarms,impacting o.erall security *** address these challenges,we pro.o.e ACIDS(Adaptive Clo.d Intrusio. Detectio. System)-*** no.el Adaptive CIDS framewo.k leverages the Pruned Exact Linear Time(PELT)algo.ithm and a Suppo.t Vecto. Machine(SVM)fo. enhanced accuracy and ***-PELT co.prises fo.r key co.po.ents:(1)Feature Selectio.:Utilizing a hybrid harmo.y search algo.ithm and the symmetrical uncertainty filter(HSo.SU)to.identify the mo.t relevant features that effectively differentiate between no.mal and ano.alo.s netwo.k traffic in the clo.d enviro.ment.(2)Surveillance:Emplo.ing the PELT algo.ithm to.detect change po.nts within the netwo.k traffic data,enabling the identificatio. o. ano.alies and po.ential security threats with impro.ed precisio. co.pared to.existing appro.ches.(3)Training Set:Labeled netwo.k traffic data fo.ms the training set used to.train the SVM classifier to.distinguish between no.mal and ano.alo.s behavio.r patterns.(4)Testing Set:The testing set evaluates ACIDS-PELT’s perfo.mance by measuring its accuracy,precisio.,and recall in detecting security threats within the clo.d *** evaluate the perfo.mance o. ACIDS-PELT using the NSL-KDD benchmark *** results demo.strate that ACIDS-PELT o.tperf

关键词： Adaptive clo.d IDS harmo.y search distributed denial o. service(DDo.) PELT machine learning SVM ISo.CID NSL-KDD

Heat and Mass Transfer o. No.-Newto.ian Peristaltic Flo. in a Channel in Presence o. Magnetic Field: Analytical and Numerical Analysis

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Applied Mathematics 2024年第8期15卷 568-583页

作者： md. Maruf Hasan md. Enamul Karim md. Abdus Samad Department o. Mathematics Comilla University Comilla Bangladesh Department o. Applied Mathematics University of Dhaka Dhaka Bangladesh

A study has been arranged to.investigate the flo. o. no.-Newto.ian fluid in a vertical asymmetrical channel using peristalsis. The po.o.s medium allo.s the electrically co.ductive fluid to.flo. in the channel, while a unifo.m magnetic field is applied perpendicular to.the flo. directio.. The analysis takes into.acco.nt the co.bined influence o. heat and mass transfer, including the effects o. So.et and Dufo.r. The flo.’s no.-Newto.ian behavio. is characterized using a Casso. rheo.o.ical mo.el. The fluid flo. equatio.s are examined within a wave frame o. reference that has a wave velo.ity. The analytic so.utio. is examined using lo.g wavelengths and a small Reyno.ds number assumptio.. The stream functio., temperature, co.centratio. and heat transfer co.fficient expressio.s are derived. The bvp4c functio. fro. MATLAB has been used to.numerically so.ve the transfo.med equatio.s. The flo. characteristics have been analyzed using graphs to.demo.strate the impacts o. different parameters.

关键词： Stream Functio. Mass Transfer Vertical Channel Casso. Fluid

Structure Design o. Underwater Micro.Ro.o.

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Mo.ern Mechanical Engineering 2024年第1期14卷 12-24页

作者： md Shahriar Sujan Jo. Ho.lader md Jahangir Alam md Al Imran Tapu Co.lege o. Harbo. Co.stal & o.fsho.e Engineering Hohai University Nanjing China Department o. Co.puter Science and Info.matio. Techno.o.y College of Computer and Information Hohai University Nanjing China Co.lege o. Civil and Transpo.tatio. Engineering Hohai University Nanjing China

A submergible ro.o. mo.el has been presented, and fo. 3D printing measures, their parts have been mo.ified eno.gh. It has been sho.n in o.r design that using printable co.necto.s—a few engines and weight arrangements can be carried o.t, permitting distinctive mo.ing pro.pects. After presenting o.r co.figuratio. and delineating a bunch o. po.ential structures, a helpful mo.el dependent o. o.en-so.rce equipment and pro.ramming arrangements has been presented co.ditio.ally. The mo.el can be effectively tried in a few makes-a plunge streams and lakes thro.gho.t the planet. The unwavering quality o. the printed mo.els can be strained distinctly in generally shallo. waters. No.etheless, we accept that their accessibility will inspire the o.erall po.ulatio. to.co.struct and test submerged ro.o.s, subsequently accelerating the impro.ement o. imaginative arrangements and applicatio.s.

关键词： Submergible Ro.o. Thruster Adapter Raspberry Pi 3D Printer o.en So.rce So.tware

Gradient o.timizer Algo.ithm with Hybrid Deep Learning Based Failure Detectio. and Classificatio. in the Industrial Enviro.ment

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Co.puter Mo.eling in Engineering & Sciences 2024年第2期138卷 1341-1364页

作者： Mo.amed Zaro.an Ibrahim M.Mehedi Shaikh Abdul Latif md.Masud Rana Department o. Electrical and Co.puter Engineering(ECE) King Abdulaziz UniversityJeddah21589Saudi Arabia Center o. Excellence in Intelligent Engineering Systems(CEIES) King Abdulaziz UniversityJeddah21589Saudi Arabia Department o. Nuclear Engineering King Abdulaziz UniversityJeddah21589Saudi Arabia Department o. Electrical and Electro.ic Engineering Rajshahi University of Engineering and TechnologyRajshahiBangladesh

Failure detectio. is an essential task in industrial systems fo. preventing co.tly do.ntime and ensuring the seamlesso.eratio. o. the system. Current industrial pro.esses are getting smarter with the emergence o. Industry ***, vario.s mo.ernized industrial pro.esses have been equipped with quite a few senso.s to.co.lectpro.ess-based data to.find faults arising o. prevailing in pro.esses alo.g with mo.ito.ing the status o. *** diagno.is o. ro.ating machines serves a main ro.e in the engineering field and industrial pro.uctio.. Dueto.the disadvantages o. existing fault, diagno.is appro.ches, which greatly depend o. pro.essio.al experienceand human kno.ledge, intellectual fault diagno.is based o. deep learning (DL) has attracted the researcher’sinterest. DL reaches the desired fault classificatio. and auto.atic feature learning. Therefo.e, this article designs a Gradient o.timizer Algo.ithm with Hybrid Deep Learning-based Failure Detectio. and Classificatio. (Go.HDLFDC)in the industrial enviro.ment. The presented Go.HDL-FDC technique initially applies co.tinuo.s wavelettransfo.m (CWT) fo. prepro.essing the actual vibratio.al signals o. the ro.ating machinery. Next, the residualnetwo.k (ResNet18) mo.el was explo.ted fo. the extractio. o. features fro. the vibratio. signals which are thenfed into.theHDLmo.el fo. auto.ated fault detectio.. Finally, theGo.-based hyperparameter tuning is perfo.medto.djust the parameter valueso. theHDLmo.el *** experimental result analysis o. the Go.HDL-FD Calgo.ithm takes place using a series o. simulatio.s and the experimentatio. o.tco.es highlight the better resultso. the Go.HDL-FDC technique under different aspects.

关键词： Fault detectio. Industry 4.0 gradient o.timizer algo.ithm deep learning ro.ating machineries artificial intelligence

A Co.parative Study o. 3D Virtual Pattern and Traditio.al Pattern Making

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Jo.rnal o. Textile Science and Techno.o.y 2024年第1期10卷 1-24页

作者： md. Ahshan Habib md. Shamsul Alam Department o. Fashio. Design & Techno.o.y Sonargaon University Dhaka Bangladesh Department o. Apparel Manufacture & Techno.o.y Sonargaon University Dhaka Bangladesh

Pattern making plays a key ro.e in the aspect o. fashio. design and garment pro.uctio., as it serves as the transfo.mative pro.ess that turns a simple drawing into.a co.sistent accumulatio. o. garments. The pro.ess o. creating co.ventio.al o. manual patterns requires a significant amo.nt o. time and a specialized skill set in vario.s areas such as grading, marker planning, and fabric utilizatio.. This study examines the po.ential o. 3D techno.o.y and virtual fashio. designing so.tware in o.timizing the efficiency and co.t-effectiveness o. pattern pro.uctio. pro.esses. The pro.o.ed metho.o.o.y is characterized by a higher level o. co.prehensiveness and reliability, resulting in time efficiency and pro.iding a diverse range o. design o.tio.s. The user is no. expected to.po.sess co.prehensive kno.ledge o. traditio.al pattern creatio. pro.edures prio. to.engaging in the task. The so.tware o.fers a range o. capabilities including draping, 3D-to.2D and 2D-to.3D unfo.ding, fabric drivability analysis, ease allo.ance calculatio., add-fullness manipulatio., style develo.ment, grading, and virtual garment try-o.. The strategy will cause a shift in the viewpo.nts and metho.o.o.ies o. business pro.essio.als when it co.es to.the use o. 3D fashio. design so.tware. Upo. reco.nizing the po.ential time, financial, and reso.rce-saving benefits asso.iated with the integratio. o. 3D techno.o.y into.their design develo.ment pro.ess, individuals will be mo.ivated to.select fo. its utilizatio. o.er co.ventio.al pattern making metho.s. Individuals will po.sess the capacity to.transfer their co.nitive pro.esses and engage in intro.pectio. regarding their pro.essio.al endeavo.s and current activities thro.gh the utilizatio. o. 3D virtual pattern-making and fashio. design techno.o.ies. To.enhance the efficacy and eco.o.ical sustainability o. designs, designers have the po.ential to.integrate 3D techno.o.y with virtual fashio. so.tware, thereby co.pliant advantages fo. bo.h co.mercial enterpri

关键词： Pattern-Making 3D Pattern Making Virtual Fashio. 3D-to.2D Unfo.ding Sustainable Designs

Design and Analysis o. Po.er and Transmissio. System o. Do.nho.e Pure Electric Co.mand Vehicle

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Jo.rnal o. Transpo.tatio. Techno.o.ies 2024年第1期14卷 31-52页

作者： md Jahangir Alam md Shahriar Sujan md. Al Imran Tapu Jo. Ho.lader Co.lege o. Civil and Transpo.tatio. Engineering Hohai University Nanjing China Co.lege o. Harbo. Co.stal & o.fsho.e Engineering Hohai University Nanjing China Department o. Co.puter Science and Techno.o.y College of Computer and Information Hohai University Nanjing China

Electric vehicles use electric mo.o.s, which turn electrical energy into.mechanical energy. As electric mo.o.s are co.ventio.ally used in all the industry, it is an established develo.ment site. It’s a mature techno.o.y with ideal po.er and to.que curves fo. vehicular o.eratio.. Co.ventio.al vehicles use o.l and gas as fuel o. energy sto.age. Altho.gh they also.have an excellent eco.o.ic impact, the co.tinuo.s use o. o.l and gas threatened the wo.ld’s reservatio. o. to.al o.l and gas. Also. they emit carbo. dio.ide and so.e to.ic ingredients thro.gh the vehicle’s tailpipe, which causes the greenho.se effect and serio.sly impacts the enviro.ment. So. as an alternative, electric car refers to.a green techno.o.y o. decarbo.izatio. with zero.emissio. o. greenho.se gases thro.gh the tailpipe. So. they can remo.e the pro.lem o. greenho.se gas emissio.s and so.ve the wo.ld’s remaining no.-renewable energy sto.age pro.lem. Pure electric vehicles (PEV) can be applied in all spheres, but their special implementatio. can o.ly be seen in do.nho.e o.eratio.s. They are used fo. lo. no.se and less po.lutio. in the do.nho.e pro.ess. In this study, the basic structure o. the pure electric co.mand vehicle is studied, the main co.po.ents o. the co.mand vehicle po.er system, namely the selectio. o. the drive mo.o. and the po.er battery, are analyzed, and the main parameters o. the drive mo.o. and the po.er battery are designed and calculated. The checking calculatio. results sho. that the po.er and transmissio. system develo.ed in this paper meets the design requirements, and the design scheme is feasible and reaso.able.

关键词： Pure Electric Vehicles Transmissio. Gears Electro.ic Differential Co.tro. Algo.ithms

Activatio. o. cerebral Ras-related C3 bo.ulinum to.in substrate(Rac) 1 pro.o.es po.t-ischemic stro.e functio.al reco.ery in aged mice

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Neural Regeneratio. Research 2024年第4期19卷 881-886页

作者： Fan Bu Jia-Wei Min md Abdur Razzaque Ahmad El Hamamy Antho.y Patrizz Li Qi Akihiko.Urayama Jun Li Department o. Neuro.o.y University of Texas Health Science Center Department o. Neuro.o.y&Psycho.o.y The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine

Brain functio.al impairment after stro.e is co.mo.;ho.ever,the mo.ecular mechanisms o. po.t-stro.e reco.ery remain *** is well-reco.nized that age is the mo.t impo.tant independent predicto. o. po.r o.tco.es after stro.e as o.der patients sho. po.rer functio.al o.tco.es fo.lo.ing *** evidence suggests that axo.al regeneratio. and angio.enesis,the majo. fo.ms o. brain plasticity respo.sible fo. po.t-stro.e reco.ery,diminished with advanced *** studies suggest that Ras-related C3 bo.ulinum to.in substrate(Rac)1 enhances stro.e reco.ery as activatio. o. Rac1 impro.ed behavio. reco.ery in a yo.ng mice stro.e ***,we investigated the ro.e o. Rac1 signaling in lo.g-term functio.al reco.ery and brain plasticity in an aged(male,18 to.22 mo.ths o.d C57BL/6J)brain after ischemic *** fo.nd that as mice aged,Rac1 expressio. declined in the *** o.erexpressio. o. Rac1,using lentivirus enco.ing Rac1 injected day 1 after ischemic stro.e,pro.o.ed co.nitive(assessed using no.el o.ject reco.nitio. test)and senso.imo.o.(assessed using adhesive remo.al tests)reco.ery o. days 14–*** was acco.panied by the increase o. neurite and pro.iferative endo.helial cells in the periinfarct zo.e assessed by *** a reverse appro.ch,pharmaco.o.ical inhibitio. o. Rac1 by intraperito.eal injectio. o. Rac1 inhibito. NSC23766 fo. 14 successive days after ischemic stro.e wo.sened the o.tco.e with the reductio. o. neurite and pro.iferative endo.helial ***,Rac1 inhibitio. reduced the activatio. o. p21-activated kinase 1,the pro.ein level o. brain-derived neuro.ro.hic facto.,and increased the pro.ein level o. glial fibrillary acidic pro.ein in the ischemic brain o. day 28 after *** wo.k pro.ided insight into.the mechanisms behind the diminished plasticity after cerebral ischemia in aged brains and identified Rac1 as a po.ential therapeutic target fo. impro.ing functio.al reco.ery in the o.der adults after stro.e.

关键词： aging angio.enesis brain-derived neuro.ro.hic facto.(BDNF) cerebral ischemia co.nitive reco.ery neurite Pak1 Rac1 senso.imo.o. reco.ery